Articles tagged with Alopecia
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A genomic study identified over 200 genetic regions linked to male pattern baldness, including genes related to hair structure and development. The research provides a formula to predict the chance of severe hair loss based on genetic markers.
Hair loss and breakage caused by acquired trichorrhexis nodosa (TN) can be reduced with proper cleansing and styling. Researchers recommend choosing the right shampoo based on hair type and minimizing frequent washing for those with tightly curled or dry hair. Conditioners, especially protein-containing ones, are also crucial for healt...
Testing for HPV types 16 and 18 in women with minor cervical lesions may help determine which patients should be referred to colposcopy. This approach could lead to more precise patient management and reduced healthcare burden.
A clinical trial found that ruxolitinib, a JAK inhibitor, significantly restored hair growth in 75% of patients with moderate to severe alopecia areata. The treatment was well-tolerated and showed promise for treating other forms of hair loss.
A survey of 122 people found that men with hair transplants were rated as more youthful, attractive, successful, and approachable compared to those without. Hair loss was associated with a negative perception of attractiveness.
Certain scalp-pulling hairstyles, such as tight ponytails and braids, are associated with traction alopecia in African-American women. Moderate-risk styles include thermal straightening, permanent waving, and wig use, while low-risk styles include loose buns and natural styles that avoid chemicals.
Researchers at Columbia University Irving Medical Center found that inhibiting the Janus kinase (JAK) family of enzymes promotes hair growth in mice and human hair follicles. The study suggests that JAK inhibitors, approved for blood diseases and rheumatoid arthritis, could be used to restore hair growth in humans.
A USC research team led by Cheng-Ming Chuong has discovered that plucking hair in a specific pattern can trigger the growth of new hairs in mice. The study used quorum sensing to understand how the hair follicle system responds to injury and found that it recruits immune cells to secrete signaling molecules that promote hair growth.
A Northwestern University study found that clinical trials for finasteride, a common hair loss treatment, inadequately reported sexual dysfunction, which may persist. The study analyzed 34 clinical trials and found no adequate information on the severity, frequency, or reversibility of sexual adverse effects.
Researchers found that propolis, a substance from honeybee hives, encourages hair growth in mice by increasing special cells involved in the process. The study suggests that propolis' anti-inflammatory compounds could help treat balding conditions.
A large cohort analysis found a significant link between male pattern baldness and aggressive prostate cancer. Men with specific hair loss patterns at age 45 were at a 40% increased risk of developing aggressive prostate cancer. The study supports earlier research suggesting a biological link between baldness and prostate cancer.
A study of 282 patients with chronic graft-vs-host disease found a link between female donors and the development of vitiligo and alopecia areata. The study identified risk factors, including sex mismatch and certain antibodies, which may lead to better understanding of autoimmune manifestations in this condition.
Researchers at Columbia University Irving Medical Center have identified the immune cells responsible for destroying hair follicles in people with alopecia areata. A small number of patients showed complete hair regrowth after treatment with an FDA-approved drug, JAK inhibitors, which eliminated attacking T cells and restored hair growth.
A 25-year-old patient with alopecia universalis has successfully regrown a full head of hair, including eyebrows and facial hair, after receiving the novel treatment. The patient's condition was previously untreatable, but the new treatment using FDA-approved drug tofacitinib citrate reversed his disease.
Researchers at Columbia University Irving Medical Center have devised a novel hair restoration method that can generate new human hair growth, potentially expanding the use of hair transplantation to women and younger patients. The approach uses dermal papilla cells from patient donations to induce hair follicle growth in tissue culture.
A meta-analysis of published evidence found a link between male pattern baldness and an increased risk of coronary heart disease, especially on the crown of the head. Men with extensive vertex baldness were 44% more likely to develop coronary artery disease than those with a full head of hair.
A genome-wide association study published in PLoS Genetics found six new loci associated with early onset male pattern baldness, including unexpected links to Parkinson's disease. The study also identified a risk score predictive of hair loss based on genotypes at eight associated loci.
A study published in the Journal of Clinical Oncology found that childhood cancer survivors experience increased anxiety, depression, and depressive symptoms due to persistent hair loss and disfigurement. The study's findings highlight the long-term impact of childhood cancer treatment on quality of life.
Scientists discovered that a prostaglandin called PGD2 and its derivative inhibit hair growth, targeting GPR44 as a promising therapeutic target for androgenetic alopecia. Elevated PGD2 levels were found in the bald scalp tissue of men with male pattern baldness.
Spanish scientists have confirmed a clear relationship between androgenetic alopecia and benign prostate hyperplasia, with men experiencing premature baldness at higher risk for BPH. The study, published in the Journal of the American Academy of Dermatology, found an association between hormone levels and prostate volume.
A study of 326 African American women found a high prevalence of central hair loss with clinical signs of scarring, linked to diabetes, bacterial scalp infections, and hairstyles causing traction. Hair styles associated with braids and weaves may lead to prolonged folliculitis and scarring.
A French study found that men who start losing hair at age 20 are twice as likely to develop prostate cancer compared to healthy men. The study also suggested that balding may be a potential risk factor for prostate cancer.
Researchers found that 5a-reductase inhibitors, used to treat BPH and hair loss, can cause significant adverse effects in some individuals, including loss of libido, erectile dysfunction, and depression. The study suggests that caution should be exercised before prescribing these medications to patients.
A study by George Cotsarelis at the University of Pennsylvania School of Medicine found that balding men retain hair follicle stem cells but lack CD200-rich and CD34-positive progenitor cells. This defect is linked to a transition problem for stem cells, providing potential new therapeutic targets for AGA treatment.
A study by Columbia researchers has identified eight genes associated with alopecia areata, an autoimmune disease affecting 5.3 million Americans, and found that drugs targeting these pathways may lead to new treatments.
A team of investigators has identified a new gene, APCDD1, which causes progressive hair loss beginning in childhood. The discovery provides insight into the process of hair follicle miniaturization, shared with male pattern baldness, and may lead to non-hormonal treatments.
A study published in Nature Genetics has identified a novel hair-loss gene variant associated with male baldness. The research found that this gene, located on chromosome 20, is inherited from both parents and may account for the similarity in cranial hair growth between father and son.
Two genetic variants on chromosome 20 increase male pattern baldness risk by sevenfold, affecting up to 14% of men. The discovery is a scientific breakthrough but does not guarantee a treatment or cure for the condition.
Researchers found that performing a standardized 60-second hair count is a reliable method for assessing hair shedding in healthy men. The study found consistent results across age groups, with an average loss of 10 hairs per minute, and demonstrated low intrapatient variability.
Researchers at the University of Bonn have identified a gene responsible for Hypotrichosis simplex, a rare hereditary form of hair loss. The study's findings offer new hope for developing targeted therapies for various forms of hair loss.
A survey of 740 Taiwanese men found a statistically significant positive association between smoking and moderate to severe androgenetic alopecia, a common type of hair loss in men. The study suggests that smoking may destroy hair follicles or damage the papilla that circulates blood and hormones to stimulate hair growth.
A multicenter study found that finasteride artificially lowers PSA levels in younger men taking it for hair growth, impacting diagnosis accuracy. The study calls for new clinical guidelines to account for this effect when evaluating PSA results.
A study found that combining finasteride with an oral contraceptive improved female pattern hair loss in 62% of patients. Hair density scores increased in 12 patients, and all participants reported no adverse reactions to the treatment.
A genetic variant of the androgen receptor gene has been found to be associated with premature balding in men, leading to more androgen receptors in the scalp. The findings suggest that this genetic defect can be inherited from the mother and may also involve other genes.
Researchers developed a mouse model that replicates human adult onset alopecia areata, shedding light on the disease's complicated genetic basis involving multiple genes. The study provides insights into treating AA and other complex polygenic diseases.
A study found that equol, a natural metabolite from soy isoflavones, blocks the effects of DHT without altering testosterone levels, reducing prostate size in rats. This molecule may offer a treatment for BPH and prostate cancer, as well as promoting healthy skin and hair growth.
Researchers created a mouse model of hair loss syndrome, which sheds light on the complex interactions between genes and their effects on human diseases. The study found that genetic background plays a significant role in determining the severity of the condition, and could potentially inform gene therapy approaches.
Researchers created genetically engineered mice lacking keratin 17, a structural protein found in hair follicles, to investigate its role in hair growth. The results show that K17 knockout mice display temporary baldness due to hair fragility and premature cell death, but eventually regrow fur at around three weeks old.
Two women with Parkinson's disease experienced hair loss while on dopamine agonists pramipexole and ropinirole. After discontinuing these medications and switching to new treatments, their hair growth resumed in both cases.
Researchers found that proteins produced by melanocytes trigger attacks on immune cells, leading to hair loss. The discovery could pave the way for more effective treatments for alopecia areata.
Researchers have determined the function of the Hairless protein, revealing its role in regulating gene expression dependent on the thyroid hormone receptor. The discovery provides molecular insight into congenital hair loss disorders and represents a stepping stone for designing therapeutic agents.
Researchers at Columbia University have identified the first human gene associated with hair loss, offering new possibilities for treating various forms of alopecia. The 'hairless' gene initiates a cascade of events that stimulate hair growth, potentially leading to more effective treatments and gene therapy.