Articles tagged with Pediatrics
This study found that increased screen time in late childhood was associated with more depressive symptoms, likely due to shorter sleep duration. Poor white matter organization during early adolescence may also contribute to this link.
Researchers at St. Jude Children's Research Hospital have identified a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML) fueled by NUP98 fusions. Targeting the complex alone or in combination with another anticancer drug significantly increased survival in AML model systems.
JMIR Publications' portfolio of journals now includes 21 titles with a Journal Impact Factor. Several journals saw significant increases in impact factor, including JMIR Medical Education, which debuted with a score of 12.5, securing the top-ranked journal spot in its category.
The Supreme Court's decision increases the likelihood of states limiting or eliminating family access to medical care. Medical professionals emphasize the need for individualized assessments and patient-centered care.
A study published in the American Journal of Human Genetics identified a novel gene, BSN, linked to neurodevelopmental disorders and epilepsy. The research used large biorepositories and computational techniques to analyze data from patients with variants of the BSN gene. Key findings include the common symptoms of epilepsy, febrile se...
Children's Hospital of Philadelphia researchers found that rare instances of SYNGAP1-related disorders can be caused by inherited genetic variants, which could help guide clinical care and influence family planning decisions. The study identified eight individuals with inherited protein-truncating variants in the SYNGAP1 gene.
The Princess Máxima Center has implemented whole genome sequencing as the standard of care for children with cancer, enabling precise diagnosis and tailored treatment. This comprehensive approach also provides valuable data for developing new treatments and researching childhood cancer development.
A study identified distinct trajectories of addictive social media, mobile phone, and video game use in US youths, finding links to increased suicidal ideation and worse mental health outcomes. The research suggests that high or increasing addictive screen use may warrant further clinical evaluation and intervention design.
A survey of 261 new fathers found that 64% took less than two weeks of leave, while 36% took more than two weeks. The main barrier was fear of losing their job. Paid leave would reduce barriers and increase take-up. Involving dads in childcare from the start is crucial for healthy outcomes.
A cohort study suggests severe neonatal morbidity is a significant risk factor for childhood mortality, highlighting the importance of preventing and identifying early signs of severe conditions. Efforts to reduce mortality through infancy and late adolescence may benefit from targeted prevention strategies.
A new study from Karolinska Institutet found that infants who survive serious health problems in the first few weeks of life have a higher risk of dying during childhood and adolescence. Children with neurological health problems had almost six times the risk of death compared to healthy children.
Researchers discovered that children with MS show signs of accelerated biological aging, even in their teenage years, which may lead to new treatment possibilities beyond immunosuppression. The study found that youth with MS had evidence of accelerated epigenetic age, a measurement of DNA chemical modifications associated with aging.
A new study reveals that states with permissive firearm laws have significantly higher rates of pediatric mortality due to gun accidents. The research highlights the need for stricter regulations to prevent such tragedies and determine which laws are most effective in reducing harm.
A NYU College of Dentistry study found that topical treatments for kids' cavities can significantly prevent decay from worsening. The use of atraumatic restorations (ART) and silver diamine fluoride (SDF) in schools kept 62% and 55% of decayed surfaces under control, respectively.
A Kennedy Krieger researcher's work on a promising oral drug, leriglitazone, has shown it can slow the progression of cerebral adrenoleukodystrophy (cALD) in all 11 trial participants. Nearly half of boys treated with the medication appeared to halt disease progression entirely.
Researchers found that childhood kidney cancers have significantly more genetic changes than previously thought, with some tumors having up to millions of changes. This discovery challenges the existing notion that childhood cancers have few genetic variants and suggests new treatment options such as immunotherapy.
A computerized decision support tool reduced the time children with lung failure spent on ventilation by shortening weaning time and improving respiratory muscle strength. The intervention group had better functional status at ICU discharge than the control group.
Researchers identified unique symptom patterns and derived research indices for infants/toddlers and preschool-aged children, highlighting the need to characterize long COVID separately across age groups. The study provides new insights into the condition's progression in early childhood.
Approximately one in three pediatric mental health ED visits resulted in prolonged stays exceeding 12 hours, with over half due to suicidal thoughts or aggressive behaviors. The study highlights significant issues with access to mental health care for children and adolescents.
The new guidelines aim to improve health outcomes by providing evidence-based recommendations for managing VTE in children. Direct oral anticoagulants are now recommended as a first-line treatment option in many cases.
Researchers at Dana-Farber Cancer Institute and Broad Institute of MIT and Harvard uncovered critical insights into the biology of embryonal tumor with multilayered rosettes (ETMR), a rare and aggressive brain tumor affecting young children. Targeting FGFR and NOTCH receptors may represent a critical vulnerability in ETMR.
A new study published in JAMA Network Open found that as preteens used more social media, their depressive symptoms increased by 35%. The research team tracked changes over time in each child to accurately assess the link between social media and depression. Experts suggest using digital habits tools to create healthier online behavior...
A retrospective study found that allogeneic hematopoietic stem cell transplant is a highly effective method for treating children with monogenic inflammatory bowel disease, resulting in sustained medication-free remission in over 90% of patients. The treatment also led to significant improvements in growth, reduced hospital visits, and...
A large study found an unexpectedly high frequency of pulmonary embolism in pediatric patients, equal to rates seen in adults. The study provides new criteria for clinicians to diagnose PE in children and raises questions about the need for earlier intervention.
Charles G. Mullighan, a leading leukemia researcher at St. Jude Children's Research Hospital, has been elected Fellow of the Royal Society. His work on genomic research has advanced the understanding and treatment of acute leukemia in children.
A new survey reveals that parents are just as concerned about their child's mental health during the summer as they are during the school year. The top worries include excessive screen time, boredom, and disrupted routines, with one in 10 parents being more concerned.
A new study reveals that synthetic opioid-involved fatal overdoses among youth aged 15-24 in the US were predominantly caused by fentanyl alone. The rates of overdose deaths involving only fentanyl increased significantly across age, sex, and race/ethnicity, with the highest rates found among males and young adults.
A recent study published in PLOS ONE found that higher maternal selenium levels during pregnancy are associated with a lower risk of streptococcal infections in children. The research tracked over 74,000 mothers and their children to explore potential links between maternal metal exposure and infection risk.
Experts recommend stopping pacifier use and thumb-sucking before two years old due to potential dental health and speech development impacts. Parents report various strategies to break the habits, including hiding the pacifier, limiting use, or using deterrents like hot sauce.
A new study found that ciliary dynamics play a significant role in the pathophysiology of bronchopulmonary dysplasia, with more severe cases showing distinct ciliary beat abnormalities. The study provides new insights into BPD mechanisms and potential therapeutic targets.
A recent survey found that over 83% of Americans believe the benefits of the MMR vaccine for children outweigh the risks, despite a current measles outbreak. The survey also showed that vaccination rates are dropping and many people lack knowledge about measles symptoms and prevention.
A child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy, showcasing the power of tailored gene editing to treat patients. The infant is now growing well and thriving after receiving three doses of the therapy with no serious side effects.
Researchers developed pragmatic models that accurately distinguish between mild, moderate and severe pneumonia in children based on evidence from 73 EDs across 14 countries. The new predictive tools are intended to complement clinician judgement in deciding whether a child’s pneumonia warrants hospitalization or intensive care.
A UC San Francisco-led study found that delivering medicine for spinal muscular atrophy (SMA) via the amniotic fluid was safe and helped prevent damage to nerve cells. The therapy used molecules called antisense oligonucleotides (ASOs), which can alter gene expression, and was tested in mice and sheep with promising results.
A new study uses explainable machine learning to predict metastasis and mortality in children with medulloblastoma, identifying key immune factors driving risk. The model provides a transparent approach to prognostic accuracy and supports personalized clinical decision-making.
A new national survey conducted by Ipsos on behalf of The Kids Mental Health Foundation, identifies parents' greatest fears for their children around screen time. Parents' top fears include privacy and safety concerns, exposure to misinformation, and not socializing in person.
Nearly 19 million children in the US are living in households with a parent struggling with substance use disorder. Children exposed to parental substance abuse are more likely to experience adverse health problems compared to those without such exposure.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
Pregnant women with fatty liver disease are at an increased risk of giving birth prematurely, with a threefold higher risk compared to the general population. The study also found that women with fatty liver disease had a 63% higher risk of caesarean section.
Research suggests that antibiotics taken during infancy, especially in the first three months, may lead to earlier onset of puberty in girls. The study, which analyzed data on over 322,000 children in South Korea, found a significant association between early antibiotic exposure and increased risk of central precocious puberty.
Research finds high levels of phthalates in mothers' urine associated with shorter anogenital distances in 3-year-old boys and girls, a marker of reproductive health and hormone disruption. The study emphasizes the need for preventive measures to protect vulnerable groups from endocrine-disrupting chemicals.
Research found that early-life growth plays a significant role in determining final adult height, accounting for about 67% of the variation. Childhood growth also accounted for a substantial proportion of the difference in adult height.
Richard Finkel, MD, is named to TIME100 Health for his pioneering work in treating spinal muscular atrophy prenatally with the orally administered drug risdiplam. This breakthrough has shown promising results, with no identifiable features of SMA observed two years after treatment.
Researchers at Nationwide Children's Hospital found that teen drivers in vehicles 6-15 years old and those with fewer driver assistance technologies had a higher risk of death in fatal crashes. The study also showed that driving newer vehicles can reduce the risk of fatal crashes for teen drivers.
A recent study published in JAMA Pediatrics found that prenatal cannabis use is associated with an increased risk of preterm birth and low birth weight. The research also suggests a potential link between cannabis use during pregnancy and smaller-than-average newborns.
A study found that parental technology use in a child's presence was negatively associated with cognitive and psychosocial outcomes, as well as screen time among young children. The effect sizes were small, highlighting the need for further research on potential impacts on physical activity, sleep, and motor skills.
A Stanford Medicine study found that VR-guided meditation reduced parental anxiety by 30% and was more effective for Spanish-speaking families. The six-minute guided meditation helps build healthy coping skills, allowing parents to manage stress in the hospital setting.
The journal is seeking submissions to a new theme issue exploring the importance of telerehabilitation and future directions for the field. Researchers will focus on implementation challenges, health equity concerns, and emerging innovations like AI-driven personalized rehabilitation.
A cross-sectional study finds a doubling in nicotine pouch past-30-day use and an increase in pouch plus e-cigarette dual use, leading to decreased exclusive e-cigarette use among US 10th and 12th graders. Prioritizing surveillance, regulation, and prevention strategies is crucial for addressing pediatric nicotine pouch use.
A study by UC San Francisco found that children with ALL living in mixed middle- and low-income neighborhoods have a 30-40% higher risk of death. In contrast, AML hospital treatments are shorter, and outpatient visits fewer, reducing challenges for underserved patients.
The American Society for Nutrition (ASN) and the Novo Nordisk Foundation have recognized eight early-career scientists making significant contributions to the fields of nutrition and obesity. These awardees are advancing our understanding of the complex relationships between diet, genetics, and disease.
The MyoStep project represents a significant advancement in pediatric mobility aids for children with cerebral palsy, addressing motor impairments that restrict participation in physical activities. The soft power suit provides a lightweight, discreet solution tailored to fit seamlessly into the lives of children and their families.
A cohort study found maternal hypertension and preeclampsia independently associated with cognitive and language development delays in preterm infants. Recognizing hypertensive disorders of pregnancy is crucial for targeted risk management strategies.
The review highlights the limitations of existing dengue vaccines, such as CYD-TDV and TAK-003, and the urgent need for more effective vaccines to protect millions of people. The Butantan-DV vaccine has shown promise with its single-dose regimen, but its efficacy against DENV-3 and DENV-4 is still unclear.
A study published in Hepatology reveals that children with metabolic dysfunction-associated steatotic liver disease (MASLD) are at a significantly increased risk of premature death and serious long-term health complications. The mortality rate was found to be nearly 40 times higher than the national average.
The study tracks maternal, fetal, and infant mortality trends in the US from 2000 to 2023. Despite improvements in some years, overall rates of maternal and infant mortality increased during the COVID-19 pandemic.
Pediatric hearts fail due to acquired and genetic disorders or congenital heart disease, requiring mechanical circulatory support (MCS) devices. However, adult devices are often used off-label in pediatric patients, deterring innovation and limiting access to life-saving technology.
The Pediatric Heart Transplant Alliance is a coalition of six leading organizations working to advance pediatric heart transplantation through research, education, and advocacy. The alliance aims to improve patient outcomes and quality of life for children with transplanted hearts.
Researchers developed a new DNA-reading technology that identified more genomic imprinting in DNA, contributing to rare pediatric diseases. The study used HiFi long-read sequencing to analyze over 200 genetic samples and found widespread parent-of-origin effects on methylation at thousands of novel loci.
Researchers found that antibiotic exposure in the first two years of life was significantly associated with a higher body mass index (BMI) in childhood. The study followed 33,095 vaginally born children in Finland to see if antibiotics before pregnancy, during pregnancy, and after birth were linked to higher BMI at age two and age 12.