Articles tagged with Protein Localization
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A new iron transporter protein, OsIET1, has been identified in rice, crucial for delivering iron to young leaves. The study reveals OsIET1 mediates inter-vascular Fe transfer, promoting optimal plant growth and productivity.
Researchers developed Localizatome to study oxidative stress-related changes in protein localization. The database provides comprehensive information on subcellular protein localization and dynamic localization changes under stress.
Researchers used CRISPR to cut a single gene from cancer cells of head and neck tumors, resulting in the elimination of 50% of the tumors after 84 days. This groundbreaking study demonstrates that some genes are essential for cancer cell survival, making them excellent targets for CRISPR therapy.
Researchers at Texas A&M University have uncovered a mechanism behind cancer progression: the stiffening of tumor cell's environment. This spreading causes increased cell proliferation and tumor growth.
A recent study published in Cell reveals that nearly one in six disease-causing mutations leads to proteins mislocalizing within the cell. The research team developed a high-throughput imaging platform to assess protein location and found that breakdowns in protein stability are a major driver of misplaced proteins.
Scientists at Stanford University have developed a new method to relocalize misplaced proteins in cells, which could lead to therapeutic treatments for diseases. The team created a class of molecules called TRAMs that convince natural shuttles to take cargo like proteins to different parts of the cell.
A long non-coding RNA called lncREST has been identified as a crucial component of the stress response during DNA replication. Its absence leads to impaired stress signalling, resulting in severe DNA defects and cell death. The discovery opens up new avenues for developing anti-tumour therapies.
A recent study reveals that CAMSAP1 plays a crucial role in regulating the structure and dynamics of manchette microtubule minus-ends, impacting male fertility during spermiogenesis. The absence of CAMSAP1 leads to abnormal sperm development, including reduced sperm quantity, decreased motility, and male infertility.
Researchers have provided new insights into the role of lipid droplet-localized CETN-SPDL1-L in regulating cone cell lipid droplet localization, crucial for light sensitivity. The study discovered centrin proteins and SPDL1-L collaborate to maintain correct lipid droplet placement.
A study published in EMBO Molecular Medicine has identified the cellular processes that lead to Parkinson's disease in patients with CHCHD2 gene mutations. The research found that a specific protein, casein kinase 1 epsilon/delta (Csnk1e/d), plays a crucial role in the disease's pathogenesis.
Researchers updated their protein localization prediction model, MULocDeep, to provide more targeted predictions for biological discoveries. The tool helps researchers design more effective experiments and advance scientific discoveries related to drug development and treating diseases like epilepsy.
A team of Chan Zuckerberg Biohub scientists developed a deep-learning method, dubbed
Researchers at Hokkaido University identified two deubiquitinating enzymes, UBP12 and UBP13, that stabilize the brassinosteroid receptor BRI1 in plant cells. This finding reveals a crucial role for these enzymes in regulating plant growth and development.
Researchers from Nara Institute of Science and Technology developed a machine learning program that accurately predicts the location of proteins related to actin in cells. The program achieved a high degree of similarity with actual images, showing promise for future applications in cell analysis and artificial cell staining.
Researchers at Sinai Health have developed a new tool to better understand the organization of living human cells. By creating a detailed map of protein localization across all compartments in human cells, the team has gained valuable insights into cellular function and disease mechanisms.
International researchers led by Tokyo Medical and Dental University investigated the RSRSP stretch of the regulatory protein RBM20, finding it essential for nuclear localization and splicing regulation. The study suggests that phosphorylation of specific serine residues in this region is crucial for RBM20's function.
Researchers found that protein aggregation has beneficial functions allowing cells to organize themselves in time and space. Protein aggregation helps create spatial patterns in transcripts, influencing protein localization and function.
Researchers discover unique structure in viral protein Rev, allowing it to penetrate nucleus and nucleoli. This finding opens new avenues for studying the relationship between protein localization and host cell impact.