Research on high blood pressure and its consequences. Covers heart-failure prediction, kidney-disease models, AI detection, and cardiovascular risk.
Researchers used a novel transgenic strategy to create ProC mice with low protein C levels, which spontaneously developed thrombosis and inflammation. The study found that maternal ProC is required for sustaining pregnancy, highlighting the role of protein C in development and disease.
A randomized trial of 202 participants showed a 23% reduction in all-cause mortality, a 30% reduction in cardiovascular disease mortality, and a 49% reduction in cancer mortality. The study found that Transcendental Meditation reduces risk factors for heart disease and other chronic disorders.
Older adults with mild hypertension did not experience significant reductions in blood pressure through exercise alone, according to a new study. However, those who lost fat and gained muscle showed more substantial benefits.
The ALLHAT study confirms diuretics are superior to newer drugs in lowering blood pressure and preventing complications. Diuretics were also found to be more effective in reducing high blood pressure and preventing stroke in black patients.
The ALLHAT study found that diuretics are superior to calcium channel blockers and ACE inhibitors in lowering blood pressure and preventing heart failure. Diuretics were also more effective in reducing high blood pressure and stroke in black patients, supporting the use of diuretics as first-line therapy for high blood pressure
A study of ALLHAT trial data reveals that thiazide-type diuretics are superior to ACE inhibitors and calcium channel blockers in reducing cardiovascular disease incidence and heart failure in both black and non-black patients. Diuretic-based treatment also showed reduced risk of myocardial infarction and fatal coronary heart disease.
Research found that Viagra increased fetal weights to normal values and completely prevented fetal resorption, suggesting beneficial effects on maternal uterine vascular adaptation and fetal health. The study's selective effect on the uteroplacental circulation avoids complications of antihypertensive therapy during pregnancy.
Research reveals kidneys and other systemic tissues have distinct roles in controlling blood pressure, challenging the dominant view that kidneys play a central role. The findings suggest that maximal efficacy of hypertension drugs requires complete blockade of receptors in both kidney and outside of kidney.
Researchers at the University of California, Irvine, have found that electroacupuncture can reduce elevated blood pressure by up to 50 percent in rats. The study suggests that acupuncture may be an effective complement to other medical treatments for patients with hypertension and cardiovascular diseases.
African-American stroke survivors with obesity have a higher risk of cardiovascular disease and metabolic syndrome. The study found that nearly all patients were overweight or obese, with diabetes increasing with BMI, and that class three obesity significantly increases the risk of recurrent stroke.
The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) found that a new treatment strategy for hypertension reduced the risk of strokes and heart attacks by 25% and 15%, respectively. The new strategy, combining calcium channel blocker amlodipine with angiotensin converting enzyme inhibitor perindopril, outperformed traditional therapy ...
A new algorithm calculates the ratio of three specific proteins in urine and blood to identify severe preeclampsia with high sensitivity and specificity. This approach may provide a more accurate diagnosis than current tests, which can be confusing and lead to premature birth.
Researchers found that black adolescents who practiced transcendental meditation for eight months experienced a significant improvement in the ability of their blood vessels to dilate, reducing their risk of cardiovascular disease. This finding suggests that meditation may be an effective way to prevent and treat heart disease.
A new study reveals that sleep loss significantly increases cardiovascular disease risk in alcoholics, disrupting heart rate and sympathetic catecholamine levels. Behavioral treatments may help alleviate sleep abnormalities and related physiological issues.
People with migraine are 43% more likely to be smokers and have high cholesterol, while those with aura symptoms are more likely to have high blood pressure and history of stroke or heart disease. The study suggests a shared predisposition toward both conditions.
A meta-analysis of 19 randomized trials found COX-2 inhibitors significantly associated with blood pressure elevation compared to NSAIDs and placebos. This increased risk may be clinically significant for patients at elevated cardiovascular risk, particularly in the elderly population.
Researchers have identified two genomic regions associated with hypertension in African Americans, which can help locate genes affecting the condition. The study uses a genome-wide scan to compare genetic variations between African and European populations.
Alcohol contributes significantly to global health, with 4% of the global burden attributed to it. Raising prices and reducing availability can lower consumption and mortality rates. However, ineffective policies hinder progress in controlling excessive drinking.
Recent studies on COX-2 inhibitors have found that celecoxib may not increase blood pressure, while rofecoxib does, and that these drugs are safe for patients with type 2 diabetes. However, patients taking warfarin with COX-2 inhibitors or NSAIDs have an increased risk of upper gastrointestinal hemorrhage.
A large multiethnic cohort study found that midlife cardiovascular risk factors, such as diabetes and high cholesterol, are strongly linked to an increased risk of dementia in later life. The study also suggests that treating these risk factors may reduce the risk for dementia.
A recent Stanford study has identified a link between genetic differences in African-Americans and an increased risk of hypertension. The research, which analyzed the genetic profiles of over 270 individuals, suggests that specific genes in regions near chromosomes 6 and 21 may contribute to high blood pressure risk in African-Americans.
Researchers at Johns Hopkins Medicine found that sildenafil can treat enlarged hearts by blocking the breakdown of cyclic GMP, a key molecule involved in heart stress. The study showed significant improvements in heart function, including increased contractility and cardiac output, even after hypertrophy had developed.
A recent study published in JAMA found that higher folate intake is associated with a decreased risk of hypertension in women. Younger and older women who consumed at least 1,000 micrograms of total folate daily had a lower risk of developing hypertension.
The global prevalence of high blood pressure is expected to increase from a quarter to a third by 2025, totaling over 1 billion adults. Developing countries are projected to bear the brunt of this increase, with three-quarters of the world's population with high blood pressure in these regions.
A new study published in Nutrition Reviews finds that a vegetarian diet can lower blood pressure and reduce the risk of stroke, heart attack, and kidney failure. By analyzing 80 scientific studies, researchers found that individual patients experience blood pressure-lowering effects from a plant-based diet.
A recent study published in BMC Medicine reveals that environmental factors are a major contributor to higher blood pressure among African Americans, contradicting the long-held assumption of a genetic predisposition. The research found significant variations in hypertension rates across different populations worldwide.
A study of 2,609 participants found that drinking outside of meals significantly increases the risk of hypertension. The research also showed that the volume of alcohol consumed played a more important role in the relationship between drinking and high blood pressure than how often a person drank.
Researchers found that diuretics plus calcium channel blockers doubled CVD death risk compared to diuretics plus beta-blockers. Monotherapy with calcium channel blockers also increased CVD death risk by 55%.
A study found that exposure to anger, negative emotions, or sudden changes in body position can increase the risk of stroke by up to 14 times within two hours. The study examined 200 people with ischemic strokes and found a link between these triggers and stroke, potentially offering new avenues for prevention and intervention.
Researchers found that bosentan treatment led to significant improvements in clinical and hemodynamic parameters of severe pulmonary arterial hypertension. A simpler method to determine optimal CPAP pressure for treating obstructive sleep apnea was also developed, showing improved results with auto-adjusted devices. Molecular methods w...
A novel AT2R gene transfer approach has been shown to prevent hypertension-related enlarged heart, cardiac fibrosis. The study found that the procedure prevented the heart from enlarging and prevented thickening of the ventricular walls.
A Medical College of Georgia study found that individuals with higher lean body mass can better regulate their blood pressure in response to stress. This is because fitness allows the body to efficiently excrete sodium, which helps lower blood pressure back to normal.
A new study reveals that obesity is tied to an increased risk for numerous health conditions, including life-threatening diseases like heart failure and serious illnesses like high blood pressure. The research also found a correlation between excess weight and various health complaints that reduce quality of life.
A positive family history of stroke increases young women's risk of both blocked and ruptured vessel strokes. High blood pressure and smoking are also strong predictors of rupture-risk, while diabetes and lack of exercise contribute to blockage-risk.
A University of Toronto study identifies immigration, lack of partner support, and readiness for hospital discharge as factors increasing new mothers' risk of developing depressive symptoms. Early detection can lead to early intervention and improved maternal and child outcomes.
Researchers found that masked hypertension, a blood pressure condition where patients have lower office readings but higher 24-hour averages, poses an independent risk for target organ damage. Emotion-cognitive variables play a significant role in how patients appraise the seriousness of their heart attack symptoms.
Researchers identified Gq signaling pathway as crucial in hypertension, finding that inhibiting this pathway could lead to new therapies for high blood pressure patients taking multiple drugs.
A study of 1,148 hypertensive patients with type 2 diabetes found that tight blood pressure control reduced the incidence of diabetic retinopathy and visual loss by 47% over seven years. The researchers discovered a lower risk of microaneurysms and blindness in the tight BP control group compared to those with less stringent policies.
A systematic review of studies found that atenolol had no significant effect on reducing death from all causes, cardiovascular causes, or incidence of heart attack. However, it showed a trend towards reduced stroke incidence and increased mortality compared to other antihypertensive drugs.
Researchers found that populations near the equator have a functional protein for salt retention, while those in cooler climates have a mutant gene producing a dysfunctional protein. This correlation suggests a shared selective pressure and could change disease gene hunting strategies.
A study by University of Illinois Chicago researchers found that nearly 60% of American adults have elevated blood pressure, with prevalence increasing among older adults, those with lower education levels and obesity. Awareness and management of hypertension remain low, particularly among Mexican-Americans.
Studies examining prehypertension reveal a significant increase in heart disease and stroke risks among affected individuals. Prehypertension is associated with unfavorable levels of other major cardiovascular disease risk factors and contributes to a substantial burden on the healthcare system.
A single genetic mutation in mitochondrial genes has been found to be associated with multiple risk factors for heart disease and stroke, including hypertension, high cholesterol, and low magnesium levels. The researchers also discovered a link between the mutation and other conditions such as hearing loss and weakened heart muscle.
A study found that a mitochondrial mutation may contribute to the development of metabolic syndrome, a cluster of disorders including high blood pressure and high cholesterol. Researchers discovered the link in a four-generation family affected by hypertension, hypercholesterolemia, and other conditions.
A review of 136 studies found bariatric surgery to be effective in achieving significant weight loss, with an average percentage of excess weight loss of 61.2%. The procedure also showed promise in resolving or improving four obesity-related disorders: diabetes, hyperlipidemia, hypertension, and obstructive sleep apnea.
A multi-center randomized controlled study found that 45 minutes of weekly self-treatment with RESPeRATE significantly reduces systolic blood pressure, with greater reductions in medicated and non-medicated patients. The device's effectiveness was correlated with slow breathing time, making it easy to use at home.
A study of over 150,000 women found that folate intake was associated with a lower risk of high blood pressure. The most significant effects were seen in younger women, who had a 29% lower risk of developing hypertension when consuming high amounts of folate.
A large study found that teenagers with insulin resistance are at a higher risk of developing high blood pressure as adults. Insulin resistance, a precursor to diabetes, was linked to increased systolic blood pressure and obesity in the long-term study.
African-American communities benefit from education programs that lower blood pressure readings. Researchers also found that changing sleeping positions can alter blood pressure, with stomach-lying positions leading to a significant drop in systolic blood pressure. Furthermore, impaired kidney function significantly increases the risk ...
Researchers warn of potential cardiovascular risks associated with the use of modafinil, a new alertness medication. A low-salt diet has also been shown to protect arteries in people with resistant hypertension, according to the study.
Two studies found that isometric hand-grip (IHG) exercise significantly lowered systolic blood pressure in participants with hypertension. Additionally, IHG improved carotid artery distensibility, while having no effect on peripheral arteries. The researchers suggest that these improvements may be due to enhanced endothelial function.
A 20-year study found that high blood pressure is associated with a decline in cognitive function in both younger and older adults. The research emphasizes the importance of reducing blood pressure levels in younger individuals to prevent cognitive decline.
A recent study published in the Journal of Dental Education found that nearly half of patients with high blood pressure at a dental clinic had never been diagnosed. The researchers advocate for regular blood pressure screening in dental offices, which could help identify hypertension early and prevent related health issues.
A study led by Mount Sinai School of Medicine researchers found that imidazole-4-acetic acid-ribotide may be a primary cause of high blood pressure and a molecular link to diabetes. The molecule binds to receptors in the brain, leading to elevated blood pressure, which can also impair insulin release.
Yale researchers found strong clinical evidence to support treating systolic blood pressure of at least 160 mm Hg in older adults. Treatment decisions should prioritize patient preferences and tolerance of therapy due to limited evidence on benefits.
Studies found strong evidence supporting treatment of systolic hypertension in older persons with SBP of at least 160 mm Hg. Treatment guidelines recommend thiazide diuretics and long-acting calcium channel blockers as first-line therapy for SH. Despite effectiveness, poor control of SH among patients is increasing.
A study of 4,223 individuals found that subclavian artery stenosis is a significant risk factor for hypertension. Patients with peripheral arterial disease are five times more likely to have SS.
A study found that about 21% of middle-aged Americans have both high blood pressure and high LDL-cholesterol, significantly increasing heart attack risk. The combined effect was 51 cases per 10,000 person-years, much higher than expected.
The Donald W. Reynolds Foundation has awarded UT Southwestern a $12 million grant to continue the Dallas Heart Study, which aims to develop new biotechnology and treatments for heart disease. The study has already made significant discoveries, including identifying key chemical signals that change stem cells into heart cells.
According to a recent study, approximately 65 million US adults now have hypertension, a 30% increase from the previous decade. The rise is largely due to the growing prevalence of obesity and an aging population.