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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Obesity plus low vitamin D may add up to a greater risk of diabetes

Research from Drexel University School of Public Health found that obese individuals with low vitamin D levels had insulin resistance 32 times more common than the general population. The combination of obesity and vitamin D deficiency may put people at a greater risk of developing Type 2 diabetes.

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Low vitamin D levels linked to weight gain in some older women

A Kaiser Permanente study found that older women with low Vitamin D levels gained an average of 2 pounds more than those with sufficient levels over nearly five years. The study, which involved over 4,600 women ages 65 and older, also found no association between Vitamin D insufficiency and weight changes in the entire group.

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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.

Treating vitamin D deficiency may improve depression

A new study found that treating vitamin D deficiency improved symptoms of depression in women, suggesting a potential link between the two conditions. The study involved three women who received oral vitamin D replacement therapy and showed significant improvement in their depression scores after treatment.

Vitamin D tests are inaccurate

A study by Loyola University Chicago Stritch School of Medicine found that two new vitamin D test kits had poor performance, with results deviating from the gold standard method by up to 25%. This inaccuracy could lead to misdiagnoses and overtreatment of vitamin D deficiency.

Investigational hormone replacement promising treatment for rare disorder

A new study presents promising results for an investigational parathyroid hormone replacement in treating hypoparathyroidism, a rare disorder marked by low calcium and high phosphate levels. The treatment effectively regulated calcium levels and reduced the need for additional vitamin D in over half of patients.

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Health benefits of vitamin D dependent on type taken

A new study funded by the Biotechnology and Biological Sciences Research Council found that vitamin D3 supplements are more effective in raising vitamin D levels in humans than vitamin D2. The research, which analyzed data from over 1,000 people, suggests that vitamin D3 may be better for overall health.

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Low vitamin D in diet increases stroke risk in Japanese-Americans

A 34-year study found that Japanese-American men who did not eat foods rich in vitamin D had a higher risk of stroke later in life. Men with the lowest dietary vitamin D intake had a 22% increased risk of stroke, while those with the highest intake had a 27% lower risk.

Hormone plays surprise role in fighting skin infections

A hormone previously associated with calcium homeostasis boosts immune response when dietary vitamin D levels are inadequate. The discovery may provide an alternative to current antibiotic therapies for treating skin infections.

Children's body fat linked to Vitamin D insufficiency in mothers

A new study published in the American Journal of Clinical Nutrition found that pregnant women with low vitamin D levels are more likely to have children with increased body fat. The research, which analyzed data from over 977 pregnant women, suggests a potential long-term health consequence for children born to mothers with vitamin D i...

Vitamin D + TB vaccine: Allies in fight against bladder cancer?

Researchers have found that a combination of vitamin D therapy and the BCG vaccine greatly improves bladder cancer survival in a mouse model, with 100% of mice surviving. The study aims to improve treatment outcomes for patients who do not respond to traditional BCG immunotherapy.

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Vitamin D supplements may protect against viral infections during the winter

Research published in the Journal of Leukocyte Biology suggests that vitamin D supplementation can strengthen innate immunity against viral infections. The study found that vitamin D insufficiency is associated with impaired immune function and lower levels of toll-like receptor 7, which regulates immune responses to viruses.

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JCI early table of contents for April 23, 2012

Researchers found vitamin D can stimulate bone cells to remove calcium from bones, potentially leading to density loss and increased fracture risk. This discovery may explain conflicting results of clinical trials examining the effects of vitamin D supplements on preventing fractures in elderly patients.

Clinical trial launches to see whether vitamin D helps treat multiple sclerosis

A new US-based clinical trial is testing whether high-dose vitamin D supplements can reduce multiple sclerosis (MS) disease activity when added to standard therapy. The study aims to determine the effectiveness of vitamin D in reducing relapse rates and improving quality of life among participants with relapsing-remitting MS.

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Vitamin D influences racial differences in breast cancer risk

African American women are more likely to have estrogen receptor (ER) negative breast cancer due to genetic variations in the vitamin D receptor. Vitamin D deficiency is also common among these women, but those with specific genetic variations may have reduced risk.

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Vitamin D shrinks fibroid tumors in rats

Researchers found that vitamin D reduced the size of uterine fibroids in laboratory rats by an average of 75% compared to untreated groups. This study provides promising evidence for vitamin D as a potential treatment for fibroids, which affect millions of women worldwide.

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Vitamin D deficiency high among trauma patients

A new study reveals that 77% of trauma patients have deficient or insufficient levels of vitamin D. Researchers found a strong link between vitamin D deficiency and increased risk of muscle weakness, bone fractures, and poor bone healing.

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Annals of Internal Medicine tip sheet, Jan. 17, 2012

Research on vitamin D supplementation in patients with severe COPD found no benefit, while CPAP treatment reduced mortality risk in women with obstructive sleep apnea. The American College of Physicians recommends discussing the benefits and harms of screening and diagnostic tests to improve healthcare quality.

Vitamin D could help combat the effects of aging in eyes

Researchers found that vitamin D reduces inflammation and debris buildup in mouse eyes, improving vision. Vitamin D also triggers macrophages to change configuration, reducing damage and promoting clear vision. The study suggests a potential simple way to prevent age-related macular degeneration.

70 percent of Europeans suffer from low vitamin D levels

A report by European Menopause and Andropause society recommends vitamin D supplements for postmenopausal women to maintain blood levels above 30 ng/ml, improving bone health and reducing fracture risk. Experts also suggest a daily intake of 600-4,000 IU/day, depending on age and risk factors.

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Annals of Internal Medicine tip sheet for Dec. 20, 2011

A recent survey of doctors and patients found contrasting opinions on electronic records, with PCPs worried about increased demands and patient confusion, but patients expressing enthusiasm for sharing notes. Meanwhile, the US Preventive Services Task Force reviewed evidence on vitamin D supplementation for fracture protection and canc...

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Low vitamin D levels do not predict the risk of acute exacerbations of COPD

A large prospective cohort study found no relationship between baseline vitamin D levels and the frequency or timing of acute exacerbations of chronic obstructive pulmonary disease (COPD) in patients with severe COPD. Vitamin D supplementation is unlikely to have an effect on AECOPD risk in these patients.

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Low vitamin D common in spine surgery patients

A study of 313 spine surgery patients found that more than half had inadequate vitamin D levels. Patients with insufficient vitamin D may benefit from taking supplements before and after surgery to aid in recovery.

Vitamin D study suggests no mortality benefit for older women

A new study led by Brown University found that vitamin D does not confer benefits against mortality in postmenopausal women, contrary to previous beliefs. The study controlled for key health factors like abdominal obesity and found no association between high or low levels of vitamin D and reduced risk of death.

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High-dose vitamin D may not be better than low-dose vitamin D in treating MS

A six-month randomized controlled trial found no added benefit from high-dose vitamin D over and above ongoing low-dose vitamin D supplementation in treating relapsing-remitting multiple sclerosis. The study involved 23 participants with MS, who received either high-dose or placebo high-dose vitamin D, and showed no significant differe...