Articles tagged with Immune System
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Researchers at UCLA have developed a gene therapy regimen that safely restores immune systems to children with ADA-deficient severe combined immunodeficiency (SCID), a devastating disease. The treatment showed promising results in restoring immune function to three out of six patients, offering new hope for these children.
Researchers have successfully restored the immune systems of some children with SCID using a refined gene therapy approach, eliminating the need for life-long injections. The treatment involves inserting a healthy copy of the ADA gene into bone marrow stem cells, preventing immune-destroying toxicity.
Research suggests cancer produces negative immune response in dendritic cells, hindering desired responses. Flawed dendritic cells could aid in preventing autoimmune disorders, however.
A new study suggests that manipulating the microbiome may be a way to regulate weight gain. Researchers found that mice raised in a germ-free environment did not gain extra weight, even on a high-fat diet. The study highlights the importance of gut bacteria and the immune system in digestion and obesity.
A clinical study found that an antibody against interferon-gamma compromised the immune systems of HIV-negative people, making them vulnerable to infections with nontuberculous mycobacteria. The study identified autoantibodies as a possible cause of adult-onset immunodeficiency in Southeast Asia.
Research reveals long-term consequences of chronic CMV infection on the immune system, including weakened responses to other viruses and increased susceptibility to infections. The study shows that prolonged CMV presence contributes to immune ageing, making older individuals more prone to infectious diseases.
Scientists have developed a new method to study how the immune system interacts with bacteria during chronic infections. The method uses 5 mm silicone tubes and combines light microscopy and electron microscopy to visualize the interaction between white blood cells and bacteria.
Human HLA genes are evolving rapidly, improving disease-fighting abilities but complicating organ transplant matching. The vast number of variants makes it unlikely to identify a perfect match through worldwide searches.
A 'fight' between bacteria and the immune system may lead to chronic diseases such as metabolic syndrome and inflammatory bowel disease. The study's findings highlight the importance of controlling the early environment through breastfeeding, a diverse diet, or probiotics.
Researchers created a model by transplanting human immune elements into an immunodeficient mouse, allowing it to mount human-like immune responses against HIV. The study successfully replicates critical host-pathogen interactions and provides a promising tool for accelerating HIV vaccine development.
Researchers at Caltech have found evidence of a link between immune irregularities and autism. The study suggests that specific changes in an overactive immune system can contribute to autism-like behaviors in mice, potentially related to prenatal experiences.
Researchers found that aging mice's dendritic cells accumulated oxidation-damaged proteins, impairing their function. Administering antioxidants reversed some effects, suggesting a potential therapy to improve vaccine responses in the elderly.
A study published in Molecular Medicine found that blocking the GRP receptor reduces extreme immune response elements and reveals a new inflammatory pathway. The research also shows that patients with septic shock have higher levels of GRP, which may explain their multiple organ dysfunctions.
A Stanford-led study found that short-term stress stimulates immune activity, mobilizing key cells to fight infections and wounds. The research offers hope for developing new treatments to improve recovery from surgery or vaccines.
A new study reports that human microbes have coevolved with humans, forming unique partnerships essential for our immune system. The findings suggest that modern hygiene and antibiotics may be contributing to the rise of autoimmune disorders by erasing these beneficial bacteria.
A recent study found that mice carrying a set of friendly microbes fail to develop a proper immune system, highlighting the importance of host-specific microbiota. The researchers suggest that a coevolved relationship between humans and their gut microbiome may be compromised by modern lifestyle factors.
Gut bacteria play a crucial role in regulating the immune system and preventing autoimmune diseases such as rheumatoid arthritis. Larger-than-normal populations of specific gut bacteria may trigger disease development, particularly in genetically predisposed individuals.
Bruce S. Rabin has made significant contributions to the understanding of the immune system's interaction with the nervous system, endocrine organs, and mental health. He has elucidated many dark corners of immunology and brought sound immunologic principles to the study of mental health and disease in humans.
Researchers have found that the omentum's fat cells can suppress the immune system by sequestering activated T cells, a finding that could lead to new drugs with fewer side effects. The omentum also helps regenerate damaged tissues through mesenchymal stem cells.
Dr. Quake recognized for revolutionary work in drug discovery, genome analysis, and personalized medicine, enabling large-scale automation of biology and improving human health outcomes. His microfluidic technology has enabled non-invasive prenatal testing and single-cell gene expression analysis.
Researchers identified an immune system deficiency that shows a fourfold higher likelihood of death. High levels of free light chains are associated with increased rates of death from cancer, diabetes, and cardiac respiratory disease.
A new antibody treatment has shown promising activity in patients with advanced kidney cancer, melanoma and lung cancer. Patients who received the treatment experienced a positive response without severe side effects.
Richard Lerner's discovery of combinatorial antibody libraries has led to the development of two market-leading drugs, Humira and Benlysta, alleviating suffering from autoimmune diseases. His work has significantly impacted disease treatment and prevention, showcasing his dedication to advancing human health.
La Jolla Institute scientists discovered a mechanism key in drug allergy, identifying HLA gene-linked hypersensitivity reactions before use in humans. The finding could lead to pre-screening of drugs at risk of causing severe reactions.
Researchers created an innovative biomimetic model of the human immune system called MIMIC®, enabling faster and more effective vaccine development. The MIMIC platform provides a novel in vitro model for evaluating human immune responses against candidate drugs, adjuvants, and vaccines.
Loyola researchers found a molecule called transforming growth factor beta (TGF-β) that can amplify the immune response in some cases and suppress it in others. This discovery could lead to the development of new drugs to regulate the immune system, such as activating it to attack tumor cells or suppressing it to prevent organ rejection.
Scientists have pinpointed the region on dengue virus that humans target with their immune system, challenging current vaccine research. The discovery reveals human antibodies bind to a complex structure on assembled dengue viruses, not small fragments as previously thought.
Researchers found that a monkey's social status affects its immune system, allowing for accurate predictions of an individual's rank. The study used microarrays to analyze gene expression levels and showed that inflammation patterns change along with social rank.
Researchers at Tel Aviv University create gold nanoparticles that trigger an immune response when coated with specific chemical residues, revealing a key link between hydrophobicity and immune system activation. This breakthrough has the potential to improve drug delivery systems and lead to more effective medications and vaccinations.
A new guideline from the American Academy of Neurology confirms IVIg as an effective treatment for Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP). The therapy has been shown to be as effective as plasma exchange in treating GBS, with long-term use also helping to manage CIDP. Serious side effects a...
Research published in BioMed Central's Journal of Cardiothoracic Surgery found that opera and classical music increased survival time before organs failed. Music may act via the parasympathetic nervous system, reducing inflammation and increasing regulatory cells.
Researchers at Cardiff University discovered a new group of cells with strong immunosuppressive properties derived from cheek tissue. These cells can completely inhibit lymphocyte action with small doses, offering promise for combating diseases like diabetes and organ rejection.
Researchers at Mayo Clinic have made significant breakthroughs in developing a new melanoma vaccine that uses a genetic combination of human DNA from melanoma cells and a cousin of the rabies virus. Early studies show a cure rate of 60% in mouse models with minimal side effects. The vaccine delivers a broad spectrum of genes derived fr...
Researchers at Sanford-Burnham discovered a chemical compound that inhibits the mutant form of LYP, a protein implicated in multiple autoimmune diseases. The findings suggest a new potential therapy for autoimmune diseases, including Type I diabetes and rheumatoid arthritis.
A new EU project, TargetBraIn, is investigating the potential of the immune system to aid in stroke recovery. The research seeks to balance the positive and negative effects of inflammation, with the goal of developing more effective treatments for this growing health issue.
AIDS experts at Johns Hopkins have developed a vaccination strategy that boosts other immune system T cells and prepares them to attack HIV before reactivating it. The approach aims to eliminate latent HIV virus from infected T cells, which has proven difficult to eradicate.
The $3.4 million grant from the U.S. Department of Health and Human Services will provide medication and treatment to uninsured patients in the Augusta area, while also expanding rapid testing and education efforts. With this funding, nearly 1,300 HIV-positive patients can receive life-long treatment with a single pill daily.
Researchers have found a new potential target for rheumatoid arthritis by developing an agent that prevents activated T cells from migrating towards the site of inflammation. The agent, PS372424, binds to a specific receptor CXCR3 on activated T cells and 'blinds' them, preventing further damage.
Research suggests that T cells play a role in stress-dependent hypertension, and that medications targeting the immune system may also help control anxiety disorders. Mice studies found that T cell deficiency led to reduced blood pressure sensitivity to stress.
Researchers at Trinity College Dublin have discovered a protein, TMED7, that can shut down part of the immune system after an infection has been cleared. This finding could lead to new ways to prevent over-activation of the immune system in diseases.
Researchers at Washington University School of Medicine are studying children with weakened immune systems to identify the viruses that make them sick. They will collect samples from 400 children and analyze them using advanced technologies to draw conclusions about which viruses cause illness.
Researchers refuted the neurodegenerative hypothesis, which suggested myelin damage occurred without an immune system attack. The study found that immune defense played a role in triggering MS-like autoimmune disease.
Research reveals that bacteria can cause disease through frontal attack or stealthy manipulation of the host's immune system. Bacteria that destroy phagocytes have low infectivity, while those with high growth rates and quorum-sensing capabilities are more infectious.
Researchers propose a new approach to treating infectious diseases by targeting tolerance to infection. This strategy aims to reduce tissue damage and promote host protection. By distinguishing between failed resistance and failed tolerance, scientists can choose more effective therapeutic approaches.
Researchers have identified a promising strategy for HIV vaccine design using mathematical techniques also used in quantum physics and stock market analyses. They found high-order evolutionary constraints in the Gag region of HIV, which could be targeted by vaccines.
Research found that micronutrient supplements before pregnancy alter gene methylation in offspring, impacting their immune system. The study's findings have significant public health implications for regions with food security issues.
Researchers at Children's Hospital Boston have identified a single viral protein called LMP1 that the immune system watches over to keep the Epstein-Barr virus in check. The study suggests two possible options for treating EBV-fueled lymphomas in immunosuppressed patients, including using CD4+ T cells and NKG2D-Fc fusion proteins.
Yale University researchers found that the circadian clock regulates a key immune system gene response to bacteria and viruses, suggesting that sleep patterns disruptions contribute to illnesses. The study also suggests that timing of vaccinations may be improved based on jet lag influence on immune system.
Research reveals that a circadian clock controls the expression and function of TLR9, an immune system protein, leading to enhanced or impaired immune responses depending on the time of day. The study's findings have significant implications for sepsis treatment and prevention.
Scientists at The University of Nottingham have identified a new molecule DC-SIGN that plays a role in damping down the body's allergic response to house dust mites. This discovery could pave the way for developing new therapies or treatments for preventing allergies.
A researcher at Indiana University has discovered a compound that could counteract HIV's ability to hijack the immune system's protection mechanism. The compound, which binds to the CD59 protein, enables antibodies and complement proteins to attack infected cells instead of just viral particles.
Scientists have developed a new method using DNA sequencing to identify cancer cells that can be targeted by the immune system. By analyzing genetic data from cancer cells and normal cells, researchers were able to identify specific mutated genes whose altered proteins trigger immune system attacks.
A study led by Uppsala University reveals that structural modifications of DNA are duplicated or lost more commonly in older individuals. This may explain the impaired immune system with age. The researchers found large rearrangements in blood cells of people over 60, as well as smaller changes in younger individuals.
A recent study suggests that seasonal variations in the immune system may impact the effectiveness of a vaccine targeting type 1 diabetes. The vaccine, which uses the GAD65 antigen, showed promise in earlier trials but failed to demonstrate significant effects in its latest phase 3 trial. The study's authors propose that factors such a...
Researchers discovered that leprosy pathogen Mycobacterium leprae manipulates micro-RNs to evade the human immune system, specifically targeting vitamin D-dependent immune pathways. This finding offers new treatment avenues for infectious diseases.
A Northwestern University study identifies a key player in the human immune system, revealing its crucial role in activating the immune response. The protein, STIM1, was found to regulate not only one function but also another critical step in immune activation.
Matthias Mann's work on mass spectrometry revolutionized the analysis of proteins, enabling quantitative analysis of cancerous tumors. Fiona Powrie's research on bacterial intestinal flora and immune system interactions opens new perspectives for treating chronic inflammatory diseases.
Scientists have identified a crucial molecule called PfSET10 that instructs malaria parasites to employ their 'invisibility cloak' to hide from the immune system. The research sheds light on how Plasmodium falciparum causes disease and evades the immune response, with implications for developing targeted treatments.
A study by the NIH found that over 32 million Americans have autoantibodies, which are proteins made by the immune system that target body tissues. The prevalence of these autoantibodies is higher among women, older individuals, and African-Americans.
Scientists at Virginia Tech have discovered a novel antiviral immune pathway in culicine mosquitoes, which produces virus-derived small RNAs similar to piwi-interacting RNAs. This finding suggests a robust immune system, but understanding how viruses overcome it remains an open challenge.