Articles tagged with Radiation Therapy
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A meta-analysis of 36 clinical trials reveals that optimal radiation therapy significantly improves patient survival rates in breast cancer patients. The analysis found a 2.9% and 6.4% absolute increase in survival at 5 and 10 years, respectively.
A new study found that radiotherapy significantly reduces breast cancer mortality and local recurrence rates, particularly in women with lymph node involvement. Radiotherapy can improve long-term survival, especially for those with a history of breast-conserving surgery or mastectomy.
A study found that women's travel distance to a radiation facility significantly impacted the use of Breast-Conserving Surgery (BCSR). The odds of receiving BCSR fell by 50% for every 5-mile increase in distance. Socioeconomic factors, such as lack of insurance and ethnicity, also negatively affected BCSR usage.
Researchers found a higher rate of pelvic fractures in women who received pelvic irradiation for cancer compared to those who did not. The study, which included 6,428 women aged 65 years and older, showed a significant increase in fracture risk for all three types of cancer diagnoses.
Researchers found that women who underwent radiation therapy for anal and rectal cancer had nearly double the rate of fractures compared to those without radiation therapy. The study also found that most fractures (90%) were hip fractures, highlighting the need for preventive measures.
A new combination treatment for glioblastoma has been found to improve survival rates without negatively affecting patients' quality of life. The study, which involved 573 patients, found no significant differences in six out of seven health-related quality of life measures after three months.
ECCO 13 study investigates post-treatment parenthood success rates in Hodgkin's lymphoma patients, with radiotherapy and chemotherapy linked to higher pregnancy success. The research highlights the importance of preserving fertility in young cancer survivors.
A Dutch study found that higher doses of radiotherapy significantly improved patient outcome over a five-year period. An anti-androgen therapy trial suggested early treatment can benefit locally advanced disease, while immunotherapy trials are showing promising results for androgen-independent prostate cancer.
Patients with early-stage non-small cell lung cancer responded well to high doses of radiation administered through extracranial stereotactic body radiation therapy. The Phase I clinical trial treated 47 individuals with the procedure, which spared them from surgery and allowed for higher doses of radiation in a shorter period.
Researchers at Johns Hopkins Kimmel Cancer Center have found hormone therapy will not diminish the value of radiation for prostate cancer. Additionally, a leukemia drug shows modest benefits in suppressing PSA levels for some men with localized prostate cancer.
Researchers at the University of Rochester Medical Center have successfully treated 72 patients with metastatic liver lesions using precision radiation therapy. The treatment resulted in a median survival time of 13 months, showing promise as an effective option for patients who previously had limited treatment options.
Researchers have found a dose-response relationship between IMRT volume and oral mucositis severity in head and neck cancer patients. Constricting IMRT dose can lessen toxic effects of treatment, reducing side effects for patients.
Combining chemotherapy with radiation therapy before surgery improves local tumor control and reduces cancer return rates. The study, published by the American Society for Radiation Oncology, suggests this treatment should be recommended for most rectal cancer patients.
A study of 869 women found that radiation therapy after surgery reduced breast cancer recurrence by almost 100%, with an overall survival rate of 97%. Radiation therapy also did not impact patients' quality of life or long-term survival rates.
A new one-week radiation treatment for breast cancer patients has shown promising results, with no patient recurrence after 48 months and 80% of women experiencing good-to-excellent cosmetic outcomes. The treatment uses MammoSite brachytherapy to deliver high doses of radiation to the surrounding tumor area.
Researchers studied 1,131 patients with early-stage Hodgkin's lymphoma and found that reducing the radiation dose from 30 Gy to 20 Gy significantly improved patient outcomes. Over 98% of patients experienced complete remission, while side effects were reduced.
A study conducted between 1988 and 1995 found that radiation therapy significantly improved five- and 10-year prostate cancer-free survival rates. The treatment reduced the risk of recurrence, cancer spread, and overall mortality in patients with advanced stage prostate cancer.
A study of 487 cancer patients found that almost twice as many used CAM therapies when treated with chemotherapy alone compared to radiation therapy. Patients reported high satisfaction with using cost-effective CAM methods like supplements, but few relied on their doctors for information on these treatments.
Researchers at the Mayo Clinic found that breast conservation surgery followed by radiation therapy can lead to favorable cosmetic results in patients with implanted breasts. The study challenged previous reports of poor outcomes.
Researchers developed a new radiation technique that targets cancer while sparing hair follicles, resulting in minimal hair loss. The study used intensity modulated radiation therapy (IMRT) on 10 patients with stage IV brain cancer, showing promising results and improved overall survival rates.
Researchers found that gene therapy using manganese superoxide dismutase plasmid liposome (MnSOD-PL) protected healthy tissue from damage during and after radiation retreatment. The therapy significantly improved survival rates and reduced side effects in lung cancer patients.
Mr. Anduri, a 30-year lymphoma survivor, is being recognized for his dedication to helping others in the local community through volunteer work with CanSurmount and the National Coalition for Cancer Survivorship. The award highlights his generous spirit and good coming out of his cancer experience.
The new ASTRO/ASRT grant program aims to establish new radiation therapy programs, addressing significant shortages in the field. Currently, there are only 71 accredited educational programs in the US, down from 125 a decade ago, and 13 states have no radiation therapy program.
A new study found that short-term hormone therapy can significantly improve the outlook for men with early-stage prostate cancer. Researchers discovered that testosterone suppression before and during radiotherapy reduced the risk of relapse by up to 44%.
A model predicts that young women treated for Hodgkin lymphoma are at increased risk of developing breast cancer, with risks rising with age and radiation exposure. Current treatment guidelines may be reconsidered to minimize these risks.
A multi-institutional effort aims to develop responses to 'dirty bombs' and other radioactive threats. The Biodesign Institute and TGen will create biodosimetry devices and diagnostic systems to rapidly analyze radiation exposure levels.
A randomized trial found that high-dose radiation therapy reduced the risk of prostate cancer recurrence by 49% compared to conventional-dose therapy. The study showed improved biochemical control and local tumor control without significant differences in overall survival rates or adverse effects.
A large study found that young children with medulloblastoma are at risk of impaired reading skills after radiation therapy, even if they receive lower doses. The greatest decline in IQ and reading skills occurred in patients younger than 7 years old.
Researchers found direct decompressive surgery plus postoperative radiotherapy to be the most effective treatment, enabling 84% of patients to walk after treatment. This approach also reduced dependence on corticosteroids and opiod analgesics, showing significant benefits for patients with metastatic cancer.
Researchers found that HIF-1 inhibition impacts tumor biology differently depending on the local environment, with proximal cells less affected. This study suggests optimizing HIF-1 blockade to maximize effects on vasculature and minimize effects on distal tumor cells.
Researchers found that immediate postoperative radiotherapy significantly improved biochemical progression-free survival for patients at risk of relapse, with a 74% success rate compared to 53%. Long-term follow-up is needed to assess its effects on distant metastases and survival.
A recent study published in The Lancet found that a single dose of chemotherapy is comparable to radiotherapy in treating stage 1 seminoma. Patients who received chemotherapy had fewer seminomas occurring in their remaining testicle and were less likely to develop tumors.
A study of 60 male and 4,181 female breast cancer patients found that men were almost six times more likely to receive radiotherapy than women with similar disease stages. The researchers concluded that men should be treated using the same guidelines as women for radiotherapy treatment.
A study of 1500 men with locally confined prostate cancer found that delaying radiation therapy did not affect overall survival, disease-specific survival, or treatment failure rates. This research provides reassurance for patients considering delayed treatment, allowing them to make informed decisions.
A daily bioadhesive buccal tablet containing 50mg of miconazole has been shown to be as effective as a four-times-daily mouth gel in treating oropharyngeal candidiasis among head and neck cancer patients. This simpler treatment schedule may improve quality of life and increase patient compliance.
Researchers have developed a new treatment called RADPLAT, which combines radiation and cisplatin delivered directly to the tumor via tiny catheters. This approach has shown encouraging results in patients with advanced stage IV-T4 disease, with high rates of local and regional tumor control and overall survival.
Researchers found that tamoxifen significantly reduced the frequency of breast enlargement and breast pain compared to radiotherapy. The study showed that tamoxifen is a more effective treatment for preventing these side effects in prostate cancer patients.
A study found that women with left-sided breast cancer had a higher risk of death from ischemic heart disease after radiation therapy, but this increased risk declined over time. Advances in radiation techniques have reduced the dose to the heart, resulting in lower mortality rates among women diagnosed with right-sided breast cancer.
A meta-analysis of nine randomized trials found no significant difference in death rates or disease progression between neoadjuvant and adjuvant systemic therapy. However, neoadjuvant therapy was associated with a higher risk of loco-regional disease recurrence when radiation therapy was used without surgery.
The addition of locoregional radiation therapy significantly improved breast cancer survival and reduced mortality in high-risk patients. A 20-year follow-up study found that the regimen resulted in a 32% reduction in breast cancer mortality and a 27% reduction in overall mortality compared to chemotherapy alone.
Researchers found that PGE2 activates AKT phosphorylation events to block bax translocation and prevent cell death in radiation-exposed mice. This mechanism suggests that PGE2 or similar drugs could reduce radiation-induced small intestine injury, but may not be effective for cancers with mutated bax.
A study of 189 breast cancer patients found no association between paclitaxel chemotherapy and radiation pneumonitis. No hospitalized cases or deaths from the side effect occurred, regardless of treatment group.
The U.Va. Health System's new TomoTherapy system provides precise radiation therapy with 3-D imaging, reducing high-dose exposure to healthy tissue and potential side effects for cancer patients. The technology also enables faster treatment times and improved accuracy in targeting tumors.
Increased investment in radiotherapy can significantly improve cure rates for European cancer patients. In the UK and Netherlands, calls for increased funding led to substantial improvements. However, under- utilization of radiotherapy is common in many EU countries due to inadequate infrastructure and staffing.
The GENEPI project aims to predict radiotherapy efficacy and side effects based on genetic, physical, and patient-related factors. It will establish a pan-European database on radiation-related morbidity, enabling researchers to investigate factors influencing individual responses to radiotherapy.
A randomised clinical trial found that post-operative radiotherapy significantly improved biological and clinical progression-free survival in men with high-risk prostate cancer. The study showed a clear benefit in terms of biological progression-free survival for men who received radiotherapy treatment in addition to surgery.
Combination therapy of radiotherapy and cetuximab significantly improves loco-regional control, median survival, and overall survival rates in patients with loco-regionally advanced squamous cell carcinoma of the oropharynx, hypopharynx, or larynx. The treatment also showed minimal enhancement of toxicity compared to radiotherapy alone.
A new radiotherapy regime has been shown to significantly reduce local disease recurrence rates in young women with breast cancer. The treatment involves adding a boost dose of radiation to the tumour bed, resulting in a 5-year local recurrence rate of 8.5% in women under 35 years old.
African-American men reported significantly higher sexual and urinary function five years after prostatectomy compared to non-Latino white men. However, they also experienced slightly more bother from changes in their function.
Intensity modulated radiation therapy (IMRT) significantly reduces radiation dose to healthy breast tissue, limiting side effects and improving treatment outcomes. By administering precise doses of radiation at the tumor site, IMRT can spare patients from skin irritation, breakdown, and scarring of the lungs.
A study by Fox Chase Cancer Center found that prostate cancer patients with intermediate-risk disease do not require long-term androgen deprivation if they receive high-dose radiation above 76 Gy. High doses of radiation were associated with better outcomes in this patient group.
A study by Mitchell Machtay found that correcting anemia does not improve tumor control or survival in head and neck cancer patients. Despite increasing red blood cell count, erythropoietin did not enhance radiation therapy outcomes.
Researchers at Mount Sinai present groundbreaking studies on prostate and breast cancer treatments, identifying genetic predictors for adverse side effects and developing tailored radiotherapy regimens. The studies aim to improve clinical trials and patient outcomes for these devastating diseases.
A new study found that prostate cancer treatment can significantly impact men's quality of life, with both radical prostatectomy and radiotherapy causing declines in sexual function, urinary incontinence, and bowel issues. The study, which followed over 1,100 men with clinically localized prostate cancer, suggests that the treatments d...
A study of over 600 older women with receptor-positive breast tumors found that tamoxifen alone was as effective as radiation therapy in preventing recurrence. The research suggests that radiation may not be necessary for these patients, improving their quality of life and reducing side effects.
Using combination therapies that include 6 months of androgen suppression therapy (AST) alongside radiation therapy (RT) improves survival rates for patients with locally advanced prostate cancer. The study found significantly higher survival rates, lower prostate cancer-specific mortality, and a reduced need for salvage AST in the com...
A randomized clinical trial found that combining six months of hormone therapy with radiation therapy reduced the risk of death from prostate cancer by two-fold. Patients treated with this combination therapy had a lower risk of requiring salvage hormone therapy in the long term.
A new study by Mount Sinai School of Medicine researchers found that combining three therapeutic modalities increases the percentage of high-risk patients who are free from recurrence after five years. A three-pronged approach that included brachytherapy, external beam radiation therapy and hormonal therapy produced an 86 percent rate ...
Accelerated partial breast irradiation (APBI), also known as brachytherapy, treats breast cancer with minimal radiation exposure. This technique reduces treatment time to four to five days and improves convenience for women with busy lifestyles or rural locations.
A study using FMISO-PET scans found that high uptake of the tracer correlates with a greater risk of tumor recurrence, while low uptake is associated with a longer survival rate. The technique may enable more precise prediction of therapeutic outcomes and improved patient treatment.