Articles tagged with Dopamine
Researchers at Vanderbilt University Medical Center have discovered a functional link between the brain's reward and stress signaling circuits. Dopamine, the chief reward signal, works through corticotrophin-releasing factor (CRF) to increase activity in a brain region involved in addiction relapse.
A Princeton University scientist has demonstrated that sugar can be an addictive substance, with lab animals showing signs of craving and relapse. The study suggests that bingeing on sugar can lead to long-lasting effects in the brain and increased motivation for other substances of abuse.
Researchers have identified a stage during dopamine neuron differentiation that may be an ideal time to collect human embryonic stem cells for transplantation to treat Parkinson's disease. Lmx1a-positive cells with TrkB surface marker can be selected using magnetic-activated cell sorting or fluorescence-activated cell sorting.
Researchers at University of California, San Diego identify cells responding to illumination by producing dopamine, a chemical message controlling pigmentation in tadpoles. This finding suggests that stimulating specific neural circuits could selectively alter brain chemistry to remedy low levels of neurotransmitters underlying human a...
Researchers found that women with decreased striatal activation in response to receiving milkshakes were more likely to gain weight over time. The study, which used brain imaging and genetic data, suggests that certain biological factors may impact one's risk for weight gain.
A new study by Eric Stice found obese people exhibit blunted reward responses in the brain's striatum, leading to increased unhealthy weight gain. The research suggests that a genetic variation affecting dopamine D2 receptors may trigger overeating in obese individuals.
Research suggests that individuals with weaker activation of brain reward circuitry when eating are more likely to be obese and gain weight over time. Those with a genetic variation associated with compromised dopamine signaling in this region are at even greater risk.
Researchers genetically modified a brain receptor to make it more sensitive to nicotine, allowing them to study the effects of dopamine production on hyperactivity in mice. This could lead to new knowledge about dopamine neurons' functions and potential treatments for conditions such as ADHD.
Researchers at Georgetown University Medical Center have identified a protein, NuIP, that regulates the Nurr1 gene critical to dopamine-releasing brain cells. Loss of NuIP function is linked to decreased numbers of dopamine-producing neurons and a decrease in expression of the dopamine transporter.
Researchers at the University of Cincinnati have found that deep brain stimulation can halt the progression of dopamine-cell loss in animal models. The study suggests that stimulating neurons with electrodes boosts the amount of BDNF, a protein that promotes neuronal growth.
Researchers discovered diazepam causes a similar change in the brain's reward-inducing dopamine cells as addictive substances. The study found neural message transmission is reinforced for up to 72 hours after ingestion of diazepam.
Researchers found that dopamine strengthens the 'go' circuit and weakens the 'stop' circuit in the brain, leading to compulsive behavior and addictive tendencies. The study also shows how Parkinson's patients' reduced dopamine levels lead to frozen motor skills.
Researchers found that genetically tweaking a part of the brain involved in learning and memory in fruit flies allowed them to stay sharp even after being deprived of sleep. This discovery may lead to new treatments for mental acuity, particularly for people who need to stay awake for extended periods.
A new study reveals a link between obesity predisposition and defective dopamine signaling in the brain's reward system. The mesolimbic system, which secretes dopamine, is found to have lower baseline levels and reduced stimulated release in obesity-prone rats.
Researchers found that pregnant mice ignore alien male urine smells after day 3 of pregnancy due to dopamine surge. This chemical change helps avoid infanticide and protects fetal development.
Researchers found a genetic change in the dopamine transporter protein that makes it behave as if amphetamine is present, leading to altered dopamine signaling and contributing to ADHD symptoms. The altered function supports a role for dopamine signaling in the disease.
Researchers identified a brain region associated with novel experiences, which may drive humans to take risks for rewards. This discovery could have implications for understanding addiction and decision-making.
A study of Kenyan nomads found that an ADHD-associated gene variant is linked to better health in the nomadic population, but malnourishment in settled individuals. This suggests that behavior differences associated with ADHD may be more or less effective depending on the environment.
Recent studies have shown that rotigotine skin patches can effectively treat restless legs syndrome (RLS) symptoms even during the day and night. The trials found significant improvements in patient symptoms, with 75% of patients rating their treatment as good or very good. No notable augmentation of RLS symptoms was observed.
A Binghamton University researcher will receive a $1.33 million NIH grant to study the side effects of Parkinson's disease treatment, with a focus on reducing dyskinesia and suppressing abnormal motor movements. The research aims to develop new treatments that can address these issues and improve patient outcomes.
A novel cell therapy using retinal pigment epithelial cells attached to gelatin bead microcarriers has shown promising results in patients with moderate to advanced Parkinson's disease. The therapy, Spheramine, has been well-tolerated and has improved symptoms such as tremor, rigidity, and balance issues for several years.
A new study by University of Minnesota researchers identifies unit burst generators in the spinal cord that control rhythmic movements such as walking. The discovery may help lead to treatments for Parkinson's disease and spinal cord injuries.
Researchers at Brookhaven National Laboratory found that increasing dopamine D2 receptor levels can reduce cocaine use in rats by 75 percent. The treatment, which involves injecting a harmless virus carrying the D2 receptor gene into the brain, has potential as an addiction therapy.
A team of researchers found that high-frequency vocalizations in male mice are associated with approach behaviors and positive emotions, linked to dopamine and acetylcholine receptors. The study provides a new method for screening emotion genes and developing drugs for controlling emotions and mood disorders.
Researchers found that dopamine can block the growth of new blood vessels in cancer cells by binding to a specific receptor on endothelial progenitor cells. This could lead to a potential treatment for cancer patients, as it slows down cancer progression and reduces tumor growth.
Researchers from Princeton University have developed a new experimental technique to study brainstem activity in humans, tracking changes in blood flow associated with dopamine levels. The findings provide critical insights into the role of brain chemicals in neuropsychiatric disorders such as addiction and Parkinson's disease.
A recent study suggests that cocaine's impact on brain metabolism may be a key factor in its addictive nature. The research, conducted at Brookhaven National Laboratory, found that the drug had significant effects on brain metabolism beyond just dopamine, even in mice lacking the gene for dopamine transporters.
A new study by University of Chicago Medical Center researchers found a remarkable overlap between the effects of nicotine and opiates on dopamine signaling in the brain's reward centers. The findings suggest that these two addictive substances share common underlying brain chemistry mechanisms.
A recent study by Gerald Haeffel and colleagues found that genetic and environmental factors interact to increase the risk of depression in adolescents. The researchers discovered that boys with rejecting mothers and a specific form of the dopamine transporter gene were at higher risk for major depression and suicidal ideation.
Vanderbilt University researchers found that aggression triggers a rewarding response in the brain, involving dopamine, which motivates individuals to engage in aggressive behavior. This study offers insights into our propensity for violence and fascination with violent sports.
Researchers identified four polymorphisms in the dopamine transporter gene associated with an altered risk of withdrawal seizures in alcohol-dependent patients. These findings may help identify patients at high risk and prevent seizures more efficiently.
A study by Einstein researchers suggests that impaired autophagy may contribute to the development of Parkinson's disease. The team found that dopamine-altered alpha-synuclein molecules interfere with lysosomal digestion, leading to toxic compound accumulation and cell death.
Researchers discover that FOXA2 specifies the floor plate and induces dopamine neuron birth, leading to motor deficits and degeneration in mice. This study provides insights into dopamine neuron development and offers potential avenues for treating neurodegenerative diseases like Parkinson's.
Scientists have identified genetic differences that predict the effectiveness of antipsychotic drugs for patients with schizophrenia, Parkinson's disease, and drug addiction. These markers may enable doctors to match patients with the most suitable therapy, improving treatment outcomes.
Researchers at the University of Illinois Chicago have received a $2.2 million grant to develop therapeutics for suppressing cocaine cravings by targeting 5-HT2 receptors in the brain. These receptors play a crucial role in controlling a person's desire to use drugs.
David Farb's abstract details how antioxidants affect dopamine release from synaptosomes, suggesting potential for treating oxidative damage in neurodegenerative diseases. Antioxidants like glutathione and NAC may rapidly stabilize dopamine release, raising their therapeutic potential.
Researchers at Saint Louis University School of Medicine discovered a key brain chemical that causes Parkinson’s disease. They found that dopamine itself is converted into DOPAL, which triggers the death of dopamine-producing cells and leads to Parkinson’s.
Genetically obese rats showed lower dopamine D2 receptor levels than lean counterparts. However, restricting food intake increased D2 receptor numbers, partially reversing age-related decline. This finding suggests a link between brain's reward system and food availability in obesity.
A new coating method mimics mussel adhesive properties, allowing for the attachment of various materials to inorganic and organic surfaces. This method has potential applications in fields such as electronics, medical devices, and water treatment.
Researchers found that insulin levels affect dopamine systems in the brain, which are involved in drug addiction and neuropsychiatric conditions. In diabetic animals, amphetamine-induced dopamine signaling was disrupted, suggesting a link between insulin status and brain function.
Scientists have identified three genes associated with dopamine functioning in the brain, predicting individual differences in learning behaviors. These genes affect implicit reward learning and change choice strategies after negative feedback. The study offers insights into the genetic basis for learning differences and potential impl...
Researchers at ESRF and CNRS used chemical nano-imaging to visualize iron distribution in dopaminergic neurons. They found that iron is stored within dopamine vesicles, which helps explain the molecular mechanisms involved in Parkinson's disease.
A new study suggests that ANKK1 gene may play a role in addictive behaviors, providing a potential explanation for inconsistent findings with the dopamine D2 receptor gene (DRD2). The research used data from the Collaborative Study on the Genetics of Alcoholism and found evidence of association between ANKK1 and addiction phenotypes.
Researchers found a link between the loss of norepinephrine and dopamine neurons and delayed Parkinson's symptoms. The study showed that both types of neurons are necessary for normal motor function.
Adults with ADHD show blunted response to methylphenidate, suggesting dopamine dysfunction may contribute to ADHD symptoms. Reduced dopamine activity is also associated with increased substance abuse in individuals with ADHD.
Researchers at University of Helsinki discover novel neurotrophic factor CDNF that protects and rescues damaged dopamine neurons, recovering function after experimental lesion. This breakthrough may lead to new treatment strategies for Parkinson's disease.
A new study suggests that stimulant treatment for attention-deficit hyperactivity disorder (ADHD) can increase the risk of future drug abuse, with age and treatment duration being key variables. The researchers found that brain chemistry changes associated with longer treatment periods may attenuate the propensity to abuse drugs.
Researchers from Yale University and others report that injecting human neural stem cells into primates with severe Parkinson's disease improved symptoms such as tremors and motor function. The study found that the stem cells survived, migrated, and had a functional impact, suggesting a potential therapeutic value.
Researchers at Northwestern University have discovered a drug that slows and may halt the progression of Parkinson's disease by rejuvenating aging dopamine cells. Isradipine, a widely used hypertension medication, restores stressed-out dopamine neurons to their youthful state, potentially extending the time L-DOPA works effectively.
A new study from USC researchers found that treadmill exercise can improve balance and stability in patients with Parkinson's Disease. The study, published in the Journal of Neuroscience, suggests that exercise may help the brain work more efficiently by allowing remaining dopamine-producing neurons to function harder.
Researchers found people taking levodopa were 95% more likely to choose symbols associated with higher monetary gains than those on haloperidol. Dopamine depletion may lead to lack of motivation in Parkinson's disease patients.
New research reveals morphine makes lasting changes in the brain by blocking a key mechanism for memory making, suggesting addiction is a disease of learning and memory. The findings may help explain how addictive drugs affect the brain and support a new theory of addiction.
Research suggests that variations in the alpha synuclein gene contribute to alcohol craving in certain individuals. The study found eight SNPs associated with alcohol craving, but not with dependence, indicating a possible subtype of alcoholics influenced by this genetic factor.
A Mayo Clinic study found a link between dopamine agonist medications and compulsive gambling in RLS patients. The medication-induced behavior worsened with increasing doses, but was reversible when the dose was reduced or alternative medication was used.
A Stanford University study suggests that boosting endocannabinoid levels in the brain may be a new treatment approach for Parkinson's disease. Researchers combined a drug with an experimental compound to trigger improved movement in mice with a condition similar to Parkinson's, showing promising results.
A team of Canadian researchers discovered a distinct dopamine signalling complex in the brain, which may have a significant role in understanding and treating schizophrenia. This novel target involves two different types of dopamine receptors that only create brain signals when both are stimulated at the same time.
A study by Marina Picciotto and colleagues at Yale University has identified a crucial gene involved in nicotine-induced behaviors in the brain. The researchers found that blocking CREB activity in the nucleus accumbens blocks nicotine reward, suggesting potential new targets for smoking cessation therapies.
Researchers found lower levels of dopamine transporters in certain brain regions of ADHD patients compared to controls. ADHD patients experienced higher levels of inattention despite similar dopamine transporter levels, indicating a complex relationship between dopamine and attention.
Researchers propose a new classification system for addictive drugs based on their effect on dopamine levels in the brain. This new classification may help in directing research towards more effective treatment of addiction.
Georgia Tech/Emory researchers used dopamine to create a polymer that stimulates nerve tissue to regrow and reconnect, offering a potential treatment for neurological disorders. The material degrades over time, allowing the nerve to grow in a hostile environment.