A nationwide study confirms the benefit of estrogen-lowering drugs before surgery for breast cancer patients. The treatment increased the likelihood that women could undergo breast-conservation surgery instead of mastectomy. After 16-week aromatase inhibitor therapy, 82% of women had successful breast-conservation surgery.
Researchers found that minor adjustments to estrogen receptor alpha and p53 genes can lead to precancerous changes in breast tissue. Testing healthy women for these gene variations may help predict future breast cancer risk.
A University of Illinois study reveals that breast milk induces unique genetic pathways in infants, differing from those in formula-fed babies. The discovery sheds light on the immune-protective components of breast milk and its role in intestinal development.
Researchers presented studies on predicting pregnancy-associated breast cancer, post-traumatic stress disorder in breast cancer patients, and novel drug candidates such as flavaglines. The conference also explored the use of circulating tumor cells and gene differences to predict survival outcomes in breast cancer patients.
Research finds that estrogen receptor status in HER2+ breast cancer is correlated with response to anti-HER therapies. Patients with ER+/HER2+ cancers may benefit more from PI3K/AKT inhibitors, while ER-/HER2+ patients may see worse outcomes with hormonal therapy alone.
Researchers at PMH discovered that progesterone alters breast stem cells, a finding with significant implications for breast cancer risk. The study shows how hormones affect breast stem cells during the reproductive cycle, providing a new pathway to understanding cell growth leading to breast cancer.
A study suggests that breast magnetic resonance imaging (MRI) can detect breast lesions missed on mammography and ultrasound, influencing surgical management choices. Breast MRI positively impacts patient management decisions, potentially reducing the need for re-intervention by accurately assessing tumor extent.
A study suggests that preoperative breast MRI can reduce local breast cancer recurrences at follow-up, particularly in young patients with dense breast tissue. The study found that patients who received a contrast-enhanced MRI prior to surgery had significantly fewer local recurrence cases.
A new study found that breast cancer risk factors differ significantly among Hispanic and non-Hispanic white women. In Hispanic women, known breast cancer risk factors were associated with only 7-36% of cases, compared to 62-75% in non-Hispanic whites.
Researchers found that women with a breast density of 75% or higher have a four-to-five-fold increased risk of breast cancer. Decreases in breast density over time may be associated with lower breast cancer risk.
Researchers have identified a new breast and ovarian cancer susceptibility gene, RAD51C, in a German study. The gene is associated with a high risk of breast and ovarian cancer, particularly in familial cases.
Researchers found a 28% reduced risk of developing breast cancer in women whose breasts decreased in density over time. The study suggests that measures of breast density may provide additional information for assessing breast cancer risk.
Researchers found that vitamin supplements reduced breast cancer risk by about 30 percent, while calcium supplements reduced it by 40 percent. Calcium supplements lost their protective effect once DNA repair capacity was accounted for.
A study published in Pediatrics found that adolescent drinking increases the risk of benign breast disease, a precursor to breast cancer. The study, which followed over 6,900 girls aged 9-15, showed that girls who drank more frequently had higher rates of benign breast disease.
Researchers discovered breast stem cells are exquisitely sensitive to oestrogen and progesterone, a finding that explains decades of evidence linking breast cancer risk to exposure to female hormones. The discovery also revealed the RANK ligand pathway is responsible for indirect control of breast stem cells in pregnancy.
A recent study published in the Journal of Clinical Oncology found that women with breast cancer before age 55 who carry an inherited mutation in BRCA1 or BRCA2 are four times more likely to develop cancer in the breast opposite their initial tumor. The study revealed a higher risk of contralateral breast cancer among younger women wit...
Researchers from the University of Gothenburg found that women with a known Western Swedish mutation in the BRCA1 gene have an increased risk of developing ovarian cancer. The study suggests that women without this mutation do not face an elevated risk, and provides clarity for targeted screenings.
A new study at the University of Illinois Chicago found that women who have given birth may be at increased risk for breast cancer due to inflammatory-related genes in their breast tissue. The researchers discovered a protective effect of pregnancy on breast cancer risk, suggesting a balance between high-risk inflammatory and protectiv...
Researchers found that women who have been diagnosed with breast cancer tend to overestimate their risk of developing cancer in the other breast. After counseling and a 12-month delay, most patients reconsidered and opted against prophylactic surgery.
Women diagnosed with breast cancer after pregnancy are 48% more likely to die than others, but risk is similar if cancer is diagnosed during pregnancy. Further investigation is needed to understand the relationship between cumulative pregnancy effects and breast cancer prognosis.
A recent meta-analysis of 14 trials found that pregnancy after breast cancer diagnosis reduces the risk of death by 42%. The study suggests that hormonal changes during pregnancy may have an inhibitory effect on breast cancer cells, and that foetal antigens may also play a role in reducing the risk of recurrence. The findings support t...
Women with rare ATM gene mutations and radiation exposure may be at higher risk for a second breast cancer in the opposite breast. Researchers found a statistically significant increase in contralateral breast cancer among women with deleterious missense variants and radiation exposure.
A new study found that breast cancers detected through palpable lumps, not mammography, were more common in women who didn't undergo annual screening. The researchers also found that clinical breast examination and breast self-examination played a crucial role in detecting breast cancer.
Postmenopausal women, especially those over 70, have a higher prevalence of cancer detected in the undiagnosed breast with MRI compared to premenopausal women. Detecting and treating both breasts at the same time may save costs and reduce patient stress.
A new clinical trial, PINC Trial, is testing the effectiveness of chloroquine in treating pre-invasive breast cancer. The trial aims to prevent breast cancer cells from becoming deadly by killing pre-invasive cancer cells using a novel therapy with chloroquine.
A study found that contralateral prophylactic mastectomy is associated with improved 5-year breast cancer-specific survival rates for younger women with early-stage, estrogen-receptor negative tumors. However, the benefit is small and does not apply to most women with breast cancer.
Researchers at Saint Louis University have found that bitter melon extract significantly induces death in breast cancer cells and decreases their growth and spread. The study, published in Cancer Research, suggests that bitter melon extract may be a promising area of research for breast cancer treatment.
Researchers found that bitter melon extract significantly decreased proliferation and induced death in breast cancer cells. The study suggests that this extract may become a chemopreventive agent against breast cancer, but additional studies are needed to confirm its efficacy.
A new study suggests that annual combined screening with both mammography and breast MRI can improve life expectancy in women with increased breast cancer risk. This approach detects early-stage cancers more effectively and provides the greatest relative mortality reduction.
A University of Melbourne study reveals a genetic link between mammographic density and breast cancer, identifying two variants associated with increased risk. The findings confirm the long-suspected connection between higher mammographic density and breast cancer.
Researchers found that prolactin reduces levels of BCL6, an oncogene linked to poorly differentiated breast cancer. Prolactin's role is mediated by Stat5a, which may lead to better diagnostic tests and new treatment options for aggressive breast cancers.
A study by researchers at Tufts University School of Medicine identifies two populations of progenitor cells that propose a new model for breast cell differentiation. One population appears to be the cell of origin for luminal-like breast cancer, which is sensitive to hormones and tends to grow more slowly.
Researchers identified a strategy to target human breast cancer stem cells by blocking the protein CXCR1. The approach selectively depleted cancer stem cells in mice xenotransplanted with human breast cancer cells, leading to reduced tumor growth and metastasis. This finding provides hope for women with breast cancer.
The new SBI and ACR recommendations suggest that breast cancer screening should begin at age 40, with annual screening recommended for average-risk patients. High-risk patients may start screening as early as age 30. The guidelines aim to reduce mortality rates from breast cancer through earlier detection.
A recent study identifies CXCR1 as a crucial protein in targeting human breast cancer stem cells. Inhibiting this protein selectively depletes the cancer stem cell population, leading to reduced tumor growth and metastasis. The findings suggest that strategies targeting CXCR1 may offer a promising approach for treating breast cancer.
A study found that only 51.6% of eligible women completed a screening MRI, with claustrophobia as the primary reason for nonparticipation. Alternative methods like ultrasound may be considered for high-risk women who cannot undergo MRI screening.
A new study by the Kaiser Permanente Division of Research found that moderate alcohol consumption is associated with a 30% increased risk of breast cancer recurrence. Post-menopausal and overweight women may be most susceptible, regardless of type of alcohol consumed.
A large population-based study of 5,042 female breast cancer survivors in China found that moderate soy food intake is safe and associated with lower mortality and recurrence rates. The study suggests that women with breast cancer may benefit from consuming soy foods as part of their treatment plan.
Researchers have discovered a protein produced during pregnancy that directly inhibits breast cancer growth. The protein, alpha-fetoprotein (AFP), may serve as a potential treatment and prevention agent for breast cancer.
A new study by American Cancer Society researchers reveals that women with high breast density are at increased risk of cancer recurrence, up to 40% higher in those without radiation. Women with low breast density may not need additional therapies following surgery.
A recent UCLA study found that women developing new-onset breast tenderness after starting estrogen plus progestin hormone replacement therapy are at a significantly higher risk of developing breast cancer. The research analyzed data from over 16,000 participants in the Women's Health Initiative clinical trial.
A study of over 2,000 women with stage II and III breast cancer found that achieving pathological complete response after treatment was not related to race. Despite racial disparities in breast cancer incidence and mortality rates, Hispanic women had better outcomes than white women.
The American Association for Cancer Research is honoring two leading breast cancer researchers, Robert Weinberg and Charles Perou, at the 32nd annual CTRC-AACR San Antonio Breast Cancer Symposium. The symposium will feature research on metastasis, genetic technology, and molecular subtypes of breast cancer.
Researchers at Northwestern University discovered a potent new chemotherapy cocktail that inhibits breast cancer cell invasion by half. The mix of dasatinib and doxorubicin targets the Src kinase enzyme, believed to play a key role in breast cancer metastasis.
A new study finds that the number of women opting for prophylactic mastectomies is rising, particularly among those with cancer in one breast. Despite limited information available, the surgery appears to be increasing, but its benefits and risks should be carefully considered.
Three medications effective in reducing breast cancer risk also have serious side effects, according to a new study. Tamoxifen, raloxifene, and tibolone reduce invasive breast cancer incidence but vary in their adverse effect profiles.
A study by Fred Hutchinson Cancer Center researchers found that obesity, alcohol use, and smoking significantly increase the risk of second breast cancer in survivors. The study suggests reducing weight, quitting smoking, and drinking in moderation to lower this risk.
Researchers at the University of New South Wales found high-risk HPV strains in 39% of ductal carcinoma in situ and 21% of invasive ductal carcinoma breast cancer specimens. The study suggests a causal role for HPV in many breast cancers, establishing the possibility of preventing some breast cancers by vaccination against HPV.
A new study published in the Journal of the National Cancer Institute found that adding clinical breast examination to mammography improves breast cancer detection rates and sensitivities, but also leads to higher false-positive rates. The study used a cohort of over 290,000 women screened between 2002 and 2003.
Researchers have identified new targets for treating breast cancer metastasis by inhibiting Brk protein expression. Additionally, a study on Wnk1 revealed its critical role in angiogenesis and heart development. Furthermore, drug abuse has been found to worsen HIV-associated neurocognitive disorders through dopamine signaling.
A new prognostic marker for human breast cancer has been identified, with elevated GLI1 protein levels associated with poor overall survival. The study found a positive correlation between GLI1 expression and tumor stage, lymph node status, and unfavorable prognosis.
Researchers at LSUHSC have identified miR-27b as a major player in the development of invasive breast cancer, found to stimulate cell growth and invasion. Meanwhile, ST14 gene suppresses tumor cell growth and may serve as an early detection marker for breast cancer.
A new study found that women with newly diagnosed breast cancer who receive MRI scans are more likely to undergo mastectomy than breast conserving therapy. This can lead to delays in treatment and unnecessary surgeries.
A study by Walter and Eliza Hall Institute scientists suggests that luminal progenitor cells, the 'daughters' of breast stem cells, are likely responsible for basal-like breast tumours in women with BRCA1 mutations. The research, published in Nature Medicine, represents a major shift in understanding how breast cancer develops.
Researchers at Thomas Jefferson University identified DACH1 as a protein that prevents cancer cell proliferation by repressing estrogen receptors in ER+ breast cancer. As DACH1 expression decreases in breast cancer, estrogen receptor presence increases, suggesting its potential as a therapeutic target.
Researchers have identified key signals supporting long-term survival of breast cancer cells after they spread to the bone marrow. The study found that activity of a cancer-related enzyme called Src is associated with late-onset bone metastasis and promotes cell survival.
A study of 577 breast cancer patients found that routine use of MRI scans was associated with delays in starting treatment and increased mastectomy rates. The study suggests that more research is needed to determine the benefits of MRI scans in evaluating breast cancer, as their disadvantages may outweigh any potential advantages.
Research by Sabrina McCormick links everyday products to breast cancer, citing industrial pollution and agricultural pesticides as contributing factors. Experts urge policymakers to ban cancer-causing chemicals in everyday products, promoting prevention over a cure.
Researchers at SNM's 56th Annual Meeting present a prototype breast imaging system combining positron emission tomography (PET) and magnetic resonance imaging (MRI) technologies. The system aims to provide highly sensitive and specific breast cancer examinations while compensating for the shortcomings of individual PET or MRI systems.
A study found that many women with breast cancer use antioxidant supplements during treatment, which may have mixed effects on their health and survival. Researchers recommend further research to determine the impact of antioxidant supplementation on breast cancer outcomes.