Articles tagged with Lungs
The five-year survival rate for Canadians with cystic fibrosis who have received a lung transplant is 67 percent, according to new research published in the Journal of Heart Lung Transplantation. Additionally, half of those who have had transplants live beyond 10 years. The study found that factors such as age at transplant and certain...
Researchers at UGA have discovered a potential treatment for pulmonary fibrosis and pulmonary hypertension using the drug triciribine. The study shows that triciribine can halt disease progression and may even reverse some of the damage to lung tissue.
Researchers at Thomas Jefferson University found that obese patients are more prone to developing acute respiratory distress syndrome (ARDS) due to a hormone imbalance. The study suggests that replacing the deficient hormone adiponectin may prevent ARDS in at-risk individuals.
Researchers at the University of Edinburgh discovered a trigger that allows breast cancer cells to spread to the lungs. Blocking these signals in mice significantly reduces secondary tumor formation. The study's findings may lead to new treatments to stop breast cancer progression.
Researchers at Helmholtz Munich have identified FKBP10 as a potential new target molecule for treating idiopathic pulmonary fibrosis (IPF), a chronic lung disease. Analysis of patient data revealed elevated levels of the protein in IPF patients, which may lead to a new therapeutic approach.
A new clinical study published in The Lancet shows that augmentation therapy can preserve lung structure and add years of life for patients with alpha-1 antitrypsin deficiency. The treatment has been found to be effective in slowing the progression of emphysema in severe cases.
A world-first study by QUT reveals that roadside air is more charged with particles than air under high-voltage power lines, with concentrations up to 15 times higher within 10 meters of a freeway. The study highlights the significant impact of motor vehicle emissions on urban air quality.
A new study from Northwestern University finds that soy supplements do not improve lung function for patients with asthma. Lifestyle and diet may play a role in managing the disease, rather than relying on individual strategies like increasing soy consumption.
A randomized trial of nearly 400 children and adults with poorly controlled asthma found that supplementation with soy isoflavone did not improve lung function or clinical outcomes. The study suggests that this supplement should not be used for patients with poorly controlled asthma.
Dead dolphins found with lung and adrenal lesions consistent with petroleum product exposure, supporting previous health assessments of live dolphins in Barataria Bay. The study suggests that contaminants from the Deepwater Horizon oil spill contributed to the high number of dolphin deaths in the affected area.
Researchers found that type II lung epithelial cells differentiated into mesenchymal cells instead of type I cells when seeded onto decellularized lung matrix. This study highlights the importance of factors like cell populations, growth medium, and stimuli in achieving physiologically appropriate environments for lung tissue growth.
Researchers found that air pollution directly impacts cognition, with particulate matter and nitrogen dioxide affecting the central nervous system via the sense of smell. Impaired lung function was also linked to cognitive decline in elderly women, regardless of air pollution exposure.
A recent study has found that shorter adults have a higher risk of dying while waiting for a lung transplant and are more likely to be placed on mechanical ventilation. The study analyzed data from over 13,000 adults initially listed for lung transplantation in the US between 2010 and 2011.
A large study found that regular aspirin use was associated with a slower progression of percent emphysema on CT scans over 10 years. Even after adjusting for confounding factors, participants who used aspirin regularly had a significantly slower rate of progression compared to those who did not.
A retrospective study found that Caucasian and Hispanic children who undergo lung transplantation are at greater risk for developing chronic kidney disease. The study also identified high tacrolimus levels and acute kidney injury as risk factors for CKD in pediatric lung transplant patients.
A new study has found an association between vitamin E concentrations and exposure to fine particulate pollution in the general population. Higher levels of alpha-tocopherol, a form of Vitamin E, were linked to lower lung function and reduced exposure to PM2.5.
A study by LSTM scientists found that household air pollution (HAP) can cause weaknesses in the immune function of the lung, leading to higher rates of pneumonia. Healthy volunteers exposed to HAP showed a weaker killing response from their macrophage cells.
Researchers at Brown and Yale implicates a specific mitochondrial protein, NLRX1, in the development of chronic obstructive pulmonary disease (COPD) from exposure to cigarette smoke. The study shows that suppression of NLRX1 is a major cigarette-induced signature of lung destruction.
Researchers identified mutations in PARN and RTEL1 genes, which cause excessive telomere shortening and lung scarring disease. The findings strengthen the link between lung fibrosis and telomere dysfunction.
Adult survivors of preterm births may have lung capacity resembling that of the healthy elderly or casual smokers by their early 20s. Premature infants are at increased risk for contracting bronchopulmonary dysplasia, a chronic respiratory condition mainly affecting infants born less than 28 weeks of age.
A study of over 8000 patients found that surgeons with higher volumes are less likely to perform high-risk pneumonectomies, leading to better long-term survival. The researchers suggest that surgeon experience is an important factor in determining surgical outcomes for non-small cell lung cancer patients.
Northwestern Medicine researchers have identified a specific bacteria as the cause of a rare and deadly lung transplant infection. The bacteria can be successfully treated with antibiotics, saving other patients who had contracted the infection.
A new study found that lung cancer surgery patients have a higher risk of developing venous thromboembolism (VTEs) than previously thought. The study, which analyzed data from 157 patients, showed that the incidence rate was 12.1%, with most events occurring after discharge from the hospital and without symptoms.
The $1.6-million gift enables world-changing research in lung diseases and quantum computing through collaboration between the University of Waterloo and Technion-Israel Institute of Technology. Researchers aim to develop targeted drug delivery systems for pulmonary diseases and advance quantum information science.
A study by the University of Michigan found that cleaner school bus fuels can improve children's health, particularly those with asthma, by reducing inflammation and airborne particles. The research suggests a potential 14 million fewer absences from school annually if all vehicles were altered to reduce emissions.
A new study found that wind instrument players have a reduced risk of developing obstructive sleep apnoea. The researchers believe this is due to increased muscle tone in the upper airways, common among wind instrument players.
A team of UC researchers will study the rare lung disease pulmonary alveolar microlithiasis, which causes 'lung stones' and reduces life expectancy by several decades. The grant will help them develop a mouse model to understand the cause of the disease and design trials for treatment.
Researchers at the University of Michigan have successfully grown a 3D mini lung from embryonic stem cells, replicating the organization of human airways. The study demonstrates a novel method for morphogenesis in a dish, enabling the creation of lung tissue with cell types found in the lungs.
A study found that UK patients with cystic fibrosis who received transplants had better survival rates than publicly insured Americans. The research suggests that a single-payer national health care system can provide complex, coordinated and expansive care with long-term outcomes similar to those achieved by private insurance.
A recent study found that sudden growth of Burkholderia multivorans preceded periods of acute illness in a CF patient. The team used an extensive collection of lung sputum samples to analyze the bacterial community, providing critical context for their research.
Researchers at the University of Cambridge have successfully grown 'mini-lungs' using induced pluripotent stem cells derived from skin cells of patients with cystic fibrosis. These mini-lungs can be used to test potential new drugs and provide a more reliable alternative to traditional animal models.
Researchers discovered a new bodily process that explains low blood oxygen in cystic fibrosis patients with infected lungs, highlighting the importance of CFTR protein function in directing blood flow. The study suggests strategies aimed at restoring or activating the CFTR protein may improve blood oxygen levels and circulation.
A study of 1144 US adults found that those with COPD had higher levels of white blood cell count and fibrinogen, as well as elevated C-reactive protein, which were linked to an increased risk of dying. Elevated fibrinogen concentrations were also modestly associated with premature death.
A study found that poor indoor air quality in nursing homes negatively affects the lung health of elderly residents, with pollutants like PM10 and NO2 linked to breathlessness and cough. The researchers called for improved ventilation and regular respiratory checks to mitigate the issue.
Critically ill patients who undergo early exercise experience marked improvements in lung, limb, and respiratory muscle function. Researchers have identified specific mechanisms by which exercise turns off pathways involved in muscle wasting.
A 20-year study found that improved air quality in Southern California led to significant gains in lung function development among millennial children. Lung growth accelerated as air pollution declined, resulting in lower rates of abnormally low lung function and reduced risks of respiratory disease.
Double-lung transplantation was associated with better graft survival in patients with idiopathic pulmonary fibrosis, but not in those with chronic obstructive pulmonary disease. The new lung allocation score system has changed demographics of single- and double-lung transplant recipients.
New connections in gene regulation have been discovered in normal lung cells that may contribute to lung tumor formation. The researchers found that the transcription factor Nkx2-1 regulates lung cell proliferation, tumor growth, and progression by binding to microRNAs.
A new study found that Aboriginal Australians have low forced vital capacity due to environmental and socioeconomic factors. This discovery challenges the previous notion of chronic obstructive pulmonary disease (COPD) being more common among Aboriginal Australians.
Researchers have discovered that inflammation causes molecular bonds to form within mucus in cystic fibrosis, making it thicker and more difficult to clear. A potential new therapeutic approach targeting disulfide bonds has been identified, offering hope for improved treatment options.
Researchers found that teen girls from rural areas were more likely to have undiagnosed asthma, with a higher rate of depression among asthmatic teens. The study suggests that depression can be a barrier to diagnosis and treatment of the disease, making it essential to address this issue.
A recent retrospective study found that Lung-RADS guidelines generated fewer false-positives than the National Lung Screening Trial, reducing unnecessary follow-up testing. The guidelines provide structured reporting tools for practices to benchmark performance and improve lung cancer screening's cost-effectiveness.
Using Lung Imaging Reporting and Data System (Lung-RADS) criteria may reduce false positives in low-dose CT lung screenings by raising the nodule size cutoff. However, this comes at the cost of reduced sensitivity.
Researchers at Montana State University have discovered a critical molecule, IL-1a, that plays a crucial role in recruiting white blood cells to fight lung infections. The molecule helps prevent mold from invading lung tissue and growing, potentially reducing the death rate associated with Aspergillus fumigatus.
A new study by the University of Rochester finds that e-cigarettes emit toxic substances harmful to lung cells, including heavy metals and nanoparticles. Flavored e-juices like cinnamon also cause more stress on lung tissue.
A large-scale Danish study shows that premature babies are more likely to suffer from asthmatic symptoms and lung conditions in early life. However, the study found that they tend to grow better and eventually suffer no more lung conditions than others as adults.
A study found that recent marijuana use is associated with symptoms of airway inflammation, while moderate lifetime smoking has no significant impact on lung function. Researchers analyzed data from over 5,000 adults and discovered a link between marijuana use and respiratory symptoms.
The University of Louisville is conducting a study to evaluate the safety and effectiveness of an investigational device called Zephyr Endobronchial Valve (EBV) for treating emphysema symptoms. The EBV blocks off diseased lung sections, allowing healthier parts to expand.
A Loyola University Medical Center study found that lung transplant patients who receive lungs from heavy drinkers are nearly nine times more likely to experience primary graft dysfunction, a life-threatening complication. These transplants also displayed poorer gas-exchange and longer ventilator stays.
A novel molecular mechanism has been uncovered that tightens the bonds between cells lining blood vessels in mice, potentially preventing fluid leakage and improving survival rates. The discovery could lead to the development of new therapies targeting acute respiratory distress syndrome (ARDS), a fatal condition in approximately half ...
Researchers at UNC Chapel Hill created inhalable vaccines targeting lung diseases by modifying particle surface charge, inducing local and systemic immune responses. This novel approach may lead to improved vaccine accessibility in low-resource areas without refrigeration requirements.
A new study supports the hypothesis that lung cancer can travel through airways to adjacent lung tissue. This finding has significant implications for diagnosis and management of primary lung adenocarcinoma.
Researchers found that decreasing CHI3L1 levels slows the spread of two different kinds of cancer to the lungs of mice. This suggests addressing dysregulation is key in fighting metastasis and may lead to new treatments, such as preventing or delaying cancer spread after surgery.
A study published in Proceedings of the National Academy of Sciences found that providing additional $67 per month to elderly residents in poor countries improves their health outcomes. Participants who received this supplement showed significant improvements in lung function and memory, as well as increased access to healthcare services.
Researchers calculate that lungs excrete 8.4kg of CO2 when 10kg of fat is fully oxidized, shedding unwanted pounds. By breathing, individuals can lose up to 200 grams of carbon daily, with exercise further increasing weight loss through increased metabolic rate.
A UBC research team has found a genetic link that can prevent sun-induced skin aging by blocking the activity of Granzyme B, an enzyme that breaks down collagen. The breakthrough could lead to new treatments for various conditions, including heart attacks and lung diseases.
A team of researchers at Tel Aviv Sourasky Medical Center developed an Induced Sputum (IS) technique to assess the effect of pollution on urban asthmatic children. The study found that IS is a more physiologically sensitive biomonitoring method than environmental sampling stations, detecting hazardous particles like mercury in the lungs.
A new long-term clinical trial found that Lung Volume Reduction Coil treatment is safe over a 3-year period. Half of the patients showed continued improvement in lung function capacity and overall quality of life.
Researchers discovered that excess lipids in the lungs trigger an inflammatory response, leading to scarring and pulmonary fibrosis. The team's findings suggest a new direction for developing novel therapies by targeting lipid handling in the lungs.
The ferret genome sequencing study provides insights into the effects of pandemic flu and cystic fibrosis on respiratory tissues. The analysis shows distinct responses in the trachea and lungs to different viruses, shedding light on the course of infection.