Articles tagged with Rat Models
The NIH-funded Center for Precision Animal Modeling (C-PAM) at UAB enables precise diagnoses and treatments by creating patient-specific disease models. C-PAM's cutting-edge capabilities will help predict possible treatments that can be tested in the models, aiding in the search for unique therapies.
A new radiotracer measures synaptic density changes in the brain after stroke, providing an objective and quantitative measure of disease progression. This method may also help detect stroke early and evaluate recovery.
A new transgenic rat model accumulates amyloid specifically in brain blood vessels, strongly mimicking human cerebral amyloid angiopathy. The rTg-DI rats exhibit progressive accumulation of brain blood vessel amyloid-associated inflammation, cognitive impairments, and microbleeds.
A recent rat model study found that preconception binge drinking can negatively affect future offspring's growth, social interactions, and pubertal development. The study also discovered that these effects can be passed down through generations, highlighting the importance of parental behavior in shaping offspring's traits.
Researchers manipulated brain activity and stress hormone levels to control self-inflicted bite wounds in rats, identifying key brain regions involved in self-injurious behavior. The study provides new insights into the regulation of compulsive self-biting and its relationship with stress and reward processing.
Researchers studied thiostrepton's effects on endometriosis using an endometriotic rat model. Thiostrepton, a FOXM1 inhibitor, reduced expression of key proteins in endometriotic lesions. This suggests thiostrepton may inhibit endometriosis growth by decreasing FOXM1 expression and exerting a pro-apoptotic effect.
TSRI scientists found that deep brain stimulation (DBS) reduces the compulsion to use heroin in rat models of addiction. DBS-treated rats kept their heroin intake stable at a low level, even after abstinence periods, whereas control rats escalated their intake.
Researchers created a genetically modified rat model of autism and intellectual disability to study Phelan-McDermid syndrome. The study found that oxytocin improved social memory, attention, and nerve cell activity in the rat model.
Researchers at TSRI find that nicotine exposure promotes alcohol dependence in rat models, with those exposed to both nicotine and alcohol showing rapid escalation of drinking behavior and compulsive consumption.
Scientists Xiangdang Liang and colleagues designed a special conduit for adhesive bonding, improving the repair of sciatic nerves in vitro and in vivo. The new method provides an equivalent repair effect while reducing operation time, making it a feasible and effective technique.
Researchers found that HSP72 protects retinal ganglion cells and lateral geniculate body in a rat model of chronic ocular hypertension from injury by blocking the activation of the stress-activated kinase/c-Jun N-terminal kinase apoptotic pathway. Zinc sulfate inhibited HSP72 expression, while quercetin induced its expression.
Researchers studied rat and mouse models of focal cerebral ischemia to develop high-quality rodent models of stroke. They found optimal methods for middle cerebral artery occlusion in rats (0.40-0.45 mm, 18-20 mm thread insertion length) and mice (0.15-0.18 mm, 9-11 mm thread insertion length).
Researchers used a rat genomic gene-chip to profile hippocampal gene expression changes after electroacupuncture therapy. The results showed that electroacupuncture regulates the expression of specific genes involved in depression, including Vgf and Igf2. These findings suggest that electroacupuncture may be a useful treatment for depr...
Scientists have successfully restored behavior in rats using a neural prosthesis after brain injury. The device, a closed-loop microelectronic system, recorded signals from one part of the brain and stimulated another to facilitate repair. Two weeks after implantation, rat models recovered nearly all function lost due to injury.
Researchers halt progressive neuron degeneration in rat model of familial ALS by switching off mutant TDP-43 expression. Recovery is possible if intervention occurs before significant motor neuron degeneration.
Researchers at Northwestern University have developed a model that simulates how rats use their whiskers to sense objects around them. The model enables further research on the human sense of touch and may provide insights into new technologies that could utilize the whisker system.
Developmental biologist Hazel Sive proposes using the term 'tool' to define biological systems that don't accurately recapitulate human disorders, but provide valuable insights. These 'tools' can be used in loss-of-function studies and screening for chemicals that affect gene activity, potentially leading to therapeutic targets.
Researchers have identified a previously overlooked brain area, the lateral habenula, as a prime locus of human depression. The area's hyperactivity is linked to depression-like symptoms and may be targeted by deep brain stimulation (DBS) for treatment.
Researchers at Northwestern University are studying the rat whisker system to gain a better understanding of how animals perceive touch. By developing models and simulating the rat's behavior, they aim to unlock the secrets of neural processing and potentially create new technologies that can mimic the senses of mammals.
A new compound has shown significant effectiveness in protecting brain cells directly affected by Parkinson's disease, a progressive and fatal neurodegenerative disorder. The compound, SR-3306, aims to inhibit JNK enzymes that play a key role in neuron survival.
Researchers identified TRPC6 as a key player in ischemic nerve cell death and found that suppressing its degradation prevents brain damage. In a rat model of stroke, they demonstrated that inhibiting TRPC6 degradation reduces nerve cell death.
Researchers developed an experimental rat model that mimics the plexiform lesion in pulmonary arterial hypertension (PAH), a life-threatening problem. The model is expected to reveal detailed cellular and molecular mechanisms of severe PAH.
In a rat model of depression, fluoxetine inhibited mast cell ultrastructural alterations and de-regulated rMCP-1 expression. Treatment with fluoxetine suggested that SSRIs are an effective therapeutic agent for some gastroduodenal diseases caused by psychological factors.
Research led by Dr. Yi-Jia Lou suggests that LTC4 synthesis enzymes contribute to liver injury in a rat FHF model, leading to accumulation of cys-LTs. The study's findings imply further investigation into the expression and activity of these enzymes in managing viral hepatitis patients.
Scientists from Berlin developed a theoretical model that shows how an orientation map develops in the brain, allowing for the emergence of place cells and head direction cells. The model analyzes realistic image data to extract information relevant to orientation, leading to the formation of cognitive maps.
A study published in BMC Biology found that G-CSF protein reduces the size of the affected brain area by a third when injected four hours after a stroke, and restores motor functions in rats. Regular delayed injections of G-CSF starting up to three days after experimental stroke are also effective.
Scientists have identified a positive feedback loop in rat whiskers that helps gather sensory information, potentially leading to new treatments for blepharospasm. The discovery could also deepen understanding of the human eyeblink circuit and its connection to neural circuits.
Researchers at UW-Madison have successfully created the world's first knockout rats using a novel combination of techniques, enabling further study of breast cancer and potential treatments. The development restores the rat as a key model for biomedical research, leveraging its genetic flexibility to gain insights into various diseases.
A team of scientists at CIIT published an up-to-date risk assessment for cancer from inhaled formaldehyde, integrating the latest mechanistic knowledge and incorporating a two-stage clonal growth model. The new model predicts lower risks for environmental and workplace exposures compared to earlier models.
VA-10,367 has been shown to enhance the recovery of function following spinal cord injury through effects on neuronal regeneration. In a peripheral nerve injury model, the compound accelerated the days to onset of foot movement and walking, leading to recovery of function.