Articles tagged with Insulin Receptors
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Researchers at Northern Arizona University are developing a breakthrough tool to detect early signs of Alzheimer's disease. The new technology uses microvesicles in the blood to identify biomarkers indicating improved neuroplasticity, which can help track the disease's progression.
A new study found that artificial sweetener aspartame triggers insulin spikes leading to blood vessel inflammation in mice, which can contribute to atherosclerosis and increased risk of heart attacks and stroke. The researchers identified an immune signal called CX3CL1 that plays a key role in this process.
A large population-based analysis found that genetic variants in the GLP1R gene are associated with cardiometabolic traits and behavioral changes, such as risk-taking behavior and anxiety. These findings suggest that any observed behavioral changes with GLP1RA medications are unlikely to be a direct result of the medication.
A Brazilian researcher at Harvard identified serotonin as the central role in postprandial hypoglycemia, a common complication of bariatric surgery. The study found that serotonin levels increase significantly after meals in affected individuals, unlike those without symptoms.
Researchers discovered a unique protective mechanism in pancreatic β-cells, relying on elevated levels of pro-survival proteins like cFLIP. This discovery challenges the dominant paradigm and offers new insights into diabetes research, potentially leading to novel strategies for preserving β-cell function.
Researchers found GLP-1 receptor agonists lower risks of certain obesity-associated cancers in patients with type 2 diabetes, suggesting potential benefits for cancer prevention in high-risk populations. The study provides preliminary evidence supporting further preclinical and clinical studies to prevent specific obesity-linked cancers.
Researchers have made a breakthrough in understanding the GIP hormone's role in regulating insulin levels and weight loss. The study, involving over 500,000 individuals, found that inhibiting the GIP receptor may result in weight loss, while activating it without arresting its signal is crucial.
A Boston College biologist is studying the mechanisms of viral insulins to develop novel therapeutics for a range of human diseases, including cancers. The researcher has identified six viruses that mimic human insulin and IGF-1, which can block an important receptor, leading to potential affordable treatments.
A Northwestern University study found that nearly two-thirds of patients discontinue or change their medication within a year, highlighting the need for better understanding of barriers to treatment adherence. The high discontinuation rate for GLP-1 RAs may be due to gastrointestinal side effects.
Scientists at Case Western Reserve University identified a novel enzyme, SCAN, which attaches nitric oxide to proteins, including the receptor for insulin action. Blocking this enzyme protects from diabetes, suggesting it may be a cause of the disease.
Researchers at University of British Columbia find a direct link between high insulin levels and pancreatic cancer, highlighting the importance of keeping insulin levels within a healthy range. The study suggests that excessive insulin overstimulates pancreatic acinar cells, leading to inflammation and precancerous cell development.
Researchers developed a computational model to analyze glucose-responsive insulin (GRI) performance in human patients. The model predicted that differences in sugar receptor behavior between humans and lab animals led to the drug's poor effect in clinical trials. This breakthrough helps researchers design better GRIs, potentially reduc...
Researchers found that clearance of p16Ink4a-positive cells did not impact β-cell mass, but improved β-cell function and proliferative capacity in a subset of HFD mice. The targeted subpopulation of β-cells is non-proliferative and non-SASP producing.
WEHI researchers have visualized how a non-insulin molecule can mimic the role of insulin, opening new avenues for an oral insulin pill. The study confirms alternative molecules can be used to turn on blood glucose uptake, bypassing insulin needs.
A new study by Université Laval researchers has identified a link between insulin receptors in brain microvessels and Alzheimer's disease. The findings suggest that drugs targeting these receptors could be effective in treating the condition, expanding the range of potential treatments.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
Researchers have designed a fast-acting injectable insulin based on the venom of the Conus kinoshitai marine snail, which doesn't form clusters like human insulin. The new hybrid insulin holds promise for better diabetes control with faster action and reduced clustering.
Researchers created a mini-insulin molecule that combines human insulin's potency with the fast-acting potential of cone snail venom, potentially improving blood sugar control. The hybrid insulin has the same potency as human insulin but acts faster, making it a prime candidate for new diabetes treatments.
Researchers found a truncated receptor called DAF-2B that acts as a decoy to capture insulin molecules, reducing insulin signaling. This discovery may offer new insights into insulin resistance, a feature of type 2 diabetes and aging.
Researchers have solved a critical piece of the puzzle by showing how insulin interacts with its receptor at a second binding site. This new understanding will allow researchers to design improved treatments for insulin-related disorders, such as diabetes.
Researchers at Harvard Medical School discovered an unexpected mechanism by which insulin triggers changes to thousands of genes. The insulin receptor is physically transported to the cell nucleus and helps initiate the expression of insulin-related genes, providing new avenues for diabetes research and potential therapeutic targets.
Researchers at Joslin Diabetes Center found impaired insulin signaling in the brain negatively affects cognition, mood, and metabolism in Alzheimer's disease. The study used a novel mouse model to demonstrate the impact of disrupting insulin and IGF1 receptors on learning, memory, and mood.
Researchers from Helmholtz Munich successfully visualize insulin receptor activation for the first time, revealing a structural change that propagates across the plasma membrane to initiate signaling cascades. This breakthrough sheds new light on insulin's biological actions and has implications for understanding diabetes and cancer.
Researchers found that heparin stimulates AgRP neurons in the hypothalamus, increasing production of a neuropeptide that stimulates food intake and contributing to increased body weight. The study suggests heparin may be a potential target for treating eating disorders and obesity.
A recent study reveals that protein CHIP regulates insulin receptor turnover, leading to anti-aging activity. In its absence, premature aging occurs due to uncontrolled protein breakdown. The researchers are now exploring mechanisms to control CHIP's activity for potential treatments.
Researchers at UT Southwestern Medical Center have identified a key regulatory mechanism of insulin signaling, linking it to the timing of cell division. Three spindle checkpoint proteins, crucial for accurate cell division, also regulate metabolism through their impact on insulin receptors.
A study found that degludec/liraglutide was associated with greater HbA1c level reduction, weight loss, and lower hypoglycemia rates compared to glargine. The medication also had more nonserious gastrointestinal adverse events.
Brown planthoppers develop short wings for breeding and long wings for travel due to insulin receptor silencing, a major factor in their pest status. Researchers found that two insulin receptors determine alternative wing morphs in planthoppers.
Researchers have deciphered how insulin binds to target cells, unlocking a protective hinge that triggers biological signals. This mechanism has attracted international study since the landmark 1969 elucidation of insulin's storage structure, enabling new molecular designs for safer and more effective insulin products.
Researchers have captured the intricate mechanism of insulin binding to cells, a crucial step in glucose uptake. This breakthrough could lead to novel insulins with improved properties, such as longer activity and reduced degradation.
A team of researchers from Case Western Reserve University School of Medicine has discovered the definitive answer to how insulin binds to cells. This breakthrough could lead to dramatic improvements in treating diabetes, including alternative oral medications and fewer injections per day.
The study demonstrated that XMetA markedly reduced elevated fasting blood glucose levels and normalized glucose tolerance in mice experimentally rendered diabetic. After six weeks of treatment, there was a statistically significant reduction in hemoglobin A1c levels in animals treated with XMetA compared to controls.
A new study reveals that chronically high insulin levels trigger hormonal changes in the pituitary gland, disrupting ovarian function and impairing fertility. Researchers suggest decreasing the pituitary's sensitivity to insulin as a potential target for treatment.
Researchers have invented a 'smart' insulin protein molecule that binds less to cancer receptors and self-assembles under the skin. This new form of insulin reduces the risk of cancer associated with obesity and excess insulin in Type-2 diabetes patients.
Scientists have determined the structure of a previously unseen part of the insulin receptor, which could lead to new treatments for diabetes. Understanding how insulin interacts with the receptor is crucial for developing effective therapies.
Scientists have identified common features of super active insulins, shedding light on their molecular structure and interaction with insulin receptors. The research holds promise for developing more sophisticated treatments for Type I diabetes, potentially offering controlled or injection-free therapies.
Researchers at Joslin Diabetes Center have identified a crucial link between insulin and glucagon levels. The study suggests that targeting insulin receptors or proteins in alpha cells could lead to the development of a new treatment for diabetes, particularly for type 1 patients who are at risk of hypoglycemia.
A study found that enhanced proteolytic activity in the circulation may be the root cause of diverse metabolic problems. The researchers showed that a drug developed for unrelated purposes was effective in counteracting this mechanism, reversing symptoms of high blood pressure, insulin resistance and immune suppression.
Neuroscientists at Cold Spring Harbor Laboratory demonstrated that insulin receptors in the brain regulate neural circuits, synapses, and dendritic growth. Insulin receptor signaling is critical for proper brain operation and may contribute to cognitive impairments like Alzheimer's disease.
Researchers at Karolinska Institutet have identified a receptor called ALK7 as crucial in regulating body fat deposition and insulin release from beta-cells. Removing the ALK7 receptor improves insulin release and decreases fat accumulation, suggesting potential new therapies for diabetes and obesity.
Scientists at Northwestern University have discovered that a toxic protein in the brains of individuals with Alzheimer's removes insulin receptors from nerve cells, rendering those neurons insulin resistant. This finding sheds light on the emerging idea of Alzheimer's being a type 3 diabetes.
A study published in Science found that maintaining a healthy lifestyle through diet and exercise can extend lifespan by reducing insulin-like signaling in the brain. The researchers discovered that mice with reduced insulin receptor substrates lived 18% longer, while also showing improved metabolic health.
A team of CSIRO scientists has determined the molecular structure of the insulin receptor, a significant breakthrough that builds on years of international research. The discovery is expected to facilitate future research into new therapies for diabetes and cancer.
Researchers at the University of Rochester Medical Center have made a groundbreaking discovery about the relationship between stress response and insulin regulation in flies. By boosting a molecular signal called JNK, they found that flies can live up to 85 days longer, opening up new avenues for understanding human diabetes and aging.
New research reveals that accumulated liver lipids originate from serum fatty acids, newly produced fatty acids within the liver, and dietary fatty acids. The study also highlights the potential role of endocannabinoids in regulating liver metabolism and appetite control. Additionally, a companion paper explores the relationship betwee...
Researchers at U of T's Molecular Design and Information Technology Centre have created the first small molecules that bind to the insulin receptor, paving the way for oral insulin development. The breakthrough could lead to a new treatment option for over two million Canadians with diabetes.
Research reveals insulin's impact on cardiac growth and development. Insulin signaling pathways regulate the expression of key genes involved in cardiac hypertrophy.
Scientists have identified a genetic defect linked to insulin resistance and adult diabetes, providing a target for potential new treatments. The Q allele of the PC-1 gene is three times more common among insulin-resistant people and twice as frequent among adult diabetics.
Scientists have identified a compound that mimics the effects of insulin in mice, offering hope for a pill-based treatment for diabetes. The new substance, L-783,281, is a nonpeptide molecule that can be absorbed through the bloodstream after being swallowed, potentially providing an alternative to insulin injections.
Scientists discover that breast tumors produce high levels of a fetal form of insulin receptor, stimulating rapid cell division and cancer growth. The finding offers a potential target for new cancer drugs, which could block or slow breast tumor growth.
A team of Canadian scientists identified a potentially useful target for drugs to treat type II diabetes and obesity by genetically engineering mice lacking a specific enzyme. The results showed that these mice resisted weight gain and insulin resistance on a high-calorie diet, suggesting a possible approach for treating the disease.
Researchers at the University of Pennsylvania School of Medicine have discovered a key step in regulating PPAR-gamma receptors, which control insulin sensitivity. The finding may lead to drugs with fewer side effects and greater efficiency for treating adult-onset diabetes.
Scientists have identified a crucial gene that controls metabolism in worms and may be responsible for diabetes. The discovery reveals that humans can live without insulin if they carry an inactive version of this gene, opening up new avenues for treating the disease.
Researchers at MGH discovered a striking similarity between the worm C. elegans' aging gene daf-2 and the human insulin receptor, implying that insulin-like control of metabolism is ancient. This finding suggests human counterparts of other worm genes may be defective in diabetes.