Articles tagged with Endocrinology
A recent study funded by tirzepatide maker Eli Lilly Inc. found that the medication resulted in significant weight loss regardless of the number of obesity-related complications patients had at the outset. The study combined data from four trials involving over 4,700 subjects with obesity or overweight conditions.
The Endocrine Society will unveil new research on male birth control and anti-obesity medications during ENDO 2024 news conferences. The society's Vitamin D Clinical Practice Guideline is also being shared publicly for the first time, featuring discussions on its recommendations.
The Joint Guideline provides guidance on diagnosing and treating GC-AI, a condition affecting at least 1% of the global population. The guideline aims to improve patient care and outcomes worldwide.
Research links higher blood sugar levels at gestational diabetes diagnosis to complications in newborns, including low blood sugar and large birth weight. Women diagnosed with gestational diabetes are also at a higher risk of developing type 2 diabetes after birth.
A large-scale Finnish study discovered a significant link between premature menopause and increased mortality risk. Women with spontaneous premature ovarian insufficiency were more than twice as likely to die of any cause or heart disease, but hormone replacement therapy reduced this risk by half for those using it for over six months.
Professor Leith Zakraoui was awarded the 2024 IOF CNS Medal for his dedicated work in advancing musculoskeletal health at both national and international levels. He has been a key figure in strengthening IOF activities in Africa and promoting education and awareness within the region.
The International Osteoporosis Foundation (IOF) and ESCEO presented awards to 20 young investigators from 16 countries for their outstanding research abstracts. The awards recognize the researchers' contributions to the prevention, diagnosis, and treatment of osteoporosis and related musculoskeletal diseases.
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
The phase 2 study found an average increased growth rate of 1.8 cm per year in children with hypochondroplasia, a significant improvement over the baseline annualized growth velocity. The treatment was well-tolerated, and some patients showed excellent responses to vosoritide.
Researchers discovered that people with hypothyroidism are more likely to have a type D personality, which is characterized by pessimism and negative emotions. Those with both conditions experienced high levels of anxiety, depression, and dissatisfaction with treatment, highlighting the need for further research to improve outcomes.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
A comprehensive review examines the impact of osteoporosis on fracture healing and the effects of osteoporosis medications. The study concludes that there is no deleterious effect of osteoporosis medications on fracture healing, and prompt treatment can reduce the risk of secondary fractures.
Researchers at Kyushu University identified a new type of tumor cell population, steroids-producing nodules (SPNs), which lead to cortisol-producing adenomas. The study provides clues into the formation and maintenance of the human adrenal cortex.
The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis have issued new guidelines for managing osteoporosis in men. These recommendations cover disease burden, fracture risk assessment, treatment thresholds, and interventions to reduce the substantial morbidity and mortality ass...
A new study published in the Journal of the Endocrine Society found significant cardiometabolic improvements in patients who underwent bariatric surgery, including lower blood pressure and cholesterol levels. The study analyzed over 7,800 patients and showed that younger females and whites experienced greater post-surgery cardiometabol...
A landmark study published in JAMA Pediatrics found that COVID vaccines are safe to administer during pregnancy, with no abnormal delays in infants when tested at 12 months and 18 months. The study of over 2,200 infants from across the country also found an increased risk of delay among male infants at 12 months but not at 18 months.
A recent study published in Hypertension reveals that aldosterone-producing adenomas are composed of multiple cell types that work together to promote tumor growth. The research identified two distinct cell fates involved in hormone production, with cells expressing genes associated with aldosterone synthesis and cortisol production.
A lack of older women in sport and exercise science studies hinders understanding of perimenopause and postmenopause effects on physical activity, athletic performance, and overall health. Researchers call for improved data collection and methodology to support female athletes and patients across the lifespan.
Middle-aged women exposed to toxic metals have fewer eggs in their ovaries as they approach menopause, according to a new study. The researchers found that higher levels of heavy metals such as arsenic and cadmium are associated with lower Anti-Müllerian hormone levels, indicating diminished ovarian reserve.
A new study published in the Journal of the Endocrine Society estimates that chemicals in plastics contribute to various diseases and disabilities in the US, resulting in significant healthcare costs. The study found that $67 billion is attributed to phthalate exposure, while PFAS exposure leads to $22 billion in health costs.
A new study published in the Journal of the Endocrine Society found that stressed women undergoing fertility treatment may experience higher blood sugar levels during pregnancy, which can lead to weaker cardiovascular health. Women who conceived through intrauterine insemination (IUI) had higher stress and blood sugar levels than those...
Research suggests that childhood sedentariness contributes to elevated cholesterol levels and premature heart attack or stroke in mid-life. Engaging in light physical activity for 3-4 hours/day may be effective in reducing high cholesterol.
A new study has found that most patients with osteoporosis want to receive information on their fracture risk, but only half of them actually get it. Patients prefer visual representations, such as graphs with a colored traffic-light system, to communicate fracture risk and are more likely to take medication if presented in this way.
A new Cochrane review has found that human insulin can be stored at room temperature for up to six months without losing potency. This breakthrough research offers hope to millions of people living with diabetes in low- and middle-income countries, particularly those with limited access to refrigeration or healthcare.
A recent study presents exciting future possibilities for managing type 1 diabetes with the repurposed drug α-difluoromethylornithine (DFMO), which may reduce insulin dependency. The researchers have established preliminary safety of DFMO for individuals with type 1 diabetes, paving the way for innovative therapies.
A recent meta-analysis found that women in low- and middle-income countries are disproportionately affected by obesity, with risks ranging from 2-3 times higher than men. This disparity is most pronounced in the Sub-Saharan region, where women are up to 10 times more likely to have obesity.
A new study identifies children at high risk of developing type 2 diabetes and strategies for prevention, including anti-obesity medication and lifestyle changes. Higher levels on certain diabetes screening tests and worsening obesity may better predict diabetes risk in children.
A new quality improvement study shows a primary care intervention reduced the number of older adult patients at risk for hypoglycemia by almost 50%. The tool facilitated shared decision-making and improved patients' daily lives, leading to de-escalation of diabetes medications causing hypoglycemia in 20% of participants.
Researchers found that women experience a significant increase in anxiety and negative feelings during the 7-day pill-free period, similar to those experienced during menstruation. Long-term pill users may benefit from mood-stabilizing effects while taking their pill.
A new study found pediatric endocrinologists are concerned about threats to their personal safety and the impact of transgender health bans on medical practice. The researchers surveyed 223 pediatric endocrinologists, with 56% providing gender-affirming care, and identified safety concerns, pressures on hospitals, and threats against p...
Women with polycystic ovary syndrome (PCOS) who follow a keto diet for at least 45 days may experience significant weight loss and improvements in reproductive hormone levels. Lower testosterone levels can also help reduce excess hair growth and other symptoms associated with PCOS.
Residency programs lack standardized menopause curriculum, with only 31% reporting any training. A national curriculum is proposed to improve patient care and address the growing need for menopause education.
Researchers at University of Galway and MIT have developed an intelligent implantable device that can sense its environment, adapt to release drugs as required, and bypass scar tissue buildup. The device uses AI to tailor drug delivery to individual patients, reducing fibrotic encapsulation and ensuring consistent dosing.
A new clinical study found that adjuvant treatment with Mitotane is not necessary for patients with low risk of recurrence if they have a complete R0 resection, low tumour stage and Ki-67 levels below 10%. This approach has shown no significant improvement in relapse rate but is associated with side effects.
A new study found an increase in precocious puberty diagnoses among girls during the COVID-19 pandemic due to poor lifestyle changes. Girls with higher body mass index scores were more likely to be diagnosed with early puberty, suggesting a link between rapid weight gain and advanced pubertal development.
Researchers found that Alzheimer's patients exhibit heightened sensitivity to light changes, which can contribute to 'sundowning' and disease progression. Light therapy could help manage these symptoms and potentially slow disease progression.
A new review describes the development and impact of a Latin American mentorship program for Fracture Liaison Services (FLS), resulting in 64 FLSs getting started and providing coverage for over 17,200 patients. The program also supports the establishment of active communities of mentors across Mexico, Brazil, Colombia, and Argentina.
Researchers at Mount Sinai discovered a new family of locally secreted molecules called 'mammokines' that play a crucial role in controlling mammary gland fat abundance. These findings have significant implications for breast health, lactation-related disorders, and metabolic syndromes.
The Capture the Fracture Partnership has successfully driven global Fracture Liaison Services implementation, effectiveness, and sustainability. The partnership's unique approach, including policy, coalitions, mentorship, and scalable solutions, has delivered impactful resources and activities to prioritize secondary fracture prevention.
A new position paper reviews TBS for fracture risk prediction, treatment initiation and monitoring in osteoporosis. The evidence-based guide provides practical guidance for clinicians to integrate TBS into clinical practice.
A comprehensive review of biochemical markers for bone fragility in diabetes identifies low bone turnover and alterations in bone quality as key factors. The study suggests that glycemic control, AGEs, and serum IGF-1 may have predictive value for fracture risk in patients with diabetes.
A new special issue of Calcified Tissue International & Musculoskeletal Research explores how the skeleton functions as both a secretory organ and an endocrine target tissue. Researchers discuss key avenues in this area of research, including deciphering hormone messages encoded in bone cell secretory products.
A large study published in the Journal of Clinical Endocrinology & Metabolism has found that moderate to light alcohol consumption does not protect against obesity and type 2 diabetes. The research, which analyzed data from over 408,000 participants, confirmed that heavy drinking increases measures of obesity and risk of type 2 diabetes.
A UK-wide study found that non-functioning pituitary microadenomas (NFPA) are more likely to shrink or disappear than grow within three years of monitoring. The study suggests that clinical guidelines should be changed, and a single scan three years after initial detection would be a safe and cost-effective way to manage NFPAs.
A recent single-hospital study found that among 82 transgender and gender-diverse adolescents treated between 2016-2018, only three chose to discontinue gender-affirming hormone therapy. The reasons for discontinuation were often due to external factors, not re-transitioning to the assigned sex at birth.
A randomized clinical trial found that rapid access to testosterone therapy significantly reduced feelings of gender dysphoria and depression among transgender adults. The study also showed a 50% reduction in suicidal ideation compared to those on a standard waiting list.
A novel 'robotic pill' has been found to safely deliver the osteoporosis medication teriparatide orally, with comparable bioavailability to traditional injections. This breakthrough technology could offer a painless and more accessible treatment option for patients suffering from chronic conditions.
Researchers found that radioactive iodine and thyroidectomy significantly increased survival rates for patients with hyperthyroidism. The treatments were associated with a decreased risk of death compared to antithyroid drugs, and had varying effects on weight gain.
A new study reveals that transgender people seen in the emergency room are sicker than cisgender individuals and more likely to be admitted to hospital. The research found a significant increase in ER visits by transgender patients between 2006 and 2018, with over half of these visits linked to chronic conditions or mental health issues.
The use of alternative thyroid hormone treatments is on the rise for hypothyroidism patients. A study found that desiccated thyroid extract (DTE) prescriptions have doubled over a decade, while T3 therapy has seen a significant increase in rural areas. Access to endocrine care may contribute to these disparities.
The Endocrine Society's new scientific statement distinguishes between normal aging and endocrine disease in older adults. Menopausal symptoms and osteoporosis are often undertreated despite being treatable.
An animal study suggests that exposure to endocrine-disrupting chemicals like PCBs during pregnancy may lead to impaired cognitive function in future generations, including attention-deficit/hyperactivity disorder-like behaviors. The study found that grandchildren of rats exposed to these chemicals performed worse on behavioral tasks a...
A study found that prenatal phthalate exposure may lead to hormonal changes in females, affecting future fertility, but not males. The study suggests sex-dependent effects of phthalates on hormone levels during critical development periods.
Research reveals that women with PCOS experience significant body image concerns, including greater self-classification as overweight and lower body satisfaction scores. This correlation may increase the risk of developing eating disorders like anorexia or bulimia.
A retrospective cohort study found a significant increase in gestational diabetes cases during the COVID-19 pandemic compared to pre-pandemic periods. The study attributed this rise to changes in population demographics and lifestyle factors related to the pandemic.
A global study predicts a significant increase in hip fractures worldwide by 2050, with the number projected to nearly double compared to 2018. The study highlights a post-fracture treatment gap in fracture prevention, particularly for men, leading to increased mortality and dependency.
Research presented at ENDO 2023 found women with PCOS died 47% earlier than those without the condition. They were also at higher risk for deaths due to cardiovascular disease, tumors, diabetes, and lung infections.
Children and teenagers with diabetes frequently employ inaccurate CGM alarm settings, which may lead to reduced usefulness of these devices. Research highlights the importance of following recommended alarm best practices to ensure patients receive real-time glycemic data while minimizing alarm fatigue.
Research suggests that aromatase inhibitors can limit the effectiveness of weight loss medications in breast cancer survivors. Studies have shown that these medications are less effective in women taking aromatase inhibitors, leading to reduced weight loss and increased risk of health complications.
A new analysis of the CLEAR Outcomes Trial found that bempedoic acid lowered LDL cholesterol levels by 21% and reduced cardiovascular events by 13%. This suggests that different classes of cholesterol drugs have similar benefits for cardiovascular health.