Yale scientists have successfully immunized mice against West Nile virus, providing a promising lead for developing a vaccine for humans. The vaccine was developed using a protein found in the virus and showed complete protection against the disease.
Researchers at Thomas Jefferson University found that daily doses of Angiostatin, combined with radiation, caused a partial response in patients with advanced cancer. The treatment was well-tolerated, with few side effects reported.
The ACS Scholars Program provides financial support to minority students pursuing undergraduate studies in chemistry and related disciplines. With over $850,000 in awards anticipated for the next two semesters, the program aims to increase diversity in the chemical sciences workforce. Students can receive up to $3,000 per year and bene...
Researchers at University Hospitals of Cleveland report promising results from Phase I trials of a new cancer drug, Combretastatin A4 Prodrug. The study showed significant reduction in tumor blood flow after infusion of the drug, with some patients experiencing complete remission and prolonged periods of freedom from disease progression.
A multidisciplinary team led by David E. Sahn will explore access to health education and nutrition, including HIV/AIDS, poverty traps, and food insecurity. The research aims to better understand the economic and social constraints that hinder Africa's poor from prospering in growth-oriented reforms.
A new NHLBI study found that high-normal blood pressure increases the risk of heart attack, stroke, and heart failure by 1.5 to 2.5 times in 10 years compared to optimal blood pressure levels. The study also showed a continuous increase in cardiovascular events with age, especially in older adults.
Researchers discovered that Foxo1 is involved in regulating glucose metabolism and promoting insulin resistance in cultured kidney cells. Increased Foxo1 activity was linked to decreased insulin sensitivity, highlighting its potential as a therapeutic target for treating related disorders.
A new patented technique uses titanium dioxide nanoparticles to bind and remove mercury from combustion exhausts, trapping the toxic metal with high effectiveness. The process leverages photocatalytic properties of titanium dioxide to oxidize mercury, making it a promising solution for controlling mercury emissions.
Researchers found that small doses of suramin enhanced chemotherapy effectiveness in treating advanced stage IIIB/IV lung cancer. The tumors halved in seven patients and didn't progress in eight, showing a potential treatment option for patients with metastatic lung cancer.
The Yale-Griffin Prevention Research Center is studying the effects of lifestyle interventions such as stretching, breathing exercises, and yoga on managing asthma symptoms. Asthma affects approximately 12 million American adults, resulting in significant healthcare costs.
Researchers found four characteristics independently associated with recent overdoses in a San Francisco Bay Area population: homelessness, lengthy prison sentences, and sex work. Targeted interventions to decrease overdose risk are urgently needed, according to the study's lead author.
Researchers at Ohio State University are studying a new treatment that blocks the production of Bcl-2, a protein overexpressed in many cancers, and found nearly half of 20 patients responding favorably. The treatment showed safety and induced disease remission in some patients.
The study found that 43.4% of elderly heart attack patients are anemic, and those with lower blood counts have higher mortality rates. Blood transfusions significantly reduce mortality risk in these patients, even at higher blood count levels than previously thought.
The project aims to improve and conserve local, traditional crops being overlooked by major international research programs. Farmers will be actively involved in selecting and multiplying varieties of neglected crops, with new technologies for better cultivation and use.
Researchers from Yale and University of Chicago discovered a 40-foot long Sarcosuchus imperator crocodile fossil, estimated to be the largest known so far. The fossil was found in Cretaceous rocks in central Niger and is believed to have lived for approximately 42 years before reaching adulthood.
Yale researchers have created a microchip that can analyze virtually all yeast proteins, holding promise for advances in studying protein function in other organisms. The technology allows for faster understanding of protein interactions and could lead to breakthroughs in diagnostic methods, drug discovery, and therapies.
Researchers found that HHV-6 inhibits early-stage HIV variants by blocking CCR5 receptors, slowing their reproduction. The harmless herpesvirus may create favorable conditions for later-stage HIV variants that use CXCR4 receptors.
A study of 1,596 children in Rochester, NY, found that 8% had Tourette's and 27% had some tic disorder, with mild symptoms being more prevalent. Research suggests that tics can be an indicator of a subtle brain developmental disorder.
The Sandia-developed decontamination formulation has been selected to help rid Capitol Hill buildings of anthrax contamination. It is a non-toxic, non-corrosive, and environmentally friendly cocktail that neutralizes both chemical and biological agents in minutes.
Preliminary findings from a deep-sea expedition have uncovered a vast array of new species in the Atlantic Ocean's abyssal plains. The discovery, part of the DIVA project, confirms the diversity of deep-sea life and reveals significant differences in sediment structure and fauna composition across different sites.
Research has identified DDR2 as a key player in the development of hepatic fibrosis, a liver disease characterized by excessive scar tissue buildup. High levels of DDR2 expression have been linked to advanced fibrosis and poor patient outcomes.
A new study from Massachusetts General Hospital suggests that HMO gatekeeping policies may not be effective in reducing specialty visits. The study found a small increase in new specialty visits, but no change in overall rates of specialist visits.
GammaDelta T cells are activated by bacterial pathogens, recognizing and responding to peptidoglycan patterns. They release pro-inflammatory cytokines to coordinate an immune response, providing innate protection against bacterial infections.
Researchers found that bone marrow-derived cells contribute to tumor blood vessel formation and promote growth. Targeting specific VEGF receptors blocks tumor formation, offering potential new therapeutic approaches.
Researchers found that patients who received intercessory prayer in addition to coronary stenting had better clinical outcomes than those treated with standard stenting therapy alone. Noetic interventions, including prayer and guided imagery, were shown to reduce adverse outcomes by 25-30 percent.
Researchers analyzed wood samples from the King Midas tomb, finding that a soft-rot fungus was fueled by nitrogen from the king's body and meat-based food sources. The study may provide insights into preserving historical sites from fungal degradation.
Researchers found that bovine thrombin causes an immune response similar to lupus in mice and can lead to post-operative complications. Bovine thrombin is a potent enzyme used in surgical procedures, but its use should be restricted to life-saving surgeries due to the risk of autoimmune responses.
Researchers are using innovative noninvasive techniques to study the developing central nervous system in early iron deficiency, which affects brain development and behavior. The study aims to understand the ties between the brain and behavior, with potential implications for creating more effective interventions.
A Yale study found that HIV patients who trust their physicians are 20% more likely to adhere to their treatment regimens. Lack of social support and mistrust in peers also hinder adherence to ART.
The MIT worldwide mobility study highlights the need to reinvent public transport and create a portfolio of mobility options to address chronic gridlock, pollution and environmental damage. The study also warns of the growing impact of air and freight transportation on carbon emissions.
Yale researchers found that diphenhydramine, a commonly prescribed sedative, increases the risk of delirium symptoms in older hospitalized patients. The study suggests that using diphenhydramine as a routine sleeping aid should be discouraged in older hospitalized patients due to potential harm
Researchers found that levels of IL-12 and TNF alpha decreased during pregnancy, while cortisol, norepinephrine, and 1,25 hydroxyvitamin D3 increased. After birth, these stress hormones surged, possibly contributing to the resurgence of immune disorders like rheumatoid arthritis and multiple sclerosis.
The Combining Medications and Behavioral Interventions (COMBINE) study evaluates the effectiveness of behavioral treatments alone and in combination with medications for treating alcoholism. Researchers at Yale University are recruiting participants to participate in the study.
A large study found that animal-based nutrients are strongly associated with increased risk of stomach and esophageal cancers. Conversely, a diet rich in plant-based nutrients, such as dietary fiber and vitamin C, may help lower cancer risk.
ChemGenex Therapeutics has developed a new anticancer drug called Ceflatonin, which uses genomics to predict possible side effects and identify key genes for treatment. The company's research demonstrates that Ceflatonin affects specific genes and cellular pathways in leukemia and solid tumors.
A six-month study found that 82% of stable methadone patients remained clinically stable under primary care physician treatment. Patients reported higher satisfaction rates and physicians felt confident in providing this type of care.
Yale University has been awarded a $1.3 million pre-center grant to prepare for the potential establishment of a Center of Excellence in Biomedical Computing. The grant aims to train new scientists in interdisciplinary areas of biomedical computing, addressing a critical shortage identified by NIH.
Researchers at Yale University have developed a novel molecule that eradicates cancer by destroying tumor blood vessels. The icon targets the inner surface of tumors expressing tissue factor, allowing it to bind and activate an immune response against cancer cells.
Researchers use SAGE to study fruitfly genome, identifying genes responsive to JNK signal that help skin form properly and understand its effects on a whole organism
A team led by Haim H. Bau will model transport of liquids, particles, and cells in microconduits to study biological interactions. They will use low-temperature co-fired ceramic tapes to fabricate prototypes.
A new study published in the Journal of Neurosurgery found that mild head injuries can cause permanent damage to the brain, with effects not felt for months. The research suggests that repetitive head injuries may be a factor in neurodegenerative diseases like Alzheimer's.
A study of 13 HIV-positive men found that those with high levels of autonomic nervous system activity responded less well to antiretroviral treatment, with some experiencing no immune recovery. Stress accelerates AIDS progression by increasing viral replication and making it harder for the body to fight off the infection.
The study aims to determine the effectiveness of meditation and/or massage in improving patients' perceived quality of life. Researchers hope to find ways to improve quality of life, particularly in the spiritual domain, for patients dying with AIDS.
Workers were more willing to pay for policies that directly benefited them than those with no direct benefit. Notably, teachers with a low probability of using paid childbirth leave had the highest willingness to pay.
Marie T. Filbin, a Hunter College neuroscience professor, has made groundbreaking discoveries related to the role of cyclic AMP in nerve regeneration after injury. Her work, conducted independently with Professor Mu-Ming Poo, could lead to novel therapies for those with spinal cord injuries.
Researchers successfully imaged single molecules of cAMP binding to receptors on the surface of living amoebae, providing new insights into chemotaxis and cell movement. The study's real-time video reveals how receptors behave when detecting cAMP gradients, allowing cells to respond faster to changes in their environment.
Research found that black raspberries can prevent esophageal cancer onset and inhibit precancerous cell growth in rats. Feeding rats with 5-10% black raspberries before and after NMBA treatment reduced tumors by 39-49% and 62-66.5%, respectively.
In a phase IIa trial, TMC125 demonstrated a rapid and strong antiviral effect, reducing HIV viral loads by up to 99.9%. The study showed that 8 out of 12 patients had their viral loads reduced to less than 400 copies/ml without any rebound or drug resistance.
The National Virtual Observatory will unite diverse astronomical databases, making it easier for researchers to access and analyze data. The project aims to streamline data analysis techniques and promote collaboration among institutions.
The NRL's Humvee-based communications system can provide two-way satellite commercial links and a private cellular telephone network. It can also handle streaming video, making it an essential tool for emergency response teams.
A researcher has developed a new detector that can identify airborne anthrax and other biological particles in under 30 minutes. The device uses lasers and acoustic sensors to detect the presence of microorganisms, offering significant improvements over existing methods.
The National Virtual Observatory will unite various astronomical databases, taking advantage of computer technology and data storage techniques. This project aims to maximize scientific insights from data, making them accessible to professional researchers, amateur astronomers, and students.
The ACP-ASIM survey found that 60% of respondents under 40 use handheld computers to access drug information and clinical references. The organization is expanding its educational resources through a Personal Digital Assistant Portal on its website.
Researchers discovered gene silencing can interrupt tumor formation in crown gall disease, producing over a 90% reduction in gall formation among genetically engineered plants. The technique has potential applications for disease-resistant rootstocks and non-transgenic crops.
Nuclear quadrupole resonance (NQR) uses low frequency radio waves to detect explosives and narcotics. The technique is effective for land mine detection, as it targets the explosives within the mine.
Researchers at Cornell University's Laboratory of Plasma Studies have developed a new X-pinch imaging technique that produces extremely high-resolution images of minute objects. The technique, which uses powerful electrical currents to create plasma, has been used to image objects as small as house fly hairs and even living ants.
The MilliWave Viscometer measures viscosity in molten materials, indicating chemistry and quality. It enables feedback control, maximizing waste loading and improving efficiency in glass production, with significant economic impact on environmental clean-up efforts.
Researchers found that active stress from a memory task increased the concentration of immune proteins in saliva, while passive stress from watching gruesome videos lowered it. The study suggests that engaging with challenges at work can boost immunity.
The FaceIt face recognition system uses local feature analysis to capture tiny components of the face, allowing it to recognize faces even when only a portion is visible. It can track up to 10 faces simultaneously and search for matches against a database at a rate of 60 million/minute.
Scientists have found a gene responsible for a rare form of hereditary spastic paraplegia, a condition that slowly robs children of their ability to walk. The discovery has opened the door to better diagnosis and treatment of the disorder, as well as insights into other spinal cord problems.