A multidisciplinary consensus updates treatment guidance for prolactinomas, emphasizing early recognition, individualized management strategies, and advanced imaging. The recommendations cover screening, assessment, diagnosis, treatment, and long-term monitoring to improve patient outcomes and quality of life.
Researchers conclude an expansion of the adenoma causing tumour apoplexy was the probable cause of her premature death. The study also suggests that long-admired Strabismus (squint) of Venus may be due to the tumor.
Research in male sheep fetuses finds that excessive prenatal progesterone exposure alters the SRD5A1 gene, crucial for processing sex hormones in brain development. The study highlights the importance of hormones in fetal development and potential links to adult disease.
The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.
A study published in Science reveals that microglia and the protein RANK are involved in regulating the hypothalamic-pituitary-gonadal axis, which controls fertility. The research found that suppressing RANK expression led to distorted reproductive function, including reduced sex hormones and hypogonadism.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
A recent systematic review has compiled and catalogued publicly available omics data on pituitary tumours, highlighting the need for standardisation and clinical annotation. The resulting catalogue facilitates the reuse of data for future research projects and precision medicine initiatives.
Research found that breast cancer flattens corticosterone release in mice, reducing quality of life and increasing mortality. Disruptions to diurnal rhythms have been linked to stress responses like insomnia and anxiety in cancer patients.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
A new study by The Endocrine Society finds a strong link between acromegaly and an increased risk of various cancers, often at younger ages than expected. Patients with the rare growth hormone disorder had higher rates of certain types of cancer, including colon, gastric, breast, lung, ovarian, prostate, and blood cancers.
Researchers compared CECS and EES techniques for treating giant and irregular pituitary tumors. The study found that CECS resulted in a higher gross tumor removal rate (66%) and lower postoperative bleeding rates compared to EES.
Researchers at University of Arizona Health Sciences identified a potential way to reduce female post-operative pain by inhibiting pituitary prolactin. Stress can increase circulating levels of prolactin, leading to worsened post-operative pain in women.
Research suggests that antibiotics taken during infancy, especially in the first three months, may lead to earlier onset of puberty in girls. The study, which analyzed data on over 322,000 children in South Korea, found a significant association between early antibiotic exposure and increased risk of central precocious puberty.
Finnish researchers found pituitary macrophages regulate hormonal balance and may be used to treat endocrine disorders. Macrophages have a local effect on hormone secretion, decreasing when removed.
Researchers at McGill University found that a protein produced in muscles helps manage the release of follicle-stimulating hormone (FSH), which promotes egg maturation. Lowering myostatin levels delayed puberty and reduced fertility, while restoring it boosted FSH levels.
Scientists at the Francis Crick Institute discovered that the balance of bacteria in the gut influences symptoms of hypopituitarism in mice. Treating mice with aspirin reversed symptoms by increasing NG2 glia, a type of brain cell involved in hormone production.
A UK-wide study found that non-functioning pituitary microadenomas (NFPA) are more likely to shrink or disappear than grow within three years of monitoring. The study suggests that clinical guidelines should be changed, and a single scan three years after initial detection would be a safe and cost-effective way to manage NFPAs.
Scientists have successfully converted human pluripotent stem cells into purified pituitary cells that secrete adrenocorticotropic hormone (ACTH), a hormone normally produced by the pituitary gland. Transplantation of these cells into mice with hypopituitarism resulted in long-lasting improvement in ACTH levels.
A multicenter international study found that medical management is a viable alternative to surgery for patients with pituitary apoplexy. The study compared outcomes in 97 patients with the condition and found no significant difference between surgical and nonsurgical treatment options.
Recent review article discusses clinical development in long-acting growth hormone (LAGH) therapy, which mimics natural GH release patterns. LAGH therapies reduce daily injection burden, improving patient compliance and treatment outcomes.
The study reveals that the pituitary gland in mice ages as a result of chronic inflammation, which can potentially be slowed down or partially repaired. The researchers found that stem cells in the ageing pituitary gland retain their regenerative capacity when taken out of an inflammatory environment.
A recent study has identified a novel gene, POU1F1, associated with a development disorder of pituitary origin in Karelian Bear Dogs. The research found that the disease is inherited recessively and can be diagnosed using a gene test, paving the way for its eradication from the breed.
Researchers found changes in gene activity in the pituitary gland of foxes selectively bred for tameness, which may explain why tame foxes are less stressed. The study suggests that domestication alters animals' reactivity to stress by modifying the way their brain centers communicate about hormone release.
Researchers at Brigham and Women's Hospital have developed a new technique to analyze specific hormones in tissue, allowing surgeons to distinguish tumor from normal gland. The technique, called MALDI MSI, can determine hormone composition in under 30 minutes, potentially improving surgical precision.
A new study using PET/CT technology found that military veterans with post-traumatic stress disorder (PTSD) often have abnormal pituitary gland function. The research suggests that hormone imbalances in the pituitary gland may be a key factor in the development of PTSD in veterans who have also suffered from mild traumatic brain injury.
Researchers at ITbM and the University of Chicago uncover the mechanism behind thyrotropin's two distinct functions, triggered by seasonal changes and metabolism. Tissue-specific glycosylation differentiates the hormone's activities without cross-interference.
Researchers at McGill University have identified a new hereditary form of hypothyroidism caused by mutations in the immunoglobulin superfamily, member 1 (IGSF1) gene. This sex-biased condition affects males more frequently than females and has significant implications for thyroid hormone deficiency diagnosis and treatment.
A team of IRCM researchers has discovered a critical mechanism of epigenetic cell programming in the pituitary gland. By reprogramming cell identity using the Pax7 gene, they identified cells expressing Pax7 protein in Cushing's disease tumours, which could lead to new pharmacological treatment options.
A team of geneticists at IRCM discovered that the pituitary gland's secreting cells form highly-structured networks. These networks allow cells to recognize and exchange signals, supporting hormone balance and function.
A Manchester-based research team has been awarded a £1.24M Wellcome Trust grant to investigate the control of genes in response to hormonal changes and inflammation. The five-year study aims to understand how tissues regulate their own functions and develop new treatments for pituitary tumours.
A 12-month study found that testosterone patches improved bone density, body composition, and cognitive function in women with low testosterone levels resulting from hypopituitarism. The patches showed few side effects, making them a potential treatment option for these women.
The pituitary gland develops from a common primordium into multiple endocrine cell types through intricate signaling and nuclear events. Researchers describe the complex interactions of transcriptional regulatory factors controlling this process.