Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have found a new treatment target for CDKL5 deficiency disorder, one of the most common types of genetic epilepsy. By boosting another enzyme's activity, they may be able to compensate for the loss of CDKL5 and potentially treat some effects on the brain in early development.
Johns Hopkins researchers have made progress toward developing a blood test to identify disease-associated changes in the brain linked to postpartum depression and other psychiatric disorders. They identified 26 placental mRNAs present in maternal blood only during pregnancy, which reflected changes occurring inside the tissues.
A global ocean of liquid water has been found beneath Mimas' icy shell, with an estimated age of 5-15 million years, suggesting recent ocean formation and potential for life to emerge. This discovery adds Mimas to the list of moons with internal oceans, including Enceladus and Europa.
Researchers at Nagoya University uncover a complex process of cultural change involving multiple stages, contradicting the 'revolution' theory on Homo sapiens' technological advancements. The study highlights the emergence of bladelet technology in the Early Upper Paleolithic as a key milestone.
The American Heart Association and The Children's Heart Foundation have pledged over $10 million in funding to research congenital heart defects. Researchers will advance their work to improve diagnosis, treatment, and prevention of CHDs, giving more children a chance to grow into healthy adults.
A microfluidic chip can remove undifferentiated cells that could form tumors before they are implanted in a patient, improving the safety and effectiveness of cell therapy. The device can sort over 3 million cells per minute without causing damage to fully-formed progenitor cells.
The American Heart Association's PREVENT risk calculator will be evaluated among diverse populations to assess its accuracy and fairness. The research aims to ensure that the tool provides accurate risk predictions for people from various racial, ethnic, and socioeconomic backgrounds.
A new study uses GPT-3 to simplify chemical analysis, achieving accuracy surpassing state-of-the-art models. The approach fine-tunes the language model with curated Q&As, enabling easy and fast discovery in low-data chemistry.
Researchers from Tokyo University of Science identify Cpeb4 protein's crucial role in mRNA splicing and osteoclast differentiation, shedding light on bone disease mechanisms. The study's findings may lead to new diagnostic techniques and treatments for conditions like osteoporosis.
Researchers investigate biomarkers from genome, transcriptome, proteins, and metabolites to help tackle the high mortality rate of pediatric sepsis. The review highlights potential biomarkers, including genomics, transcriptomics, proteomics, and metabolomics.
Monash University researchers have developed a treatment that restores the protective side of the immune system, preventing autoimmunity in people with lupus. The new method uses human cells to introduce protective molecules into defective T-regs, effectively 'resetting' the abnormal immune system.
Scientists have created an algorithm to design synthetic DNA segments that indicate the state of cells in real-time. This tool will be used to screen for anti-cancer or viral infection drugs, as well as improve gene and cell-based immunotherapies.
The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
University of Houston researcher Peter Vekilov discovers two-step incorporation into crystals, mediated by an intermediate state, solving a 40-year-old riddle. The new paradigm guides the search for solvents and additives to stabilize the intermediate state and slow down unwanted polymorphs.
Researchers discovered a new role for Mfsd7c in exporting excessive choline from the brain. The study suggests that targeting this protein could lead to therapeutic interventions for Alzheimer's disease and other neurological disorders.
Researchers discovered that reducing cholesterol levels in mice with advanced atherosclerosis leads to a decrease in the number of smooth muscle-derived cells causing plaque growth, while preserving stabilizing cell types. This finding opens up new opportunities for targeted therapies.
Researchers discovered immune system dysfunction as a potential biomarker for long COVID and myalgic encephalomyelitis/chronic fatigue syndrome. A novel treatment approach was also introduced, showing promise in reducing symptoms. The study suggests that targeting CD8 T-cell dysfunction may help alleviate symptoms of these conditions.
Researchers at Kyoto University have observed a unique phenomenon where talin constantly moves over focal adhesions as a single unit, contradicting prevailing notions. This discovery reveals that talin manages to simultaneously maintain the intercellular connection while transmitting force through dynamic molecular stretching.
Researchers at University of Virginia Health System developed a new approach to machine learning that identifies drugs minimizing harmful scarring after heart attacks. The tool predicts and explains drug effects for other diseases as well.
Researchers at MSK Cancer Center have developed a way to speed up the development of nerve cells in the lab, mirroring the human brain's maturation process. By inhibiting an epigenetic barrier, scientists can accelerate the study of neurodegenerative diseases like Parkinson's and Alzheimer's.
A team of neuroscientists has discovered that oligodendrocytes, myelin-forming cells, accelerate glucose consumption to deliver energy-rich molecules to rapidly firing axons. This communication is mediated by potassium signals and maintains axonal health.
Researchers used CRISPR to modify a tomato gene, resulting in reduced water consumption without affecting crop quality. The discovery holds implications for basic scientific knowledge and could help increase plant yields in dry conditions.
Researchers found that tomato juice can kill Salmonella Typhi and other enteric pathogens by impairing their bacterial membrane. The study identified two effective antimicrobial peptides in tomatoes that can eliminate these harmful bacteria.
A study found distinct immune responses occur quickly when diets change, with the vegan diet prompting innate immunity and the keto diet adaptive immunity. Metabolic changes and microbiome shifts were also observed, highlighting the need for further research on the health effects of these dietary interventions.
A rare disorder causing extra fingers and toes has been identified through research led by the University of Leeds, linked to a genetic mutation in the MAX gene. The study found a molecule that could potentially treat neurological symptoms associated with the condition.
Scientists mapped genetic blueprints for 51 vertebrate species, including cats, dolphins, and birds, using novel algorithms and computer software. This discovery has huge implications for understanding human health and evolution, as it allows researchers to compare complete genomes and identify DNA sequence divergence.
Researchers at Rice University have discovered a new material that exhibits both quantum correlations and geometric frustration, resulting in a unique flat band structure. This finding provides empirical evidence of the effect in a 3D material and has implications for understanding exotic features in materials science.
Researchers at Pennington Biomedical aim to investigate the effects of intermittent fasting and calorie counting on healthspan. Participants in the DiAL-Health study will be compensated up to $2,500 for their involvement.
A team of MIT scientists has detected 18 new tidal disruption events (TDEs) using infrared observations, more than doubling the catalog of known TDEs. The discoveries reveal that these star-shredding black holes occur in a range of galaxies across the entire sky, not just dusty galaxies.
A recent study discovered a causal link between oncofoetal ecosystems and liver cancer recurrence, highlighting their potential as biomarkers for treating hepatocellular carcinoma (HCC). The research found that oncofoetal reprogramming contributes to EMT, tumour cell proliferation, and response to immunotherapy.
Researchers have discovered that tumours with mitochondrial DNA mutations are up to two and a half times more likely to respond to immunotherapy, opening a new avenue for improving cancer treatment. This finding could enable doctors to identify patients who would benefit most from immunotherapy before starting treatment.
Researchers at Tokyo University of Science have developed a novel approach to synthesize dibenzothiophene s-oxides, which feature highly reactive functional groups. This method surpasses conventional methods and enables the creation of a wide range of molecules with diverse properties.
A new American Heart Association scientific statement emphasizes the need for increased awareness of cerebral venous thrombosis (CVT) to facilitate prompt medical treatment. The statement updates guidelines for diagnosing and managing CVT, focusing on advancements in treatment approaches.
Researchers confirm ancient lake sediments at Jezero crater on Mars using radar imaging, revealing eons of environmental changes and potential signs of past life. The discovery supports the search for evidence of life in Perseverance rover's soil and rock samples.
Scientists have successfully replicated QS-21, a potent vaccine adjuvant, in an alternative plant host for the first time. This breakthrough enables the production of this highly valued compound in a more sustainable manner.
Researchers at UTA developed a novel learning-based framework to predict Alzheimer’s disease progression. The DETree strategy can pinpoint clinical status within the disease spectrum, allowing for more accurate planning and potential applications in other diseases with multiple stages of development.
A recent study published in Nature Plants reveals that O-glycosylation of the transcription factor SPATULA promotes Arabidopsis style development. The experimental study sheds new light on the mechanisms underlying plant organ symmetry.
Researchers discovered that cisplatin chemotherapy enhances the immune system's ability to fight bladder cancer by modulating the immune response and damaging DNA in cancer cells. This approach may lead to durable disease control in a subset of patients with metastatic bladder cancer.
A new study funded by NIHR has led to the UK government approving digital pathology for cancer screening samples. This technology enables faster reporting and improved care for patients with bowel, breast, lung, and cervical cancers. The use of digital pathology will help reduce risk of sample loss or damage and allow pathologists to r...
Researchers at NIAID have successfully created a strain of Coxiella burnetii without the genetic flaw that makes it virulent, enabling safe use in laboratory settings. The new strain, NMII-E, has implications for diagnostic sensitivity and vaccine development.
Researchers found that intrinsically-photosensitive retinal ganglion cells (ipRGCs) use both microvillous and ciliary signaling mechanisms simultaneously. This discovery reveals a new pathway for transmitting light signals to the brain, which may have ancient origins on the evolutionary scale.
Researchers studied how epithelial cells sense small changes in their environment using ion channels. They found that even small movements can trigger rapid intracellular calcium changes via mechanosensitive cation channels, which play a key role in touch sensation and other physiological functions.
Researchers developed a novel deep learning method to study crystal structure and molecular interactions of perchlorate salts. The analysis revealed that the explosives' nature is linked to chemical bonding and intermolecular interactions.
Researchers at Universiteit van Amsterdam developed an autonomous chemical synthesis robot with integrated AI, outperforming human chemists in terms of speed and accuracy. The 'RoboChem' system can perform various reactions while producing minimal waste and delivering results quickly.
Groundbreaking research reveals key insights into plant-AM fungi interactions, including the roles of two proteins, CKL1 and CKL2, which control lipid flow essential for fungal survival. This symbiosis could lead to advances in agricultural sustainability and crop resilience.
Researchers have developed a model-free approach to identify topological systems, enabling the discovery of new materials. The method uses experimental approaches to measure topologically protected soft or fragile spots in unknown mechanical metamaterials.
Researchers have found that the key step to protein formation can occur in droplets of pure water, where amino acids connect to form peptides with the same 'L' handedness. The discovery resolves a paradox and provides new insights into the early stages of life's chemical evolution.
The NSF and Kavli Foundation launched a joint grant program to explore the impact of environmental changes on neural systems. Researchers will investigate novel mechanisms underlying adaptation and resilience in animals, aiming to advance our understanding of basic biology.
Researchers at Rice University have discovered a promising new immunological pathway to treat stubborn bone tumors in breast cancer patients. The glyco-immune checkpoint axis, involving protein Siglec-15, plays a crucial role in hiding bone tumors from the immune system.
Researchers developed an mRNA therapeutic that combats ovarian cancer by producing functional p53 protein, shrinking and killing tumors. The treatment is effective against metastases and has shown promise in preclinical studies.
A study combines retinal imaging, genetics, and big data to estimate the likelihood of developing eye and systemic diseases. The researchers identified significant associations between retinal layer thickness and increased risk of various diseases, including ocular, neuropsychiatric, cardiac, metabolic, and pulmonary diseases.
Researchers found that high levels of FSP1 are associated with relapse after cisplatin treatment in head and neck squamous cell carcinoma. Targeting FSP1 can attenuate tumor stemness and downregulate invasion and metastatic rates, suggesting a potential new approach for treating drug-tolerant persister cancer cells.
Researchers analyzed settlement patterns on the Ordos Plateau from Neolithic to present, finding they clustered in southern and eastern areas less affected by deserts. Settlement sizes varied with fractal characteristics indicating agglomerated pattern, influenced by natural factors and human activities.
Research finds that stable caregiver relationships in childhood may increase optimal heart health, while adversity and abuse can lead to poor cardiovascular health. Lower income as an adult may also introduce additional adversity, making the relationship between caregiver-child adversity difficult to see.
Researchers at Jefferson Lab measure proton's mechanical properties, including internal pressure and shear stress, using a framework connecting gravity to the strong force. This breakthrough reveals new details about the distribution of the strong force inside the proton.
A research team at HKUMed has identified PLK4 as a novel therapeutic target for acute myeloid leukaemia (AML) carrying the TP53 mutation. The study found that PLK4 inhibition induces DNA damage, cell ageing and abnormal cell division, triggering the immune system via the cGAS-STING pathway.
Researchers found that one in five adults reported difficulty walking a kilometre, and those with more limitations had significantly higher fracture risks. The study suggests asking about walking ability could help identify individuals needing further screening and prescribe interventions to prevent fractures.
Researchers develop compound that reduces size of kidney cysts and improves kidney function in mouse models of ADPKD. The compound, originally designed to treat cancer, works by exploiting kidney cyst cells' vulnerability to oxidative stress.
Researchers identified genetic variants that predict response to treatment for preterm birth, a condition affecting one in 10 infants. High levels of mutations in certain genes are associated with lower response rates, suggesting a precision framework for future drug development.
Researchers found a correlation between cortical gray matter thickness and dementia risk, with thinner ribbons indicating higher risk. The study suggests that this biomarker could be used to identify people at high risk of dementia, potentially allowing for early intervention.