Articles tagged with Acetylation
Researchers found OXCT1 to be a key regulator of colorectal cancer liver metastasis, with low expression linked to increased metastasis. OXCT1 suppression promotes oncogenic signaling through the CDK8/beta-catenin complex, highlighting its potential as a novel therapeutic target and prognostic biomarker.
Researchers at KAIST have developed a groundbreaking technology capable of selectively acetylating specific RNA molecules within the human body using the CRISPR-Cas13 system. This breakthrough enables precise, programmable control of RNA function and is expected to open new avenues in RNA-based therapeutic development.
Researchers from Bar-Ilan University discovered a link between protein modifications and extended lifespan in long-lived mammals. The study identified posttranslational modifications associated with increased resilience against age-related diseases, such as cancer and diabetes.
Researchers at Aarhus University discovered that RNA modification N4-acetylcytidine (ac4C) plays a key role in stress granule formation and function. Acetylated transcripts are localized to stress granules, regulating their assembly and dispersal.
Researchers found that Angelica gigas extract improves vascular function in high-fat diet rats, reversing endothelial dysfunction and increasing NO bioavailability. The extract regulates IRE1α sulfonation and RIDD signaling, promoting NO production via the SIRT1-eNOS axis.
UiB researchers and their international team have found that N-terminal acetylation protects proteins from degradation, affecting cell longevity and motility. This discovery provides new insights into the function of a common protein modification in human cells.
The study reveals MOF's critical role in maintaining mitochondrial integrity through protein acetylation. COX17 is identified as a key target of MOF-mediated acetylation, stimulating its function and regulating oxidative phosphorylation.
Researchers develop a technique to visualize carnitine distribution in muscle fiber cells, finding higher concentrations in slow-type fibers. The study reveals rapid transport of carnitine into muscle cells during contraction, shedding light on metabolic processes and potential therapeutic applications.
Researchers at Iowa State University have identified a metabolic switch that can be modified to control fat production, which could lead to more effective treatments for childhood obesity and cancer. The discovery involves altering the acetylation levels of fatty acid synthase, an enzyme critical to de novo lipogenesis.
Macrophage PPARγ acetylation decreases energy expenditure and worsens insulin sensitivity, glucose tolerance, and lipid metabolism in mice fed a high-fat diet. This impairment promotes macrophage infiltration, adipose fibrosis, and hepatic steatosis.
The Gerlich Group at IMBA found that histone acetylation establishes a sharp surface boundary on chromosomes, resisting microtubule perforation. Chromatin phase separation and DNA looping by condensin cooperates to build mitotic chromosomes with unique physical properties.
Heidelberg University researchers have identified a key protein HYPK that regulates N-terminal acetylation, prolonging plant protein life and enhancing drought resistance. This mechanism appears to be ancient, retained across various organisms.
A study found that SIRT2 activation by PM2.5 exposure triggers airway inflammation, bronchial hyperresponsiveness, and organ damage in mice. Triptolide inhibition of p65 reduced PM2.5-induced effects, suggesting a novel therapeutic strategy against PM2.5 toxicity.
A team of researchers from the University of Tsukuba found that genes on the X chromosome in male fruit fly germ cells are not subject to dosage compensation, unlike other cells. The absence of this process may affect sex determination in Drosophila PGCs.
New study reveals that N-terminal acetylation shields proteins from degradation and inhibits programmed cell death, opening up new approaches for cancer therapy. IAPs play a wider role in protein quality control, recognizing defective proteins for destruction, and triggering apoptosis in tumor cells.
Penn researchers found that epigenetic changes disable protective pathways and enable pro-disease pathways in older brain cells with Alzheimer's Disease. These changes can be targeted by drugs, suggesting a new approach to treating early-stage disease.
Researchers studied histone modifications in zebrafish development, finding that H3K27 acetylation awakens the genome for transcription. This epigenetic factor determines gene function and is conserved across species, including mammals.
Researchers repurposed salsalate to reverse tau-related dysfunction in an animal model of frontotemporal dementia, effectively lowering tau levels and rescuing memory impairments.
Researchers at the Gladstone Institutes have identified a unique change in protein structure that guides the production of RNA from DNA. The study sheds light on key aspects of transcription, including polymerase pausing and acetylation, which are crucial for precise transcription and cellular processes.
Researchers at Johns Hopkins have successfully manipulated yeast life span by removing and restoring a protein function related to aging. By restoring this function, the organism's life span is dramatically extended. The discovery reveals molecular components of an aging pathway that appears related to one regulating longevity in humans.
Scientists identify a gene that controls hemicellulose acetylation, a major obstacle to producing biofuels from non-food sources. Blocking this enzyme could lead to a 10% reduction in bioethanol price and pave the way for more cost-effective production of biofuels.
Researchers at St. Jude Children's Research Hospital identified a chemical known as an acetyl group that serves as a key to mediate protein interactions, which are essential for cell function. The discovery has implications for drug discovery and understanding basic mechanisms governing protein interactions.
Researchers found that acetylation regulates DNA maintenance, favoring protection of genetic information. This discovery may lead to interventions enhancing the body's natural preservation of genetic info, potentially delaying aging-related diseases.
Researchers at The Wistar Institute have described the complete atomic structure formed by a yeast HAT and one of its associated proteins, revealing how a particular histone acetylation event works. This finding provides a crucial step towards understanding epigenetics and its related processes.
Researchers found that tau acetylation contributes to Alzheimer's disease and other neurodegenerative diseases. Inhibiting tau acetylation may be a new approach for reducing tau-related pathology.
A University of Georgia study identifies a critical enzyme called MEC-17 that regulates microtubule acetylation in the nervous system. The finding could lead to new treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's, which have altered levels of acetylation marks on microtubules.
Researchers at Loyola Medicine have discovered protein acetylation, a common molecular reaction in bacteria that affects protein function and gene regulation. This finding has significant implications for understanding bacterial physiology and developing new drugs to combat harmful bacteria.
New research from UNC suggests that acetylation of metabolic enzymes plays a key role in regulating cellular metabolism. The study identified approximately 1,000 new proteins with acetyl groups, expanding the previously recognized repertoire of 50, and found that altering metabolic fuels can alter acetylation levels.
Researchers have detected 3,600 acetylation switches in 1,750 proteins, significantly expanding the number of known modifications. This discovery sheds light on how protein regulation is affected by diseases like cancer, Parkinson's, and Alzheimer's.
Researchers at Massachusetts General Hospital discovered a strategy to remove abnormal huntingtin protein from brain cells, accelerating its breakdown and removal through normal cellular processes. This finding could lead to new treatments for neurodegenerative disorders like Huntington's, Alzheimer's, and Parkinson's diseases.
A team of Brown University researchers has made a major breakthrough in understanding the biochemical process of cytokine receptor signal transduction. They found that acetylation, another chemical process, plays a central role in activating interferon receptors and triggering an immune response.