Articles tagged with Pediatrics
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A new study found that Texas' 2021 ban on abortion in early pregnancy was associated with unexpected increases in infant and neonatal deaths in Texas between 2021 and 2022. Congenital anomalies also surged in Texas, but not elsewhere in the US.
Research links exposure to racism during childhood to increased depression and metabolic health issues, while racial socialization can mitigate these effects. Pediatric clinicians are advised to incorporate conversations about race and racism into clinical visits, building trust and affirmation.
St. Jude researchers found that early surveillance after genetic predisposition discovery detects new, treatable tumors in 70% of cases. This approach can avoid chemotherapy and radiation, improving outcomes for children with cancer.
Researchers found that colder temperature exposure increases oxidative stress in the nasal cavity, leading to worsened asthma symptoms in children. The study used nasal fluid samples and measured malondialdehyde (MDA) levels as a biomarker of oxidative stress.
A new study finds that pediatric readiness in emergency departments can significantly reduce mortality by up to 76% while requiring a low annual cost of implementation, ranging from $23,775 to $145,521. Hospitals with high pediatric readiness can improve survival rates without breaking the bank.
A newly developed adolescent health questionnaire has been successfully adapted across pediatric primary care, increasing discussions about sensitive topics such as tobacco use, sexual behavior, and mental health. The questionnaire has improved data collection rates, with up to 95% of visit records capturing information on these topics.
A post-pandemic surge in pediatric RSV hospitalizations was observed, with older children requiring advanced respiratory support. The study suggests that novel vaccine strategies could reduce the overall burden during future RSV seasons.
A phase II clinical trial found trametinib effective in treating pediatric patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML), with seven of ten patients alive after two years. The treatment showed antitumor activity and downregulated inflammatory signaling, offering hope for JMML patients and their families.
Researchers at the University of Gothenburg have identified clear stress patterns among children undergoing dental treatment, particularly during anesthetic injections. The study used a sensor tool to monitor hand movements and sweating, revealing that invasive treatments were significantly more stressful for longer periods.
Researchers at the University of Michigan Health Rogel Cancer Center discovered that pediatric DIPG tumors have a distinct metabolic pathway that allows them to evade treatment. By inhibiting this pathway, radiation therapy became effective in killing cancer cells.
The Kids First DRC has introduced an upgraded data portal to streamline big data search and analysis, improving collaborative pediatric research outcomes. The new portal integrates diverse datasets, including genomic information from the Children's Brain Tumor Network, to foster cross-disciplinary research.
Researchers found that mono-canalicular Lacrijet stent insertion is a safe and effective treatment for congenital nasolacrimal duct obstruction in children, with success rates unaffected by age or previous failed probing. The study suggests early assessments and stenting as an option for pediatric epiphora management.
Researchers discovered that T-cell aging is not limited by organismal age, and healthy T cells can proliferate indefinitely. The epigenetic clock of T cells shows that death is not the end, and these cells do not plateau with age, defying traditional notions of cellular aging.
A study published in Frontiers of Public Health found that educational interventions, including telesimulation-based team training and customized tools, can significantly reduce child mortality rates in pediatric intensive care units (PICUs) in low- and middle-income countries. The interventions led to a sustained decline in mortality ...
A new study by Dr. Marianne Gausche-Hill reveals that pediatric readiness in emergency departments can decrease child mortality rates by up to 76% while being cost-effective, ranging from $4 to $48 per patient. The research emphasizes the importance of prioritizing pediatric care capabilities in emergency settings.
A new study found that adolescents with higher rates of prediabetes often experience adverse social determinants of health, such as food insecurity and low household income. Screening for these non-medical factors may help identify youth at risk of progressing to type 2 diabetes.
Children and adolescents with acute SARS-CoV-2 or MIS-C and severe neurological manifestations are at high risk for long-term impairment. Early intervention and screening may be beneficial to assist recovery.
The study found that 1 in 5 children and adolescents experience excess weight, with rates varying by region. Excess weight is linked to multiple factors, including inherent, behavioral, environmental, and sociocultural influences.
The number of calls to US poison centers has increased sharply, with a 233.9% rise in intentional exposures among adults. The severity of unintentional exposures also increased, with 37.4% more cases resulting in severe harm and 65.3% more deaths.
Researchers found no difference in post-operative infection rates between patients treated with and without antibiotics prior to surgery. The study suggests that pre-surgical antibiotic treatment may not be necessary for pediatric elbow fractures.
Researchers developed a soft fabric necklace called Joey to monitor Kangaroo Mother Care practices with preterm infants. The device tracks vital signs and estimates KMC duration with an average accuracy of 96%, providing early detection of potentially life-threatening issues.
Researchers found that restricting screens in bedrooms and at mealtimes has the biggest impact on reducing screen time and addictive behavior. Parents who model healthy practices at home also see a decrease in their child's screen use. Limiting and monitoring screen time can reduce usage by 1.29 hours and 0.83 hours, respectively.
Researchers at Nationwide Children's Hospital developed a highly accurate prediction rule to identify children at risk of cervical spine injuries, allowing for reduced use of CT scans and decreased radiation exposure. The rule is easy to use and relies solely on symptoms and physical examination, with the potential to improve clinical ...
Longitudinal study finds that higher baseline body mass index is associated with more depressive symptoms over time. Children's cognitive performance also declines as they enter adolescence, highlighting the importance of monitoring children with overweight or obesity for depression problems.
The COVID-19 pandemic has had a profound impact on mental health, with increased rates of anxiety, depression, and attempted suicides. The interruption of major life milestones and prolonged social isolation have been particularly traumatizing for children and adolescents.
A genomic study uncovers germline ARID1B and mitochondrial variants that may drive pediatric chordoma genesis, a rare and aggressive bone tumor. The study found aberrant indels and haywire mitochondria in 22% of pediatric chordoma samples.
A new screener tool helped families enroll in WIC and SNAP programs, leading to better health outcomes. The tool was successful in connecting 21 out of 56 families who requested benefits application support, highlighting its potential to improve access to nutrition resources.
A new study using next-generation molecular sequencing and DNA methylation profile analysis identified a rare type of pediatric brain tumor with specific genetic alterations. The tumors were found to be clinically aggressive but some responded well to chemotherapy, highlighting the need for personalized treatment strategies.
Individuals living with sickle cell disease who experience delays in transitioning to adult care are twice as likely to be hospitalized, according to a study. Patients who transition within six months have more outpatient visits and better health outcomes.
Sharon Giordano and Richard Gorlick will be honored with Special Awards at the 2024 American Society of Clinical Oncology Annual Meeting for their dedication to improving cancer treatment and patient outcomes. Their research has made significant contributions to the field of oncology, with a focus on breast cancer and pediatric oncology.
A study found that professional interpreters and respectful relationships between parents and medical staff improve trust and quality care. Parents desire active listening, collaboration, and consideration of their children's religious, spiritual, and cultural needs to build trust and receive comprehensive care.
A study of 2,814 men found that cardiovascular health in older age was worse for fathers compared to nonfathers, despite lower death rates. Fathers may have a more robust social support system and lower rates of depressive symptoms contributing to these findings.
Researchers discovered that children with the worst outcomes had significantly fewer microbial species overall, but marked populations of Staphylococcus bacteria and viruses. The study used metagenomic next-generation sequencing to analyze lung fluid samples from 229 pediatric patients, revealing links between microbiome composition an...
A novel real-time PCR method has been developed to detect and identify the emerging zoonotic foodborne pathogen E. albertii, which is often misidentified as E. coli. The study found that E. albertii can survive in the human intestinal tract for approximately four weeks.
A national study found a significant increase in the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) among adolescents and young adults in the US. Female adolescents showed a higher increase in GLP-1RA usage compared to males, highlighting the need for education on potential safety risks during pregnancy.
A new study reveals the challenges faced by autistic girls, women and gender diverse people in healthcare, education and society. Autistic young people express a pressing need for tailored support at school, better understanding of their experiences and strengths, and specialised mental health services.
Researchers at the University of Oklahoma have created a new structured clinical interview to screen for multiple sleep problems in children. This tool allows clinicians to assess children for various sleep disorders simultaneously, providing a more comprehensive view of their sleep issues.
A study found that access to consultative support increases pediatric primary care provider comfort in providing gender-affirming care. Providers with fewer than 10 years of experience and those trained in pediatrics were more likely to agree that consultative support would improve their ability to provide this care.
A recent study found that 87.8% of families with medically-complex children reported having to make significant employment changes due to lack of in-home nursing. The study also revealed that 37.9% of families reported extended hospital stays solely due to lack of access to available in-home nursing.
Research finds daily high temperatures and prolonged extreme heat events significantly increase risk of asthma hospital visits among children. Children from vulnerable populations are particularly affected by climate-sensitive events, highlighting the need for targeted interventions to mitigate health disparities.
Researchers discuss the benefits of CAR-T therapy in treating B-cell lineage acute lymphoblastic leukemia (B-ALL) in children. The therapy, tisagenlecleucel, has shown promising results and is now priced at $508,250, a more manageable cost compared to other gene therapies.
New studies by University of Michigan physicians highlight the need for improved diagnosis coding to target efforts to optimize antibiotic use and reduce risk. Inappropriate prescriptions occur in up to 35% of adults treated in emergency departments, with similar rates seen in clinics serving Medicaid patients.
Researchers have developed a non-invasive optical-acoustic imaging method using short laser pulses to create images of muscle tissue. This breakthrough technology has the potential to improve diagnosis and treatment of spinal muscular atrophy (SMA), a rare genetic disorder causing muscle degeneration.
Researchers at Uppsala University have developed an artificial tactile system that can detect pressure by touch in a similar way to the human nervous system. The technology has the potential to restore lost functionality to patients after a stroke, as well as enhance interactions between humans and robots.
New research emphasizes the importance of integrated care for children with epilepsy and co-occurring psychiatric conditions. The study reveals that fragmented care can lead to negative outcomes, including disjointed treatment plans and inadequate seizure control.
The study, conducted by Children's Hospital Colorado, found improvements in symptoms and quality of life for children diagnosed with celiac disease after participating in a mass screening program. Mass screening for pediatric celiac disease may become more common in the US, following similar conclusions drawn from European studies.
A new study found that transgender preteens reported 13 hours of daily recreational screen time, which was 4.5 hours more than their cisgender peers. The researchers highlight the importance of managing the risks associated with excessive screen use for this vulnerable population.
A recent study published in JAMA Pediatrics reveals that harsh anti-immigrant rhetoric and actions can significantly damage parent-child relationships in Latino families, leading to a higher risk of mental health problems for the adolescents. The researchers found that one out of every four kids in US high schools are of Latin American...
Researchers created a new model to study the effects of undernutrition on the microbiome, which can help identify specific microbes that impact development. The model mimics early childhood experiences and shows promise in understanding the underlying causes of stunted growth and other harmful effects of undernutrition.
The American College of Cardiology and American Heart Association have released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy. The guideline recommends exercise as part of a healthy lifestyle, including low-to-moderate intensity recreational activities, while also introducing a...
A new study conducted by researchers at Nationwide Children's Hospital found increases in exposures to delta-8 THC, delta-10 THC, and THC-O acetate among young children, teens, and adults. The study highlights the importance of safe storage practices and improved regulation of these products.
A study published in JAMA Pediatrics reveals that children diagnosed with hypertension are at a higher risk of major adverse cardiac events later in life. Improved detection, follow-up, and control of pediatric hypertension may reduce the risk of adult cardiovascular disease.
A pediatric observation unit with a psychiatric comanagement model significantly lowers pediatric emergency department length of stay and inpatient psychiatric admission rates. This innovative approach also avoids contributing to 30-day readmission rates, presenting potential savings for inpatient psychiatric resources.
A new intervention called FACE Rare improved spiritual and emotional well-being of families with life-limiting rare diseases. The study found that the counseling tools were safe, effective and increased feelings of peace among families.
Researchers will discuss key findings on pediatric mental health, vaccination, autism diagnosis, social determinants of cardiovascular health, and treatment of bronchiolitis. Studies examine the relationship between socioeconomic factors and hypertension in youth, long wait times for autism evaluations, and the impact of HPV vaccine up...
Researchers at the University of Chicago show that a drug molecule targeting RNA modifications associated with neuroblastoma suppresses tumor growth in mice. High levels of METTL3 expression were linked to significantly lower survival rates in patients, suggesting it drives tumor growth.
The American Journal of Respiratory and Critical Care Medicine has released the ATS 2024 International Conference Abstracts, featuring research on heat exposure and RSV among other topics.
A new mRNA cancer vaccine has been shown to trigger a vigorous immune response in both human patients and pet dogs with glioblastoma, the most aggressive form of brain cancer. The breakthrough treatment, which uses a personalized approach and novel delivery mechanism, demonstrates promising results in early clinical trials.
Researchers validated pediatric emergency department guidelines promoting safer CT scan use, finding both predictive rules safe and effective in minimizing unnecessary radiation exposure. The study enrolled thousands of children and adolescents nationwide, showing high accuracy in identifying cases requiring immediate intervention.
A study by Cincinnati Children's Hospital Medical Center found that children aged 3-5 consume a significant portion of their daily calories during the hour after picking up from childcare, with high amounts of added sugar and salt. Experts recommend preparing healthy snacks in advance to instill healthier habits.