Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at UMass Amherst have discovered a potential new medical therapy for Lyme disease using lactate dehydrogenase inhibitors typically used to combat cancer. The study found that these inhibitors substantially impacted Borrelia burgdorferi growth, making them promising candidates against Lyme infections.
Researchers at Cornell University have developed a multimodal platform to image solar-powered microbes, enabling the study of energy conversion pathways and the potential for improving efficiency. The platform revealed the functional roles of hydrogenases in driving CO2 fixation and electron transport.
Researchers will survey residents of two Louisville neighborhoods to identify features that promote health and well-being. The project aims to create a 'universal basic neighborhood' that has all necessary community assets to help residents thrive.
Researchers found a genetic link that explains how certain individuals store fat at the abdomen but remain protected from type 2 diabetes. This discovery could pave the way for personalized medicine, tailoring treatments to individual genetic variations.
CHOP and Penn Medicine researchers have developed a proof-of-concept model for delivering gene editing tools directly into diseased blood cells within the body. This approach aims to reduce costs and increase access to gene therapies for blood disorders, which currently require chemotherapy and stem cell transplants.
Researchers at the University of Manchester's National Graphene Institute discover new physics in ancient graphite, finding a 2.5D Hofstadter’s butterfly effect that modifies both surface and bulk states.
Scientists at North Carolina State University have successfully grown high-quality thin films of the recently discovered superconductor material KTaO3. The researchers found that the material retains its superconducting properties even when exposed to extremely high magnetic fields.
A new study using ancient DNA found that workers buried more than 500 years ago came from different parts of the Inca Empire, including Amazonia. The analysis supports historical documentation and archaeological studies, providing insights into the genetic histories and lifeways of Machu Picchu's occupants.
Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...
A first-in-human study demonstrates the efficacy of a novel PRMT5 inhibitor, JNJ-64619178, in treating advanced solid tumors. The treatment showed manageable dose-dependent toxicity and achieved preliminary antitumor activity in patients with various cancer types.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
The American Heart Association has funded seven new scientific research projects to explore the connection between migraines, strokes, and cardiovascular disease. The studies will analyze existing datasets using machine learning and aim to create a collaborative group of experts to uncover the causes of increased risk.
Researchers have developed a new bioelectronic technology to map fast electrical signals in plants, revealing how plants respond to touch and stress. The study uses a multi-electrode array technology on the Venus Flytrap, demonstrating that electrical signals originate from sensory hairs.
A team of researchers, including RIT's Joel Kastner, have discovered new evidence of how planets as massive as Jupiter can form through gravitational instability around a young star. The discovery was made using images from the ESO's Very Large Telescope and the Atacama Large Millimeter/submillimeter Array.
A study by Rensselaer Polytechnic Institute found that IT peers may deter business students from entering the field. However, women without IT experience are more likely to receive positive messages and pursue careers in IT. Firms should consider the potential negative impact of peer advice when recruiting and developing IT talent.
Researchers investigated the fatigue behavior of 2D hybrid organic-inorganic perovskites (HOIPs), discovering they can survive over one billion cycles, outperforming most polymers under similar loading conditions. The study provides insights into designing and engineering these materials for long-term mechanical durability.
A new study highlights the key problem with how computer security guidelines are created, citing complexity and lack of prioritization as major issues. Researchers recommend curating information and using clear messaging to make guidelines more accessible and user-friendly.
Researchers developed a bioinformatic tool that selects parts of proteins to elicit strong immune responses. This approach, grounded in immunological theory, was four times more efficient than current methods, suggesting better vaccine protection against diseases.
The study used electronic health record data from over 200,000 children to describe patterns of pediatric allergies across the US, validating the 'allergic march' pattern. It also found that eosinophilic esophagitis (EoE) is more common among non-White patients than previously reported.
A study by Dana-Farber Cancer Institute researchers found that gliomas can arise from epigenetic changes, which affect gene activity without altering DNA sequence. The findings pinpoint two genes, an oncogene and a tumor suppressor, whose activities are epigenetically altered in human gliomas.
Researchers at the University of Virginia Health System discovered that improper calcium signaling in mitochondria accelerates chronic inflammation, leading to age-related conditions. Increasing calcium uptake in macrophages may help prevent harmful inflammation and its effects on the brain.
The study, published in Advanced Functional Materials, reveals a novel light-activated material that can be used to effectively reshape and thicken damaged corneal tissue, promoting healing and recovery for patients with keratoconus. The technology has tremendous potential to impact millions of people suffering from corneal diseases.
Rafael de Cabo, PhD, receives the 2023 Irving S. Wright Award from the American Federation for Aging Research (AFAR) for his groundbreaking contributions to aging research. The award recognizes his work on caloric restriction, age-targeting therapeutics, and healthy aging interventions.
A new study reveals that the cellular chaperone protein GRP78 migrates to the nucleus under stress and alters gene activities, allowing cancer cells to become more mobile and invasive. This discovery offers potential new approaches for cancer treatment, including down-regulating GRP78 activity or preventing it from binding to ID2.
University of Melbourne researchers have discovered that T cells patrol the human eye, protecting it from pathogens and inflammation. The study uses a new imaging technique to capture dynamic behavior of these cells in response to different stimuli.
Dr. Ankuda's work aims to improve Medicare policies supporting older adults with functional disability and serious illness, particularly those with Alzheimer’s disease or related dementias. She has received multiple awards and citations for her research on the Medicare Advantage program.
Researchers at EMBL Heidelberg discovered that mutations in the RBM20 gene cause familial DCM by disrupting normal RNA splicing, leading to detrimental cytoplasmic granules. Targeted gene editing via CRISPR-Cas9 and restoring nuclear localisation of RBM20 could improve therapy options for patients.
Researchers have found that gut health is the main determinant of systemic inflammation and disease progression in HIV. By targeting the root cause of problems, therapies may be able to slow the progression of the virus by preserving gut integrity.
A team of researchers at the University of Notre Dame analyzed nearly 600 colonial notes to understand Franklin's innovative techniques for making paper money. They found distinctive security features, including pigments and materials like muscovite that made his bills harder to counterfeit.
A new 'fly-to-bedside' resource has been developed to sort through the complexities of SARS-CoV-2 virus-host interactions. Researchers found that nine out of 10 non-structural proteins resulted in wing defects, providing a basis for understanding how viral proteins affect host proteins.
A muscle-building supplement called beta-hydroxy beta-methylbutyrate (HMB) has been shown to reduce plaques and increase factors for neuronal growth in mice with Alzheimer's-like pathology. The study found that HMB stimulates a nuclear hormone receptor to improve memory and learning in mice with Alzheimer's disease.
A study published in The Lancet Healthy Longevity found that metformin may promote healthy ageing by reducing biomarkers of ageing and increasing telomere length. The research team used genetic analysis to identify variants associated with metformin use, suggesting a potential role for the drug in promoting healthy longevity.
Dr. Eric Lazartigues has been recognized for his groundbreaking research on salt-sensitive hypertension and the role of the brain renin-angiotensin system in regulating blood pressure. His work has led to a deeper understanding of hypertension's impact on cardiovascular diseases and mortality.
Researchers at the Medical University of South Carolina have identified a novel class of compounds that effectively lower cholesterol, triglycerides and apoB in human liver-like cells. These molecules work independently of the LDLR pathway and offer a new treatment regimen for patients with familial hypercholesterolemia.
A new algorithm has been created to search fungal genomes for clusters of genes likely to result in interesting biological compounds. The algorithm, trained on a newly described type of chemistry in fungi, has discovered over 1,300 fungal species with biosynthetic gene clusters centered on isocyanide chemistry.
Researchers have discovered a new enzyme, SbSOMT, that unlocks the potential for health-promoting compounds in sorghum. The enzyme catalyzes the production of O-methylated stilbenes, which have been shown to possess anti-ageing, anti-neurodegeneration, and anti-diabetes properties.
A study published in Science reveals that ganglia in the neck region are responsible for disrupting melatonin production and causing sleep disturbances in people with heart conditions. Researchers found that macrophages accumulate in the ganglion, leading to inflammation and scarring, which can be treated with drugs.
Researchers at UBC Okanagan have developed a new method to incorporate used plastic bottles into clay soil stabilization in landfills, strengthening the soil and preventing pollutants from escaping. This innovative approach has the potential to divert millions of metric tons of plastic waste from landfills each year.
Researchers at Rice University have discovered a metal oxide that can enable terahertz technology for quantum sensing. The material, strontium titanate, exhibits unique properties that allow it to interact strongly with terahertz light, forming new particles called phonon-polaritons.
Researchers from Sandia National Laboratories have discovered that metals can heal themselves by fusing back together microscopic cracks without human intervention. This breakthrough could lead to the development of self-healing machines and structures, reducing wear and tear damage and making them safer and longer-lasting.
A new study by researchers at the National Institutes of Health found that women diagnosed and treated for breast cancer have increased biological aging compared to those who remain free of breast cancer. Radiation therapy showed the strongest association with faster biological aging, while surgery had no effect.
Researchers at Children's Hospital of Philadelphia found that NSAIDs exacerbate C. difficile infections by disrupting epithelial cell mitochondria, sensiting them to toxins. The study shows that NSAIDs and C. difficile toxins work synergistically to increase virulence, leading to increased disease severity and mortality.
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
A novel stress signalling system has been discovered by SMART researchers, enabling bacteria cells to adapt and survive against the immune system and certain antibiotics. The breakthrough discovery of RlmN as a stress sensor may lead to the development of new therapies to combat antimicrobial resistance.
Lacking Medicare coverage for screening CTC may contribute to greater income-based differences in its use compared to other recommended screening strategies or diagnostic CTC. Medicare coverage of CTC could reduce income-based disparities for individuals avoiding optical colonoscopy due to invasiveness or complication risk.
Researchers at Georgia Institute of Technology have developed a new type of battery using aluminum foil that shows promising performance for safer, cheaper, and more powerful batteries. The batteries have higher energy density and greater stability than conventional lithium-ion batteries.
Researchers at Linköping University found that Wnt signalling can have varying effects on cells depending on the signal duration and receiving cell type. This discovery sheds light on how cells determine their identity, revealing a new type of cell behavior related to genome instructions.
Researchers have discovered molecular crystals with exceptional iodine capture capacities, which could prevent radioactive waste from damaging reactor coatings. The crystals can be reused and have potential applications beyond iodine capture, including carbon dioxide capture and lithium-ion battery materials.
A new study by NASA and Japan's Osaka University suggests that rogue planets, drifting through space without a star, may outnumber stars with orbiting worlds. The Roman Space Telescope could discover up to 400 Earth-mass rogue planets, according to the findings.
Mutations in parkin gene break down contacts between lysosomes and mitochondria, disrupting essential metabolite supply to mitochondria. Restoring these contacts may represent a new therapeutic opportunity for Parkinson’s disease.
Researchers found that mannose inhibits the growth of certain types of cancer cells, making them more vulnerable to chemotherapy. Mannose has been shown to trigger 'honeybee syndrome' in these cells, which impairs DNA synthesis and replication.
Lancaster University researchers have developed a novel scanning thermal microscopy approach to directly measure the heat conductivity of two-dimensional materials. This breakthrough enables the creation of efficient waste heat scavengers generating cheap electricity, new compact fridges, and advanced optical and microwave sensors and ...
A team from Ames National Laboratory solved the structure of boron monoxide, a compound first discovered in the 1940s, using new nuclear magnetic resonance (NMR) methods and techniques. The researchers found that the material forms nanosheets with a turbostratic arrangement.
Researchers at MUSC have identified a potential novel biomarker for sepsis, which can be predicted by the contents of extracellular vesicles in the bloodstream. This discovery could lead to more accurate diagnosis and personalized treatment strategies for sepsis patients.
A groundbreaking study has uncovered potential treatments for inflammatory disorders by targeting specific receptors involved in the immune response. Researchers created mimetic peptides that successfully reduced inflammation in human immune cells and provided significant protection against toxic shock in mice.
Griffith University researchers have developed a method to control the assembly of virus capsids using DNA origami templates. This technique allows for precise control over the shape, size, and topology of viruses, which could lead to breakthroughs in vaccine development and delivery systems.
A study published in Alcohol: Clinical and Experimental Research found that a group of genes involved in neuronal plasticity and pain perception are also associated with alcohol use disorder (AUD) risk. These genes work together to influence neural communication, leading to changes in brain function that can contribute to AUDs.
Researchers have made groundbreaking progress in confining light to subnanometer scales using a novel waveguiding scheme. The approach generates an astonishingly efficient and confined optical field with applications in light-matter interactions, super-resolution nanoscopy, and ultrasensitive detection.
Scientists have discovered that genes required for complex behaviors like learning, memory, and aggression originated around 650 million years ago. This finding has significant implications for understanding the evolutionary origin of these behaviors and their neural circuits.
Researchers have discovered a way to identify pregnant women at risk of preeclampsia by examining lipids in their blood during pregnancy. The approach worked regardless of whether the women were on aspirin therapy, and could predict the risk of preeclampsia with significant accuracy.