Articles tagged with Lungs
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A recent study published in the Journal of Thoracic Oncology suggests that pleurectomy/decortication (P/D) is a superior approach to extrapleural pnemonectomy (EPP) for patients with early-stage malignant pleural mesothelioma. P/D resulted in significantly better survival rates and lower mortality and morbidity compared to EPP.
A major study published in the Journal of Clinical Investigation has identified a method to stop bladder cancer from metastasizing to the lungs. The study found that adding the protein RhoGDI2 to tumors reduces versican production, blocking the ability of cancer cells to grow in the lungs.
Cystic fibrosis patients are vulnerable to Pseudomonas infection, which can be deadly. Researchers at Queen's University are working on a vaccine to combat this threat.
A study found that consuming large amounts of cured meats can exacerbate chronic obstructive pulmonary disease (COPD), leading to hospital readmissions. The researchers believe that the nitrites used as preservatives in cured meats damage tissue in the lungs.
Researchers found that inhalation of interferon-gamma three times a week for at least 80 weeks improved lung function in patients with idiopathic pulmonary fibrosis. The treatment was well-tolerated and showed no systemic side effects.
Researchers discovered that natural killer T cells reduce the accumulation of inflammatory monocytes, leading to decreased lung injury and improved outcomes in severe flu infections. The study provides a platform for new approaches to mitigate the deadly effects of all flu strains.
A large population-based study found strong association between reduced lung function and increased risk of heart failure. Lower FEV1 readings by spirometry were predictive of heart failure, independent of other CVD risk markers.
A large study found that women with a history of migraine are 40% more likely to develop depression than those without. Researchers hope their findings will encourage doctors to discuss depression prevention with migraine patients.
Researchers have successfully identified the underlying mechanism of ischemia-reperfusion injury in isolated lungs, a major complication in lung transplantation. The study highlights two key proteins responsible for increased vascular permeability and inflammation, paving the way for potential therapeutic interventions.
The current lung transplant system allocates organs based on proximity rather than medical urgency, resulting in sicker patients being left waiting. This can lead to a decrease in the overall benefits of transplantation and an increase in mortality rates for those most in need.
Research reveals that pneumonic plague bacteria transform the lungs into a permissive environment for microbial proliferation. Without symptoms, these bacteria grow and reproduce rapidly, leading to rapid disease progression and high mortality rates. This unique ability is exclusive to Yersinia pestis.
A study found that adding proton pump inhibitor lansoprazole to anti-inflammatory treatment did not improve symptoms or lung function in children with poorly controlled asthma. The use of lansoprazole was associated with increased adverse events, including upper respiratory tract infections and bronchitis.
A new NIH-funded study found that treating silent acid reflux does not improve asthma control in children. Researchers found that acid reflux medication, such as lansoprazole, can actually increase the risk of respiratory problems like sore throats and bronchitis.
A new study suggests that extracorporeal membrane oxygenation (ECMO) support in awake, non-intubated patients may be an effective strategy for bridging patients to lung transplantation. The study found a higher six-month survival rate among awake ECMO patients compared to conventional mechanical ventilation.
Researchers at Baylor College of Medicine have identified the specific immune response induced by cigarette smoke as the cause of emphysema. The study found that antigen-presenting cells and genes like interleukin-17 play a crucial role in the development of the disease.
A Loyola University Chicago study discovered that patients who died from smoke inhalation injuries had lower inflammatory responses in their lungs compared to those who survived. Researchers found that immune system modulators were present at lower concentrations in the lungs of deceased patients, contradicting expectations.
Researchers at the University of Melbourne have discovered a potential new treatment for smoking-related lung diseases like COPD. The protein SAA plays a key role in chronic inflammation and lung damage in COPD, hindering natural healing in the lungs.
A new study published in the Journal of the American Medical Association found that occasional marijuana use is not associated with long-term loss of lung function. Marijuana smoke was shown to increase lung air flow rates and capacity, but only up to moderately high levels of use.
A study of 5,115 participants found that occasional marijuana use was not associated with adverse effects on lung function. Higher FVC and FEV1 were observed in those with higher lifetime exposure to marijuana.
A study analyzing lung and spleen tissue from patients who died of sepsis revealed biochemical, cellular, and histological findings consistent with immunosuppression. The research found evidence of impaired immunity in patients with sepsis, which could have important therapeutic implications.
A new study found that adding inhaled dry powder mannitol to standard therapy for cystic fibrosis improved lung function over 52 weeks. The treatment showed a significant improvement in forced expiratory volume in one second (FEV1) and fewer pulmonary exacerbations compared to the control group.
A study published in the Journal of Thoracic Oncology found that a breath test using Metabolomx's colorimetric sensor array can detect lung cancer and differentiate between its types with high accuracy. The test shows promise as a non-invasive, rapid, and inexpensive companion diagnostic for early lung cancer detection.
A University of Georgia study documents declines in lung function among firefighters working at prescribed burns, suggesting a link between smoke and particulate matter exposure. The research underscores the need for improved occupational exposure limits to protect workers' health.
A new report highlights the global impact of medical misdiagnosis, revealing over a million people diagnosed with TB develop an incurable but manageable fungal infection. Chronic pulmonary aspergillosis (CPA) can progress slowly and may lie undetected for years until symptoms appear.
Researchers published a study on following patients with retrievable IVC filters to improve placement success and patient follow-up. The study supports existing guidelines developed by the Society of Interventional Radiology for safe filter placement.
A recent study published in The Lancet found that patients with autoimmune diseases are at a higher risk of developing blood clots on the lung. The research, which involved 535,000 patients, reveals that 31 out of 33 autoimmune diseases studied were associated with an increased risk of pulmonary embolism.
A Wayne State University research team is working on a roadmap for identifying novel therapeutic targets to restore function to the mutated CFTR protein in cystic fibrosis patients. The goal is to alleviate severe lung and bowel problems associated with the disease.
Researchers found that dyslipidemia and elevated heart rate increased the risk of developing abnormal lung function, while elevated amylin levels reduced this risk. The study suggests that systemic inflammation may play a role in promoting lung function impairment after particulate exposure.
Researchers at National Jewish Health have discovered a natural lipid, POPG, that inhibits influenza infections in cell cultures and mouse models. The molecule suppresses inflammatory responses, viral propagation, and cell death associated with influenza infection.
Researchers found that the structure of lion and tiger vocal folds, including fat and viscoelastic properties, determines the low-frequency roars. The study challenges previous assumptions about the causes of loud roaring in these big cats.
Four Michigan State University researchers are working on new projects to combat cystic fibrosis, using funds from the $110,000 grant from Hunt for a Cure. The studies aim to develop new treatments and prevent bacterial infections, with a focus on understanding the role of molecules, genes, and biofilms in the disease.
A panel of blood proteins can predict patient survival in idiopathic pulmonary fibrosis, guiding treatment plans and identifying those in urgent need of a lung transplant. The biomarker panel has predictive power that may also help design more effective research trials.
The NIH has halted a trial of a commonly used triple-drug therapy for idiopathic pulmonary fibrosis (IPF) after it was found to worsen outcomes. The study showed that patients receiving the treatment had higher mortality, hospitalizations, and adverse events compared to those on placebo.
A new analysis found that coughing is more common in patients with advanced idiopathic pulmonary fibrosis and predicts rapid disease progression. The study suggests that patients who cough may have a worse prognosis, benefiting from closer monitoring and aggressive treatments.
Researchers discovered that corticosteroids are ineffective for COPD patients due to reduced HDAC2 activity, which is caused by S-nitrosylation from cigarette smoke. Sulforaphane treatment restored HDAC2 activity and improved corticosteroid sensitivity in COPD patients.
Researchers at Trudeau Institute found a link between the formation of new lymphoid tissue in the lungs and protection from tuberculosis. The study, published in The Journal of Immunology, may lead to improved vaccines and therapies for fighting deadly disease.
Scientists at Salk Institute discovered a new form of RDS in newborn mice and traced it to cellular receptor for thyroid hormone. Drugs used for treating overactive thyroid glands saved mice with deadly genetic alteration mimicking the lung problem, offering clues for new treatments.
Researchers have discovered a critical protein called calpain that contributes to the development of pulmonary hypertension in adults. Blocking this protein may prove effective in preventing narrow, scarred blood vessels and treating the condition.
Researchers found that a specific enzyme, iNOS, plays a key role in the development of emphysema. Blocking this enzyme with an inhibitor can prevent disease progression. The study also shows promising results for reversing lung damage using this approach.
A new study found that cigarette smoke affects the lungs in a way similar to cystic fibrosis, causing dry cough and chronic bronchitis. The study suggests that treatments for cystic fibrosis might also help people with smoking-related diseases.
Researchers will develop medical treatments to counteract lung injuries caused by chlorine gas exposure. The proposed treatments target impaired lung function and pulmonary edema with rolipram, and prevent inflammation with triptolide.
Researchers identified cells and signaling molecules that trigger lung repair in mice. Fibroblast growth factor 10 (FGF10) induces epithelial cells to revert to a stem-cell state, proliferate, and repopulate the lung lining.
Researchers at University of California, San Diego, have made a groundbreaking discovery blocking the progression of lung fibrosis in mice. By targeting a specific phosphorylation pathway, they found that it may contribute to the development of lung injury and fibrosis.
Researchers discovered that a previously unrecognized population of immune cells in the lungs orchestrate the body's repair response following flu infection. The activation of these cells is central to tissue repair at lung surfaces and could promote wound healing following other respiratory infections.
The study reveals regional and temporal variations in organ donation across the UK, with Wales consistently outperforming its neighbors. England and Scotland have lower organ donation rates, while Northern Ireland surprises with high lung donation rates.
A new study cautions that thoracic imaging protocols must carefully balance radiation doses to the breast and lungs. The study found that changing protocols can reduce breast radiation dose by over 50% and lower lung radiation dose. Researchers emphasize the need for caution when planning CT protocols.
A new method of surfactant delivery without intubation has been shown to reduce the need for mechanical ventilation and improve lung function in premature babies. The study found that infants treated with this method spent less time on mechanical ventilation and had a lower need for oxygen.
A new study found that moderately premature babies have reduced lung function at 8-9 years old, which can cause breathing difficulties. However, these issues may improve as the child grows older, according to a research presented at the European Respiratory Society Annual Congress.
A new study reveals that people with COPD are at a high risk of developing cardiovascular disease, highlighting the need for routine screening. The study found that 50.1% of patients with COPD had cardiovascular conditions, compared to 41% of those without COPD, emphasizing the importance of identifying comorbidities in clinical practice.
Researchers have identified 16 new genetic variants associated with lung function, shedding light on the molecular basis of lung diseases like COPD. The discovery could lead to targeted treatments and improved patient care.
Cyclists inhale more black carbon than pedestrians, potentially causing lung damage, according to a study led by Professor Jonathan Grigg. The researchers found that cyclists have 2.3 times more black carbon in their lungs when compared with pedestrians.
A new study by researchers from the UK found a link between living in river valley areas and an increased frequency of COPD symptom exacerbations. The unique climate in these areas, with high humidity and low dew point, retains particles and pollutants that can worsen lung symptoms.
Children with severe therapy-resistant asthma (STRA) have poorer lung function and worse symptoms due to lower levels of vitamin D. The study found that vitamin D deficiency is associated with increased airway smooth muscle mass, making breathing more difficult.
Researchers have developed a technique to observe cystic fibrosis cellular intricacies, revealing the role of CFTR in regulating ENaC activity. The study found that healthy CFTR prevents ENaC overactivity, while defective CFTR allows it to occur.
Researchers have discovered a protein called ubiquitin ligase Nedd4L as a new regulator of cystic fibrosis. Mice lacking Nedd4L in the lung developed cystic fibrosis-like disease, highlighting a promising therapeutic target. Enhancing Nedd4L function or inhibiting ENaC may alleviate symptoms of the disease.
A new study from the University of Pittsburgh School of Medicine found that anti-reflux surgery can preserve lung function in patients with end-stage pulmonary disease both before and after transplantation. The procedure was associated with improved lung function, reduced episodes of acute rejection and pneumonia, and may help extend t...
A minimally-invasive procedure aimed at reducing lung inflation and shortness of breath in patients with severe emphysema has failed to demonstrate sustained long-term effects. Despite initial improvements, the procedure's durability was lacking, with no significant differences noted between treatment and sham groups after six months.
A US patient has received the world's first transplanted lungs treated with an experimental repair process. The treatment, part of a national study, uses STEEN SolutionTM to evaluate suitability of donor lungs for transplantation. If successful, it could increase transplantable lung supply and reduce wait times.
Researchers at The Wistar Institute have discovered protein signals responsible for preserving anti-viral antibody memory. The study highlights how BLyS and APRIL sustain cells that produce antibodies against viruses, crucial knowledge for vaccine development.
A new study by the National Institutes of Health (NIH) has found that adding azithromycin to daily treatment regimens for chronic obstructive pulmonary disease (COPD) can lower frequency and severity of flare-ups. The medication was shown to improve breathing ability and overall well-being in patients with COPD.