Articles tagged with Lungs
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Researchers found a genetic risk factor for pulmonary fibrosis in people with the MUC5B gene variant, associated with increased lung inflammation and scarring. The study suggests that pulmonary fibrosis may be part of a larger syndrome, potentially leading to early detection and treatment.
A new device, Lung Volume Reduction Coil (LVRC), has shown significant improvements in lung function, ability to exercise, and quality of life for patients with severe emphysema. The device, implanted through a minimally invasive procedure, gathered and compressed diseased lung tissue, allowing healthy tissue to function more efficiently.
Researchers have discovered that carnitine supplements can normalize blood vessel dysfunction associated with congenital heart defects and even prevent damage after corrective surgery. High daily doses of carnitine for the first four weeks of life may also prevent endothelial dysfunction in children with heart defects.
Researchers found that ambrisentan treatment worsened IPF progression and hospitalization rates. Assessing acute changes in Lung Allocation Score can inform organ wait-list strategies to reduce post-transplant mortality. Inexpensive behavioral interventions helped TB patients in poor countries quit smoking, offering a basis for effecti...
A new pumpless paracorporeal lung assist device has been successfully used to support young children with severe respiratory failure until they can undergo a lung transplant. The device helped patients recover or reach the average wait time for pediatric donor lungs, offering improved survival chances.
A consortium of scientists found that breathing ultrafine particles from engineered nanomaterials can cause lung inflammation and damage. The study examined the health effects of two types of nanomaterials and showed similar findings across different labs.
Researchers discovered that lungs with fluid in the lungs no longer pump water out as believed, but instead pump it in. This finding has important implications for treating lung edema, a common symptom of heart disease.
Scientists studying the Human Coronavirus-Erasmus Medical Center have discovered a potential treatment strategy for the new Middle East virus. The researchers found that certain compounds could treat the infection by altering lung cells' response to infection, which might help prevent the virus from reproducing.
Researchers found that tumors with ALK gene rearrangements can harbor up to 20% of additional mutations, including EGFR and MET genes. These coexisting mutations may impact treatment response to targeted therapies.
A commonly used drug, ACE inhibitor, can limit radiation damage to the lungs and heart in cancer patients. The study found that this treatment improved the heart's function and decreased fibrosis in the heart after irradiation.
The study found that lymph node volumes were estimated at 30% lower in low-dose scans compared to high-dose scans. Lung nodule volume was also significantly affected, with 46% lower volumes in low-dose scans.
Researchers from BUSM have developed a genetic signature for COPD from airway cells, providing a new way to study the disease and monitor patient response to treatments. This approach has shown consistent gene-expression changes in both airway and lung tissue cells in individuals with COPD.
A study using neutrons has explained how ozone causes severe respiratory problems by attacking the fatty lining of lungs. The attack leads to increased surface tension, impairing oxygen and carbon dioxide exchange.
The new software tool, CANARY, uses data from existing CT images to match each pixel of the lung nodule to one of nine unique radiological exemplars. This classification method has an excellent correlation with microscopic analysis and may help address issues with current screening methods.
A new nuclear medicine technique can detect early changes to the lung caused by cigarette smoke exposure, providing a noninvasive method for studying lung dysfunction in preclinical models. This technique has the potential to be applied clinically to study and diagnose the early stages of COPD.
Scientists at the University of Pittsburgh School of Medicine identified a biological pathway that triggers excessive inflammation in pneumonia and sepsis, leading to improved lung function and survival in animal models. The team developed small molecules to inhibit this protein, offering hope for new treatments for these conditions.
A recent study found that vitamin D levels in the blood are linked to improved lung function in adults. The study also discovered that people with a history of tuberculosis had lower vitamin D levels, which improved when levels rose.
A study published by the International Association for the Study of Lung Cancer found that 54% of patients with early stage node-negative lung adenocarcinoma had tumors with at least one biologically relevant mutation. The researchers also discovered mutations associated with drug resistance in these patients.
A Yale University study found that hyperoxia can activate stress pathways in developing lungs, leading to conditions like bronchopulmonary dysplasia. Blocking Cox2 with a pain drug reversed BPD in mice, suggesting it as a potential treatment target.
Researchers at the University of Pittsburgh are developing a wearable artificial lung to serve as a bridge to transplant or recovery in patients with acute and chronic lung failure. The device, called PAAL, is designed to provide longer-term respiratory support while maintaining excellent blood compatibility.
A study found significant variation in vena cava filter use among California hospitals, with some hospitals using them up to 38.96% of the time. Hospital characteristics such as small bed count, rural location, and private status were associated with increased VCF use.
Researchers discovered that maxillary sinuses change size to accommodate different climates, affecting nasal cavity shape and function. The study found a significant correlation between nose size and sinus volume in both African and European populations.
Researchers at National Jewish Health have discovered a naturally occurring lipid, POPG, that reduces inflammation and inhibits infection by the influenza virus and RSV. The lipid offers a promising approach for the prevention and treatment of these respiratory infections.
A study found that lung ultrasound can detect asymptomatic lung congestion in dialysis patients, who are at high risk of premature death and cardiac events. Treating this condition may improve cardiovascular health and prevent deaths.
The Harvard Wyss Institute's Lung-on-a-Chip has won a UK award for its potential to revolutionize drug development by reducing animal testing. The device, which mimics the complex functions of the human lung, has been used to study a life-threatening condition and identify potential new therapies.
A Johns Hopkins study of patients with acute lung injury found that one in three ventilated ICU patients developed PTSD symptoms lasting up to two years. The researchers suggest that preventing and treating PTSD in these patients is crucial, as it can impair quality of life and slow recovery.
Scientists at the University of Pennsylvania School of Medicine have discovered a way to repair lung damage caused by asthma and chronic obstructive pulmonary disease (COPD) by tweaking gene expression. They found that epigenetic regulators, including HDAC2, play a critical role in regulating lung development and regeneration.
Pulmonary fibrosis is a scarring of the lungs that causes shortness of breath and fatigue. Researchers identified a mechanosensitive cellular signaling pathway in myofibroblasts, which promotes survival and prevents normal cell disappearance after wound healing.
Scientists successfully use parthenogenic stem cells to develop functional heart muscle and treat pulmonary fibrosis. Researchers find that inhibiting a protein called ROCK attenuates myofibroblast survival and prevents lung scarring.
Researchers from Cardiff University have discovered hundreds of fungal particles in the lungs of asthma sufferers and healthy individuals alike. The study reveals that asthma patients have a distinct array of fungal species not present in healthy lungs, potentially leading to new treatment avenues.
A study published in JAMA Pediatrics found that reduced lung function in infancy is associated with wheezing beyond childhood. The study, which followed participants from birth to age 18, suggests that early airway function and later exposures such as smoking may contribute to the development of obstructive respiratory diseases.
A recent study reveals that cigarette smoke-induced miRNA expression alterations, specifically the repression of miR-487b, play a crucial role in lung carcinogenesis. Loss of miR-487b increases oncogene expression and enhances tumor proliferation, invasion, and metastasis in both normal and cancer cells.
Researchers discovered that steroid drugs can suppress a molecule key to rapid bone loss in rib fractures, reversing bone loss and improving lung function. The study's findings challenge the conventional understanding of steroids as causing bone loss.
Two new methods for detecting and measuring the levels of antisense drugs in cells have been developed, allowing researchers to track PMO delivery to individual cells and quantify its presence in tissue. These methods will advance the field of PMO research and provide valid alternatives to current time-consuming detection techniques.
A University of Liverpool study found that people with cystic fibrosis who live in deprived areas have lower weight, height, and BMI compared to those from more affluent areas. They are also more likely to experience worse lung function and pick up severe lung infections.
Researchers identify metabolic switch that turns on aggressive infection in antibiotic-resistant Pseudomonas aeruginosa. The discovery could lead to new treatments for cystic fibrosis patients and superbugs.
Researchers at Temple University Health System have identified a potential target for treating sepsis: the STIM1 protein. By blocking its activity, they halted a cascade of cellular events that lead to out-of-control inflammation and protected lungs from severe damage. The findings may lead to new treatment strategies against sepsis.
Scientists use magnetic levitation to create laboratory techniques for growing tissues virtually identical to those found in people's bodies. Researchers combined four cell types to replicate bronchiole deep inside the lung, creating realistic lung tissue.
A UT Arlington bioengineering researcher, Kytai Nguyen, is working on a drug-delivery portion of a project to develop nanoparticles that will stimulate lung growth and remodeling. The project aims to help patients with destructive lung diseases by introducing drugs through inhaled nanoparticles.
A UAlberta research team found that medications for Pulmonary Arterial Hypertension (PAH) could have adverse effects on the heart. ERAs decrease the strength of contraction in diseased right ventricles, which may be beneficial due to increased endothelin levels.
Researchers have identified specific volatile organic compounds (VOCs) produced by certain bacteria, which can be used to diagnose lung infections. The findings suggest a potential breath test to detect bacterial infections, such as tuberculosis, in just minutes.
A new study validates the IASLC/ATS/ERS classification for lung adenocarcinomas among Japanese patients, revealing prognostic value in histologic subtypes. The classification identifies specific molecular markers, such as EGFR and KRAS mutations, associated with prognosis and treatment outcomes.
A recent UC Davis study reveals that general thoracic surgeons perform the majority of complex noncardiac thoracic surgeries, including esophageal and lung procedures. The research supports the recognition of general thoracic surgery as a distinct specialty, benefiting patients in selecting surgeons for specific procedures.
Dr. Bernard Thébaud's team presents promising findings on treating bronchopulmonary dysplasia (BPD), a lung disease affecting thousands of premature newborns annually. Their study suggests the use of human umbilical cord-derived stem cells as a potential treatment, paving the way for further research and clinical trials.
A study identified a single gene, ABCA3, associated with significant cases of respiratory distress syndrome (RDS) in full-term babies. The researchers found that mutations in this gene account for about 10% of RDS cases and can be treated with neonatal intensive care.
The University of California - Los Angeles Health Sciences successfully performed the nation's first
The study provides the first report of state-level COPD prevalence, revealing significant regional variations. Nationwide, 6% of non-institutionalized adults reported having COPD, with higher prevalence in select states.
The UK BiLEVE study aims to discover the genes affecting lung function and susceptibility to COPD. Researchers will analyze data from 50,000 UK Biobank participants to identify genetic variants associated with COPD, shedding light on why some people are more prone to lung disease.
A new study by a University of British Columbia medical resident found that hypothermic patients in cardiac arrest have a 50% chance of surviving if transported to a hospital with advanced heart and lung support equipment. Non-invasive rewarming techniques, such as hot air blankets, are recommended for mild cases.
Exosomes from mesenchymal stem cells reduce lung inflammation and prevent pulmonary hypertension in a mouse model. The findings suggest exosome research could lead to new stem cell-based therapies for chronic lung disease and other inflammatory conditions.
Researchers found that maternal smoking during pregnancy increases lung function issues in children and grandchildren due to increased levels of proteins such as fibronectin, collagen, and nicotinic acetylcholine receptors. The effects are so long-lasting that stop-smoking education for expectant mothers is necessary.
A study by multiple institutions found that roflumilast increased lung function in moderate and severe COPD patients, with significant improvements in FEV1 after 6 months. Roflumilast was compared to placebo, showing consistent increases in lung function across treatment groups.
Children with sleep apnea who underwent tonsil and adenoid removal experienced improved asthma scores, while lung function remained unchanged. The study suggests a potential treatment option for managing asthma symptoms in children.
Researchers found a carbon-dioxide-sensitive neural circuit in ancient fish that likely evolved into the lungs of vertebrates. This discovery sheds light on the origins of air breathing and its role in vertebrate evolution.
Research suggests that pulmonary vaccine delivery can induce a local immune response more effectively than traditional injections, potentially combating pathogens that cause pulmonary diseases. The unique physiology of the respiratory tract makes it an attractive alternative to injections.
Dr. Rehan's research aims to understand the long-term impact of maternal smoking on childhood asthma, as well as its potential effects on future generations. Studies have shown that nicotine exposure during pregnancy can alter lung development and increase asthma risk.
A new study found that exposure to traffic-related air pollution during infancy is associated with decreased lung function at age eight, especially in boys and children sensitized to common allergens. The findings suggest early exposure may have long-term adverse effects on respiratory health.
A portable normothermic perfusion device has been tested on a group of twelve transplant patients, showing safe and effective preservation of donor lungs. The device has the potential to greatly improve transplant success and expand the pool of adequately-functioning donor lungs.
Research suggests that maintaining healthy lungs may be crucial for retaining problem-solving and processing speed in older adults. The study found no link between poorer lung health and loss of stored knowledge or memory, but showed a correlation between reduced pulmonary function and steeper declines in cognitive abilities.
A new approach to lung scanning, called parametric response mapping, allows for better distinction between early-stage small airway disease and emphysema in patients with chronic obstructive pulmonary disease (COPD). The technique enables precise diagnosis and treatment planning, as well as tracking COPD progression over time.