Research found that hypomethylating agents (HMAs) activated the oncofetal protein SALL4 in up to 40% of patients with MDS, resulting in poor patient survival. This activation is linked to demethylation and upregulation of oncogenes, suggesting a need for additional combination therapy.
Scientists have discovered a small molecule that bypasses ADAR1 suppression and directly activates tumor cell death by ZBP1, inducing highly immunogenic cell death and destroying fibroblasts supporting tumor growth. This approach has the potential to improve the effectiveness of immunotherapy in treating therapy-resistant tumors.
The Fannie and John Hertz Foundation has awarded fellowships to 13 doctoral students who will focus on defending the nation's digital infrastructure against cyberthreats and developing more efficient electronics. The recipients also aim to create biomedical devices to aid rehabilitation and cancer diagnostics.
A new training program at MUSC and Clemson University aims to make future data scientists aware of health inequities, particularly in rural communities. The SC BIDS4HEALTH program will build on existing relationships with HBCUs and community groups across the state.
A study by Flinders University researchers reveals how hospital bacteria adapt and resist antimicrobial medications, including colistin. The findings provide potential new therapies for treating multi-drug resistant bacterial infections, highlighting the growing threat of antibiotic resistance.
MIT researchers develop an interactive design pipeline enabling users to create customized robotic hands with tactile sensors. The platform streamlines the process, allowing users to adjust palm and fingers and integrate tactile sensors, resulting in complex tasks like picking delicate items or using tools being performed flawlessly.
Researchers simulated COVID-19 transmission on a university campus, finding that universal mask usage and high vaccination rates can curb new infections. The study suggests that at least 93% of students should be vaccinated during highly transmissible variant outbreaks.
A community-led network of low-cost sensors found concerning levels of air pollution in Belmont County, Ohio, exceeding WHO guidelines on many days. The study highlights the limitations of EPA sensors and suggests a clear link between fracking and poor air quality.
Northwestern University engineers created a tiny, remote-controlled walking robot resembling a peekytoe crab. The robot is smaller than a flea and can bend, twist, crawl, walk, turn, and jump due to its shape-memory alloy material and elastic resilience.
A team of researchers has identified the ancient bird species behind giant prehistoric eggs in Australia, resolving a years-long debate. The study found that the eggs belonged to a unique duck-like line of megafauna known as the 'Demon Ducks of Doom', which was laid by the Genyornis newtoni bird.
Researchers have identified the genetic causes of three mitochondrial diseases and proposed 20 additional possibilities for further investigation using a new approach. The study provides a platform to better understand how mitochondria's hundreds of proteins work together, which could lead to improved diagnoses and treatments.
A project dubbed Cinderella aims to improve breast cancer surgery patient satisfaction by evaluating aesthetic results objectively. Researchers have developed a software, BCCT.core, that can automatically classify the aesthetic quality of surgery outcomes, distinguishing between good and bad results with high precision.
Researchers will investigate neural mechanisms during learning in individuals with traumatic brain injury (TBI) with and without clinical depression. The study aims to identify new knowledge about the effect of depression on the injured brain, which may lead to interventions for rehabilitation.
A new Virginia Tech study found that anoxic conditions can lead to a vicious cycle of oxygen loss in lakes, causing them to become sources of nutrients downstream. The study's findings suggest that climate change and excess pollutant runoff are exacerbating this issue.
Researchers at Brigham and Women's Hospital studied mRNA vaccine safety in pregnant women, finding no Spike protein expression in placentas. The study provides further evidence of mRNA vaccine safety, supporting expanded vaccination efforts for vulnerable populations.
Researchers used CRISPR technology to modify the ratio of amylose and amylopectin in potatoes, increasing culinary and industrial uses. The study found that potatoes with high amylopectin content have potential applications in bioplastics, food additives, adhesives, and ethanol production.
A study in Hebei Province found low emergy sustainability index and high greenhouse gas emissions from maize production. The research suggests optimizing yield and nitrogen use efficiency gaps and promoting transition towards sustainable agriculture practices, such as adopting technologies like 4R technology and digital agriculture.
Researchers at Tsinghua University Press have developed a novel solution to recycle excavated soil and rock into construction products through sintering utilization. The study found that using this method can save nearly 270 million yuan in disposal costs while meeting environmental standards.
A study by Weill Cornell Medicine investigators has revealed the cause and potential precision therapies for a type of aggressive blood cancer called diffuse large B cell lymphoma (DLBCL). The research found that SETD2 gene mutations can lead to an accumulation of DNA damage, causing cancer cells to grow uncontrollably.
A study discovered that snakes and lizards have lost a major type of T cell, γδ T cells, which has raised questions about their immune system. The loss is believed to be an evolutionary adaptation, prompting research into how these animals compensate for the missing T cells.
Lab-grown plant material can be precisely controlled for physical and mechanical properties, such as stiffness and density. The researchers use a 3D bioprinting process to grow custom shapes and sizes of plant material.
Researchers discovered a specific glycoprotein, RPTP zeta S3L, that connects to CD33 receptors in the brain, limiting its ability to clean up harmful proteins. This finding may lead to new drug targets and early diagnostics for Alzheimer's disease.
Researchers at the University of Chicago Medicine Comprehensive Cancer Center and the University of Amsterdam have identified a new mechanism that prompts T cell responses, including MHC-I cross-dressing. This discovery may lead to improved vaccine design and targeted cancer treatment strategies.
Researchers at TU Darmstadt have developed a scalable quantum network that enables secure key exchange and protection of sensitive information. The system uses entanglement-based time-bin coding to distribute photons to users, ensuring robust security against eavesdropping attacks.
A new study has found that most dinosaurs were warm-blooded, contrary to long-standing debate. By analyzing molecular waste in fossilized bones, researchers inferred dinosaur metabolic rates and found they were generally high.
The study found that the adapted version of the Re-Engineered Discharge (RED) Program, RED for Depression (RED-D), reduced hospital readmissions among patients with depressive symptoms by 48% and 70% at 30- and 90-day marks. The program included post-discharge depression treatment and transition support.
A Concordia study analyzed gender patterns in AI over two decades, finding women are making strides despite underrepresentation. Notably, female-male collaboration has increased, while core positions held by women remain scarce, tied to factors like family obligations and male-dominated environments.
A new study suggests that goldfish pose a significant risk to native biodiversity in rivers and lakes. With insatiable appetites and bold behavior, goldfish can outcompete other species for resources, leading to catastrophic outcomes.
A new method measures individually measurable aerosol values during exercise, revealing moderate aerosol emissions at medium exertion and exponential increases above that point. The study suggests special protective measures are needed for high-intensity training to reduce infection risk.
Research reveals pridopidine enhances autophagy in ALS model, reducing toxic protein aggregation and promoting neuronal health. The study supports pridopidine's potential as a treatment for neurodegenerative diseases like Huntington's disease and Alzheimer's.
Researchers at QuTech have demonstrated the first non-adjacent node-to-node teleportation of quantum information in a network, leveraging entangled states and quantum processors. This breakthrough enables future applications like secure data sharing and precise quantum sensors.
Researchers found that birds infected with lipopolysaccharide from bacteria reduced their body temperature by 2°C to conserve energy. In contrast, chicks fed and warm did develop fever. The study suggests that regulated hypothermia is an energy-saving response during severe infection, prioritized over maintaining a fever.
A team of scientists has discovered the molecular triggers of parosmia, a distorted sense of smell, and identified compounds responsible for triggering the sense of disgust. The study found that certain highly potent odor molecules in coffee can lead to this experience.
The Endocrine Society's ENDO 2022 news conferences will showcase the latest research on diabetes, obesity, thyroid health, and reproductive conditions. Key findings include the impact of chemicals in hair care products on breast cancer cells and the effects of childhood obesity on male infertility.
A global analysis of firearm suicide data found that deaths from self-inflicted shootings decreased worldwide between 1990 and 2019. However, an increase in firearm suicides was observed in 31 countries, particularly in developing nations, suggesting a need for targeted public health efforts to reduce these deaths.
Australian researchers have discovered specific gene networks rewired to drive peanut allergy remission through a combination treatment of probiotic and oral immunotherapy. This network reprogramming shuts down the allergic immune response responsible for causing food allergies.
A team of researchers led by Arizona State University's Antia Botana discovered a new high-temperature superconductor in nickelates, a material that could pave the way to room temperature superconductivity. The discovery was made possible by combining theoretical models with experimental results using supercomputers.
Recent research by scientists at Duke University has found that ordinary silicone wristbands can absorb semi-volatile organic compounds firefighters are exposed to while working, tracking their risk of cancer. The study reveals strong associations between active firefighting and exposure to certain contaminants.
Archaeologist Veerle Rots has made groundbreaking discoveries about Neanderthal technology and cognitive development, challenging previous assumptions. Her research at TraceoLab reveals that Neanderthals were more innovative and strategic than thought, with a concept of hafting dating back to at least 250,000 years ago.
New research from a stalagmite reveals that the Pueblo cultural development coincided with drier climatic conditions in the southwestern US. The study suggests that climate change played a significant role in shaping the region's cultural history, challenging previous assumptions about the impact of megadroughts on civilizations.
New data analyses from RedHill's Talicia H. pylori eradication clinical trials program showed high eradication rates and favorable safety and efficacy profiles in patients with diabetes. The study found that Talicia maintained high eradication rates of 91.7% and 84.1% in patients with and without diabetes, respectively.
Research found that men taking abiraterone or enzalutamide plus hormone therapy had a higher risk of metabolic and cardiovascular issues than those undergoing hormone therapy alone. This increased risk was observed in patients with Medicare health insurance, who were significantly older than those in clinical trials.
A study of nomadic pine siskins found that pairing with settled male birds triggered signs of ending migration, including reduced restless flying and body mass loss. This suggests that social cues play a role in migratory decisions for unpredictable animals like pine siskins.
A new systematic review and meta-analysis published in The BMJ provides a comprehensive understanding of the adverse outcomes associated with gestational diabetes mellitus during pregnancy. The study found that women with gestational diabetes had increased odds of caesarean section, preterm delivery, and infant complications.
Researchers are utilizing UAVs to capture real-time images of rice crops, extract crop phenotypic traits from the images, and analyze that information to discover superior, high-yielding rice genotypes. The team aims to develop automated algorithms to identify key traits and select best-performing rice genotypes.
Scientists have observed the crystallization of nickel's two structural forms, cubic and hexagonal, in a liquid solution using liquid-phase electron microscopy. This breakthrough has significant implications for understanding nickel-based catalysts and their applications.
Cornell researchers have designed a micro-sized artificial cilial system using platinum-based components that can control the movement of fluids at a scale similar to biological cilia. The technology could enable low-cost diagnostic devices for testing blood samples, manipulating cells or assisting in microfabrication processes.
Researchers from NTU and NUS found a link between NAFLD and blood vessel damage, leading to increased risks of cardiovascular diseases. High levels of chemokines attract immune cells into blood vessels, causing inflammation and damage.
Case volumes grew by 180% as the eConsult service launched a sub-specialty COVID-19 group in March 2020. The service provided real-time data advice from infectious disease specialists on novel coronavirus, reducing unnecessary specialty referrals and saving time and money.
Research suggests that NF-κB over-activation is associated with improved outcomes in patients with HPV-positive head and neck cancer. An RNA-based classifier trained on tumors with specific mutations may improve prognostic classification, aiding in treatment personalization.
Researchers developed a tool to analyze facial movements in common marmosets, finding they have more facial expressions than previously thought. The study suggests that facial expressions may be more ancient and prevalent among social animals.
A new self-powered fabric, developed using triboelectric nanogenerators, can monitor and correct poor posture in real-time. The technology uses machine learning algorithms to provide immediate feedback and has been shown to accurately recognize the wearer's posture 96.6% of the time.
Researchers at Eötvös Loránd University found that dogs with higher attachment scores spend more time in deep sleep and relax better in new environments. The study suggests a similarity between dog-owner relationships and human-child relationships.
A Princeton study shows that environmental benefits from restored croplands are lost when they are recultivated, and most land is left abandoned for only about 14 years. The researchers found that significant environmental benefits will be lost within 30 years, highlighting the need for policy incentives to restore habitats.
A team of researchers at NYU Abu Dhabi has discovered a novel structural modification in AMP-activated protein kinase that could pave the way for more effective cancer treatments. The study found that a specific enzyme cleaves and traps the protein in the cell nucleus, rendering it resistant to chemotherapy and radiotherapy.
A new AI approach can diagnose osteoporosis from hip X-rays with superior diagnostic performance than traditional methods. This could lead to faster treatment and reduced risk of fractures. Researchers developed a deep-radiomics model using image processing and analysis to identify patterns associated with disease.
A team of scientists has confirmed that the earliest humans in Australia consumed eggs from a two-metre tall bird called Genyornis, which became extinct 47,000 years ago. The ancient proteins found in eggshell fragments provide conclusive evidence for this species.
A new study reveals that tidal flats in the southeastern US are under pressure from urbanization, leading to erosion and loss of these critical ecosystem guardians. The research highlights the need for sustainable management plans to mitigate the impacts of urban expansion on coastal environments.
A new study found that vaccinated people with mild breakthrough COVID-19 infections can experience debilitating long COVID symptoms. Vaccination reduced the risk of death by 34% and long COVID by 15%, but not all manifestations were prevented. Researchers emphasize the need for additional layers of protection to mitigate risks.
Researchers at Hiroshima University have discovered a new non-radioactive compound that can be used to stain and image viruses in clear detail using TEM. The Preyssler-type phosphotungstate molecule is a good alternative to radioactive uranyl acetate, providing easy-to-use and stable results.