Articles tagged with Obesity
A team of scientists has developed an ex vivo gene therapy approach to treat obesity and diabetes in mice by implanting cells expressing the CPT1AM protein, which plays a key role in metabolic diseases. The study shows promising results, reducing weight, fatty liver, cholesterol, and glucose levels in obese mice.
A new study from Uppsala University found that consuming junk food can lead to shallower deep sleep, which can impact hormonal release and brain activity. The researchers monitored the sleep patterns of healthy participants who followed a healthier diet and an unhealthier diet in a randomised order.
A recent study published in Translational Psychiatry found that obesity significantly increases the likelihood of developing mental disorders, including depression and anxiety, across all age groups. Women were found to be at a higher risk for most diseases compared to men.
Researchers identified five subtypes of heart failure using machine learning, including early onset and atrial fibrillation related. These subtypes have different mortality risks, with some patients at higher risk of dying within a year after diagnosis.
A study of 438,000 UK Biobank participants found that adherence to healthy lifestyle factors was associated with a reduced risk of various obesity-related diseases. However, this association was modest in adults with obesity, suggesting that a healthy lifestyle may not entirely offset health risks.
A clinical trial found that a telephone-based weight loss program can help breast cancer patients with overweight or obesity lower their weight by a significant degree. Women who received the program lost an average of 4.8% of their baseline body weight, compared to a 0.9% increase in the control group.
Researchers found that participants who were physically active in the afternoon had greater reductions in blood sugar than those most active at other times of day. This study suggests timing of activity may be important for managing blood glucose levels.
A study of 12,000 medical students found that poor eating habits established during post-secondary studies can contribute to future health issues. The researchers call for universities to provide healthy, affordable food options to prevent long-term problems.
Researchers found that focusing on satiety and satiation through the consumption of fruits and vegetables can lead to better weight loss outcomes. Both diet programs increased levels of satiation and satiety among participants, as well as promoting better quality of life and emotional well-being.
A new weight loss tool called PATHWEIGH was developed to address clinician barriers in providing patient care that addresses weight. The tool has shown early success and has been implemented in a health system's primary care clinics, improving weight management efforts among patients with obesity.
A new study from the University of South Australia shows that the Mediterranean diet is not only good for health but also for your weekly budget. Compared to the typical Australian Western diet, the Mediterranean diet costs less, with a family of four saving $28 per week and nearly $1500 per year
A randomized trial found that very low carbohydrate diets led to greater improvements in systolic blood pressure, glycemic control, and weight compared to the DASH diet. The addition of extra support did not have a statistically significant effect on outcomes.
Primary care clinicians reported a range of experiences with telemedicine, from ease of adoption to challenges in conducting physical exams and diagnostic testing. The study also found that telemedicine had both positive and negative impacts on providers and patients, highlighting the need for clear regulations and adequate staffing pr...
Researchers from Aarhus University conducted an online experiment showing that repeated exposure to food images can induce satiety, reducing the desire for more. The study found that participants who viewed pictures of orange M&M's 30 times chose a smaller portion than those who only saw them three times.
Teenagers living with obesity who experience uncontrolled hunger are more likely to perceive their weight as negative, worried about its health effects, and actively trying to lose weight. They also report greater dissatisfaction with their body image and higher rates of bullying.
A study found that semaglutide use for one year decreases the 10-year atherosclerotic cardiovascular disease (ASCVD) risk score in patients with overweight or obesity. The treatment also leads to significant improvements in metabolic parameters, such as blood pressure, cholesterol, and fasting glucose levels.
A multicentre, one-year real-world study found semaglutide effective for weight loss in patients with overweight and obesity, with 82% losing over 5% body weight. The medication also improved metabolic parameters, including blood pressure and cholesterol levels.
Researchers analyzed cortisol and cortisone levels in over 6,300 individuals to find a strong link between long-term hair cortisone levels and future cardiovascular disease. People with higher cortisone levels were twice as likely to experience a cardiovascular event, especially those aged 57 or younger.
Research suggests whole body cryostimulation improves cholesterol and blood sugar levels in individuals with obesity. After two weeks, the WBC group experienced a greater reduction in waist circumference and blood glucose levels compared to the sham treatment.
Research suggests that simple initiatives to promote lower-calorie options on delivery apps can significantly reduce the average excess calorie content of orders. The interventions tested included pre-selecting smaller portions, positioning lower-calorie foods and restaurants more prominently, and displaying calorie labels.
A new analysis of the SURMOUNT-1 study shows that tirzepatide improves body composition across a range of adult age groups, with significant reductions in fat mass. The treatment also results in a clinically meaningful improvement in body composition, with only one-quarter of weight lost being lean mass.
A Dutch study found that individuals who feel safe in their neighborhoods lose more weight during lifestyle interventions. Those with higher scores on a safety scale experienced greater decreases in weight and waist circumference, regardless of sex, age, or education level.
Researchers have identified a new mechanism of communication between fat cells, opening up avenues for novel obesity treatments. The discovery centers on tunnelling nanotubes, which allow distant cells to communicate directly and transfer cargos.
A team of researchers has discovered a group of brain cells that boosts appetite during obesity by producing the appetite-stimulating molecule NPY and making the brain more sensitive to it. These findings have the potential to take the development of anti-obesity medication into a new direction.
A new study suggests that cold exposure in the morning may be more effective at boosting metabolism and burning fat than in the evening, especially in men. In women, however, there was no significant difference in response to cold exposure times, but they were more tolerant of cold in the morning.
Research finds past obesity associated with greater depressive symptoms and impaired psychological wellbeing, even after weight loss. Past obesity may be 'psychologically scarring', increasing the risk of early death by around 30%.
A new substudy of the STEP TEENS trial shows that semaglutide significantly reduces levels of liver enzymes, including alanine aminotransferase (ALT), which are indicators of liver damage. The study found improvements in ALT levels with weight loss of ≥10%.
Research suggests weight gain between ages 17-29 increases aggressive prostate cancer risk by 13% and fatal prostate cancer risk by 27%. Preventing weight gain in young adulthood may reduce prostate cancer risk. The study analyzed data from over 250,000 Swedish men, finding a significant association between weight gain and prostate can...
A new treatment combining a swallowable gastric balloon with the anti-obesity drug liraglutide is safe and effective for boosting weight loss. Participants lost an average of 19% of their initial body weight and reduced BMI by 4.5kg/m2 after 8 months of treatment.
A UK study of over 420,000 adults reveals that those with existing cardiovascular disease and overweight or obesity are five times more likely to suffer a stroke and four times more likely to have a heart attack than those with extreme obesity. The study highlights the substantial impact of living with both conditions on individuals, p...
The National Institutes of Health is enrolling 10,000 participants in a landmark precision nutrition study. The study aims to develop algorithms predicting how individuals respond to different foods and diets based on genetic, lifestyle, and environmental factors.
A study found that muscle fat accumulation, known as myosteatosis, is associated with a higher risk of major adverse events and death in asymptomatic adults. The presence of muscle fat was comparable to the mortality risk associated with smoking or type 2 diabetes.
A study published in Cell Reports found that saturated fatty acids promote the immune escape of oral cancers in mouse models. Obesity helps establish a type of tumor microenvironment that promotes tumor progression by suppressing STING-type-I interferon pathway and NLRC3.
A new study found that ear acupuncture with beads can help reduce waist circumference, body fat, and BMI in men living with obesity. Participants who received auricular acupuncture with beads lost an average of 10.4cm off their waist circumference and 4% of total body fat.
Researchers at Indiana University School of Medicine discovered a strong association between obesity and clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that increases the risk of blood cancer. The study found that obesity causes inflammation, which can lead to rapid growth of mutated blood cells.
Research reveals both metabolically healthy and unhealthy obesity types linked to increased risk of various obesity-related cancers, with stronger association in metabolically unhealthy obesity. Metabolically unhealthy women face higher risks for endometrial, liver, and kidney cancers.
Researchers discover that senescence-associated secretory phenotype (SASP) can induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells, promoting tumor progression and aging-related features. SASP's dual role in cancer involves both antitumoral and tumorigenic effects.
Researchers found that fatty liver cells secrete proteins and genetic material that promote the spread of colorectal cancer to the liver. This condition is likely underdiagnosed, affecting over 40% of patients with colorectal cancer, according to a new study published in Cell Metabolism.
Researchers found that high-fat diets increase levels of gut-derived bacterial toxins and systemic inflammation, promoting atherosclerosis. The study suggests targeting interventions for individuals at risk of developing heart disease.
A recent study found that a vast majority of tweets about obesity are negative, with only 8.25% containing positive sentiments. The analysis suggests that Twitter activity spiked around significant political events, including comments from influential politicians and celebrities.
A new UK study found that people who believe individuals are to blame for living in poverty are more likely to oppose weight discrimination laws. The researchers also discovered a connection between stigmatizing views on weight and greater prejudice towards larger-bodied individuals.
Researchers found that people with severe obesity have a higher risk of severe COVID-19 outcomes and may need more frequent booster doses. Immunity declines faster in obese individuals, putting them at greater risk of infection over time.
Overweight and obesity in early adulthood are associated with increased risks of colorectal cancer and non-colorectal gastrointestinal cancers. The study highlights the need for further exploration into the mechanisms driving these associations.
A new study found that being overweight or obese during early and middle adulthood increases the risk of gastrointestinal cancers in later life. The research also suggests that frequent aspirin use does not modify this increased risk.
Researchers at McMaster University have found that solriamfetol is the most effective treatment for excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea (OSA). A systematic review of 14 clinical trials and analysis of data from various databases revealed solriamfetol to be the best option.
Maynooth University research finds that the obesity treatment drug GLP-1 can restore the body's natural cancer-killing defences by boosting NK cell function. The study shows independent benefits of GLP-1 on cancer risk, beyond its weight loss effects.
A study in Kenya's Nairobi city found that preadolescents' diets are shifting towards unhealthy Western patterns, leading to increased obesity. Researchers suggest interventions using peer counselors and lay health educators to promote healthy lifestyles.
Recent cluster analyses identify novel risk stratification concepts to better implement precision medicine in clinical practice. Metabolically unhealthy individuals, regardless of weight, face a higher CVD risk compared to obese, metabolically healthy peers.
A new study published in JMIR Diabetes found that Fitterfly's diabetes digital therapeutics program improved glycemic control and weight management in participants with type 2 diabetes. The 90-day program led to significant reductions in hemoglobin A1c levels and body weight.
A recent study published in PLOS ONE found that patients with Type 2 diabetes who have full chewing function have significantly lower blood glucose levels compared to those with impaired chewing ability. The research highlights the importance of dental care and occlusal function in managing blood sugar levels.
The 'Low Oxygen and Weight Status' study will investigate the effects of low oxygen levels on weight loss and health outcomes in adults with obesity. Participants will be randomized to sleep in an altitude tent or normal conditions, while following a weight loss diet. The study aims to inform new strategies for improving metabolic health.
A study by researchers at Umeå University found that diet plays a much stronger role in shaping the intestinal microbiota composition than previously thought. The study also suggested that intestinal defense molecules may help protect against metabolic disorders when consuming an unhealthy Western-style diet.
Researchers at West Virginia University found that bariatric surgery significantly reduces the risk of major cardiovascular events and death in patients with NAFLD. The study included 9,374 adult patients with NAFLD and obesity, who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy.
A study supported by the National Institutes of Health found that younger women are nearly twice as likely to be rehospitalized after a heart attack as men. The disparity is largely due to higher rates of risk factors such as obesity and depression among women, which contribute to more adverse outcomes.
New research published in the journal SURGERY found that obesity is associated with increased risk of complications following surgery, including infection, blood clots, and kidney complications. Patients with overweight or obesity had higher risk-adjusted odds of developing these post-operative outcomes compared to those of normal weight.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
A Maynooth University study published in Science Signaling has found that the MYC protein is essential for MAIT cell growth, proliferation, metabolism, and function. The researchers also discovered that MYC is defective in people with obesity, providing a mechanism to explain why MAIT cells are impaired in this condition.
The grant aims to develop accurate household food waste measurement methodologies and metrics. Innovative technologies will help create impactful interventions to minimize and eliminate food waste in the United States and globally.
Researchers found that long siestas (30+ minutes) increased the risk of obesity, metabolic syndrome, and high blood pressure. In contrast, short siestas were associated with improved systolic blood pressure levels.
A large national study found that preteens carrying excess weight have notable differences in cognitive performance, brain structures, and brain circuitry. The association is concerning as it suggests that excess BMI may impact brain development and function.