Articles tagged with Obesity
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New research reveals that excess weight or obesity is more deadly than previously thought, with about 1 in 6 US deaths related to it. The study challenges the 'obesity paradox' and highlights the pitfalls of using body mass index (BMI) as a health metric.
Researchers found 21 Alzheimer's disease-related genes associated with obesity, including those linked to neuro-inflammation and amyloid-beta protein deposition. Obesity in midlife and women is more closely linked to dementia risk than late life or men.
Researchers reveal Akt2's role in insulin-regulated metabolism, initiating energy production and nucleic acid synthesis. The study provides new insights into metabolic disorders like diabetes, paving the way for targeted therapeutics.
Researchers at UTHSC are conducting a study on interactive technology to aid weight loss in overweight and obese adults. The CHAMPS program will deliver a weight loss program via internet, patient portal, text messaging, and phone calls to reduce barriers and promote significant weight loss.
Researchers identified 91 genes associated with fat distribution in women, which may lead to metabolic health issues. The study found that a specific gene, SNX10, is linked to higher waist-to-hip ratios and cardiovascular disease risk in women.
The Strategically Focused Research Network on Obesity has published its findings, revealing new information about the causes of obesity and its link to cardiovascular disease. The research team made significant strides in understanding the interface between obesity and cardiovascular disease, including the role of a specific drug target.
A team of researchers from the University of Minnesota Medical School identified approximately 100 genes associated with fat deposition in women. One gene, SNX10, was found to be strongly associated with cholesterol and triglycerides, which has implications for cardiovascular health.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.
A recent study found that adults with type 1 diabetes are at a high risk of being overweight or obese, but only half receive lifestyle recommendations to manage their weight. The study also highlighted the importance of individualized patient education in improving weight management for these patients.
A new study from Karolinska Institutet found that exercising in the early active phase increased gene expression involved in fat breakdown and thermogenesis, leading to a higher metabolic rate. This effect was independent of food intake and may prove beneficial for people who are overweight.
Researchers from Mount Sinai Health System presented studies on the association between obesity and adverse outcomes in forceps-assisted vaginal deliveries, as well as the utility of cervical length surveillance after cerclage placement for predicting preterm birth. Additionally, a new tool for managing postpartum hemorrhage was showca...
A high-fat diet allows the immune system to eliminate a parasitic worm that causes long-lasting infections in the large intestine. This discovery may lead to new treatments for millions suffering from intestinal parasitic infections worldwide.
Researchers at the University of Calgary discovered a reduction in brain function's brake signal contributes to decisions about eating in obese mice. The study found that when this region is disabled, lean mice continue to overeat despite feeling full.
Macrophages adapt their metabolism according to the organ they reside in, reveals Spanish scientists. This discovery highlights a vulnerability of macrophages that contributes to chronic inflammatory diseases and could be exploited therapeutically for conditions like cardiovascular disease and type 2 diabetes.
A new study finds that age-related abdominal fat is associated with lower muscle density, leading to less effective muscle function. This accumulation of visceral adipose tissue may represent a modifiable risk factor for poor musculoskeletal outcomes with aging.
According to hyperfunction theory, menopause is also a disease. Aging is a quasi-programmed disease that can be partially treatable by rapamycin. The author suggests that slowing aging may delay the onset of diseases like prostate cancer, obesity, and hypertension.
A new study found that people in highly walkable neighborhoods are more likely to engage in adequate physical activity and have lower BMIs, but the association differs among Black, Hispanic, and Asian populations. The study highlights persistent inequities in physical activity due to systemic racism and policy barriers.
Researchers discovered that glucose takes longer to reach the nucleus accumbens in obesity-prone rats, leading to excess glutamate levels. This defect in neurotransmitter recycling process may contribute to overeating behavior and obesity.
A new study finds that obesity-related neurodegeneration mimics Alzheimer's disease, with grey matter atrophy patterns similar in both groups. The researchers suggest that controlling excess weight could lead to improved health outcomes and slowed cognitive decline.
A new poll by Michigan Medicine and U-M found that 13% of people aged 50-80 experience addiction to highly processed foods, with higher rates among women and those in poor physical or mental health. The survey used a standardized questionnaire to measure addictive eating habits.
Researchers found that spinal cord stimulation improved insomnia severity index and Epworth sleepiness scale scores by at least 30% in 39.1% and 28.1% of participants, respectively. The study also established minimally clinical important difference values to gauge treatment success.
The number of cardiovascular disease-related deaths in the US rose significantly between 2019 and 2020, with Asian, Black and Hispanic populations most affected. The largest single-year increase since 2015 was seen in CVD deaths among these populations, highlighting structural and societal disparities.
A study analyzing São Paulo City's built environment from 2015 to 2020 found that physical activity promoting structures increased, particularly in high-income areas. The growth varied by income level, with lower-income parts benefiting least from new bike paths and sports facilities.
Research published in BMJ Open found that carrying excess weight from mid-life onwards increases the risk of physical frailty in older age. The study tracked over 4500 participants and found that obesity and high waist circumference were associated with a higher risk of pre-frailty/frailty, highlighting the importance of maintaining a ...
Researchers from the University of Tsukuba found that web-based interventions are effective in promoting weight loss in people with overweight and obesity. The most effective components include social support, self-monitoring, behavioral goal setting, and personalized information.
A study by researchers from the University of Tsukuba found that ELOVL6 deficiency increases ceramide levels, leading to enhanced airway inflammation and reduced treatment efficacy in patients with severe asthma. Modulating lipid composition may provide a novel approach for treating resistant asthma.
A recent study found that college students reporting high levels of loneliness were more likely to have altered diet quality and engage in sedentary behavior. The research suggests that interventions targeting loneliness may also promote health improvement among this population.
A new study from Tufts University finds that dollar stores have doubled their share in rural areas, with households headed by people of color and lower-income households relying heavily on them. The growth of dollar stores raises concerns about the nutritional value of their food offerings and potential displacement of local grocers.
A six-year study published in the Journal of the American Heart Association found that reducing overall calorie intake was a stronger determinant of weight change than meal timing. The research suggests that limiting total eating window during the day may not be as effective for controlling weight as previously thought.
A recent gene expression study has discovered 45 novel genes associated with body mass index (BMI), shedding light on the biology of obesity and potential treatments. The research, conducted in a diverse multiethnic cohort, highlights the importance of genetic factors in obesity and opens doors to new biomarkers and therapeutic targets.
A new study by the University of Coimbra found that higher coffee intake is associated with reduced NAFLD severity in overweight people with T2D. Caffeine and polyphenols in coffee may help alleviate liver fibrosis and improve glucose homeostasis.
Researchers at WashU Medicine discovered a link between obesity and diabetes, highlighting the importance of an enzyme in fatty acid processing. The study suggests that defects in this enzyme contribute to insulin hypersecretion and beta cell failure, paving the way for potential therapeutic interventions.
A Canadian study reveals that obesity reprograms immune system cells, making them destructive to the eye as it ages. The research sheds light on the molecular mechanism behind AMD and may lead to tailored treatments in the future.
A recent study found that education about gene-by-environment interaction (G X E) causes of eating behaviors can positively affect attitudes toward people with higher weight. Participants who received G X E education reported higher empathy and held fewer stigmatizing attitudes.
A new study from York University sheds light on biological underpinnings of sex differences in obesity-related disease. Female mice grow more new blood vessels to supply fat tissue with oxygen and nutrients, whereas males have a high level of inflammation-associated processes.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
A collaborative study between University of Galway and Brunel University London found that patients with severe obesity respond differently to a dietary weight loss programme based on their genes. The research identified a
Researchers at Baylor College of Medicine discovered that Grb10 promotes leptin activity in the brain, which may help overcome leptin resistance. This finding suggests that increasing Grb10 activity could lead to weight loss by decreasing food intake and increasing energy expenditure.
Researchers at Salk Institute discover thousands of previously unknown microproteins in brown and white fat tissue, finding that one, Gm8773, increases feeding activity in mice. This discovery could lead to the development of a therapeutic to promote weight gain in certain disease situations.
Research found that approximately 40% of Danish population has gut microbes that extract more energy from food, leading to a higher risk of obesity. This composition of gut microbes is also associated with faster digestion and greater nutrient extraction.
A study by Nagoya University researchers has identified EP3 neurons as crucial in maintaining a stable body temperature of 37°C in mammals. The discovery could lead to the development of technologies that artificially adjust body temperature to treat heat stroke, hypothermia, and obesity.
A study published in Journal of Hepatology found that non-alcoholic fatty liver disease (NAFLD) can cause a decrease in oxygen supply to the brain and inflammation to brain tissue. The research identified Monocarboxylate Transporter 1 (MCT1) as a potential therapeutic target for protecting against NAFLD-induced brain dysfunction.
A study published in Circulation found that walking between 6,000 and 9,000 steps per day significantly lowers the risk of a cardiovascular event in older adults. For those who are least active, even small increases in daily step count can have a substantial impact on heart health.
A recent study by University College London reveals that the COVID-19 pandemic has exacerbated mental health issues and food insecurity among individuals living with obesity. Nearly half of participants reported worsening mental health, while nearly a third experienced severe depression. Food insecurity also increased significantly, wi...
A new study found that chronic inflammation in lactating mothers with obesity may contribute to low milk production. The researchers analyzed fatty acid and inflammatory marker profiles in blood and breast milk, finding a strong correlation between the two in non-obese mothers but not in those with chronic inflammation.
Researchers at UCLA Health have found that masks can prevent not only COVID-19 but also whooping cough, while obesity is linked to an increased risk of stroke and cognitive impairment. The institute has also designed a clinical trial to reduce the use of low-value treatments for Alzheimer's disease.
A Christmas-themed physical activity intervention during Advent showed promise for increasing physical activity and reducing sedentary time among inactive adults. The study, published in the BMJ, found that participants who received a daily email with physical activity ideas reported participating in more moderate-to-vigorous intensity...
A study published in JAMA found that patient satisfaction with their physicians is associated with the likelihood of following through with metabolic or bariatric surgery. The research suggests that high-quality care and strong patient-physician relationships are crucial for successful surgery completion.
Researchers confirmed smoking and obesity increase COVID-19 severity, with ACE2 mediating detrimental effects. Lower socioeconomic position also increases COVID-19 risk, highlighting social inequalities.
Females with more subcutaneous fat are protected against brain inflammation, a risk factor for dementia and stroke. Removing subcutaneous fat increases brain inflammation in females, even on low-fat diets.
A study followed over 7,000 Canadians for three years to find that being female, physically active, and not obese were key to maintaining excellent health. Factors such as high income and social support also played a crucial role in optimal aging.
A study of 159 consultations between doctors and patients with obesity found that weight loss advice was rarely effective and mostly consisted of generic tips like eating less and being more active. Doctors often offered unsupported guidance and stigmatizing stereotypes, hindering patient progress.
A large longitudinal study found that weight-loss surgery significantly reduces urinary incontinence episode frequency in adults with severe obesity. After seven years, improvements persist despite some weight regain, offering a durable benefit to patients.
Researchers found that when nursing mother mice are fed a low-fiber diet, their offspring's microbiome is permanently altered, resulting in gut inflammation and obesity. The study suggests that regular fiber intake helps fuel the microbiome, allowing diverse bacteria to thrive.
Engaged feeding practices, such as recognizing fullness cues and responsive feeding, can help parents guide their children towards healthier eating habits. By adopting these practices, parents can create a positive relationship with food that lasts into adulthood.
A study suggests that visceral fat cells, rather than subcutaneous fat cells, are more susceptible to infection by the COVID-19 virus. This increased susceptibility leads to a higher viral load and production of pro-inflammatory cytokines, which can exacerbate severe disease.
A new study of twins found that consistent exercise can change the molecules in the human body that influence gene behavior, leading to lower signs of metabolic disease. The study suggests that markers of metabolic disease are strongly influenced by how a person interacts with their environment, rather than just their inherited genetics.
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
Research highlights importance of long-term screening and healthy lifestyle behaviors in reducing cardiovascular disease risk among young cancer survivors. Factors such as sociodemographic status, income, education, smoking status, and physical activity levels are associated with increased or decreased CVD risk.
A new study shows that paying cash to people with obesity for losing a specific amount of weight works better than offering free tools like weight-loss programs and wearable fitness trackers. Incentives tied to actual weight lost were most effective in the short term, while goal-focused financial rewards performed better in the long run.