Articles tagged with Kidney
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A new national program using Carnegie Mellon University's computer algorithm successfully matched transplant candidates with living donors, enabling the first kidney transplants. The program aims to increase the number of kidney paired-donation transplants by creating a national pool of mismatched donor-recipient pairs.
Researchers have discovered a new treatment option for dialysis-related anemia using FG-2216, which increases erythropoietin (EPO) production in both healthy individuals and patients with end-stage renal disease. The study's findings suggest that the kidneys of dialysis patients retain significant EPO production capacity.
Researchers analyzed over 920,000 adults and found that a faster kidney filtration rate and higher protein levels in the urine increased the risk of acute kidney injury. The study suggests using both kidney function data and proteinuria to identify individuals at risk.
Research highlights disparities in kidney donation, particularly among low-income individuals and black patients. Efforts are needed to minimize barriers and increase access to transplant care for underrepresented groups.
A diet high in fruits and vegetables can help maintain kidney function in patients with reduced kidney function due to high blood pressure. Conversely, melatonin has been shown to improve short-term sleep quality in dialysis patients but does not provide long-term benefits.
A new study found that low amounts of albumin in the urine, even at clinically insignificant levels, strongly predict faster cognitive decline in older women. This association was strongest for verbal fluency scores, suggesting albuminuria may be an early marker of diffuse vascular disease.
Researchers analyzed data from a nationwide study of over 5,200 adults and found that African Americans have faster rates of decline in kidney function compared to white Americans. Hispanic participants also showed faster declines, but with varying effects by country of origin.
A study by Elizabeth Hedgeman and colleagues found that earlier nephrologist care is associated with lower ESRD incidence and improved patient outcomes. Patients who received recommended care were in better health, more prepared for dialysis, and had a 40% lower risk of death during the first year after developing ESRD.
Research shows that moderate drinking can help prevent diabetes and premature death in kidney transplant recipients, but excessive weight may be detrimental. On the other hand, low dialysis calcium levels have been linked to an increased risk of sudden cardiac arrest among patients on dialysis.
A recent study found that patients who started dialysis at higher levels of kidney function had an increased risk of premature death. In contrast, home-based hemodialysis was shown to be cost-effective and provide potential benefits for kidney disease patients.
The Symplicity HTN-2 trial shows that deactivating nerves in the kidneys using radiofrequency energy can significantly reduce blood pressure in patients with treatment-resistant hypertension. The study found a large reduction in systolic blood pressure, and the technique was applied without major complications.
Scientists have discovered how kidney filters become damaged in renal failure, leading to increased permeability and protein loss in the urine. A new class of drugs called endothelin A receptor antagonists shows promise in reducing protein levels, promising relief for patients with diabetes and high-salt diets.
A national pilot program utilizing a Carnegie Mellon-developed algorithm is matching living kidney donors with medically compatible transplant candidates. The initial run of the computer matching process successfully matched seven people in need of a kidney transplant with suitable donors, expanding kidney paired-donation transplants.
Researchers found that hormone therapy has no effect on prostate size in middle-aged men, while a study on presumed consent policies suggests it may increase deceased kidney donation rates but lower living donor rates. Additionally, high co-pay costs are linked to increased prescription abandonment rates, highlighting the need for affo...
A new urine test has shown promise in detecting acute kidney injury (AKI) by identifying specific markers in the urine. Elevated levels of monocyte chemoattractant protein-1 and its mRNA were found in urine samples from both mice and human patients with AKI, suggesting a potential diagnostic marker.
The American Society of Nephrology (ASN) is convening a Summit on the Nephrology Workforce to address the growing crisis in kidney care. The summit aims to increase interest in nephrology careers, particularly among underrepresented minorities and women.
The VITAL study found that paricalcitol reduced residual albuminuria in patients with type 2 diabetic nephropathy, particularly those with high dietary sodium intake. The study suggests that paricalcitol could be an important adjunctive treatment for kidney protection in resistant diabetes patients.
Scientists at Max Delbrück Center for Molecular Medicine identified a key transcription factor, Grhl2, that regulates the expression of cell junctional molecules E-cadherin and claudin 4. This discovery sheds light on the development of diseases such as spina bifida and potentially impacts kidney function.
Kidney failure affects nearly half a million US individuals, with 48% being 60 years or older. Elderly patients are now more likely to receive a kidney transplant due to increased access to organs from living and deceased donors, as well as improved survival rates while waiting.
Researchers found that high erythropoietin levels are associated with increased mortality in older adults. High levels were linked to higher mortality rates independently of other factors, highlighting the hormone's potential prognostic value.
A new study published in the Journal of the American College of Surgeons found that airbags significantly reduce the risk of kidney injury in car crashes. The research analyzed over 2,800 records and found a 45-52% reduction in renal injuries with airbag deployment.
A study found that measuring three biomarkers in a single blood sample can improve physicians' ability to identify patients at high risk of developing CKD. The biomarkers included homocysteine, aldosterone, and B-type natriuretic peptide.
Researchers at NYU have developed a method to prevent the growth of crystals that form cystine kidney stones by using a synthetic inhibitor. This breakthrough may lead to a new approach to preventing cystine stones and offers hope for individuals affected by this disease.
Research highlights that kidney disease patients' blood pressure management needs are not one-size-fits-all, with age, race, and diabetes affecting mortality risk. The rate of kidney function decline also significantly impacts patient prognosis, suggesting a need for tailored strategies to protect kidney function.
Researchers at Heidelberg University Hospital developed a therapy concept to treat high-risk patients with sensitized kidneys, achieving comparable transplant survival rates as non-immunized patients. After one year, 95% of transplanted kidneys were still functioning.
A study published in Archives of Internal Medicine found that hormone therapy after menopause increases the risk of developing kidney stones by approximately 20 percent. The research calls into question the long-held belief that estrogen protects women from the disease, and clinicians need to consider the risks and benefits of hormone ...
Postmenopausal women taking estrogen therapy are at a higher risk of developing kidney stones, according to a study. The research found a significant increase in kidney stone development, with a fivefold greater risk in women with a history of kidney stones.
A recent study published in Cell Metabolism has identified podocytes as a crucial factor in the development of kidney failure in diabetes. The researchers found that these cells become less responsive to insulin, leading to similar kidney disease symptoms in mice with normal blood sugar levels.
A recent study led by St. Michael's nephrologist Dr. Ramesh Prasad has found that South Asian patients are more than twice as likely to suffer a heart attack after a kidney transplant compared to Caucasian, black and East Asian men and women.
Two new studies reveal racial disparities in kidney disease among African Americans, including higher rates of kidney failure, premature death, and lower rates of living donor transplants. The findings emphasize the importance of addressing these disparities to improve health outcomes for this population.
A DASH-style diet, rich in fruits, vegetables, and dairy products, may help prevent kidney stones by increasing urinary volume and citrate levels. The study suggests that a DASH-style diet could be an effective way to reduce the risk of kidney stone recurrence.
Researchers at Boston Children's Hospital discovered a new approach to treating polycystic kidney disease by inhibiting c-Met receptor activity, reducing cyst size and number. The compound showed promise in animal models, potentially leading to clinical trials in humans.
Patients over 50 and obese recipients are at higher risk of transplant renal artery stenosis (TRAS). Elevated triglyceride levels, CMV infection, and delayed graft function also significantly increase the risk. Researchers found that age and obesity increased TRAS by 190% and 697%, respectively.
A study found that kidney transplants showing fibrosis and inflammation after one year are at increased risk of long-term transplant failure. Routine biopsies can help identify these abnormal signs and predict potential targets for early preventative treatment.
A study reveals that individuals with prior non-kidney organ transplants are more likely to be listed for a kidney transplant before dialysis initiation. This trend adds to the list of organ allocation challenges, as these patients have higher waitlist mortality rates and shorter lifespans compared to those with prior kidney transplants.
A team of scientists is investigating the role of endothelin in salt excretion to develop new antihypertensive therapies. They are studying rats deficient in B receptors, which can lead to unbalanced salt levels and hypertension.
Researchers identify a genetic mutation in the immune system causing chronic kidney disease in Cypriot families, with symptoms including blood in the urine and progressive kidney malfunction. The mutation dates back to a single common ancestor over 16 generations ago.
Research found that black and Hispanic kidney donors are more likely to develop hypertension, diabetes, and chronic kidney disease compared to white donors. The study highlights the need for better pre-donation counseling and post-donation follow-up to address these health disparities.
A study has found that kidneys from cardiac-death donors have equivalent graft survival and function to those from brain-dead donors. This breakthrough increases the potential supply of donor organs, alleviating the shortage on the kidney transplant waiting list in the UK.
Patients with DVA/DoD insurance are more likely to undergo an arteriovenous fistula, a procedure that improves survival rates. The study highlights the need for improved kidney-related care for patients before they start dialysis.
A study reveals that HIV-infected injection drug users are more likely to develop proteinuria, a marker of kidney disease, which can lead to kidney failure. Clinicians should aggressively screen this population for proteinuria and consider them candidates for medical treatments that protect the heart and kidneys.
Researchers discovered that patients with high levels of albuminuria have a significantly increased risk of developing acute kidney injury, highlighting the importance of monitoring kidney function. By recognizing these warning signs, individuals can take proactive steps to prevent preventable forms of acute kidney injury.
Research identifies APOL1 gene variants associated with increased risk of kidney disease in African-Americans. The genetic variants may have evolved as a survival mechanism against parasitic disease in Africa.
A morning urine test is superior for detecting declining kidney performance in patients with diabetic kidney disease. The albumin:creatinine ratio from a first morning urine sample predicts worsening kidney problems more accurately than other methods.
A study published by the American Society of Nephrology found that corticosteroid treatment can prevent or delay loss of kidney function in patients with IgA nephropathy. The addition of an immunosuppressant drug, such as azathioprine, did not provide additional benefits.
A study found individuals with high resting heart rates and low beat-to-beat heart rate variability have a higher risk of developing kidney disease. The autonomic nervous system's behavior may be a sentinel marker for late-stage kidney disease.
Research by UC Health cardiologists found that while worsening kidney function is common among heart failure patients, those with transient worsening kidney function have better outcomes than those with persistent kidney failure. The study of 467 patients also showed a significant difference in mortality rates between the two groups.
A new allocation formula developed by Johns Hopkins researchers can predict which donor kidneys are most likely to be delayed or discarded. The formula could potentially speed up the organ allocation process for hard-to-place kidneys, improving transplant outcomes and saving lives.
Researchers found that early asymptomatic kidney damage in type 1 diabetes leads to a significant increase in mortality, while normal kidneys offer no increased risk of death. The study involved 658 participants and followed them for 20 years.
Researchers at TGen discovered a genetic biomarker with significant association to kidney failure in American Indians in Arizona. The study found evidence of some lesser associations between kidney failure and four other markers, all linked to the SUCNR1 gene.
Recent guidelines call for lower target blood pressure levels in CKD patients, but a critical review finds the data is not definitively supported by scientific evidence. The author suggests that doctors should make individualized decisions about blood pressure control for their patients with kidney disease.
Researchers at Indiana University School of Medicine successfully treated acute kidney injury in laboratory experiments using genetically reprogrammed cells producing a protein that aids kidney development. The treatment, administered intravenously, showed significant improvements in kidney function and reduced physical damage.
A new study found that living kidney donors with metabolic syndrome experience a decline in renal function more than twice as fast as those without the condition, highlighting the need for corrective measures before donation.
A study found that patients living in predominantly black areas are less likely to receive pre-dialysis kidney care from a specialist, despite having declining kidney function. The researchers investigated the effect of residential area racial composition on access to and quality of kidney-related care before starting dialysis.
Researchers found a new complication of stem cell therapy: angiomyeloproliferative lesions at injection sites, which can lead to kidney failure and death. The study highlights the need for further research to determine the circumstances that cause these masses to form and strategies to avoid them.
Researchers at the University of Leeds have found a protein, CLC-5, that plays a crucial role in treating Dent's disease, a rare genetic disorder causing kidney stones and failure. The study reveals that faulty CLC-5 delivery impairs endocytosis, leading to vitamin and hormone loss.
A Mayo Clinic study found that interrupting blood flow for more than 20 minutes during kidney cancer surgery increases the risk of chronic kidney disease. Limiting ischemia time can help avoid this complication.
A study found that bevacizumab increases the risk of severe urinary protein loss by more than four-fold in patients, highlighting the need for monitoring kidney health when prescribing this cancer drug. Patients with kidney cancer or receiving high doses of bevacizumab are at greatest risk.
The study reveals that Wilms tumor cells share epigenetic characteristics with normal kidney stem cells, highlighting the critical role of chromatin in tumor development. This discovery may provide new avenues for therapy and shed light on other pediatric cancers.
A UNC study finds that most kidney dialysis patients are unprepared for emergencies like hurricanes, which could disrupt life-saving treatment. The survey of North Carolina patients highlights the need for better disaster preparedness education and awareness.