Articles tagged with Lungs
A new study reveals that prenatal exposure to air pollution can have persistent effects on lung function development in children with asthma. The research found associations between nitrogen dioxide and particulate matter exposure during pregnancy and lower pulmonary function growth in childhood.
A new study reveals that a combination of three drugs used to treat idiopathic pulmonary fibrosis can lead to increased risk of death and hospitalization. The researchers found no improvement in lung function or slowing of disease progression with the treatment, highlighting the importance of rigorous testing methods.
A new NIH-funded study finds that concentrated saline therapy does not reduce antibiotic use in infants and preschoolers with cystic fibrosis. The study highlights the need for more research on treatments tailored to younger children with this disease.
Experimental video game technology helps therapists monitor patients' arm rehabilitation after stroke, improving recovery outcomes. A UK-led gene therapy approach has shown promising results in treating hereditary blindness, with no adverse effects reported.
Researchers found that tenasin-C gene expression and nodule size can predict lung cancer with improved accuracy. The study used bronchoscopic microsampling to collect fluid from lung nodules, showing promise for a less invasive diagnostic technique.
LA BioMed has received a Grand Challenges Explorations grant to develop an innovative treatment for premature infants using aerosolized synthetic lung surfactant. The project aims to reduce breathing problems in preterm babies by providing a non-invasive approach.
Researchers at the University of Michigan have discovered a new type of cell in mice that causes asthma symptoms even in the presence of steroids. Similar cells were found in humans with asthma, suggesting a possible target for new treatment options. Further research is needed to explore the role of these cells in human asthma.
A study found that lung procedure patients who watched a 30-minute preparation video reported less anxiety, physical pain, and higher satisfaction with their operative experience. The video also helped patients prepare for post-operative care and quit smoking.
Researchers found that PAX5 stabilizes MYC protein levels in B cells, correlating with poor patient survival. Additionally, STIM1 regulates calcium signaling to control fat preference, while IL-12 production is decreased in diabetic patients with increased infection risk.
Michael Young, a lung transplant recipient, credits his new lungs for giving him the joy of breathing again. His remarkable survival story highlights UT Southwestern's exceptional Lung Transplant Program, with an 86% one-year and 75% three-year survival rate.
Scientists found that Burkholderia cenocepacia bacteria interfere with cells' ability to fight infection, exacerbating the disease in cystic fibrosis patients. Rapamycin, an existing drug, helped control the infection in mice, suggesting autophagy as a potential target for new treatments.
A new study by Harvard researchers found a significant association between long-term fine particle air pollution exposure and higher rates of hospital admissions for pneumonia, heart attacks, strokes, and diabetes in older adults. The study used novel prediction models to estimate zip code concentrations of fine air particles and compa...
Researchers identified peroxiredoxin 2 as a key protein in predicting pulmonary metastases in breast cancer patients. The protein protects tumor cells from oxidative stress and promotes growth and proliferation in the lung. Modulating PRDX2 levels may provide a new therapeutic approach to prevent lung metastases.
Researchers at Boston University School of Medicine have derived a population of pure lung and thyroid progenitor cells in vitro that successfully mimic the developmental milestones of lung and thyroid tissue formation. The purified cells can be used to develop new gene and cell-based therapies for lung diseases.
A University of Michigan study found that older adults who get infections are at a higher risk of hospitalization for deep vein or lung blood clots. Infections were the most common predictor of hospitalization for venous thromboembolism, which can be life-threatening.
Researchers at BUSM discovered the liver's regulatory function in responding to lung infections. The study found that hepatocytes generate blood proteins that change concentration during an acute phase response, which prevents bacterial spread.
Children with asthma by age seven already had significant airflow deficits and increased bronchial responsiveness as neonates, according to a new study. Lung function deficits also progressed throughout childhood in the study, suggesting potential for early intervention.
A study published in the British Medical Journal found that carefully adjusting mechanical ventilator settings can reduce mortality rates in patients with acute lung injury. The researchers evaluated 485 patients and found that lower breath sizes and reduced pressure can have a significant impact on survival.
A new study from the University of Cincinnati found that children exposed to high levels of secondhand smoke who also had allergic sensitizations during early childhood are at greater risk for decreased lung function. Lung function among girls was six times worse than in boys who were exposed to similar levels of both secondhand smoke ...
Researchers implemented a new CT imaging protocol for lung-nodule biopsies, reducing the radiation dose by 66% while maintaining image quality. The study focused on minimizing patient exposure and promoting safer procedures.
Researchers at the University of Southampton are using 3D imaging to create personalized maps of how inhaled drugs work within the lungs. This unique visualization will help optimize drug administration and inform future treatments for diseases like asthma and cystic fibrosis.
A new website provides access to genomic data on chronic lung disease, making it easier for researchers to analyze and gain insights. The site offers a range of data types and tools for different user groups, including quantitative scientists, basic investigators, and translational scientists.
A recent study published in the Journal of Thoracic Oncology suggests that pleurectomy/decortication (P/D) is a superior approach to extrapleural pnemonectomy (EPP) for patients with early-stage malignant pleural mesothelioma. P/D resulted in significantly better survival rates and lower mortality and morbidity compared to EPP.
A major study published in the Journal of Clinical Investigation has identified a method to stop bladder cancer from metastasizing to the lungs. The study found that adding the protein RhoGDI2 to tumors reduces versican production, blocking the ability of cancer cells to grow in the lungs.
Cystic fibrosis patients are vulnerable to Pseudomonas infection, which can be deadly. Researchers at Queen's University are working on a vaccine to combat this threat.
A study found that consuming large amounts of cured meats can exacerbate chronic obstructive pulmonary disease (COPD), leading to hospital readmissions. The researchers believe that the nitrites used as preservatives in cured meats damage tissue in the lungs.
Researchers found that inhalation of interferon-gamma three times a week for at least 80 weeks improved lung function in patients with idiopathic pulmonary fibrosis. The treatment was well-tolerated and showed no systemic side effects.
Researchers discovered that natural killer T cells reduce the accumulation of inflammatory monocytes, leading to decreased lung injury and improved outcomes in severe flu infections. The study provides a platform for new approaches to mitigate the deadly effects of all flu strains.
A large population-based study found strong association between reduced lung function and increased risk of heart failure. Lower FEV1 readings by spirometry were predictive of heart failure, independent of other CVD risk markers.
A large study found that women with a history of migraine are 40% more likely to develop depression than those without. Researchers hope their findings will encourage doctors to discuss depression prevention with migraine patients.
Researchers have successfully identified the underlying mechanism of ischemia-reperfusion injury in isolated lungs, a major complication in lung transplantation. The study highlights two key proteins responsible for increased vascular permeability and inflammation, paving the way for potential therapeutic interventions.
The current lung transplant system allocates organs based on proximity rather than medical urgency, resulting in sicker patients being left waiting. This can lead to a decrease in the overall benefits of transplantation and an increase in mortality rates for those most in need.
Research reveals that pneumonic plague bacteria transform the lungs into a permissive environment for microbial proliferation. Without symptoms, these bacteria grow and reproduce rapidly, leading to rapid disease progression and high mortality rates. This unique ability is exclusive to Yersinia pestis.
A study found that adding proton pump inhibitor lansoprazole to anti-inflammatory treatment did not improve symptoms or lung function in children with poorly controlled asthma. The use of lansoprazole was associated with increased adverse events, including upper respiratory tract infections and bronchitis.
A new NIH-funded study found that treating silent acid reflux does not improve asthma control in children. Researchers found that acid reflux medication, such as lansoprazole, can actually increase the risk of respiratory problems like sore throats and bronchitis.
A new study suggests that extracorporeal membrane oxygenation (ECMO) support in awake, non-intubated patients may be an effective strategy for bridging patients to lung transplantation. The study found a higher six-month survival rate among awake ECMO patients compared to conventional mechanical ventilation.
Researchers at Baylor College of Medicine have identified the specific immune response induced by cigarette smoke as the cause of emphysema. The study found that antigen-presenting cells and genes like interleukin-17 play a crucial role in the development of the disease.
A Loyola University Chicago study discovered that patients who died from smoke inhalation injuries had lower inflammatory responses in their lungs compared to those who survived. Researchers found that immune system modulators were present at lower concentrations in the lungs of deceased patients, contradicting expectations.
Researchers at the University of Melbourne have discovered a potential new treatment for smoking-related lung diseases like COPD. The protein SAA plays a key role in chronic inflammation and lung damage in COPD, hindering natural healing in the lungs.
A study of 5,115 participants found that occasional marijuana use was not associated with adverse effects on lung function. Higher FVC and FEV1 were observed in those with higher lifetime exposure to marijuana.
A new study published in the Journal of the American Medical Association found that occasional marijuana use is not associated with long-term loss of lung function. Marijuana smoke was shown to increase lung air flow rates and capacity, but only up to moderately high levels of use.
A study analyzing lung and spleen tissue from patients who died of sepsis revealed biochemical, cellular, and histological findings consistent with immunosuppression. The research found evidence of impaired immunity in patients with sepsis, which could have important therapeutic implications.
A new study found that adding inhaled dry powder mannitol to standard therapy for cystic fibrosis improved lung function over 52 weeks. The treatment showed a significant improvement in forced expiratory volume in one second (FEV1) and fewer pulmonary exacerbations compared to the control group.
A study published in the Journal of Thoracic Oncology found that a breath test using Metabolomx's colorimetric sensor array can detect lung cancer and differentiate between its types with high accuracy. The test shows promise as a non-invasive, rapid, and inexpensive companion diagnostic for early lung cancer detection.
A University of Georgia study documents declines in lung function among firefighters working at prescribed burns, suggesting a link between smoke and particulate matter exposure. The research underscores the need for improved occupational exposure limits to protect workers' health.
A new report highlights the global impact of medical misdiagnosis, revealing over a million people diagnosed with TB develop an incurable but manageable fungal infection. Chronic pulmonary aspergillosis (CPA) can progress slowly and may lie undetected for years until symptoms appear.
Researchers published a study on following patients with retrievable IVC filters to improve placement success and patient follow-up. The study supports existing guidelines developed by the Society of Interventional Radiology for safe filter placement.
A recent study published in The Lancet found that patients with autoimmune diseases are at a higher risk of developing blood clots on the lung. The research, which involved 535,000 patients, reveals that 31 out of 33 autoimmune diseases studied were associated with an increased risk of pulmonary embolism.
A Wayne State University research team is working on a roadmap for identifying novel therapeutic targets to restore function to the mutated CFTR protein in cystic fibrosis patients. The goal is to alleviate severe lung and bowel problems associated with the disease.
Researchers found that dyslipidemia and elevated heart rate increased the risk of developing abnormal lung function, while elevated amylin levels reduced this risk. The study suggests that systemic inflammation may play a role in promoting lung function impairment after particulate exposure.
Researchers at National Jewish Health have discovered a natural lipid, POPG, that inhibits influenza infections in cell cultures and mouse models. The molecule suppresses inflammatory responses, viral propagation, and cell death associated with influenza infection.
Researchers found that the structure of lion and tiger vocal folds, including fat and viscoelastic properties, determines the low-frequency roars. The study challenges previous assumptions about the causes of loud roaring in these big cats.
Four Michigan State University researchers are working on new projects to combat cystic fibrosis, using funds from the $110,000 grant from Hunt for a Cure. The studies aim to develop new treatments and prevent bacterial infections, with a focus on understanding the role of molecules, genes, and biofilms in the disease.
A panel of blood proteins can predict patient survival in idiopathic pulmonary fibrosis, guiding treatment plans and identifying those in urgent need of a lung transplant. The biomarker panel has predictive power that may also help design more effective research trials.
The NIH has halted a trial of a commonly used triple-drug therapy for idiopathic pulmonary fibrosis (IPF) after it was found to worsen outcomes. The study showed that patients receiving the treatment had higher mortality, hospitalizations, and adverse events compared to those on placebo.
A new analysis found that coughing is more common in patients with advanced idiopathic pulmonary fibrosis and predicts rapid disease progression. The study suggests that patients who cough may have a worse prognosis, benefiting from closer monitoring and aggressive treatments.
Researchers discovered that corticosteroids are ineffective for COPD patients due to reduced HDAC2 activity, which is caused by S-nitrosylation from cigarette smoke. Sulforaphane treatment restored HDAC2 activity and improved corticosteroid sensitivity in COPD patients.
Researchers at Trudeau Institute found a link between the formation of new lymphoid tissue in the lungs and protection from tuberculosis. The study, published in The Journal of Immunology, may lead to improved vaccines and therapies for fighting deadly disease.
Scientists at Salk Institute discovered a new form of RDS in newborn mice and traced it to cellular receptor for thyroid hormone. Drugs used for treating overactive thyroid glands saved mice with deadly genetic alteration mimicking the lung problem, offering clues for new treatments.
Researchers have discovered a critical protein called calpain that contributes to the development of pulmonary hypertension in adults. Blocking this protein may prove effective in preventing narrow, scarred blood vessels and treating the condition.