Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have discovered a previously unknown mechanism behind immune tolerance, where B cells teach T cells to ignore the body's own proteins. This failure can lead to autoimmune diseases such as Multiple Sclerosis-like Neuromyelitis optica.
Researchers at UCSF used clinical data and a precision medicine approach to identify early risk factors for Alzheimer’s disease, predicting its onset with 72% accuracy. High cholesterol, osteoporosis, and erectile dysfunction were found to be predictive factors in both men and women.
Researchers found that a compound called BAM15 makes mitochondria less efficient at producing energy, extending life span and improving body composition in fruit flies. The study also showed reduced age-related decline in motor activity. Further studies are needed to confirm these findings in humans.
Researchers at Purdue University have discovered a new type of emergent particle, the six-flux composite fermion, which explains rare quantum states in host materials. This discovery expands our understanding of topological electron physics and has significant implications for the ordering of known fractional quantum Hall states.
Researchers at Texas A&M University have discovered that meningiomas in humans and dogs share remarkable genetic similarities. This breakthrough could lead to the development of novel treatments applicable to both species, including access to therapy not available elsewhere for dog owners.
Researchers at University of Dundee have identified a breakthrough class of molecular glue that binds proteins together, paving the way for new drugs to target cancers and neurodegenerative diseases. This innovation uses targeted protein degradation technology to recruit disease-causing proteins to a cellular waste bin.
Madhu Kannan, a University of Minnesota Medical School assistant professor, has been selected for the Chan Zuckerberg Initiative's Collaborative Pairs Pilot Project Awards to explore innovative approaches to understanding human prion diseases. The project will utilize cutting-edge approaches combining gene editing and neural activity i...
Researchers at MIT have observed a rare electronic state in which electrons become fractions of their total charge without the need for external magnetic fields. This effect, known as the fractional quantum anomalous Hall effect, has significant implications for the development of topological quantum computing.
Chronic exposure to E551 may reduce oral tolerance to dietary proteins and increase intestinal inflammation, potentially worsening coeliac disease symptoms. Researchers found daily exposure to E551 worsened levels of inflammation markers associated with the disease in mice.
A study by UC Davis Health found that a single dose of BCG reduced liver tumor burden and extended the survival of mice with liver cancer. The vaccine boosted the body's immunity, leading to tumor shrinkage and improved liver function.
University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures. This discovery could be useful in treatment to reverse Alzheimer’s Disease impact by degrading amyloid plaques.
Baleen whales developed novel larynx structures to produce low-frequency vocalizations, but these adaptations limit their communication range. Human-made noise masks their voices, reducing their ability to communicate over vast distances.
Researchers at UT Health Science Center, in collaboration with Oak Ridge National Laboratory and the University of Tennessee, Knoxville, will develop new radiopharmaceutical therapies to treat cancer. The team aims to advance precision cancer treatment using targeted alpha-emitting radioisotope constructs.
Scientists at Tokyo University of Science used deep learning to predict single-molecule magnets from a pool of 20,000 metal complexes, identifying 70% accuracy in distinguishing between SMMs and non-SMMs.
Researchers at PPPL create simulation codes that can accurately predict plasma behavior, reducing the manufacturing and design cycle of silicon chips. This innovation could help the US regain a leadership role in chip industry production.
A UNLV-led research team has made groundbreaking discoveries about how cells detect and destroy disease-causing proteins using complex nanomachines called cullin-RING ligases. The findings may accelerate drug discovery studies and provide insights into human disease.
New research led by Johns Hopkins Medicine reveals that age-related changes in fibroblast cells enable pancreatic cancer tumor growth. The study found that older patients have poorer prognoses due to altered proteins released by fibroblasts, which promote cancer cell growth and spread.
A new screening tool has been developed to catch endometrial cancer cases earlier, saving lives. The partnership between Pennington Biomedical's Metamor Institute and the LSU School of Medicine has already screened over 2,000 women and found abnormal bleeding in many cases.
Research reveals a rich diversity of beneficial fungi living in boreal forest trees, with implications for forest health. The findings suggest that these fungi are adapted in highly specific ways to their local conditions, making them sensitive to future climate change.
Researchers have published novel spatial omics algorithms and tools in GigaScience and GigaByte journals to analyze biological data-based spatial information. These new methods enable the discovery of spatial domains, improvement of data quality, and better clustering of cells.
Researchers have confirmed a new method for precise body composition analysis using 3D surface scans and dual-energy X-ray absorptiometry. This approach yields accurate measurements of fat, lean muscle, and bone, surpassing commercial software in clinical settings.
A new blood test uses the biomarker BD-tau to predict functional outcomes in patients after ischemic stroke. Higher levels of BD-tau are associated with more severe outcomes.
Researchers have made groundbreaking discoveries about the reproduction of giant Antarctic sea spiders, a phenomenon known as polar gigantism. The study found that these creatures do not carry their young like most other species, but instead attach them to rocks for several months before hatching.
The FDA has approved omalizumab for the reduction of allergic reactions, including anaphylaxis, in adults and children aged 1 year and older with food allergy. The approval is based on data from a Phase 3 clinical trial sponsored by NIAID.
The commercial space sector has seen significant growth, with over 2,660 satellites launched into orbit in recent years. International collaborations are also expanding, enabling diverse perspectives and new ideas to emerge in science and space exploration.
Researchers developed a framework for standardizing biomarker development and validation to improve the prediction of age-related health outcomes. The study highlights the need for expanded focus on functional decline, frailty, chronic disease, and disability, and calls for harmonization of omic data to enhance reliability.
Researchers use a new technique to isolate energetic electron motion in liquid water, providing a window into electronic structure on an attosecond timescale. This breakthrough resolves long-standing debates about X-ray signals in liquid water and opens up a new field of experimental physics.
In a groundbreaking study, researchers observed that battery ions change direction and return to previous positions before resuming their random travels. The 'fuzzy memory' of the ions lasts just a few billionths of a second but will help scientists predict ion behavior.
Researchers at the University of Gothenburg discovered how proteins deform to create efficient transport routes for electrons, powered by solar energy. This finding could lead to more efficient solar cells and batteries.
Researchers at North Carolina State University are developing a suite of performance metrics to standardize the evaluation of self-driving labs in chemistry and materials science. These metrics aim to compare different lab technologies and identify areas for improvement, ultimately advancing the field and accelerating discovery.
Researchers at Tokyo University of Science achieve first total synthesis of merrillianin, a complex sesquiterpene with potential anti-rheumatic activity. The breakthrough method involves 30 reaction steps and could lead to the development of new treatments for nervous system diseases.
Researchers at the University of Liverpool have discovered a new solid material that rapidly conducts lithium ions, replacing liquid electrolytes in current battery technology. The discovery provides a platform for optimising chemistry to enhance material properties.
Researchers have discovered that a rare type of lipid, with two polyunsaturated fatty acyl tails, promotes ferroptosis, a form of cell death. This finding could lead to new treatments for neurodegenerative diseases and induce cancer cell death.
Chemical reactions were long thought to occur along minimum energy paths. However, researchers have now observed 'roaming' reactions that stray from this path even in highly excited energy states. This discovery has significant implications for understanding atmospheric chemistry and the production of molecular oxygen.
A recent study by Professor Joseph Michalski and his team has revealed a vast number of diverse volcanoes in Mars' ancient crust, including lava domes, stratovolcanoes, calderas, and large shields of ash. These findings suggest that intense volcanism occurred on ancient Mars, causing the crust to collapse into the mantle.
Researchers developed a test to predict which heart attack patients are likely to experience dysfunction after receiving mechanical pumps. The test measures pulmonary vascular compliance and its adaptability, helping doctors prevent right ventricle failure.
Researchers discovered that blocking efferocytosis pathway prevents immunosuppressive activity in macrophages, restoring T cell activation and reducing metastatic tumour burden. The study found PDAC metastases to show high levels of immunosuppressive macrophages, promoting tumour growth.
Researchers have identified macrophages, immune cells that gobble up foreign substances, in the pleural cavity around the lungs. These cells play a crucial role in reducing inflammation and disease during flu infections.
Researchers use bacteriophages to target and kill drug-resistant bacteria, with a patient experiencing complete resolution of infection after combination therapy. However, immune response may lead to recurrence, highlighting need for further clinical trials.
Researchers discovered a 4,750-year-old circular plaza with monumental megalithic stones in northern Peru's Callacpuma archaeological site. The structure dates back to the Late Preceramic Period and is one of the earliest examples of such architecture in the Americas.
Researchers have proved the existence of altermagnetism, a new type of magnetism that offers distinct advantages for next-generation magnetic memory technology. Altermagnets exhibit strong spin-dependent phenomena like ferromagnets while possessing zero net magnetization.
A study of over 1,000 tumors across 10 different cancers reveals complex interplay of immune cells in tumors. The research aims to identify patient groups more responsive to immunotherapy and develop new treatment strategies.
A new study from the University of Ottawa proposes using vanoxerine, a drug initially developed for cocaine addiction, to potentially treat advanced colon cancer. Vanoxerine has been found to suppress cancer stem cell activity in colon cancer patients' tissues and tumours implanted in laboratory animals. The drug works by interfering w...
Researchers at Cornell University have created a new version of the Vibrio natriegens microbe to speed up biological discovery, enabling cost-effective and scalable synthetic biology experiments. This microbe can be engineered within hours and works effectively without costly equipment, making it ideal for testing protein variants.
Research reveals oxytocin neurons in mouse brain modulate object recognition memory, with activation boosting long-term memory and implicating Alzheimer's disease. Oxytocin's role in social memory also highlighted, suggesting a potential link to loneliness or limited social engagement.
A new U of M Medical School study reveals that bias-based bullying amplifies emotional distress in youth with multiple marginalized social positions, such as race, ethnicity, and LGBTQ+ status. The research analyzed over 80,000 students and found a significant reduction in emotional distress among those who experienced no bias-based bu...
A team of physicists and veterinary scientists at Purdue University has developed a method to detect chemoresistance in cancer patients using biodynamic imaging (BDI). This technique measures the motions inside cancer cells and how they respond to chemotherapy, identifying patients who will not respond to treatment. The study shows pro...
The new advisory highlights the dramatic advances in understanding and treatment of cardiovascular diseases over the past century. These advancements have saved millions of lives and reduced heart disease death rates by more than half since 1950.
Researchers at Dartmouth's Geisel School of Medicine and Thayer School of Engineering have made significant breakthroughs in understanding how antibodies combat herpes simplex virus (HSV) infections. The study reveals that antibody effector functions play a critical role in protecting against HSV, which may lead to new treatments for n...
Researchers have discovered five new species of eyelash vipers, characterized by their unique enlarged spine-like scales positioned atop their eyes. These vipers are also polychromatic, with different morphs exhibiting distinct colorations.
A new American Heart Association scientific statement emphasizes the need for increased awareness of heart disease as a major health risk for women, particularly those with pregnancy complications. Early detection and treatment of risk factors may help prevent future heart attack, heart failure, and stroke.
The Redox Medicine Society will host its 26th International Conference on Redox Medicine in Paris, featuring keynotes, sessions, and round-table discussions on advancements and applications in clinical settings. The conference aims to facilitate innovation and excellence in the field of redox medicine.
Researchers have identified a network of neurons controlling right-left movements in the brain, which may help treat Parkinson's disease. The discovery provides insight into how essential movements are produced by the brain.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
Chemical simulations can be sped up by resetting them, a new study from Tel Aviv University found. This technique, called stochastic resetting, overcomes the timescale problem, allowing for more accurate predictions of slow processes.
A gene variant in Andean people is associated with reduced red blood cell count, enabling them to thrive at high altitude. The study aims to understand genetic differences underlying variation in oxygen saturation among COPD patients.
Researchers developed a UV-sensitive tape that can transfer 2D materials like graphene with ease, reducing damage and increasing efficiency. The new technology allows for flexible plastics to be used in device substrates, expanding potential applications.
Scientists at Brookhaven Lab demonstrate new genetic strategy to boost plant oil content by protecting the oil-protector protein, resulting in 54% more oil accumulation in leaves and 13% more in seeds. This approach can increase biomass energy content and provide sustainable fuels.
Researchers found that combining chemotherapy drugs triggers 'cell blasters' to kill cancer, leading to longer survival rates in patients with tumors having increased NETs. The study's novel discovery paves the way for designing new cancer treatments.
A new technique enables researchers to identify and control a greater number of atomic-scale defects in diamonds, which can be used to build larger systems of qubits for improved quantum sensing. This approach uses a specific protocol of microwave pulses to locate and extend control to additional defects.