Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a method using artificial intelligence to track changes in brain synapses, enabling better understanding of how connections change with learning, aging, injury and disease. Machine learning was leveraged to enhance image quality, allowing for detection and tracking of individual synapses.
UofL researchers, led by Jun Yan, will investigate the causes of immune system overresponse in COVID-19 patients, leading to severe lung disease and death. They aim to develop methods to predict, prevent or control this response with potential treatments for other conditions.
A University of Virginia-led study challenges traditional understanding of associative polymers' behavior, revealing that reversible bonds slow down polymer movement without creating a rubbery network. This discovery has implications for materials used in sustainability, health, and engineering applications.
The study found that the immune response to spinal-cord injuries is impaired in older individuals, leading to weaker cell responses and reduced recovery. The researchers identified an essential role for the meninges surrounding the spinal cord in mounting the immune response, paving the way for new therapeutic approaches.
Researchers updated their protein localization prediction model, MULocDeep, to provide more targeted predictions for biological discoveries. The tool helps researchers design more effective experiments and advance scientific discoveries related to drug development and treating diseases like epilepsy.
Researchers found two antimicrobial agents that are more effective in treating the disease-causing agent Treponema pallidum in a laboratory setting. The discovery opens new doors in understanding the disease and finding ways to prevent infection and intervene.
Researchers at Colorado State University have made a groundbreaking discovery in understanding how mountains form, revealing that deep Earth processes are the primary drivers of mountain building in subduction zones. By combining novel data sets and techniques with traditional geomorphology measurements, the team generated a long-term ...
Researchers, led by Elizabeth King, aim to develop a knowledge base on complex genetic traits using fruit fly models. The project seeks to address the scientific knowledge gap in this field by focusing on interconnectedness among multiple factors.
University of Washington researchers have detected atomic vibrations, also known as phonons, in a two-dimensional atomic system. The discovery could help encode and transmit quantum information through light-based systems.
A new kind of superconducting vortex has been found, dividing the magnetic flux into a wider range of values than previously thought. This discovery challenges the prevailing understanding of superconductivity and potentially opens up new possibilities for superconducting electronics.
Researchers identified mRNAs and long non-coding RNAs targeted by stress granule proteins, which accumulate AD-associated gene transcripts in these structures. SGs may play a key role in regulating AD development through the impairment of protein neurohomeostasis.
Researchers have developed strong and ductile titanium alloys by integrating alloy and 3D-printing process designs, enabling new sustainable applications in aerospace, biomedical, and energy technologies. The breakthrough utilizes circular economy thinking to produce alloys from industrial waste and low-grade materials.
A new study reveals the molecular structure of UCP1, allowing scientists to develop therapeutics that activate it to burn excess calories. This breakthrough could combat obesity and related diseases like diabetes by activating brown fat tissue.
Researchers at Ulsan National Institute of Science and Technology have made a breakthrough in creating ultra-photostable avalanching nanoparticles that can perform unlimited photoswitching. This achievement has significant implications for fields like optical probes, 3D optical memory, and super-resolution microscopy.
A WVU researcher is developing a data-driven approach to enhance roadway maintenance operations, incorporating AI analysis of real-time data from sensors on consumer cars and roadside observation stations. The goal is to minimize time and resources spent on less affected roadways, reducing winter maintenance costs and time.
Researchers presented findings on pembrolizumab for brain metastases, virtual mind-body interventions for post-treatment survival, and dynamic HER2-low status in triple negative breast cancer. The studies aim to improve treatments and outcomes for patients with cancer.
The study reveals the life cycles of four Lonomia Walker species, characterized by unique morphological features. New parasitoids and host plants have also been discovered, shedding light on the complex relationships within this genus.
Alternative gene splicing has been linked to an increased risk of alcohol use disorder (AUD), according to a recent study published in Molecular Psychiatry. The researchers identified 27 exon skipping events that may contribute to AUD risk, opening up new possibilities for finding new therapeutics.
The James Webb Space Telescope has discovered a massive plume of water vapor on Saturn's moon Enceladus, stretching over 6,000 miles. This finding has significant implications for the search for life beyond Earth, as it suggests that Enceladus may have the necessary ingredients for habitability.
A low-cost catalyst developed by Argonne National Laboratory can produce clean hydrogen from water at a lower cost, making it an ideal choice for replacing fossil fuels and reducing greenhouse gas emissions. The new catalyst uses cobalt instead of expensive iridium, significantly reducing the cost and increasing efficiency.
Astronomers at MIT and University of Wisconsin have discovered two validated planets, K2-416 b and K2-417 b, in Kepler's last week of high-quality data. The third planet candidate, EPIC 246251988 b, orbits its star every 10 days and is slightly farther away from Earth than the other two.
Two researchers will receive $1 million each for their five-year studies on new medication-based approaches to repair damaged aortas, as well as the effects of exercise on healing heart muscle and brain tissue after a heart attack or stroke. The American Heart Association's Merit Award supports innovative research with high impact.
Researchers found that distant cancers alter liver function by inducing fat accumulation and inflammation in liver cells. The process involves secretion of extracellular vesicles containing fatty acids, which reprogram the liver to resemble fatty liver disease.
Researchers at the University of Córdoba have identified the composition of a Roman perfume over 2,000 years old, with patchouli being the primary scent. The perfume was found in a vessel made of quartz and sealed with dolomite and bitumen, allowing for its preservation.
Researchers have discovered that HER3 plays a crucial role in promoting cell survival in metastatic colorectal and pancreatic cancer. The surrounding liver microenvironment activates HER3, making it an emerging therapeutic target for these types of cancer.
New research from Bigelow Laboratory for Ocean Sciences reveals that coccolithophores can survive in low-light conditions by taking up dissolved organic forms of carbon. This finding challenges current understanding of the biological and alkalinity pumps driving carbon transport in the ocean.
A team of researchers has identified TAK1 as a regulator of skeletal muscle mass, slowing down disease progression and improving muscle function in Duchenne muscular dystrophy. By targeting this protein, they can suppress muscle fiber death and enhance myofiber growth, offering a promising new approach to treatment.
Researchers discover a molecule that destroys aged cells without affecting healthy ones, paving the way for delaying tissue ageing. Testing with animal models will now begin to explore its potential anti-cancer effects and improve life expectancy.
NERC has invested £25 million in a host of high-risk, high-reward research projects tackling key unanswered questions about our planet. The projects cover geology, atmospheric science, biodiversity and ecology, with research spanning 3-4 years and funding up to £1.3 million.
A Rensselaer research team led by Sangwoo Lee found that crystal structures are not always regularly arranged. The discovery has implications for materials used in semiconductors, solar panels, and electric vehicle technologies.
Scientists have discovered weak, fossilised sediments beneath the seafloor of Antarctica's eastern Ross Sea, which led to massive underwater landslides. These layers made the area susceptible to failure due to past climate change.
Astronomers have discovered an Earth-sized exoplanet, LP 791-18 d, which orbits a small red dwarf star in the constellation Crater. The planet may experience volcanic flare-ups as frequently as Jupiter's moon Io, potentially making it habitable for life. However, more research is needed to confirm its atmosphere, water content, and hab...
Researchers at Michigan Medicine have discovered a new nutrient source that pancreatic cancer cells use to grow in the absence of glucose. Uridine is found in the tumor microenvironment and its exact source remains unknown. Blocking uridine metabolism may lead to new treatment options for pancreatic cancer.
A new machine learning-based model predicts individual cardiac surgery patient mortality risk with improved performance over current population-derived models. The model uses electronic health records to provide personalized risk assessments, offering a significant advantage over existing benchmarks.
A team of scientists led by NYU Abu Dhabi researcher Mohamad Ali-Dib discovered an Earth-sized exoplanet named LP 791-18 d. The planet may be carpeted with volcanoes and sustain water in liquid form, making it potentially habitable.
Researchers developed a computational platform called IRIS to discover tumor antigens from alternative RNA splicing, expanding cancer immunotherapy targets. Hundreds of predicted TCR targets were found to be presented by human leukocyte antigen molecules.
A €2.5million European research programme, FRIETS, is increasing the shelf-life of berries through high-precision agriculture and innovative processing methods while maintaining quality. The four-year project combines precision agriculture strategies with dehydration and edible coating methods to discover healthier food alternatives.
Researchers developed a 'Skeletal Age' metric to assess impact of fractures on mortality, revealing a loss of one to seven years of life depending on gender, age, and bone site. The online calculator measures bone fragility to help doctors and patients understand fracture risks.
Researchers developed a novel combination therapy that eradicates tumors in select patients, with prolonged survival rates. The therapy has shown promise in treating glioblastoma, a notoriously difficult-to-treat primary brain cancer.
Researchers discovered a new genetic variant in the Reelin gene that provides protection from Alzheimer's disease. The variant was identified through clinical assessments, genetic and molecular studies, and neuropathological analysis of two patients with a similar genetic predisposition to developing early-onset Alzheimer's disease.
Researchers developed a computational approach to predict diabetic kidney disease using DNA methylation markers from a blood sample. The model can use this information to assess current and future kidney function, enabling early detection and prevention of kidney disease in people with type 2 diabetes.
A team of Virginia Tech scientists has identified a brain pathway responsible for synchronized movement in individuals, including mice, without rehearsal. The study provides an underlying mechanism for coordinating group behavior, which is essential for understanding social communication in humans and developing therapies for ADHD, ASD...
Researchers at Nanyang Technological University found that cells near wavy shaped wounds moved in a swirling manner, while those near straight wounds moved in straight lines. This discovery reveals that the swirling motion is crucial for gap-bridging and accelerates wound healing in wavy wounds.
Researchers at Purdue University have discovered that superconductive images are actually 3D and disorder-driven fractals. The team used fractal mathematics to characterize the shapes of electrons in a cuprate high-temperature superconductor, revealing patterns that challenge current understanding of quantum materials.
Researchers have found sedimentary archives in sand dunes that can reconstruct reliable, multi-millennial fire histories. The discovery aims to expand scientific understanding of fire regimes around the world and uncover the role of humans on fire history.
A new method developed by Cornell researchers provides tools to interpret discarded X-ray crystallography data, enabling better understanding of proteins' movement, structure, and function. This breakthrough could lead to designing new drugs targeting specific proteins.
A Rensselaer researcher has used artificial intelligence to discover novel van der Waals (vdW) magnets with large magnetic moments. These two-dimensional vdW magnets have the potential to advance science and technology in data storage, spintronics, and quantum computing.
Researchers discovered that scalloped hammerhead sharks close their gill slits during deep dives to prevent heat loss and keep warm. This unique behavior allows them to hunt effectively in cold water depths.
Two NYGC research teams have been selected as grant recipients under the NIH Common Fund SMaHT Network. The first team will generate a high-quality somatic variant catalog leveraging three core sequencing assays, while the second team will develop innovative tools for studying somatic mosaicism using a single-cell multi-omics approach.
The study used magnetic resonance imaging (MRI) to measure acute pressure changes inside the heart, discovering that pressure increases when patients receive a specific medication called adenosine. This technology can help doctors better diagnose and monitor patients with heart disease and heart failure.
Researchers used cancer proteomics data to identify gene candidates for therapeutic targeting, focusing on protein kinases in uterine endometrial cancer cells. Public molecular resources and multi-omics data analysis can prioritize genes of interest for future studies.
Scientists at CNIO identify succinylation as a poorly studied mechanism in cancer research; mutated DLST protein prevents succinylation, leading to pseudohypoxia and tumor growth. Succinylation is crucial for protein function and may be linked to various diseases.
Researchers from Aston University and the University of York discovered new insights into how the human brain makes perceptual judgments of the external world. They found that humans can exploit 'defocus blur' to infer perceptual scale, but this process is crude and more heuristic than metrical analysis.
Scientists have defined a basic toolkit for forming tubular organs in animals, which is thought to be the foundation of organ development in vertebrates. The study uses the sea star as a model organism and reveals that cells can proliferate and migrate simultaneously during tube formation.
Researchers at Mount Sinai have discovered a previously unknown way in which the brain and immune system interact in multiple sclerosis. They found that the inflammatory protein interleukin-3 (IL-3) coordinates this communication, inciting the recruitment of immune cells to the brain and exacerbating brain inflammation.
Researchers developed a new probe to measure pH levels in cells, revealing a constant conversion rate from endosomes to lysosomes. The probe's ability to track pH changes enables faster diagnosis and potential treatments for lysosomal diseases.
The 'Low Oxygen and Weight Status' study will investigate the effects of low oxygen levels on weight loss and health outcomes in adults with obesity. Participants will be randomized to sleep in an altitude tent or normal conditions, while following a weight loss diet. The study aims to inform new strategies for improving metabolic health.
Researchers at UVA Health System have made a breakthrough discovery about the role of microglia in seizure disorders. The study suggests that enhancing microglial activity could be a promising approach to preventing and managing seizures, offering new hope for patients who don't respond to existing treatments.
Researchers discovered that gamma delta T cells can effectively combat triple-negative breast cancer by targeting stress-induced molecules and phosphoantigens. Counteracting metabolic changes with zolendronate makes immunotherapy more efficient.
A study by University of Helsinki researchers identifies specific Desulfovibrio bacterial strains as a primary cause of Parkinson's disease in most cases. The findings suggest that these bacteria can trigger aggregation of the alpha-synuclein protein, potentially leading to disease progression.