Scientists from SLAC National Accelerator Laboratory have gained valuable insights into producing nitroxide, a molecule with potential applications in the biomedical field. The team employed advanced X-ray spectroscopic techniques to understand the intricacies of the nitroxide production process and its bond-breaking mechanism.
The NYSCF – Robertson Stem Cell Investigator Awards support promising early career scientists with cutting-edge research, providing $1.5 million over five years for seed funding. The latest cohort includes three talented researchers who will join the thirteenth class of NYSCF – Robertson Stem Cell Investigators.
Researchers found 13 mummified leaf-eared mouse cadavers atop 4-mile-high volcanoes, with DNA analysis revealing a distinct population from lower-altitude mice. The discovery suggests the rodents ascended without human assistance and have adapted to extreme conditions.
NTU Singapore has expanded its research collaborations with French partners to push the boundaries of science. The university has inked six new partnerships and renewed existing collaborations across various fields, including quantum physics, nuclear energy, and sustainability.
Scientists at UNSW Sydney have created a new material that can mimic human tissue, fight bacteria, and heal itself. The hydrogel material is made from simple peptides and has implications for biomedical research, medicine, and manufacturing technology.
A new study finds that certain gut-dwelling fungi amplify excessive inflammation in severe COVID-19 and cause long-lasting changes in the immune system. Patients with these fungi may benefit from specialized treatments targeting the fungi or immunological changes they instigate.
An international team recorded real-time chemical activity in the human brain using clinical electrodes, providing insights into the brain's chemistry and its implications for various medical conditions. The groundbreaking methodology has opened a window to never-before-seen brain activity.
The Marine Biological Laboratory (MBL) has been awarded $4.3 million by the Massachusetts Life Sciences Center to expand its imaging capabilities. The grant will support the procurement of two state-of-the-art microscopes that can perform advanced imaging techniques, including 2D and 3D reconstruction from electron and light microscopy.
Researchers discovered that a single mutation in a key synaptonemal complex protein can cause infertility in mice and is likely to have the same effect in humans. This finding may lead to new technologies for treating male infertility by pinpointing the exact location of the defect.
Researchers found that tumour cells escape immunotherapy by losing or changing BCMA and GPRC5D targets on their surface. This understanding has led to the suggestion of periodically profiling myeloma cells throughout a patient's treatment course to adapt treatment strategies.
Researchers at the University of Texas Health Science Center discovered a gene therapy approach that can restore motor functions in mice with Contactin-Associated Protein 1 (Cntnap1) mutations. The study found that turning on the normal gene earlier improves the rescue outcome, and the next phase is to test this approach in humans.
Researchers at Tufts University developed a genome-scale metabolic model to identify potential new treatment targets for Lyme disease. The model successfully predicted two compounds that selectively target Lyme bacteria while leaving other helpful bacteria untouched.
A study published in The Lancet found that adding an anti-inflammatory painkiller called piroxicam to the morning-after pill increased pregnancy prevention by 94.7% compared to the pill alone. The combination regimen showed no significant difference in adverse effects.
The WVU School of Medicine and Benjamin M. Statler College of Engineering and Mineral Resources will support clinical trials and engineering technology development. The project aims to improve care and rehabilitation for people with neurological disorders through novel physician-engineer programs and human research.
A study by Dr Veronica Lamarche discovered that equal consumption was more important than levels of drunkenness in perceiving consensual sex. Hook-ups where one partner is drunker are more likely to be seen as non-consensual, coercive, and dangerous.
A study investigated how algorithms compare to human judgment in music plagiarism disputes, with mixed results. While algorithms matched human decisions in 83% of cases, they struggled with non-musical factors and controversy surrounding high-profile cases.
Researchers identify mechanism by which specific protein condensates transition from liquid to solid states, enabling stability and transmission of mechanical forces. MEC-2 proteins' biological function switches with rigidity maturation, facilitating mechanosensation.
Lucas Bowman Sutton, a Rensselaer doctoral student, has been awarded the US Department of Energy's Office of Science Graduate Student Research award to conduct research on the circadian clock at Oak Ridge National Laboratory. He will utilize the Spallation Neutron Source to differentiate proteins that regulate timekeeping in living cells.
A new study found that racial and ethnic disparities persist in access to chiropractic care and physical rehabilitation for adults with low back pain, with Hispanic adults being less likely to use these services. The study also found that policy changes are needed to address these gaps in access, particularly in underserved communities.
Researchers from HonorHealth Research Institute, City of Hope, and TGen have developed a biomarker panel that detects small amounts of RNA genetic material in the bloodstream, enabling early detection of pancreatic cancer. The test has shown robust diagnostic accuracy and offers promise for improving survival rates.
Researchers discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy. Cancer cells respond to radiation by rewiring metabolic signaling pathways using lactic acid instead of glucose.
Researchers have identified a new mechanism by which phages evade CRISPR-Cas immune systems in bacteria, revealing a potential approach to make gene editing safer and more efficient. This discovery could lead to the development of bespoke anti-CRISPRs to neutralize CRISPR-Cas systems and provide an alternative to antibiotics.
A new method developed by Rice University scientists uses a high-temperature electrothermal process to remove multiple pollutants simultaneously, including heavy metals and organic contaminants. The process leaves soil particle size and mineral composition unchanged, while improving water infiltration rate and nutrient availability.
A novel strategy utilizing phosphorus nanolayers mitigates electrode-level heterogeneity in fast-charging lithium-ion batteries. The graphite-phosphorus composite exhibits consistent cycle retention, high Coulombic efficiency, and improved lithiation uniformity.
Researchers at Gwangju Institute of Science and Technology (GIST) have developed a deep learning-based biosensing platform called DeepGT, which can accurately quantify nanoscale bioparticles, including viruses. The platform harnesses the advantages of Gires-Tournois biosensors and AI to refine visual artifacts and extract relevant info...
Researchers developed a human in vitro model of radiation-induced lung injury, closely mimicking the complexities of the disease. The Human Lung Alveolus Chip recapitulates hallmarks of RILI, including DNA damage, inflammation, and injury to lung cells and blood vessels.
The ATLANTIS trial found that amitriptyline significantly improved IBS symptoms, with participants taking the medication reporting a bigger improvement in symptom scores after six months. The medication was well-tolerated and showed no significant impact on anxiety or depression scores.
The High Performance Data Facility Hub will provide researchers with unprecedented data management resources, accelerating scientific discovery through seamless access to large and complex datasets. The hub will be led by Jefferson Lab and partner with Lawrence Berkeley National Laboratory.
Algae have adapted to cope with nutrient starvation by evolving a new cellular machinery that allows them to use sunlight for growth without iron. This discovery holds promises for biotechnology developments that could enhance crop productivity and support marine ecosystems.
Researchers discovered BMAL1 is significantly upregulated in senescent cells and modulates the senescence program through AP-1. The study highlights a previously unappreciated role of BMAL1 in regulating cellular senescence and circadian clock components.
A new study reveals that innate CD8+ lymphocytes play a crucial role in limiting tuberculosis infection, and an inflammatory molecule called Interleukin-15 could be used to boost vaccine efficacy. Researchers found that these cells create a 'bottleneck' preventing bacteria from establishing active infection.
A new study by Children's Hospital of Philadelphia found that virtual driving assessments can predict crash risk in newly licensed young drivers. Drivers with major issues on the VDA had an 11% higher crash risk, while those with no issues had a 10% lower risk.
NJIT has received a $6 million NSF grant to translate science and engineering discoveries into market-ready technologies. The grant will fund up to 10 researchers for seed funding of $50,000 to $100,000 per project over four years. NJIT aims to become a regional leader in research translation.
Scientists have discovered the open and closed states of the coronavirus E ion channel, which could help develop antiviral drugs to reduce inflammation. The study's findings provide insights into the channel's structure and function, allowing researchers to design molecules that can bind to it and prevent inflammation.
The discovery of a complete Anachlysictis gracilis skeleton in Colombia provides new insights into the species' weight, estimated at around 23 kg, and diet as a hypercarnivore. The fossil's analysis suggests it preyed upon small mammals, such as marsupials and rodents, and possibly primates.
Researchers at Johns Hopkins have published a guide for prioritizing the next steps in completing the human genome catalog. The study highlights the importance of cataloging non-coding RNA genes and enhancing databases of gene variations that cause illness and disease.
Researchers from Icahn School of Medicine at Mount Sinai and the University of California San Diego will lead a new data integration hub aiming to accelerate novel therapeutics and cures for diseases. The grant, worth $8.5 million, is part of the NIH Common Fund's efforts to enhance data findability, accessibility, interoperability, an...
Researchers from the University of Virginia Health System have made significant discoveries about the genetic influences on fatty acid metabolism in diverse populations. The study found broad similarities among groups but also notable differences, highlighting the need for genetic studies in diverse groups.
Researchers found that honey bee drones exhibit synchronized hyperactivity periods, coinciding with their flight periods, and adapt their behavior to reduce energy consumption. This study reveals the complexity of drone behavior in the hive.
A new study doubles the number of protein families known up until now and identifies many novel structure predictions using a massive analysis of 1.3 billion proteins. The researchers leveraged AI methodologies to unravel the roles of previously unknown protein sequences, expanding the horizons of potential functions.
Researchers found distinct similarities between starquakes and earthquakes, but a difference with solar flares. The team analyzed nearly 7,000 bursts from three repeater FRB sources, comparing them to earthquake and solar flare data.
A study by Johns Hopkins Children's Center investigators found that delaying surgical treatment of the anterior cruciate ligament (ACL) in some children is associated with a higher risk of new tears in the meniscus and cartilage. Adults, on the other hand, showed no significant increase in such risk.
Researchers at the University of Virginia Health System are developing computer models to better understand the cellular processes and gene activity of multi-drug resistant bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The goal is to identify vulnerabilities in these bacteria and advance the development of new treatments.
Researchers have created a magnetoelectric material that can directly stimulate neural tissue, potentially treating neurological disorders and nerve damage. The material generates an electric signal that neurons can detect, overcoming previous limitations.
Researchers at Mount Sinai Hospital developed an algorithm called HistoAge that predicts age at death based on human brain tissue specimens using artificial intelligence, revealing insights into aging mechanisms and neurodegenerative diseases like Alzheimer's disease.
Researchers found that genetic variations in four genes were more common in people with CRPS than those with chronic back pain. However, men were more likely to have these genetic variants but less likely to develop the condition. This suggests that sex-specific mechanisms may be at play, which could influence treatment responses.
Researchers discovered that the short-chain fatty acid propionate can reduce metastases in mice with experimental lung cancer. The substance also increases the effectiveness of Cisplatin, a commonly used drug for lung cancer patients. Funding is now sought to identify patients who may benefit from propionate treatment.
A WVU researcher is developing new methods to fast-track the discovery of quantum materials, which could lead to breakthroughs in fields like quantum computing and superconductors. The goal is to streamline the discovery process using computational and experimental tools.
The Nuclear Science Advisory Committee has released a new long range plan, prioritizing the capitalization of substantial research investments to advance discovery in nuclear physics. The plan recommends increasing the research budget and continuing effective operation of national user facilities.
A new national ALS research consortium, Access for All in ALS, has been launched with a $16.7 million NIH award. The consortium will include 34 clinical sites nationwide and generate a longitudinal biorepository linked to detailed clinical information.
New research confirms the age of the White Sands footprints using multiple lines of evidence, including radiocarbon dating and pollen analysis. The study provides strong support for the 21,000 to 23,000-year age estimate, resolving a controversy sparked by earlier results.
The Army Research Laboratory has chosen Texas A&M University for its High-Throughput Materials Discovery for Extreme Environments Center (HTMDEC). The center aims to develop novel materials for extreme conditions, reducing experimentation costs and duration. By leveraging machine learning, physics-based simulations, and collaboration, ...
The interdisciplinary team, led by Kaiyuan Yang, will focus on leveraging the spin and charge of electrons in multiferroics to process and store information. The goal is to improve energy efficiency for computing devices, potentially reducing energy consumption by three orders of magnitude.
Researchers find evidence supporting Modified Newtonian Dynamics (MOND) as an alternative to Planet Nine hypothesis. MOND predicts precise orbital clustering in the outer solar system, which could be indicative of a modified law of gravity at play.
A new study published in the Journal of Marketing presents the Comparative Method of Valuation as a more accurate way to measure customers' willingness to pay. The study finds that existing methods can provide vague and inaccurate results due to their inability to capture relevant comparisons or context.
A new study reveals that changing nutrient use can reprogram immune cells, potentially treating cancer and infections. By blocking choline metabolism, researchers found a 'tremendous reprogramming of the immune profile' in mice, suggesting this knowledge could lead to novel therapies.
The Keck School of Medicine of USC has received a $2 million grant from the California Institute of Regenerative Medicine to further enhance its cutting-edge cGMP Laboratory. The funding will support the adoption of advanced technologies, including an electronic quality management system and optimized cell therapy manufacturing processes.
Researchers developed a novel approach to predict therapeutic targets for aging and age-related diseases. They trained a domain-specific BioGPT model on biomedical literature, which improved its performance in identifying prospective targets.
Researchers at Argonne National Laboratory have developed an autonomous microscopy technique that uses AI to selectively target points of interest for scanning, speeding up the experimental process and allowing for greater efficiency in facilities with limited beam time. This innovative approach has the potential to accelerate scientif...
Researchers at Cornell University have characterized volcanic ash samples from 40 explosive eruptions to provide a comprehensive dataset. The study found that the composition of volcanic ash varies significantly with grain size, tectonic setting, and chemistry, particularly in finer particles where salts increase and glass and iron oxi...