Articles tagged with Endocrinology
A global study predicts a significant increase in hip fractures worldwide by 2050, with the number projected to nearly double compared to 2018. The study highlights a post-fracture treatment gap in fracture prevention, particularly for men, leading to increased mortality and dependency.
Research presented at ENDO 2023 found women with PCOS died 47% earlier than those without the condition. They were also at higher risk for deaths due to cardiovascular disease, tumors, diabetes, and lung infections.
Children and teenagers with diabetes frequently employ inaccurate CGM alarm settings, which may lead to reduced usefulness of these devices. Research highlights the importance of following recommended alarm best practices to ensure patients receive real-time glycemic data while minimizing alarm fatigue.
Research suggests that aromatase inhibitors can limit the effectiveness of weight loss medications in breast cancer survivors. Studies have shown that these medications are less effective in women taking aromatase inhibitors, leading to reduced weight loss and increased risk of health complications.
A new analysis of the CLEAR Outcomes Trial found that bempedoic acid lowered LDL cholesterol levels by 21% and reduced cardiovascular events by 13%. This suggests that different classes of cholesterol drugs have similar benefits for cardiovascular health.
An animal study suggests that exposure to endocrine-disrupting chemicals like PCBs during pregnancy may lead to impaired cognitive function in future generations, including attention-deficit/hyperactivity disorder-like behaviors. The study found that grandchildren of rats exposed to these chemicals performed worse on behavioral tasks a...
A study found that prenatal phthalate exposure may lead to hormonal changes in females, affecting future fertility, but not males. The study suggests sex-dependent effects of phthalates on hormone levels during critical development periods.
The Endocrine Society will discuss emerging technology and diabetes research, including a scientific statement on hormones and aging. Researchers will share studies on various aspects of endocrinology, such as PCOS, obesity, and endocrine-disrupting chemicals.
Researchers found that rural patients with diabetes met fewer of the D5 metric criteria, including no tobacco use and blood pressure control, compared to urban patients. Rural patients also had fewer outpatient visits and endocrinology visits, which may contribute to poorer health outcomes.
Recent research at Mississippi State University has discovered melatonin's various health benefits for cattle, including antioxidant properties that alleviate oxidative stress and potentially controlling body temperature. The hormone also alters the microbiome and promotes skeletal muscle growth in cattle.
Researchers at UCLA Jonsson Comprehensive Cancer Center have found a potential therapeutic target, IL-21, to reduce endocrine autoimmune side effects from checkpoint immunotherapy. A specific group of immune cells play a central role in this autoimmune attack and blocking IL-21 prevents thyroid autoimmunity.
A long-term study found that women experiencing moderate to severe hot flashes after menopause are more likely to develop metabolic syndrome and hypertension. Hormone replacement therapy may help prevent these conditions.
The European Society of Endocrinology, ESE Foundation, and other partners mark the second European Hormone Day to promote better understanding of hormone roles and encourage change in health policy. The 'Milano Declaration' calls for stronger inclusion of endocrine health perspective in European policies.
Research finds that low vitamin D levels are associated with an increased risk of developing long COVID syndrome in patients who have previously contracted COVID-19. The study suggests that individuals with low vitamin D levels should have their levels checked after recovering from COVID-19.
Anzela Niraula won the 2023 Endocrine Images Art Competition with her image of microglia mandala, highlighting its significance in endocrine research and obesity pathogenesis. The prize includes complimentary registration to ENDO 2023 or 2024.
The new FRAXplus beta version offers a more user-friendly platform to refine risk factor information, allowing clinicians to explore the impact on individual patients. The tool provides helpful features such as saved data and export options to facilitate sharing.
Professor Nicholas Harvey received the prestigious IOF Olof Johnell Science Award for his outstanding scientific contributions to osteoporosis. The award recognizes his work on fracture risk assessment tools and musculoskeletal research.
Professor Bess Dawson-Hughes has been recognized with the 2023 IOF President’s Award for her significant contributions to advancing osteoporosis research and treatment. Her extensive body of work has led to a greater understanding of nutrition's role in age-related bone loss.
The International Osteoporosis Foundation (IOF) has awarded five young investigators grants for their research on nutritional factors and musculoskeletal health. The winners' projects focus on various aspects of diet, exercise, and bone health, with potential to lead to clinical advances or preventative strategies.
The Build Better Bones platform provides practical guidance on strengthening bones through targeted exercises and bone-healthy nutrition. The platform also offers helpful information for caregivers, including support with daily tasks and medical specialty knowledge.
The IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases is the largest international scientific event devoted to musculoskeletal disorders. The congress presents new clinical advances and research on osteoporosis, osteoarthritis, sarcopenia, frailty, and rare skeletal disorders.
Children born to mothers infected with COVID-19 during pregnancy may experience altered growth patterns and increased weight gain in early life, which can lead to a higher risk of obesity, diabetes, and cardiovascular disease. The study highlights the importance of long-term follow-up and prevention strategies for pregnant individuals.
A new study found that girls born to obese mothers are at higher risk of developing obesity or overweight, with similar BMI and fat mass to their mothers. The association was not seen in boys or daughters from non-obese fathers.
A growing connection between diabetes, oral health, and dementia highlights the importance of dental care and diabetes management as we age. Older adults with both poor oral health and diabetes experience accelerated cognitive decline, emphasizing the need for regular dental visits and adherence to diabetes treatment.
A remote hypertension program, operated by Mass General Brigham, successfully supported patients through the COVID-19 pandemic in achieving their blood pressure goals. Participants who enrolled during the pandemic reached and maintained their goal blood pressures an average of two months earlier than in the pre-pandemic period.
A new economic model estimates the health benefits and budget impact of Fracture Liaison Services, showing significant reductions in fragility fractures, hospital bed days, and social care costs. The model suggests that FLS implementation would lead to improved patient outcomes and cost-effectiveness.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that phthalate exposure may contribute to a higher incidence of diabetes in women. The research, which studied 1,308 women over six years, showed that White women exposed to high levels of certain phthalates had a 30-63% higher chance of developing diabetes.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
The Endocrine Society's Clinical Practice Guideline provides suggestions for the treatment of hypercalcemia of malignancy, a common and life-threatening metabolic complication of cancer. Treatment options include intravenous bisphosphonates or denosumab medications, with denosumab recommended as the preferred choice.
A new study found that intermittent fasting can lead to complete diabetes remission in people with type 2 diabetes, with 55% of participants discontinuing their medication and maintaining it for at least a year. The study also showed that diabetes medications costs decreased by 77% after intermittent fasting.
Women who take more steps per day have a lower risk of developing type 2 diabetes, with those taking 10,700 steps daily being 44% less likely to develop the condition. The study analyzed over 5,700 participants and found a significant correlation between physical activity and reduced diabetes risk.
Research finds that increased body weight is associated with higher levels of inflammation, signs of gut permeability, and poorer asthma control. The study suggests that targeting the gut could be an effective treatment target for improving asthma control in patients with obesity. Weight loss may also improve symptoms for these patients.
A team of researchers has assembled the first reference genome for the Nile rat, a genetic template that may be used to investigate Type 2 diabetes. The Nile rat is prone to diet-induced diabetes and exhibits a clear diurnal pattern, making it an ideal model for studying this complex disease.
A new study published in the Journal of Clinical Endocrinology & Metabolism reveals that pancreas transplantation can provide up to 90% of recipients with diabetes freedom from insulin therapy and glucose monitoring. Despite high success rates, transplant numbers have declined due to lack of consensus criteria, education, and resource ...
The IOF and ESCEO position paper recommends retaining the current WHO diagnostic criteria for osteoporosis, which has served the field well. The paper suggests that distinguishing between diagnostic and intervention thresholds can help improve treatment of patients at high risk of fractures.
A review article by Osaka Metropolitan University researcher Professor Noritoshi Kawate explores the use of INSL3 as a hormone indicating gonadal functions in domestic animals. The study reveals that INSL3 secretions in bulls and male goats are stimulated by luteinizing hormone, making it a reliable fertility indicator.
Prof. George P. Chrousos has made significant advancements in endocrine research, especially in stress biology and the HPA axis. His work has opened new horizons in understanding complex human disorders such as anxiety, depression, and metabolic syndrome.
Researchers found geographical differences in PCOS symptoms among Black and white women, with regional variations affecting body mass index and hormone levels. The study suggests genetic and environmental influences on the disease's manifestation, highlighting the need for precision medicine tailored to specific needs.
The Endocrine Society advocates for a personalized approach to telehealth visits in endocrine care. This policy perspective highlights the benefits of incorporating telehealth into care plans, including increased convenience and reduced disparities in healthcare access.
A rat study found that excessive blue light exposure is associated with earlier puberty onset, reduced melatonin levels, and increased reproductive hormones. This suggests a potential risk for childhood development and future fertility.
Children with obesity who lose weight show increased hunger-related brain activity, despite changes in gut hormone levels. This disconnect may underlie why many people regain weight after a strict diet, highlighting the need for targeted treatments.
A 12-month video-based weight loss programme has shown significant improvements in metabolic health and dietary behaviour among children with obesity. The study, presented at the European Society for Paediatric Endocrinology Meeting, found that participants lost weight and made better food choices.
A recent study by Johns Hopkins Children's Center researchers found a significant rise in type 2 diabetes cases among children during the COVID-19 pandemic. The increase was largely attributed to reduced physical activity and weight gain due to lockdowns and virtual learning.
A recent case study at Kobe University reports a 15-month recovery process for a patient with impaired ACTH secretion due to COVID-19. The research team successfully restored hormone levels through ACTH replacement therapy, and the patient's condition improved significantly after one year and a half.
A team of researchers at Mount Sinai discovered a molecular mechanism involving carbohydrate response-element binding protein (ChREBP) that plays a key role in glucose toxicity and beta-cell death. Increasing expression of an alternate form of ChREBP or activating nuclear factor-erythroid factor 2 can preserve beta-cell mass.
A recent study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that vegan participants who engaged in regular resistance training had stronger bones than those who did not. The study also showed that vegans and omnivores who performed resistance training had similar bone structure.
A recent study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that people with sedentary lifestyles and unhealthy sleep behaviors are at risk for developing fatty liver disease. Moderate improvement in sleep quality was related to a 29% reduction in the risk for fatty liver disease.
A new study found that growth hormone reduces liver fat and inflammation in patients with nonalcoholic fatty liver disease, improving liver function tests and markers of inflammation. The study showed significant improvements in liver health after administering growth hormone to 41 participants for 6 months.
A mouse study suggests that active testosterone therapy can lead to fewer and less developed eggs retrieved during IVF. Discontinuing testosterone therapy appears to have no significant impact on reproductive capacity, however.
Research suggests that high fructose consumption is associated with a higher chance of developing non-alcoholic fatty liver disease (NAFLD), especially among Mexican Americans and non-Hispanic Blacks. The study analyzed data from over 3,200 participants and found that those consuming the highest amount of fructose were at greatest risk.
Research presented at the Endocrine Society's annual meeting found that COVID-19 pandemic stress led to disturbed ovulation in many women. Nearly two-thirds of participants experienced short luteal phases or anovulation, indicating a significant impact on reproductive health.
A study of 56 transgender youth found that longer treatment with puberty-delaying medications was associated with lower bone mineral density. The researchers recommend discussing the impact of these medications on bone health and exploring interventions to improve bone health.
A new study found that teens' consumption of ultra-processed foods decreased significantly during the COVID-19 pandemic and continued to decline even after restrictions eased. This reversal took place due to changes brought by the pandemic, including school closures and working from home.
A new study suggests that probiotic bacteria, particularly Lactobacillus, may enhance the effectiveness of tamoxifen and other endocrine-targeted therapies in reducing ER+ breast cancer risk. The researchers found elevated levels of Lactobacillus in breast tissue of mice treated with tamoxifen, leading to decreased breast tumor formation.
Researchers developed an AI model to analyze thyroid ultrasound images, identifying nodules unlikely to be cancerous with a sensitivity of 97%. This technology could reduce the number of unnecessary biopsies and assist radiologists in choosing which nodules should undergo biopsy.
A randomized controlled trial shows significant improvements in testosterone replacement therapy for men with poorly-controlled type 2 diabetes and hypogonadism. The treatment improved symptoms, libido, and quality of life, as well as delayed verbal recall, a potential early sign of dementia.
A new study presented at ENDO 2022 found that inactivated and mRNA COVID-19 vaccines do not cause significant fluctuations in thyroid function or increase the risk of emergency department visits among patients treated for hypothyroidism. The research suggests that these vaccines can be a safe option for this vulnerable population.
A new study by Vertice Pharma confirms that drinking coffee does not affect the absorption of a liquid formulation of levothyroxine. The research suggests that patients can take their medication with coffee without worrying about reduced absorption. This finding could lead to more flexibility in dosing and improved patient outcomes.
Research found that patients using insulin have a higher risk of fractures compared to those using metformin, particularly in non-obese and well-controlled diabetic patients. Routine fracture risk assessments are recommended for these individuals.
Two experimental male contraceptive pills, DMAU and 11β-MNTDC, have shown promising results in lowering testosterone levels without unacceptable side effects. The study found that 75% of men who took the active drug were willing to use it in the future, compared to 46.4% of those taking a placebo.