Articles tagged with Discovery Research
Researchers identify mechanism by which specific protein condensates transition from liquid to solid states, enabling stability and transmission of mechanical forces. MEC-2 proteins' biological function switches with rigidity maturation, facilitating mechanosensation.
Lucas Bowman Sutton, a Rensselaer doctoral student, has been awarded the US Department of Energy's Office of Science Graduate Student Research award to conduct research on the circadian clock at Oak Ridge National Laboratory. He will utilize the Spallation Neutron Source to differentiate proteins that regulate timekeeping in living cells.
A new study found that racial and ethnic disparities persist in access to chiropractic care and physical rehabilitation for adults with low back pain, with Hispanic adults being less likely to use these services. The study also found that policy changes are needed to address these gaps in access, particularly in underserved communities.
Researchers from HonorHealth Research Institute, City of Hope, and TGen have developed a biomarker panel that detects small amounts of RNA genetic material in the bloodstream, enabling early detection of pancreatic cancer. The test has shown robust diagnostic accuracy and offers promise for improving survival rates.
Researchers discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy. Cancer cells respond to radiation by rewiring metabolic signaling pathways using lactic acid instead of glucose.
Researchers have identified a new mechanism by which phages evade CRISPR-Cas immune systems in bacteria, revealing a potential approach to make gene editing safer and more efficient. This discovery could lead to the development of bespoke anti-CRISPRs to neutralize CRISPR-Cas systems and provide an alternative to antibiotics.
A new method developed by Rice University scientists uses a high-temperature electrothermal process to remove multiple pollutants simultaneously, including heavy metals and organic contaminants. The process leaves soil particle size and mineral composition unchanged, while improving water infiltration rate and nutrient availability.
A novel strategy utilizing phosphorus nanolayers mitigates electrode-level heterogeneity in fast-charging lithium-ion batteries. The graphite-phosphorus composite exhibits consistent cycle retention, high Coulombic efficiency, and improved lithiation uniformity.
Researchers at Gwangju Institute of Science and Technology (GIST) have developed a deep learning-based biosensing platform called DeepGT, which can accurately quantify nanoscale bioparticles, including viruses. The platform harnesses the advantages of Gires-Tournois biosensors and AI to refine visual artifacts and extract relevant info...
Researchers developed a human in vitro model of radiation-induced lung injury, closely mimicking the complexities of the disease. The Human Lung Alveolus Chip recapitulates hallmarks of RILI, including DNA damage, inflammation, and injury to lung cells and blood vessels.
The ATLANTIS trial found that amitriptyline significantly improved IBS symptoms, with participants taking the medication reporting a bigger improvement in symptom scores after six months. The medication was well-tolerated and showed no significant impact on anxiety or depression scores.
The High Performance Data Facility Hub will provide researchers with unprecedented data management resources, accelerating scientific discovery through seamless access to large and complex datasets. The hub will be led by Jefferson Lab and partner with Lawrence Berkeley National Laboratory.
Algae have adapted to cope with nutrient starvation by evolving a new cellular machinery that allows them to use sunlight for growth without iron. This discovery holds promises for biotechnology developments that could enhance crop productivity and support marine ecosystems.
Researchers discovered BMAL1 is significantly upregulated in senescent cells and modulates the senescence program through AP-1. The study highlights a previously unappreciated role of BMAL1 in regulating cellular senescence and circadian clock components.
A new study reveals that innate CD8+ lymphocytes play a crucial role in limiting tuberculosis infection, and an inflammatory molecule called Interleukin-15 could be used to boost vaccine efficacy. Researchers found that these cells create a 'bottleneck' preventing bacteria from establishing active infection.
A new study by Children's Hospital of Philadelphia found that virtual driving assessments can predict crash risk in newly licensed young drivers. Drivers with major issues on the VDA had an 11% higher crash risk, while those with no issues had a 10% lower risk.
NJIT has received a $6 million NSF grant to translate science and engineering discoveries into market-ready technologies. The grant will fund up to 10 researchers for seed funding of $50,000 to $100,000 per project over four years. NJIT aims to become a regional leader in research translation.
Scientists have discovered the open and closed states of the coronavirus E ion channel, which could help develop antiviral drugs to reduce inflammation. The study's findings provide insights into the channel's structure and function, allowing researchers to design molecules that can bind to it and prevent inflammation.
The discovery of a complete Anachlysictis gracilis skeleton in Colombia provides new insights into the species' weight, estimated at around 23 kg, and diet as a hypercarnivore. The fossil's analysis suggests it preyed upon small mammals, such as marsupials and rodents, and possibly primates.
Researchers at Johns Hopkins have published a guide for prioritizing the next steps in completing the human genome catalog. The study highlights the importance of cataloging non-coding RNA genes and enhancing databases of gene variations that cause illness and disease.
Researchers from Icahn School of Medicine at Mount Sinai and the University of California San Diego will lead a new data integration hub aiming to accelerate novel therapeutics and cures for diseases. The grant, worth $8.5 million, is part of the NIH Common Fund's efforts to enhance data findability, accessibility, interoperability, an...
Researchers from the University of Virginia Health System have made significant discoveries about the genetic influences on fatty acid metabolism in diverse populations. The study found broad similarities among groups but also notable differences, highlighting the need for genetic studies in diverse groups.
Researchers found that honey bee drones exhibit synchronized hyperactivity periods, coinciding with their flight periods, and adapt their behavior to reduce energy consumption. This study reveals the complexity of drone behavior in the hive.
A new study doubles the number of protein families known up until now and identifies many novel structure predictions using a massive analysis of 1.3 billion proteins. The researchers leveraged AI methodologies to unravel the roles of previously unknown protein sequences, expanding the horizons of potential functions.
Researchers found distinct similarities between starquakes and earthquakes, but a difference with solar flares. The team analyzed nearly 7,000 bursts from three repeater FRB sources, comparing them to earthquake and solar flare data.
A study by Johns Hopkins Children's Center investigators found that delaying surgical treatment of the anterior cruciate ligament (ACL) in some children is associated with a higher risk of new tears in the meniscus and cartilage. Adults, on the other hand, showed no significant increase in such risk.
Researchers at the University of Virginia Health System are developing computer models to better understand the cellular processes and gene activity of multi-drug resistant bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The goal is to identify vulnerabilities in these bacteria and advance the development of new treatments.
Researchers have created a magnetoelectric material that can directly stimulate neural tissue, potentially treating neurological disorders and nerve damage. The material generates an electric signal that neurons can detect, overcoming previous limitations.
Researchers at Mount Sinai Hospital developed an algorithm called HistoAge that predicts age at death based on human brain tissue specimens using artificial intelligence, revealing insights into aging mechanisms and neurodegenerative diseases like Alzheimer's disease.
Researchers found that genetic variations in four genes were more common in people with CRPS than those with chronic back pain. However, men were more likely to have these genetic variants but less likely to develop the condition. This suggests that sex-specific mechanisms may be at play, which could influence treatment responses.
Researchers discovered that the short-chain fatty acid propionate can reduce metastases in mice with experimental lung cancer. The substance also increases the effectiveness of Cisplatin, a commonly used drug for lung cancer patients. Funding is now sought to identify patients who may benefit from propionate treatment.
A WVU researcher is developing new methods to fast-track the discovery of quantum materials, which could lead to breakthroughs in fields like quantum computing and superconductors. The goal is to streamline the discovery process using computational and experimental tools.
The Nuclear Science Advisory Committee has released a new long range plan, prioritizing the capitalization of substantial research investments to advance discovery in nuclear physics. The plan recommends increasing the research budget and continuing effective operation of national user facilities.
A new national ALS research consortium, Access for All in ALS, has been launched with a $16.7 million NIH award. The consortium will include 34 clinical sites nationwide and generate a longitudinal biorepository linked to detailed clinical information.
New research confirms the age of the White Sands footprints using multiple lines of evidence, including radiocarbon dating and pollen analysis. The study provides strong support for the 21,000 to 23,000-year age estimate, resolving a controversy sparked by earlier results.
The Army Research Laboratory has chosen Texas A&M University for its High-Throughput Materials Discovery for Extreme Environments Center (HTMDEC). The center aims to develop novel materials for extreme conditions, reducing experimentation costs and duration. By leveraging machine learning, physics-based simulations, and collaboration, ...
The interdisciplinary team, led by Kaiyuan Yang, will focus on leveraging the spin and charge of electrons in multiferroics to process and store information. The goal is to improve energy efficiency for computing devices, potentially reducing energy consumption by three orders of magnitude.
Researchers find evidence supporting Modified Newtonian Dynamics (MOND) as an alternative to Planet Nine hypothesis. MOND predicts precise orbital clustering in the outer solar system, which could be indicative of a modified law of gravity at play.
A new study published in the Journal of Marketing presents the Comparative Method of Valuation as a more accurate way to measure customers' willingness to pay. The study finds that existing methods can provide vague and inaccurate results due to their inability to capture relevant comparisons or context.
A new study reveals that changing nutrient use can reprogram immune cells, potentially treating cancer and infections. By blocking choline metabolism, researchers found a 'tremendous reprogramming of the immune profile' in mice, suggesting this knowledge could lead to novel therapies.
The Keck School of Medicine of USC has received a $2 million grant from the California Institute of Regenerative Medicine to further enhance its cutting-edge cGMP Laboratory. The funding will support the adoption of advanced technologies, including an electronic quality management system and optimized cell therapy manufacturing processes.
Researchers developed a novel approach to predict therapeutic targets for aging and age-related diseases. They trained a domain-specific BioGPT model on biomedical literature, which improved its performance in identifying prospective targets.
Researchers at Argonne National Laboratory have developed an autonomous microscopy technique that uses AI to selectively target points of interest for scanning, speeding up the experimental process and allowing for greater efficiency in facilities with limited beam time. This innovative approach has the potential to accelerate scientif...
Researchers at Cornell University have characterized volcanic ash samples from 40 explosive eruptions to provide a comprehensive dataset. The study found that the composition of volcanic ash varies significantly with grain size, tectonic setting, and chemistry, particularly in finer particles where salts increase and glass and iron oxi...
The university will use its expertise to create better wide bandgap semiconductors for the US defense, with potential applications in electric vehicles, power grids, and quantum technologies. The hub aims to build 'lab to fab' capability for semiconductors and enhance fundamental research.
Researchers developed a new theoretical framework called Assembly Theory, which bridges physics and biology to understand how complexity and evolution emerge. The theory explains and quantifies selection and evolution, providing new insights into the physics underlying biological complexity and evolutionary innovation.
Scientists at Johns Hopkins Medicine have identified a protein mutation in CD8+ T cells that can make them more effective against cancer and infections. The mutated T cells were found to be more active when stimulated, persist longer, and expand in great numbers during the initial immune response.
Rice University bioengineers Jerzy Szablowski and Julea Vlassakis have received the National Institutes of Health Director’s New Innovator Award for their creative research projects on gene expression and cancer interactions. Szablowski is developing noninvasive methods to map gene expression, while Vlassakis is studying complex single...
Researchers discovered that around 13% of brain proteins differ between males and females, with some proteins more abundant in females and others in males. The study also found that genetic variation influences protein expression, with sex-related differences prominent at the protein level.
Researchers found that administering precursors of Elovanoids improved neurological deficit in an experimental model of ischemic stroke. The study identified a cascade of gene responses and sheds light on potential new therapeutic avenues for treating ischemic strokes.
Researchers at the University of Massachusetts Amherst have developed a new method for DNA detection that is 100 times more sensitive than traditional methods. This breakthrough enables fast and accurate disease diagnosis, reducing wait times for lab processing from days to minutes.
A University of Melbourne research team is developing an oral therapeutic to restore the activity of common antibiotics used to treat community-acquired bacterial pneumonia. The project aims to combat antibiotic-resistant bacteria and reduce healthcare costs, with potential applications in low- and middle-income countries.
Holford's research will focus on developing new directions for using cephalopod venoms in drug discovery and exploring their evolutionary dynamics. Her study has broad applications for science, including understanding venom gland biology and the molecular mechanisms behind bioactive compounds.
Researchers at Northwestern University identified a new evolutionarily conserved RNAi-based form of cell death called Death Induced by Survival gene Elimination (DISE), which targets essential survival genes in cancer cells. This mechanism is ancient and effective against all cancers tested.
Researchers created a tiny 3D cell culture model that mimics the function of lymphatic vessels to explore how inflammatory substances affect the lymphatic system. They found that certain cytokines cause cells to tighten their junctions, leading to reduced fluid drainage and swelling. Inhibiting a protein called ROCK2 reversed lymphedem...
A new study published in Exp. Mol. Med. has identified Thrap3 as a key player in exacerbating non-alcoholic fatty liver disease (NAFLD) by inhibiting AMPK, a crucial regulator of fat metabolism. Inhibiting Thrap3 expression presents a promising avenue for treating NAFLD.
Researchers at the University of Sheffield have discovered a genetic scar that enables pneumonia-causing bacteria to become resistant to antibiotics. The study found that mutations in the pde1 gene act as an evolutionary gateway for this resistance, threatening patient treatment and highlighting the need for control measures.
A significant breakthrough sheds light on Parkinson's disease mechanisms, revealing that mitochondrial DNA damage triggers the spread of debilitating symptoms. The researchers' findings offer promising potential for innovative treatments and diagnostics.
Researchers have discovered a new species of calcifying phytoplankton, Calciopappus curvus, found in the Sargasso Sea near Bermuda. The species is distinct from others in its genus and boasts intricate skeletons that may aid movement or protection.
Armida Labs, a UCR-founded pharmaceutical company, has received a $400,000 NIH Small Business Innovation Research grant to develop its breakthrough pancreatic cancer therapy Targefrin. The grant will enable the company to gather industry-standard data for human clinical trials.