Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A 12-year study by Pennington Biomedical researchers found that metabolic surgery provides better results, less regression, compared to medical or lifestyle intervention for patients with class 1 obesity. The study showed significant improvements in glycemic control and weight loss, with high rates of diabetes remission.
A team of researchers from WEHI has solved a long-standing mystery about how the protein Optineurin recognises and removes damaged mitochondria. The discovery provides new insights into the Parkinson's disease pathway and could potentially lead to new treatments for the condition.
Researchers have identified cut marks on a fossil leg bone that suggest butchery and likely cannibalism by humans' close evolutionary relatives around 1.45 million years ago. The analysis of 3D models revealed nine clear matches for stone tool damage, which was found to be located in areas suitable for removing flesh.
Researchers at MD Anderson Cancer Center have engineered a new model of aggressive renal cell carcinoma, highlighting molecular targets and genomic events that trigger chromosomal instability. The loss of interferon receptor genes plays a pivotal role in allowing cancer cells to become tolerant of chromosomal instability.
A recent study by the Hebrew University of Jerusalem has unveiled crucial insights into the brain's ability to regulate fentanyl consumption. The research discovered that claustral neurons can modulate fentanyl intake, suggesting a potential target for intervention in fentanyl addiction.
Researchers at Aarhus University have discovered a new method to activate the complement system using bispecific single-domain antibodies, termed BiCEs. These molecules can specifically target cancer cells and activate the complement system, leading to the killing of targeted cancer cells.
The American Heart Association has launched a $20 million initiative to tackle health challenges in rural America, focusing on novel solutions to heart disease disparities. The Health Equity Research Network on Rural Health aims to explore innovative ways to address unique obstacles faced by rural communities.
The £72 million investment will support cutting-edge research in fluid dynamics, biological sciences, and astronomy. It aims to maintain the UK's position as a science superpower and accelerate innovation in various fields.
Researchers at Tel Aviv University have developed an innovative gene therapy that shows promise in treating Dravet syndrome, a severe developmental epilepsy affecting children. The treatment was found to be effective in improving epilepsy, protecting against early death, and enhancing cognitive abilities.
A Rensselaer Polytechnic Institute researcher used high hydrostatic pressure to examine conformational dynamics of human tRNA, finding excited states that play a role in both normal function and HIV infection. The study suggests new insights into RNA function and potential targets for therapeutics.
Researchers found that iron selenide undergoes a collective shift in orbital energy during the nematic transition, rather than coordinated spin shifts. This discovery opens up new avenues for discovering unconventional superconductors and improving existing materials.
The study found that preferential use of pulmonary MRA for diagnosing PE in the general population helped conserve iodinated contrast media. This substitution reduced iodine usage by approximately 27 liters during the specified time period, which is a noteworthy benefit considering the shortage's impact.
Researchers at the University of Vienna have created a speciation atlas for polyoxometalates (POMs), a type of metal compound. The atlas provides predictive models and databases to accurately determine POM structure and behavior under various chemical conditions, enabling scientists to make the most accurate results and discoveries.
A preclinical study has uncovered the role of Y chromosome gene KDM5D in regulating anti-tumor immune responses and promoting metastasis in male patients with KRAS-mutated colorectal cancer. The study reveals that mutant KRAS drives upregulation of KDM5D, leading to reduced cell adhesion and immune recognition by the immune system.
Researchers at the University of Queensland have uncovered the atomic structure of the Langya virus, a highly infectious virus with pandemic potential. The study aims to develop broad-spectrum human vaccines and treatments for Henipaviruses, which cause severe disease and have the potential to get out of control.
A groundbreaking study finds that microbial life can exist without plate tectonics, challenging a fundamental theory of geology. Zircon crystals from the Barberton Greenstone Belt reveal a stagnant lid regime on ancient Earth, leading to continent formation and potentially habitable conditions.
Recent studies in the New Journal of Pharmaceutical Analysis feature novel diagnostic tools, RNA sequencing-based workflows, and mechanical property evaluations to enhance cancer and cardiovascular disease treatment outcomes. These innovations aim to improve the therapeutic effect of drugs and promote personalized medicine.
Researchers at Weill Cornell Medicine have discovered a DNA molecule that folds into a four-way junction structure, allowing it to mimic the activity of green fluorescent protein (GFP). This breakthrough could lead to the development of new DNA-based fluorescent tags for rapid-diagnostic tests and various scientific applications.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a molecular mechanism contributing to congenital heart defects in infants with Down syndrome. The study found that an abnormal interferon response inhibits key molecular events required for heart development, leading to impaired cardiogenesis.
Researchers at Purdue University have demonstrated tunable moiré magnetism in twisted double bilayers of chromium triiodide, a material that can be used for spintronics. This discovery suggests a new class of material platform for spintronics and magnetoelectronics.
A University of Essex-led study found that fast-oscillating brain waves linked to brief pain and touch differ widely in scans, with individual patterns stable across time. The research challenges previous findings on the relationship between pain and gamma oscillations.
Researchers have identified a gene in the placenta that produces a defense mechanism against viral infections, protecting fetuses during pregnancy. This discovery could lead to the development of new anti-viral treatments.
Researchers developed a new therapeutic molecule that activates WNT signaling to restore the blood-brain barrier's normal function. The treatment showed promise in treating conditions such as multiple sclerosis and ischemic stroke by reducing the severity of strokes and improving survival rates.
Researchers developed Precious1GPT, a multimodal transformer-based approach for aging clock development and feature importance analysis. The model utilizes methylation and transcriptomic data to predict biological age and identify disease-related genes, providing a pathway for therapeutic drug discovery.
Researchers at SRI International have identified genes that enable insects to produce terpenes, a key component of their chemical communication. This breakthrough provides a roadmap for understanding how these chemicals are used and could lead to new ways to protect crops and prevent insect-borne diseases.
A team of SUTD researchers discovered a novel intrinsic nonlinear planar Hall effect, proposing a mechanism to characterize novel materials and their complex behaviors. This effect could lead to new designs in nonlinear rectifiers or terahertz detectors for long-range communications.
Researchers have found evidence of 20 million years of 'hot spot' magmatism under the Cocos plate, with a long-lived melt channel that originated from a mantle plume. The study suggests that this channel is regionally extensive and may be a widespread source for intraplate magmatism.
A recent Markey Cancer Center study reveals persistent cancer disparities in Appalachian Kentucky. The research found striking disparities in cancer incidence and mortality rates compared to the rest of the country, with a focus on lung, colorectal, cervical, and oral cancers.
Rensselaer Polytechnic Institute researcher Scott Forth is investigating the mechanical code underlying mitosis to combat cancer. His lab aims to determine how chromosomes are segregated during cell division, with potential insights into new diagnostics and treatments.
A new gene variant, RBL1, has been identified in a type of rice that can be modified to improve performance without yield penalties. This breakthrough could lead to more disease-resistant rice crops with high yields, addressing a major threat to the industry and meeting growing global demand.
A new study at Tel Aviv University found that older bats do indeed suffer from age-related hearing loss, but at a relatively slow rate compared to humans. The researchers believe that bats have developed special adaptations to cope with their noisy environment, which could provide insights into human hearing loss.
Scientists have discovered a rare type of white dwarf pulsar, shedding light on stellar evolution and the origin of strong magnetic fields. The newly detected pulsar, J1912-4410, has a size similar to Earth but a mass at least as large as the Sun.
A new armoured dinosaur, Vectipelta barretti, has been described from the Isle of Wight, revealing differences in neck and back vertebrae and a unique spiky armour. The discovery provides new insights into ankylosaur diversity in the Wessex formation during the Early Cretaceous period.
Researchers have successfully controlled chemical reactions by manipulating electromagnetic fields in an infrared cavity, improving understanding of reactivity and products formation. The discovery offers a new path for quantum physics to regulate chemical reactions.
Researchers have discovered how Golden staph, a common bacterial infection, hides inside human cells to avoid detection. The study used InToxSa, a new methodology that enables the study of Golden staph behavior on a large scale.
Researchers at the University of Cincinnati have discovered two existing drugs that show signs of being effective in treating lymphangioleiomyomatosis (LAM), a rare and devastating lung disease. The study found that these drugs target a novel pathway dysregulated in LAM, which could lead to the development of a cure.
New research from the University of Manchester reveals that areas rich in marine life are significantly impacting our ecosystems and climate. The study found that urea, a nitrogen-rich compound, is being transported over long distances through the atmosphere to benefit nutrient-deficient environments.
Researchers found rock-forming elements in the atmosphere of WASP-76 b, which suggests it might have accreted a smaller Mercury-like planet. The discovery provides unprecedented insight into the presence and abundance of rock-forming elements in giant planets.
Researchers discovered the abundance of rock-forming elements in WASP-76 b's atmosphere, which matches its host star and our own Sun closely. The team found that certain elements are depleted due to temperature conditions, providing insight into the sensitivity of giant planet atmospheres.
Researchers found that psychedelic drugs such as LSD, psilocybin, and MDMA reopen critical periods in mice, enabling them to learn from their social environment. The length of time the critical period stayed open varied among drugs, with some lasting up to four weeks.
Researchers at Georgia Institute of Technology have discovered a gene that drives the switch between chronic and acute P. aeruginosa infections. The gene encodes a small RNA called SicX, which plays a vital role in bacterial respiration under low oxygen conditions.
Scientists at the Stowers Institute for Medical Research have uncovered the structure of the first step in amyloid formation for Huntington's disease. The team proposes a new method for treating not only Huntington's but potentially dozens of other amyloid-associated diseases by preventing the initial, rate-limiting step from occurring.
Researchers found tiny salt crystals in an asteroid sample, indicating the presence of liquid water. The discovery challenges previous assumptions that ordinary chondrite asteroids lack hydrated minerals.
The InVADER Mission successfully deployed a high-tech laser laboratory on the ocean floor, marking a paradigm shift in ocean research and exploration. The Laser Divebot collects compositional data without disturbing the environment, removing the need for physical samples.
CHOP researchers have developed stable, universal MHC-I molecules that can be produced rapidly at scale, allowing for the development of effective and universal immunotherapies. These engineered MHC-I molecules promote peptide exchange across multiple HLA allotypes, covering various forms.
The USC Stem Cell team is developing artificial kidney organoids using human stem cells and synthetic biology. They aim to create a functional kidney that resembles the real thing in function but not in form.
Scientists have developed a novel photonics system that can measure low-energy dynamics of complex physical phenomena with high time resolution. This breakthrough approach combines terahertz spectroscopy and real-time monitoring to facilitate discoveries in materials science.
Researchers have identified a second circumbinary planet, BEBOP-1c, in the TOI-1338/BEBOP-1 system using state-of-the-art instruments. The newly discovered planet has a mass 65 times larger than Earth and orbits both stars at once.
A new study by Children's Hospital of Philadelphia found that the quality of life and self-esteem of children with short stature are associated with coping skills and social supports, rather than their height. The researchers suggest that addressing short stature through a broader, psychosocial approach might have a more positive impac...
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.
Winship Cancer Institute has received renewal of its National Cancer Institute-designated Comprehensive Cancer Center designation, solidifying its position as Georgia's only NCI-designated Comprehensive Cancer Center. The designation recognizes Winship's strong research programs, robust shared resources, and first-rate scientists.
The Shape Up! Keiki research study aims to create a better way to measure and describe health from body shape, focusing on identifying obesity risks in young children. Participants aged 5 years or younger will be compensated $200 for their time.
Researchers from Universitat de Barcelona and Universitat Internacional de Catalunya discuss the non-receptor protein tyrosine kinase Src as a good example of an oncogene. Targeting the Src N-terminal regulatory element (SNRE) has potential as oncotargets to inhibit Src activity only in cancer cells.
Researchers found that introducing magnetic defects into topological insulators leads to competing ferromagnetic and antiferromagnetic interactions, which control the material's magnetic order. This discovery could have significant implications for reducing energy footprints in computing and electricity transmission.
Researchers have calculated the heavy quark diffusion coefficient, which describes how quickly quarks and gluons transfer their momentum to heavier quarks. The calculation reveals that heavy quarks are strongly interacting with the surrounding plasma, making it difficult for them to change direction.
LSU Health New Orleans researchers found that a combination therapy using Neuroprotectin D1 and Resolvin D1 boosted brain cell survival, growth, and stability. The therapy showed promising results in reducing lesion volume and improving neurological function in acute ischemic stroke models.
Scientists at the University of Illinois Chicago have discovered a peptide from fruit flies that protects insects from bacterial infections by binding to ribosomes in bacteria. The peptide, called drosocin, inhibits translation termination when the ribosome reaches the stop signal at the end of the gene.
Researchers at Sanford Burnham Prebys have discovered a new treatment for autoimmune diseases using LY3361237, an antibody that activates BTLA to inhibit the immune system. The study provides insight into the molecular biology of the immune system and could lead to the development of more effective therapies.
Researchers discovered that targeting specific blood vessel enzymes can enhance immunotherapy effectiveness and prevent breast cancer metastasis. By disabling the enzyme DNMT1 in blood vessels, doctors may bolster anti-tumor immune cells entry and increase patients' response to treatment.
Researchers discovered that air quality monitoring stations worldwide are collecting eDNA, providing a treasure trove of biodiversity data. This could solve the global problem of tracking biodiversity at massive scales, with thousands of locations and decades of historic data.