Articles tagged with Pediatrics
Research by Carolyn Drews-Botsch finds that patching after age 4 does not significantly impact vision, but less-aggressive protocols may be suitable for families with distress. Optotype acuity assessments in 4-year-olds can predict visual acuity at age 10.
The Pediatric Long COVID Extension for Community Healthcare Outcomes (ECHO) program has successfully trained nearly 100 healthcare professionals across the US, equipping them to diagnose and manage long COVID in children. The program aims to bridge access gaps and empower community providers.
A new study reveals significant barriers to including non-English speakers in health research, with common reasons including lack of training and budget constraints. Researchers recommend increased access to interpretation and translation services, guidance on budgeting, and methods training to improve inclusion.
A new study found that exosomes from children with pediatric obstructive sleep apnea (OSA) disrupted blood-brain barrier integrity, leading to cognitive impairments. The research suggests a broader impact on barrier function and identifies potential biomarkers for OSA-related neurocognitive dysfunction.
Recent research reveals that avapritinib, a PDGFRA inhibitor, demonstrates potent activity against pediatric high-grade glioma tumors with PDGFRA alterations. Clinical trials in patients showed an initial clinical response and improved survival rates, suggesting the potential for avapritinib as a therapeutic option.
A study using machine learning models found that people with IBD are at risk for premature death when developing other chronic health conditions earlier in life. Chronic conditions like arthritis, hypertension, and mood disorders were common causes of death among those with IBD.
A study found a disproportionate increase in firearm homicide rates among children under 17 and adults over 30 following the COVID-19 pandemic. The peak victimization risk shifted from age 21 to 19, highlighting a change in the association between age and firearm victimization risk.
The Mount Sinai Hospital has launched a new center focused on advancing artificial intelligence (AI) driven outcomes in children's health. The center aims to improve diagnostics, personalize treatments and optimize healthcare delivery for youth and adolescents. Dr. Benjamin S. Glicksberg will lead the Center.
A new study from the University of Colorado Anschutz Medical Campus identified significant mitochondrial dysfunction in lymphoblast cell lines from children with Dravet syndrome, a severe form of epilepsy. The findings suggest that mitochondrial defects play a role in the metabolic dysfunction observed in Dravet syndrome.
Researchers at Dana-Farber Cancer Institute have identified a potential targeted therapy, avapritinib, for pediatric high-grade gliomas. The treatment resulted in tumor reduction and clinical improvement in 3 out of 7 patients with this currently incurable form of brain cancer.
Researchers developed a new diagnostic platform that classifies brain tumors based on the body's cancer-fighting immune response. The approach tailors treatment options to each patient's unique immune profile, offering improved diagnostics and potential for immunotherapies to revolutionize childhood leukemia treatments.
The Chinese Medical Association has released updated guidelines for pediatric mycoplasma pneumoniae infection, emphasizing a multi-faceted diagnostic approach and evidence-based treatment strategies. The guidelines highlight the importance of accurate diagnosis and responsible antibiotic use to combat rising resistance.
The review article examines the relationship between anemia and retinopathy of prematurity, focusing on iron deficiency and underlying molecular mechanisms. Anemia reduces oxygen delivery to the retina, exacerbating hypoxia and promoting pathological neovascularization.
A new approach has been tested, bringing together child health services, specialist care, and the municipality, resulting in faster support for young children with autism. The average age at which children are diagnosed with autism has fallen from three years and eight months to two years and seven months.
A new study found that adenotonsillectomy, a surgical procedure for enlarged tonsils and adenoids, significantly reduces medical office visits and prescription medicine use in children with mild sleep-disordered breathing. The surgery was associated with a 32% reduction in healthcare encounters and a 48% reduction in prescriptions.
A randomized trial found that adenotonsillectomy surgery reduced healthcare utilization in children with mild sleep-disordered breathing by 32% fewer doctor visits and 48% fewer prescriptions. This effective early intervention supports reducing behavioral, neurocognitive, cardiovascular, and cardiometabolic issues.
A recent NIH-supported clinical trial found that adenotonsillectomy significantly reduces medical office visits and prescription medicine use in children with mild sleep-disordered breathing. The surgery was tied to a 32% reduction in health care encounters and a 48% reduction in prescriptions used among participants.
A study by Charité - Universitätsmedizin Berlin and the German Rheumatology Research Center identified the Epstein-Barr virus as the trigger for Multisystem Inflammatory Syndrome in Children (MIS-C). The virus reactivates due to a weakened immune system, leading to an excessive inflammatory response.
A new study found that waist-to-height ratio is more accurate than BMI in estimating body fat in children. The study included 7,600 children and found that 64% of those classified as BMI-overweight had normal fat according to waist-to-height ratio.
A new study reports that Raman spectroscopy, a noninvasive technique, can distinguish between abnormal FCD type II tissue and healthy brain cells with remarkable accuracy. This method could provide real-time guidance for surgeons to more accurately identify and remove affected tissue during surgery.
A responsive parenting intervention demonstrated a significant reduction in child weight outcomes from age 3 to 9 compared to a control group. The intervention's benefits were most pronounced among female participants, and its long-term effects may be sustained with a life-course approach.
A recent study analyzed 44 systematic reviews on pediatric PROMs, highlighting the most recommended tools and identifying gaps in methodological quality. The research underscores the need for more diverse and high-quality studies to improve the selection and application of PROMs in pediatric healthcare.
Researchers develop individualized management strategies for pediatric postural orthostatic tachycardia syndrome (POTS) based on underlying mechanisms like central hypovolemia and hyperadrenergic states. A tailored approach using biomarkers can lead to faster symptom relief, fewer hospital visits, and improved long-term outcomes.
The COVID-19 pandemic has been associated with negative developmental trends in kindergarteners, persisting beyond the pandemic's onset. The study highlights troubling trends in kindergarteners' development before and during the pandemic, underscoring the need for further research.
Researchers at West Virginia University found that babies born to teen mothers weigh less and are smaller for their gestational age. The study highlights the role of social, geographical, and educational factors in teen pregnancy prevention.
The study found that nearly 1-in-3 young people now live with pediatric onset conditions that significantly affect their lives. Young adults are more likely to develop chronic conditions if they have lower socioeconomic status.
Fentanyl poisoning among US children has surged by 924% and 1,506% for teens aged 13-19 over the past eight years. Parents are advised to be vigilant about hidden fentanyl risks and know the signs of overdose symptoms to save their children.
A new study identifies neighborhood amenities, parental mental health, emotional support networks, regular reading routines, and limited screen time as protective factors for improved school readiness. The research highlights the critical role of family routines and parental supports in shaping early child development.
Dr. Sahera Dirajlal-Fargo and Dr. Colleen Fant, both physicians at Lurie Children's Hospital, have been appointed as co-directors of the Center for Global Pediatric Health. The center will focus on collaboration between the Havey Institute for Global Health and Lurie Children's to improve global pediatric health outcomes.
Children who frequently miss school due to abdominal complaints are more likely to have gut-brain axis disorders like IBS, which can be missed by medical tests. The study found that frequent absences were nearly five times more likely to be caused by functional GI disorders than specific illnesses.
The Mount Sinai Parenting Center will expand its marquee programs to educate healthcare providers on social, emotional, and cognitive development during early childhood. The $2.2 million grant will support the training of an additional 30,000 primary care providers through the Keystones of Development Provider Portal.
A community-wide preventive intervention significantly reduced reported cases of both substantiated and unsubstantiated child sexual abuse at the population level. The study's findings suggest that targeted interventions can effectively mitigate child sexual abuse rates.
A recent study found that the NIH provides critical funding for pediatric clinical trials in diseases not prioritized by industry. Pediatric research in asthma and lung diseases has been chronically under-funded, highlighting the need for increased funding.
A new study published in JAMA Pediatrics found that coordinated, community-wide primary prevention efforts can significantly reduce child sexual abuse rates. The study showed a 17% decrease in substantiated cases and a 34% drop in unsubstantiated cases compared to a control group.
Researchers found that omalizumab significantly improved treatment outcomes for multi-food allergy patients compared to oral immunotherapy. A total of 36% of omalizumab recipients could tolerate at least 2 grams of multiple food allergens, while only 19% of oral immunotherapy participants achieved this threshold.
This disorder has diverse etiologies, variable presentations, and different therapeutic responses. The proposed diagnostic algorithm can differentiate pediatric MF subtypes to improve patient outcomes.
Researchers report an increase in adult VZV-related CNS infections, particularly since 2019, with a notable rise in aseptic meningitis cases. The study suggests that universal varicella vaccination may be contributing to the decline in natural immunity, leading to reactivation and CNS complications.
The Global Pediatric Pulmonary Alliance recommends prophylactic mAbs as the best available preventive measure against RSV. A single dose of long-acting mAbs can provide season-long protection to infants, with real-world evidence supporting this strategy.
A recent survey by Northwestern University found that fathers who take at least two weeks of leave are more likely to report their infant being breastfed at eight weeks. Additionally, families where dads took at least two weeks off had a higher rate of continued breastfeeding at eight weeks compared to those with shorter leave.
A new study suggests that mRNA COVID-19 vaccination may protect against post-COVID condition symptoms in children. The findings support the benefits of vaccination beyond acute protection, encouraging increased pediatric uptake.
Heavy screen use, particularly social media and video games, is associated with an increased risk of developing manic symptoms in U.S. preteens. The study found that prolonged screen time can lead to behaviors characteristic of bipolar-spectrum disorders, including inflated self-esteem, decreased sleep needs, and impulsivity.
Researchers found significant disparities in behavioral flag incidence among racially and socioeconomically marginalized pediatric patients. Black or African American patients younger than 8 years were disproportionately affected.
A retrospective natural history study of 30 patients with single large-scale mitochondrial DNA deletion syndromes (SLSMD) reveals a broader clinical presentation than previously thought. The study identifies key molecular details, including a recurrent deleted region in the MT-ND5 gene and elevated levels of biomarker GDF-15.
Kimberly Stegmaier appointed as Chair of Pediatric Oncology at Dana-Farber Cancer Institute and Associate Chief of Division of Hematology/Oncology at Boston Children's Hospital. She will focus on acute leukemias and pediatric solid tumors, pioneering genomic approaches to identify new therapies for childhood cancer.
The joint venture aims to build the world's preeminent pediatric cancer center, increasing access to care and clinical trials. Collaborative operations will launch in early 2026, featuring a focus on new facilities with latest medical technology.
The joint venture will unite the nation's largest comprehensive pediatric system with a top pediatric cancer program and the nation's leading comprehensive cancer center. The collaboration aims to accelerate improved outcomes for patients in Texas and around the world, increasing access to clinical trials and innovative treatments.
The Childhood Obesity Prevention, Evaluation and Treatment Toolkit provides healthcare providers with practical guidance for preventing, evaluating, and treating childhood obesity. The toolkit is grounded in scientific evidence and offers actionable treatment approaches for children and adolescents dealing with overweight and obesity.
A new study found that children with avoidant restrictive food intake disorder (ARFID) are at a higher risk of developing intellectual disability, autism, gastro-oesophageal reflux disease, epilepsy, and chronic lung diseases. They also experience more medical diagnoses and require longer hospital stays than other children.
The Damon Runyon-St. Jude Pediatric Cancer Research Fellowship aims to address a funding gap for pediatric cancer research. The program supports innovative projects that could significantly impact the diagnosis or treatment of one or more pediatric cancers.
A new study found that white children were nearly twice as likely to have completed genetic testing, despite similar rates of test requests. The study also showed that insurance coverage for genetic testing was denied at higher rates for Black children, with disparities that could not be fully explained by socioeconomic factors.
Children exposed to low to moderate levels of prenatal alcohol showed characteristic facial changes that persisted until age 6 or 8. No linear association between alcohol exposure and facial shape was found, suggesting other factors at play.
A new study led by researchers at Mount Sinai Hospital found that children with high-threshold peanut allergy can be treated with a safe and effective approach, allowing them to tolerate larger doses of peanut butter. The treatment involves gradually increasing doses over 18 months, resulting in sustained unresponsiveness to peanuts fo...
A recent study found that from 2009 through 2020, child victims in mass shootings were most likely to be killed by parents or family members. The research highlights the often-overlooked role of domestic violence in these tragic events.
Researchers report that eating increasingly higher doses of peanut butter enabled 100% of children with peanut allergy who initially tolerated half a peanut to consume three tablespoons without an allergic reaction. The therapy could potentially fulfill an unmet need for about half of children with peanut allergy, who already can toler...
A comprehensive review explores metronomic chemotherapy's potential to improve survival prospects for children with high-risk and relapsed/refractory neuroblastoma. Early studies report promising results, including disease control rates up to 45%, particularly in high-risk patients.
Two comprehensive datasets from the Gabriella Miller Kids First Pediatric Research Program explore childhood cancers and congenital disorders. The new datasets aim to identify genetic causes and links between these diseases in children, ultimately supporting the development of improved treatments.
The partnership aims to accelerate discoveries and develop life-changing therapies for children with cancer and rare diseases. By combining expertise in pediatric care and cutting-edge technology, the organizations hope to make significant strides in understanding and treating devastating childhood diagnoses.
Eleven scientists will be recognized for their individual exceptional professional achievements and contributions to stroke care and research. Four groundbreaking scientists are devoted to stroke research, while six others will be recognized for their new research findings presented during the meeting.
A study published in JAMA Pediatrics found that post-COVID condition (PCC) continues to affect US children with significant activity limitation. The research highlights the importance of examining PCC severity and its impact on school attendance, emphasizing the need for continued investigation into this ongoing issue.
A recent study found that half of US adolescents spend at least 66 minutes per day on their smartphones during school hours, with the majority using messaging and social media apps.