Articles tagged with Lungs
A new study by the University of Rochester finds that e-cigarettes emit toxic substances harmful to lung cells, including heavy metals and nanoparticles. Flavored e-juices like cinnamon also cause more stress on lung tissue.
A large-scale Danish study shows that premature babies are more likely to suffer from asthmatic symptoms and lung conditions in early life. However, the study found that they tend to grow better and eventually suffer no more lung conditions than others as adults.
A study found that recent marijuana use is associated with symptoms of airway inflammation, while moderate lifetime smoking has no significant impact on lung function. Researchers analyzed data from over 5,000 adults and discovered a link between marijuana use and respiratory symptoms.
The University of Louisville is conducting a study to evaluate the safety and effectiveness of an investigational device called Zephyr Endobronchial Valve (EBV) for treating emphysema symptoms. The EBV blocks off diseased lung sections, allowing healthier parts to expand.
A Loyola University Medical Center study found that lung transplant patients who receive lungs from heavy drinkers are nearly nine times more likely to experience primary graft dysfunction, a life-threatening complication. These transplants also displayed poorer gas-exchange and longer ventilator stays.
A novel molecular mechanism has been uncovered that tightens the bonds between cells lining blood vessels in mice, potentially preventing fluid leakage and improving survival rates. The discovery could lead to the development of new therapies targeting acute respiratory distress syndrome (ARDS), a fatal condition in approximately half ...
Researchers at UNC Chapel Hill created inhalable vaccines targeting lung diseases by modifying particle surface charge, inducing local and systemic immune responses. This novel approach may lead to improved vaccine accessibility in low-resource areas without refrigeration requirements.
A new study supports the hypothesis that lung cancer can travel through airways to adjacent lung tissue. This finding has significant implications for diagnosis and management of primary lung adenocarcinoma.
Researchers found that decreasing CHI3L1 levels slows the spread of two different kinds of cancer to the lungs of mice. This suggests addressing dysregulation is key in fighting metastasis and may lead to new treatments, such as preventing or delaying cancer spread after surgery.
A study published in Proceedings of the National Academy of Sciences found that providing additional $67 per month to elderly residents in poor countries improves their health outcomes. Participants who received this supplement showed significant improvements in lung function and memory, as well as increased access to healthcare services.
Researchers calculate that lungs excrete 8.4kg of CO2 when 10kg of fat is fully oxidized, shedding unwanted pounds. By breathing, individuals can lose up to 200 grams of carbon daily, with exercise further increasing weight loss through increased metabolic rate.
A UBC research team has found a genetic link that can prevent sun-induced skin aging by blocking the activity of Granzyme B, an enzyme that breaks down collagen. The breakthrough could lead to new treatments for various conditions, including heart attacks and lung diseases.
A team of researchers at Tel Aviv Sourasky Medical Center developed an Induced Sputum (IS) technique to assess the effect of pollution on urban asthmatic children. The study found that IS is a more physiologically sensitive biomonitoring method than environmental sampling stations, detecting hazardous particles like mercury in the lungs.
A new long-term clinical trial found that Lung Volume Reduction Coil treatment is safe over a 3-year period. Half of the patients showed continued improvement in lung function capacity and overall quality of life.
Researchers discovered that excess lipids in the lungs trigger an inflammatory response, leading to scarring and pulmonary fibrosis. The team's findings suggest a new direction for developing novel therapies by targeting lipid handling in the lungs.
The ferret genome sequencing study provides insights into the effects of pandemic flu and cystic fibrosis on respiratory tissues. The analysis shows distinct responses in the trachea and lungs to different viruses, shedding light on the course of infection.
Researchers found that Canadians with cystic fibrosis are living almost 20 years longer than they did two decades ago, with the median survival age increasing to 50.9 years. The death rate declined from 1.4 deaths per year in 1990 to 0.99 deaths per year in 2012.
Asthma is a widespread disease that causes genetic damage in peripheral blood, leading to oxidative stress and DNA damage. The study found four types of systemic effects, including protein damage, which can result in unstable chromosomes and increase the risk of other diseases.
LA BioMed researcher Frans J. Walther is receiving Phase II funding to develop an aerosol form of synthetic lung surfactant, which could reduce complications in premature babies. The grant will support the development of a new treatment that can be easily administered in resource-limited settings.
Researchers discovered flu infection prompts immune cells to migrate to gut, altering bacterial composition and causing inflammation that promotes tissue injury. Blocking inflammatory molecules or antibiotics attenuates intestinal injury, suggesting relief options for flu-induced gastrointestinal symptoms.
Analysis of over 600 small cell lung cancer and neuroendocrine tumors identified common molecular markers, including EGFR amplification, that could reveal new therapeutic targets. The study found notable differences in biomarker expression between SCLC and NET tumors.
A study analyzing Medicare claims found that biopsies accounted for 43.1% of $38.3 million in diagnostic costs for patients with ultimately negative lung cancer diagnoses. Lung biopsies were also the most expensive test, with a median cost of $3,784 and an average cost including complications of $37,745.
Research shows that primary care providers who know guideline recommendations for low-dose computed tomography (LDCT) screening are more likely to order LDCT for high-risk individuals. This knowledge gap is highlighted by a survey of over 200 primary care providers, which found that 48% knew three or more guideline components.
Researchers found that exposure to traffic-related air pollutants during the second trimester of pregnancy is associated with reduced lung function in preschool children. Higher levels of benzene and NO2 were linked to impaired lung function, particularly among allergic children and those from lower social classes.
A team of scientists found that female mice are more resistant to respiratory infections due to the presence of an enzyme called nitric oxide synthase 3, which is triggered by estrogen. The researchers hope to develop drugs targeting this enzyme to improve resistance to common lung infections.
Scientists identify tannic acid as a potential treatment for bacterial lung infections in cystic fibrosis patients, counteracting the harmful effects of the Staphylococcus aureus enzyme SMaseC. The discovery suggests that tannic acid may improve therapeutic outcomes for CF patients.
Researchers created a nano-optical sensor to detect trace levels of lung infection in breath, aiming for commercial availability. The device could also monitor environmental conditions.
Research found that prenatal BPA exposure was associated with reduced lung function and increased odds of wheezing in young children. The study examined 398 mother-infant pairs and found a significant link between early pregnancy BPA exposure and respiratory issues.
Researchers at Ohio State University found that ibuprofen can reduce lung inflammation in elderly mice, improving their immune response to tuberculosis. By lowering inflammation, ibuprofen made the lungs of old mice appear younger and more effective at fighting infection.
Researchers have synthesized a material that can absorb large quantities of oxygen from the air and store it, potentially revolutionizing medical devices and artificial photosynthesis. The material, containing cobalt, can be used to bind, transport, and release oxygen in various scenarios.
MIT researchers develop a scaling law to estimate the risk of brain injury for humans and animals, revealing that humans are more vulnerable due to thinner skulls. The method may aid in diagnosing traumatic brain injury and developing protective helmets.
A new study by University at Buffalo confirms that COPD patients breathe easier and report improved health status when using the Lung Flute, a hand-held respiratory device. The six-month study shows significant improvements in symptoms and quality of life.
A new analysis found that FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions with high rates of histoplasmosis or tuberculosis. Misdiagnosis could lead to unnecessary tests and surgeries, with potential complications and mortality.
Researchers at Yale University have discovered a microRNA mimic, miR-29, that can reverse the effects of pulmonary fibrosis in mouse models. The treatment uses intravenous delivery and has shown sustained effects on lung tissue. Further studies are needed to evaluate its therapeutic potential for human idiopathic pulmonary fibrosis.
Researchers discovered using plants to produce an enzyme may improve treatment for life-threatening lung high blood pressure. The study found that replenishing ACE2 protein helped decrease pulmonary blood pressure and increase pulmonary blood flow in rats.
Researchers discover how stem cells combat lung disease by targeting macrophages, reducing inflammation and improving bacterial clearance. This breakthrough brings hope for new treatments for acute respiratory distress syndrome (ARDS) patients.
A new study using data from over 3000 children found that factors such as birth weight, gestational age at birth and lung function, growth and other measures at 8 years can predict lung function during mid to late teenage years. The researchers discovered that weight at birth had a small effect on lung function in teen years.
A new observational study investigates the prevalence of paradoxical bronchoconstriction after using β2 agonists in smokers and ex-smokers with Chronic Obstructive Pulmonary Disease (COPD). The study reveals that African-American patients are twice as likely to experience a paradoxical response, leading to worse respiratory outcomes.
A secondary analysis of the National Lung Screening Trial (NLST) data found that both cancer prevalence and positive predictive value of lung cancer screening were higher in the 65+ cohort than in the under-65 cohort. Clinicians should share age-specific estimates of screening benefits and harms with patients to make an informed decision.
A study found that tear gas exposure can lead to respiratory symptoms such as coughing, chest pain, and phlegm production in protesters, with the effects lasting up to two weeks. Researchers also discovered that people living near protest areas were exposed to harmful lung health effects from tear gas use.
A new study confirms a strong link between air pollution and lung health in European adults, with people suffering from obesity particularly vulnerable. The findings emphasize the importance of educating about clean air and urge policymakers to update guidelines to meet WHO-recommended air quality standards.
Research found that cystic fibrosis patients have a deficiency in the immune system, specifically with HLA-DQ molecules on their cells. This deficiency affects the body's ability to fight off infections and is linked to the disease's progression.
Researchers at Indiana University have isolated a process that damages the lungs of donors who suffered from traumatic brain injury, which may lead to improved lung transplant outcomes. The study found that fluid accumulation in the lungs occurs within hours after head trauma, limiting oxygenation and reducing lung function by nearly 80%.
Scientists have found that Pseudomonas aeruginosa colonizes the nasopharynx before migrating to the lungs, leading to chronic infections. This new understanding provides an opportunity for developing treatments at the initial site of infection.
The Life Sciences Discovery Fund awarded nearly $750,000 in Proof of Concept grants to Washington state organizations to translate health-related technologies from the lab to the marketplace. Funding supports development of products for lupus treatment and at-home lung function monitoring.
Researchers discovered a peptide mimicking high-density lipoprotein (HDL) protein helps reduce oxidized lipids in pulmonary hypertension, improving heart and lung function. The study also found elevated levels of oxidized proteins in rodents with the disease, which can be targeted for treatment development.
Researchers discovered that club cells, which normally protect against inhaled microbes, contribute to prolonged inflammation during flu infection. Targeting these cells may help shorten flu symptoms by reducing lung damage.
Scientists at Monash University developed an x-ray imaging system that allows researchers to monitor the effectiveness of treatments for cystic fibrosis. This breakthrough enables non-invasive assessment of treatment efficacy on airway surfaces, accelerating development of new treatments.
NREL researchers Art Nozik and Keith Emery have been included in the Thomson Reuters' Highly Cited Researcher list, citing over 22,000 and 10,000 times respectively. Their work has greatly increased solar cell efficiency and established NREL as a leader in photovoltaics measurements.
A synthesized version of tumor necrosis factor's tip appears to work like a doorstop to keep sodium channels open inside the lungs' air sacs, clearing excess fluid. The TIP peptide may help patients survive pneumonia by targeting bacterial toxins and promoting natural defense mechanisms.
A NUS study shows that artesunate, a common anti-malarial drug, can effectively control asthma with improved treatment outcomes and lesser side effects. The research reveals artesunate's ability to suppress airway inflammation and produce anti-inflammatory effects similar to those of dexamethasone.
Scientists from The University of Manchester discovered that drugs used to treat asthma and pneumonia become ineffective due to the body's natural circadian rhythm. The study found that cells lining the lung airways have their own internal clock, which regulates inflammation in the lungs.
A new study by UNC researchers provides evidence that could help improve CF pharmacotherapies. They found that a mutant CFTR protein loses its ability to function properly when in the presence of two drugs, suggesting that drug developers should take this destabilization effect into account.
ROS1 gene fusions were detected in 12 out of 492 specimens examined for lung adenocarcinoma using RT-PCR and IHC tests. ROS1 positive patients are significantly younger than the entire population, but there are no associations with gender or smoking history.
Researchers found nine variants in the CFTR gene associated with pancreatitis, sinusitis, and male infertility, but leave the lungs unaffected. The study identifies mechanisms behind these conditions, paving the way for treatments and potential medications.
Preliminary research found that patients with serious heart and lung conditions have a narrower range of facial expressions, particularly the ability to register surprise. This can help doctors prioritize care and avoid unnecessary tests.
A multidisciplinary research team led by David Eckmann has successfully alleviated pulmonary inflammation in mice using targeted drug delivery with nanocarriers. The study, published in PLOS One, shows that steroids can access hard-to-reach lung endothelial cells and prevent inflammation.
Researchers have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, expanding therapeutic targets and potentially identifying treatable mutations. The study found that 75% of patients with lung adenocarcinoma have actionable mutations that can be treated with existing or under-development drugs.
A study found significant variation in the use of minimally invasive surgery among US hospitals, with some offering it to only a fraction of eligible patients. Surgical complications are estimated to cost $25b annually in the US and can be reduced by using minimally invasive surgery.
Researchers found that a host genetic factor exacerbates lung damage in severe TB and suggests why gene mutations rendering it inactive are common. The study also showed that drugs targeting P2X7R could be used to treat aggressive forms of TB.