A study at the University of Helsinki discovered a new type of degenerative brain disease, limbic-predominant age-related TDP-43 encephalopathy (LATE), prevalent among the oldest old. LATE is associated with similar symptoms to early Alzheimer's but progresses more slowly and is milder.
Researchers from Sandia National Laboratories have successfully miniaturized a motion sensor using silicon photonic microchip components, achieving unprecedented accuracy and reducing size by a thousand times. This breakthrough enables precise navigation even in GPS-denied areas, posing significant national security risks.
A nationwide children's hospital implemented an automated Caring Contacts texting system to provide ongoing care and support to youth at risk for suicide. The intervention helped patients feel hopeful and supported, with 83% reporting feeling moderately to very hopeful and 88% feeling moderately to very supported.
The 2024 Europlanet Science Congress (EPSC2024) will be held in Berlin from September 8-13, covering a wide range of planetary research topics. Over 1,200 scientists from Europe and worldwide are expected to attend the fully hybrid meeting.
A recent study reveals that urban trees are more negatively impacted by heat waves and drought than their rural counterparts. The research highlights the challenges urban trees face in the context of climate change, underscoring the importance of tailored urban forestry management to protect tree species and reduce urban heat islands.
Researchers developed a faster and more precise method to separate particles in fluids, enabling quicker sorting of cells in blood samples and removal of pollutants in water. The improved technique uses specially engineered channels and high polymer concentrations to guide particles and increase accuracy.
A new study published in PLOS One found that most people view humor as an effective parenting tool, leading to improved relationships between parents and children. The research team surveyed 312 people aged 18-45 and discovered a correlation between a parent's use of humor and the quality of their relationship with their children.
Researchers found that mature trees increased wood production by an average of 9.8% under elevated CO2 levels, supporting their role as medium-term carbon stores and natural climate solutions. This increase was not accompanied by a corresponding rise in leaf or fine-root production.
A new study provides a detailed map of healthy breast cells, shedding light on how breast cancer develops and the genetic ancestry-dependent variability in breast tissue. The research aims to identify new treatment targets and improve understanding of breast cancer development.
Researchers at Florida State University have shown potential of a new treatment for pediatric brain cancer by enhancing natural killer immune cells to improve their ability to attack the disease. The study, published in Bioactive Materials, provides a critical part in addressing a major clinical need for children with brain cancer.
A mathematical model shows that quicker decisions are influenced by initial bias, while slower decisions are less biased. The model predicts that with more information, decision makers are more likely to behave rationally.
Edith Brown Weiss advocates for a Planetary Trust to ensure a just and robust Earth system for present and future generations. She proposes six critical commitments for the UN Summit of the Future, including integrating the future into decision-making and practices.
Five pioneering firms in agriculture, manufacturing, and pharma retail have demonstrated businesses can catalyze social and environmental change. They address complex issues using scientific methods, partner with NGOs, and prioritize purpose alignment.
Scientists studied multiple fossil specimens of Moschorhinus kitchingi to understand how it evolved its body structure to withstand extreme conditions. The research suggests that its robust skeleton and powerful build gave it an advantage in the late Permian period.
A new study by Umeå University found that people with type 2 diabetes have difficulty eliminating beta-amyloids, which may contribute to Alzheimer's disease. The researchers suggest that preventing or managing type 2 diabetes could reduce the risk of cognitive decline.
Researchers developed a simple, cost-effective method to study ubiquitination, a critical protein modification process involved in diverse cellular functions. The Ub-POD method quickly labels targets of E3 ligase enzymes directly in human cells, allowing for the identification of new substrates and expanding therapeutic options for dis...
Researchers at Pusan National University found compact cities reduce consumption-based carbon emissions through efficient public transportation, mixed land use, and pedestrian-friendly communities. This study supports the argument that compact city development is crucial for achieving carbon neutrality.
A national cohort study found that no routine clinical lab test can aid in diagnosing post-acute sequelae of SARS-CoV-2 infection. Ongoing inflammation is thought to contribute to symptoms like anosmia and PASC. Researchers also discovered a link between SARS-CoV-2 and diabetes risk, independent of PASC symptoms.
This comprehensive review revolutionizes the 'medicine and food homology' principle, integrating ancient dietary practices with modern living to enhance health and prevent diseases. The study's findings have profound implications for personalized nutrition, disease prevention, and treatment.
Researchers developed a learning-based approach called LVWS to schedule robots and enable voluntary waiting, resulting in faster task completion. This method outperformed other approaches by up to 23% suboptimality, demonstrating its potential to improve manufacturing, agriculture, and warehouse automation.
The UFZ forest condition monitor tracks dynamic changes in Germany's forests due to climate change extreme events. The index displays seasonal and annual maps of forest condition, highlighting areas with severe damage, such as the Harz region.
UMass Amherst researchers have identified the 'quality control' regulator for protein folding, a crucial process that ensures essential cellular functions. The discovery of this regulator, Sep15, could lead to new treatments targeting misfolded proteins associated with diseases like Alzheimer's and cystic fibrosis.
A new heart MRI technique accurately estimates pressures inside the heart to predict heart failure risk in a general population. Key risk factors identified include age over 70, high blood pressure, obesity, alcohol consumption, and male gender.
A Rice-built reactor system can convert nitrates into green ammonia and purified water, decarbonizing ammonia production and treating nitrate-contaminated water. The innovative three-chamber system uses recyclable ions to improve reaction efficiency and eliminates the need for high concentrations of supporting electrolytes.
The researchers argue that accurate assessment of driving skills in older adults is crucial to mitigate harm and improve safety on the road. Comprehensive driving evaluations are estimated to cost $500-$800, a significant expense that may deter those who need it most.
Child tablet use at age 3.5 years was associated with more expressions of anger and frustration by the age of 4.5 years, suggesting a potential cycle deleterious for emotional regulation. Later, child proneness to anger/frustration at age 4.5 years was linked to increased tablet use by age 5.5 years.
Researchers discovered novel genetic variations that influence relapse risk in children with standard-risk B-cell acute lymphoblastic leukemia (SR B-ALL). The study highlights the importance of genomic profiling in accurately determining patient risk and tailoring treatment intensity.
Research finds that people with criminal justice system contact are less likely to have bank accounts after release, facing significant barriers like identification and proof of residence. The study highlights the importance of access to banking in reintegration and economic stability.
A study of nearly 30,000 US caregivers found that comprehensive mental health coverage laws reduced difficulties in accessing care for children. Caregivers from diverse backgrounds faced more challenges, highlighting the need for culturally sensitive services.
Researchers developed a new spectroscopy method using tunable lasers, enabling precise tracking of the laser's color at every point in time. The technique offers higher power and spectral stability compared to existing methods, making it suitable for various applications including LIDAR and spectroscopy.
A USC study found that terms like climate change and global warming are more familiar to people than alternative terms, generating more concern about Earth's warming. The study also revealed that perceptions of climate-related issues vary by political affiliation.
Researchers at UC San Diego School of Medicine used intracranial EEG to study co-rippling in the cortex, finding synchronized activity between neurons enables integration of information and conscious thought. This breakthrough has potential implications for understanding neurological and psychiatric disorders and human experience.
A team of scientists has found evidence for a large underground reservoir of liquid water on Mars, which could be a promising place to look for life on the planet. The reservoir is estimated to cover most of the Martian surface and is located in tiny cracks and pores in rock beneath the surface.
Research published in ACS Environmental Science & Technology found that freezing can alter microplastics' sink-or-swim tendencies, with some polymers becoming larger and more buoyant after thawing. This could accelerate the accumulation of microplastics in freshwater lake or river sediments.
Researchers discuss diverse BRAF alterations found in human cancers and strategies to inhibit them. Class I BRAF inhibitors represent a landmark achievement in precision oncology, with FDA-approved dabrafenib/trametinib for metastatic BRAF p.V600E-mutant solid tumors.
A recent study analyzing over 1.5 million patients' electronic health records found that mild cognitive impairment (MCI) is significantly underdiagnosed in rural areas of West Michigan. Researchers discovered a higher rate of MCI skippers, where patients progress directly to dementia without a prior diagnosis, in these communities.
A Mass General Brigham study highlights inconsistencies in generative AI that can affect patient safety if not addressed. The researchers found 'drift' (model performance changes over time) and 'nondeterminism' (inconsistent results between runs) in their tests, emphasizing the need for repeated testing and monitoring.
EPFL researchers have created an energy-efficient method for nonlinear computations using scattered light from low-power lasers. The new approach is scalable and up to 1,000 times more power-efficient than state-of-the-art digital networks, making it suitable for realizing optical neural networks.
Researchers have discovered a direct correlation between the hydration shell of biosensors and their fluorescence behavior. The study used terahertz spectroscopy to analyze energy transfer between carbon nanotubes and water., The findings provide a general design principle for developing optimal biosensors with improved performance.
A new study finds that reduced sulfur emissions from shipping industry likely contributed to nearly 20% of record-breaking 2023 warmth, while regulations also accelerated warming. Further research is needed to understand the magnitude of climate response.
Researchers propose a new parameter to compare mantle-derived magmas from different depths, revealing constant oxidation state since Hadean, contradicting previous assumptions on O2 levels rise. The study integrates thermal state and redox state, providing insights into Earth's multi-sphere system co-evolution history.
A study published in Cardiovascular Research Journal found that a gene deficiency in patients with atrial fibrillation leads to reduced energy production in heart cells. PITX2-deficient cardiac cells have smaller and less efficient mitochondria, pushing the heart into an oxygen-deficient stress state.
A new USC study led by Caleb Finch shows how feeding mice the drug GSM-15606 provided protection against air pollution-related increases in proteins linked to Alzheimer's disease. The results indicate that GSM-15606 may one day have a role as a preventive measure against Alzheimer's in people living with air pollution.
Researchers developed DeepLens design method based on curriculum learning to optimize complex lens designs. The approach considers key parameters like resolution, aperture, and field of view, providing optimal solutions without human intervention.
Researchers infer that Mars' crust has stores of liquid water, essential for a habitable planet. The study suggests that liquid water in the mid-crust is the most plausible explanation for the data collected by the InSight lander.
Researchers from Tsinghua University developed an innovative monitoring system for real-time flood inundation depth monitoring and prediction in subway tunnels. The system can quickly determine the flow rate and entry point of floodwater, forecasting future flood trends at a relatively low cost.
A new study found that routine laboratory tests are not reliable for diagnosing Long COVID, with no biomarker among 25 clinical laboratory values providing a clinically useful diagnosis. The researchers suggest treating symptoms rather than relying on lab results to diagnose the condition.
A study led by ISGlobal estimates that heat caused over 47,000 deaths in Europe in 2023, with southern European countries being the most affected. The mortality rate was higher in women and people over 80 years old, and without societal adaptation processes, it would have been 80% higher.
A new study from the Fritz Haber Institute reveals a way to control CO2 reduction by manipulating the catalyst's structure, addressing a major challenge in scaling up this technology. The developed process allows for precise control over the distribution of CO2 reduction products.
A new index uses inflammatory cell proportions to predict tissue healing and outcomes in patients with ulcerative colitis. The index, called the inflammatory cell enumeration index (ICEI), was developed by analyzing data from 220 patients who achieved healing.
Researchers at UCLA developed a new class of tunable dynamic material that mimics the inner workings of push puppets, enabling precise control of structural shape and flexibility. The material has potential applications in soft robotics, reconfigurable architectures, and space engineering.
Researchers at KERI have developed a novel approach to treat metabolic syndrome by stimulating cerebral cortex electrically through scalp. Clinical trials involving 60 participants showed significant appetite suppression and reduction in emotional eating. The technology has the potential to provide an easy and simple method for daily a...
A new study suggests that an anti-inflammatory antibody treatment can be used to prevent heart transplant rejection. The treatment was found to block an innate immune response that drives dangerous inflammation in transplanted hearts, leading to prolonged organ survival.
A new study by the University of Exeter and Oxford found that integrated forest restoration plans deliver over 80% of benefits in all three areas - capturing carbon, nurturing biodiversity, and supporting human livelihoods. Socioeconomically disadvantaged groups benefit disproportionately from this approach.
A study published in Neuron reveals that neurons are wired to connect seemingly unrelated concepts, enhancing the brain's ability to predict what we see based on past experiences. Visual experience influences the organisation of feedback projections, which store information about the world.
A team of researchers led by Associate Professor Ken Natsuga found that cell-cell adhesion governs pattern formation in keratinocytes. Starvation also plays a crucial role in the formation of these patterns, which are influenced by cell proliferation and differentiation.
Researchers at ISTA discovered that misaligned protein filaments 'die' and re-assemble to form a well-aligned ring structure essential for bacterial cell division. This mechanism could lead to the development of synthetic self-healing materials.
A team led by Emory researchers found strong evidence supporting a new understanding of the mechanism behind Alzheimer's disease. They identified more than 20 proteins that co-accumulate with amyloid beta, suggesting they may play an important role in brain damage rather than the amyloid itself.
A recent study by Binghamton University Political Science Professor Jeffrey L. Yates found that U.S. presidential elections significantly impact local prosecutor races. The researchers analyzed data from the nation's top 200 districts and discovered that incumbent prosecutors with the same party affiliation as a successful president ha...
A global study predicts significant increases in cancer cases and deaths among men between 2022 and 2050, with widening disparities by age and country's economic status. Disparities are projected to worsen, with poorer survival rates observed among older men and those living in low-human development index countries.