Researchers at Columbia University Irving Medical Center have identified Sirtuin 1 as a key driver of neuroendocrine prostate cancer, an aggressive form of the disease. Genetic or pharmacological inhibition of Sirtuin 1 prevents tumor growth in mice and lays the groundwork for future clinical studies aimed at developing new treatments.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·TypeExperimental study·DateMay 28, 2026
Researchers found SIRT6 is essential for maintaining protein homeostasis, regulating the protein life cycle to prevent protein aggregates that contribute to neurodegenerative diseases. Reduced SIRT6 levels play a critical role in aging and age-related neurodegeneration.
SourceBen-Gurion University of the Negev·JournalAging Cell·TypeExperimental study·DateApr 19, 2026
A systematic review of 24 studies suggests resveratrol can enhance the quantity and quality of egg cells, called oocytes. The compound may also treat infertility related to endometriosis and obesity.
SourceAnglia Ruskin University·JournalInternational Journal of Molecular Sciences·TypeSystematic review·DateJan 30, 2025
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Researchers at CCM Biosciences have discovered novel enzyme activators that fully restore the activity of Sirtuin-3, a master regulator of cellular energy production. These compounds hold significant potential for addressing age-related disorders such as Alzheimer's and Parkinson's diseases.
SourceCactus Communications·JournalPhysical Review X·TypeComputational simulation/modeling·DateJan 8, 2025
Researchers discover a molecular mechanism controlling PAX5, key regulator of B-cell maturation. Increasing SIRT7 activity may boost PAX5 levels in leukemic cells, inducing cell death.
SourceJosep Carreras Leukaemia Research Institute·JournalNature Immunology·TypeExperimental study·DateOct 21, 2024
A review of existing literature on caloric restriction (CR) reveals its benefits on cardiovascular health, including reduced cholesterol levels, improved endothelial function, and enhanced vascular renewal. CR's role in regulating sirtuin activity is also explored, with seven identified sirtuins mediating cardiovascular benefits.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateApr 8, 2024
A recent review highlights the positive effects of caloric restriction on cardiovascular health, linked to sirtuin activation and improved lipid metabolism. The study suggests that caloric restriction regulates metabolic processes via NAD+ levels, activating SIRT1 and modulating cardio-protective pathways.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateMar 28, 2024
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This study found that SIRT6 activation improves DNA damage repair efficiency and reduces baseline DNA damage in chondrocytes from older donors. MDL-800 treatment also lowered p16 promoter activity and decreased DNA damage in murine cartilage explants, supporting the concept of SIRT6 as a critical regulator of DNA repair.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateDec 19, 2023
A new study found that HSP10 treatment improved exploratory preferences, object contacts, and swimming time in aged mice, while also increasing proliferating cells and differentiated neuroblasts. The protein also mitigated age-related gene reductions and increased sirtuin 3 levels.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateDec 12, 2023
A novel study found that honokiol promotes healing of rotator cuff injury and may be an effective treatment for humans. The study suggests that SIRT3 activation plays a protective role in alleviating aging-induced fibrocartilage degeneration and promoting rotator cuff healing.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateJun 20, 2023
Researchers identified three novel dual-purpose therapeutic targets using PandaOmics, which could treat both aging and glioblastoma multiforme. The target hypotheses include cyclic nucleotide gated channel subunit alpha 3 (CNGA3), glutamate dehydrogenase 1 (GLUD1) and sirtuin 1 (SIRT1).
SourceImpact Journals LLC·JournalAging-US·TypeComputational simulation/modeling·DateMay 2, 2023
Researchers discover that brain cells die from lack of energy when autophagy, a natural cleaning process, malfunctions. Compounds boosting NAD levels can improve neuron survival and combat age-related neurodegeneration.
SourceUniversity of Birmingham·JournalCell Reports·TypeObservational study·DateApr 27, 2023
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Researchers use cryo-electron microscopy to visualize a sirtuin enzyme bound to a nucleosome, clarifying how it accesses DNA and histone proteins to modulate gene expression. The study provides insight into the function of SIRT6 in humans and other animals.
SourcePenn State·JournalScience Advances·TypeExperimental study·DateApr 14, 2023
Researchers found that Sirtuin 7 regulates brown adipose tissue functions, leading to suppressed energy expenditure and thermogenesis. The study reveals a molecular pathway involving protein deacylation and mRNA binding, which will have implications for treating hypermetabolic conditions like cancer and obesity.
SourceKumamoto University·JournalNature Communications·TypeExperimental study·DateJan 19, 2023
Researchers found drastic differences in microglia marker Iba1 and factors influencing Sirt1 levels and activity between elder groups. Preserving microglia and Sirt1 functional efficiency is crucial for longevity.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateNov 10, 2022
A study from University of California, Davis, and Harvard Medical School reveals multiple new sirtuins in early branching animals like jellyfish, sea sponges, and sea anemones. These proteins are involved in metabolism and DNA repair, playing a crucial role in the unique longevity strategies of these animals.
SourceUniversity of California - Davis·JournalMolecular Biology and Evolution·TypeExperimental study·DateSep 22, 2022
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A preclinical study found that age-related decline in two sirtuin enzymes alters mitochondrial dynamics, weakening cardiac contractions in response to ischemia-reperfusion injury. Boosting SIRT1/SIRT3 levels may help protect against such injuries, potentially reducing heart attack complications and deaths.
SourceUniversity of South Florida (USF Health)·JournalAging Cell·TypeExperimental study·DateAug 24, 2021
The Estée Lauder Companies' research focuses on defending skin from environmental stressors and aging, demonstrating the antioxidant benefit of eucalyptus extract. The team discovered that activating sirtuins with key ingredients increases skin fibroblast activity to combat aging.
Researchers found that aging contributes to a decline in intestinal stem cells, which can lead to disorders of the gastrointestinal tract. Boosting these cells with a compound called nicotinamide riboside (NR) reverses this effect and provides protection against age-related damage.
SourceMassachusetts Institute of Technology·JournalAging Cell·DateMar 28, 2019
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Researchers at Baylor College of Medicine discovered a new approach to treating age-related diseases by stabilizing telomeres and restoring sirtuin activity. This method shows promise in improving liver disease outcomes in a mouse model.
SourceBaylor College of Medicine·JournalCell Metabolism·DateMar 28, 2019
A study from the University of Eastern Finland has found that anthocyanins in berries increase SIRT6 enzyme levels and decrease cancer genes in human cells. The findings suggest a potential role for anthocyanins in preventing cancer growth, paving the way for new drug development.
SourceUniversity of Eastern Finland·JournalScientific Reports·DateApr 5, 2018
Researchers at MIT have found a compound that promotes new blood vessel growth, boosting endurance in elderly mice by up to 80 percent. The study suggests that this restoration of muscle mass could help combat age-related frailty and related conditions.
SourceMassachusetts Institute of Technology·JournalCell·DateMar 22, 2018
A new study found that boosting Sirt4 gene activity extends healthy lifespan in fruit flies, with a 20% increase in longevity seen in modified flies. The researchers also discovered that Sirt4 plays a crucial role in regulating metabolism and fasting responses.
SourceBrown University·JournalProceedings of the National Academy of Sciences·DateJan 29, 2018
Researchers found that an intermittent feast-and-famine diet increased sirtuin proteins, which promote longevity and protect against age-related diseases. The diet also decreased insulin levels, potentially having an anti-diabetic effect.
SourceUniversity of Florida·JournalRejuvenation Research·DateFeb 27, 2015
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Researchers have identified a key gene in energy metabolism, revealing its crucial role in regulating fat storage. The Sirt7 gene plays a central role in the process, enabling mice to maintain normal weight despite high-fat diets, suggesting new therapeutic approaches for obesity and metabolic disorders.
SourceMax-Planck-Gesellschaft·JournalCell Metabolism·DateApr 30, 2014
Researchers found that SRT1720 supplementation significantly extended mouse lifespan by 8.8% while reducing body weight, improving muscle function, and lowering cholesterol levels. The study suggests a potentially promising strategy for improving human health and longevity.
Researchers have identified widespread regulation of proteins involved in metabolism by the mitochondrial sirtuin, SIRT5. This study found that SIRT5 selectively removes specific sites of succinyl modifications in over 140 different proteins, leading to disruptions in metabolic pathways.
SourceBuck Institute for Research on Aging·JournalCell Metabolism·DateDec 10, 2013
Researchers at Columbia University Medical Center have identified a mechanism that can give energy-storing white fat some of the beneficial characteristics of energy-burning brown fat. By activating a cell receptor called ppar-gamma, scientists found that sirtuins boost metabolism by promoting the browning of white fat.
SourceColumbia University Irving Medical Center·JournalCell·DateAug 2, 2012
New research confirms resveratrol's role in prolonging lifespan and health through SIRT1-activated mitochondrial function. Studies using mouse models show that without SIRT1, resveratrol has no beneficial effect on energy production.
SourceHarvard Medical School·JournalCell Metabolism·DateMay 1, 2012
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A new NIH study reveals that resveratrol's health benefits come from inhibiting phosphodiesterases (PDEs), not directly activating sirtuin 1. This finding may pave the way for resveratrol-based medicines and offer alternative treatments for diseases like type 2 diabetes, Alzheimer's disease, and heart disease.
SourceNIH/National Heart, Lung and Blood Institute·JournalCell·DateFeb 2, 2012
A study published in Nature found that sirtuin genes do not affect animal longevity, contrary to previous claims. Instead, dietary restriction was shown to increase lifespan independently of sirtuins.
A study by University of Wisconsin-Madison scientists identifies Sirt3 as a crucial enzyme in the aging process, which helps to slow down aging by reducing free radicals produced by mitochondria. The findings provide a rational basis for devising interventions to retard aging and improve health in old age.
SourceUniversity of Wisconsin-Madison·JournalCell·DateNov 18, 2010
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A study led by the University of Southern California found that SIRT1 protein is essential for recall in mice, but over-expression did not improve performance; instead, it raised questions about supplementing with sirtuin activators.
Researchers found that SIRT1 enzyme helps turn off body's generation of fats and cholesterol under fasting conditions. The study suggests that targeting SIRT1 could lead to new treatments for conditions involving elevated cholesterol and lipid levels.
SourceMassachusetts General Hospital·JournalGenes & Development·DateJun 30, 2010
Researchers strengthen the connection between sirtuins and calorie restriction's life-extending effects by targeting a brain system controlling growth and lifespan length. The findings suggest that drugs boosting sirtuin production could help fight diseases of aging, improving health in later life.
SourceMassachusetts Institute of Technology·JournalGenes & Development·DateDec 14, 2009
Researchers at UT Southwestern Medical Center have found that the brain plays a vital role in mediating resveratrol's anti-diabetic actions. When injected into the brain, resveratrol alleviated inflammation and activated sirtuin proteins, which may help prevent diet-induced diabetes.
SourceUT Southwestern Medical Center·JournalEndocrinology·DateOct 15, 2009
A new study found that resveratrol improves diabetes by targeting the brain, potentially leading to orally-delivered medications. Activating sirtuins in the brain mediates resveratrol's beneficial effects, which could lead to more effective targeted diabetes treatments.
SourceThe Endocrine Society·JournalEndocrinology·DateOct 6, 2009
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A new study reveals that Sirt3 helps protect the mouse heart by blocking cardiac hypertrophic response through Foxo3a-dependent antioxidant defense mechanisms. Mice lacking Sirt3 developed enlarged hearts, while those overexpressing Sirt3 were protected from cardiac hypertrophy under similar conditions.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 3, 2009
Scientists have discovered that DNA damage can lead to a decrease in gene regulation, contributing to aging. A specific sirtuin protein helps regulate gene expression and maintain DNA repair, but its dysfunction can result in chronic gene activation and aging phenotypes.
A new review article highlights the potential of sirtuins to treat diseases of aging such as Type 2 Diabetes and mitochondrial disorders. Early clinical studies suggest that SIRT1 activation may lower glucose and improve insulin sensitivity.
SourcePure Communications Inc.·JournalNature Reviews Drug Discovery·DateOct 1, 2008
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Research reveals that life-extending proteins can have damaging effects on brain cells, depending on the circumstances. The findings suggest a complex role for sirtuins, which can both protect against aging and promote oxidative stress.
SourceCell Press·JournalCell Metabolism·DateJul 1, 2008
Scientists at Sirtris developed potent SIRT1 activators, 1000 times more effective than resveratrol, to treat Type 2 Diabetes and age-related diseases. These findings hold promise for a new approach to treating metabolic and other diseases of aging.
SourcePure Communications Inc.·JournalNature·DateNov 28, 2007
A new study from The Wistar Institute suggests that a component of the common vitamin B3, nicotinamide, binds to sirtuin molecules and inhibits their activity. Activating these enzymes could have anti-aging effects and help counteract age-related health problems like obesity and type II diabetes.
SourceThe Wistar Institute·JournalMolecular Cell·DateFeb 8, 2007
Sirtuins have been implicated in the health benefits of calorie restriction, which is known to lengthen life span. The discovery reveals that sirtuins directly control specific metabolic enzymes called AceCSs, transforming them into a form that allows the body to utilize acetate as an energy source.
SourceUniversity of Wisconsin-Madison·JournalProceedings of the National Academy of Sciences·DateJun 19, 2006
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Researchers at Cold Spring Harbor Laboratory have identified SIRT7 as a key regulator of cellular metabolism and longevity. The study reveals that SIRT7 promotes the activity of key enzymes involved in glucose and lipid metabolism, leading to improved energy balance and lifespan.
SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateApr 16, 2006
A new study found that the food additive dihydrocoumarin inhibits the activity of Sir2p and SIRT1 enzymes in yeast, which are forms of sirtuin also found in humans. This inhibition increases cell toxicity and decreases lifespan by up to 30%.
SourceUniversity of California - Berkeley·JournalPLOS Genetics·DateDec 15, 2005
Scientists at The Wistar Institute discovered a binding site that, if blocked, could activate the protein to promote genomic stability and decrease cancer. By analyzing the molecular details of how sirtuins work, researchers identified potential activators using virtual libraries of molecules.
SourceThe Wistar Institute·JournalProceedings of the National Academy of Sciences·DateMay 17, 2004
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Researchers at The Wistar Institute report new insights into the role of sirtuins in gene expression, revealing a mechanism likely to be general for the entire sirtuin enzyme family. This discovery may offer an explanation for the connection between metabolism and aging.
SourceThe Wistar Institute·JournalStructure·DateNov 4, 2003
A group of polyphenols found in red wine and vegetables have been shown to activate sirtuins, enzymes that help cells survive environmental stresses and may promote longevity. These molecules, called STACs, were found to stimulate human sirtuin SIRT1, increasing cell survival rates.
Researchers discovered that sirtuins, a family of proteins controlling cellular respiration, may play a crucial role in extending lifespan. Sirtuins modify an enzyme to convert acetate into acetyl-CoA, a key component of energy production.
SourceJohns Hopkins Medicine·JournalScience·DateJan 6, 2003
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