Articles tagged with Huntingtons Disease
Scientists have discovered that mutant protein fragments selectively accumulate in the nuclei and axon terminals of neurons in the brain affected by Huntington's disease. This accumulation is thought to inhibit neurotransmitter release, causing the death of specific neurons.
Researchers used a mouse model to identify changes occurring in nerve cells before the onset of Huntington's disease. They identified several signaling molecules that could be targeted for future therapies.
Researchers have created a transgenic mouse model of Huntington's disease, exhibiting progressive behavioral and motor dysfunction. The mice developed similar neuropathological changes to those seen in human Huntington's disease, with symptoms worsening as the abnormal gene load increased.
Researchers at Emory University report that a growth factor stimulation increases new neurons in the brain's striatum and cortex, raising hope for treating neurodegenerative diseases. The study confirms previous findings on adult mammalian forebrain's capacity to produce new neurons.
A $6.5-million study, the largest of its kind, aims to prevent deterioration in patients with Huntington's disease. The CARE-HD trial tests two treatments: experimental drug Remacemide and nutritional supplement CoQ10 to slow disease progression.
A transgenic mouse model of Huntington's disease has been developed, exhibiting symptoms resembling chorea and epileptic seizures. The R-6 strain is the first known mouse model to display these characteristics, allowing researchers to study the disease's progression.