A study found that breast cancer survivors, especially older women, are at a greater risk of dying from non-cancer causes than from breast cancer. Factors such as pre-existing diseases like heart disease and osteoporosis are associated with this increased risk. The researchers also found that women with cancer cells in the lymph nodes ...
Researchers found that BRCA1 plays a role in regulating breast stem cells, which can develop into cancers. Women with BRCA1 mutations have a high incidence of breast cancer due to the unregulated proliferation of these stem cells.
The Joni Gladowsky Breast Cancer Foundation has funded CSHL's innovative breast cancer research, led by Dr. Senthil Muthuswamy, to develop alternative treatment strategies for early-stage breast cancer. The foundation aims to identify genetic differences between benign and malignant lesions to prevent cancer progression.
The study found significant variation in breast cancer risk among BRCA1 and BRCA2 carriers, with younger age at diagnosis associated with increased risk for relatives. The research highlights the need for accurate estimation of risks and tailored interventions.
Breast cancer patients who received tamoxifen or chemotherapy had a reduced risk of developing a second cancer in the other breast. Chemotherapy was associated with a 43% risk reduction, lasting up to 10 years, while tamoxifen use resulted in a 34% risk reduction that persisted for five years.
Most general surgeons fail to discuss breast reconstruction with breast cancer patients before surgery. Researchers found only 33% of eligible patients had this conversation. Younger, more educated patients were more likely to have the discussion, leading to greater willingness to consider mastectomy.
The CTRC-AACR San Antonio Breast Cancer Symposium combines basic, translational, and clinical research to advance breast cancer research. The symposium aims to attract thought-leaders and high-quality papers in basic and translational breast cancer research.
A new risk prediction model for African American women has been developed and tested, providing more accurate estimates of breast cancer risk compared to the widely used Gail model. The model, known as CARE, accurately predicted the number of cancers observed in African American women in most subgroups.
Researchers used PET/CT to diagnose and stage inflammatory breast cancer, detecting disease earlier than traditional methods. The study achieved a 95% accuracy rate in identifying cancerous areas and involved 41 women with the aggressive form of breast cancer.
A study by Nicholas M. Perry found that urban women have denser breasts and are nearly four times more likely to develop breast cancer than rural women. Regular breast screening with digital mammography is advised for all women, especially those with dense breast tissue.
A new model for predicting breast cancer risk in postmenopausal women is as accurate as the Gail Model, but easier to use. The model uses only three factors: age, family history of breast cancer, and previous breast biopsy.
A new model for predicting estrogen receptor-positive breast cancer risk in postmenopausal women performs almost as well as the standard Gail model and could be used to identify high-risk women. Smoking is associated with rectal cancer, while drugs like ZD6126 may cause heart damage due to cardiovascular changes.
A large European study found that an extra high-dose radiation boost after breast-conserving surgery significantly reduces the risk of breast cancer recurrence in young women. The study also showed that women of all ages benefited from the boost dose, but younger women were most likely to be free of cancer 10 years after treatment.
Three Einstein researchers have received $700,000 in grants from the Breast Cancer Research Foundation to study gene expression profiling, epigenetic changes, and metastasizing tumor cells. The studies aim to predict clinical outcomes, identify drug-resistant breast cancer cells, and develop new treatments.
A study found that increased sunlight exposure reduces the risk of advanced breast cancer in women with light skin color. The researchers measured skin color and compared sun exposure between women with breast cancer and those without, finding a significant difference.
Women who overcome breast cancer are at a higher risk of developing cardiovascular disease due to therapies that damage the heart and blood vessels. Exercise is crucial in maintaining heart health during treatment, and early evaluation of cardiovascular risk factors can help prevent complications.
Researchers have discovered that Notch gene stimulates breast cancer stem cells, which can cause the disease to recur. A potential new drug therapy targeting this gene could lead to a faster treatment in hospital clinics within a few years.
Scientists at Jefferson University have found a new molecular evidence of the role of prolactin in breast cancer. The hormone stimulates a signaling pathway that may regulate the growth and survival of breast cancer cells. Inhibiting the Jak1 protein could represent a new drug target for treating breast cancer.
The American Cancer Society report shows a decline in breast cancer mortality rates, but African American women and women of other racial and ethnic groups have benefited less from advances. The report highlights the importance of increased mammography screening and reduced obesity to combat breast cancer.
Researchers identified a region on chromosome 5p associated with dense breast tissue, a known risk factor for breast cancer. Women with dense breasts are three to five times more likely to develop breast cancer than those with less dense breasts.
A multicenter study compared screening methods in high-risk women, finding that MRI accurately identifies tumors missed by mammography and ultrasound. The study suggests that women at high risk for breast cancer can benefit from undergoing screening MRI to detect more cancers.
A study by the Cancer Research Network found that regular post-therapy surveillance lowers the rate of death from breast cancer in older women. The researchers examined nearly 2,000 patients age 65 and older with stage I and II breast cancer and found that annual mammograms can decrease death rates.
A study found a significant association between the Western-style 'meat-sweet' diet and an increased risk of breast cancer among postmenopausal Chinese women, particularly those with estrogen receptor-positive tumors. The research suggests that low consumption of this dietary pattern may protect against breast cancer.
A recent study published in the Journal of Clinical Oncology found that women with atypia in their breast tissue are nearly eight times more likely to develop breast cancer. The study, led by Mayo Clinic, improved risk prediction by taking into account age at diagnosis and multiple sites of atypical hyperplasia.
A Swedish study found that women who develop breast cancer are more likely to die from the disease if their daughters or sisters also have it. Research suggests a woman's breast cancer prognosis predicts survival of her first-degree relatives, with those whose mothers died within five years having a 70% chance of survival.
Researchers found that pleiotrophin expression activates stromal cells to remodel the tumor microenvironment, inducing tumor angiogenesis and aggressive breast cancers. PTN secretion from human breast cancer cells may be sufficient to shift progression to a more aggressive form of breast cancer.
Researchers at Deakin University have identified a rogue cell type that may contribute to the spread of breast cancer. By studying a cell model mimicking human breast tissue, they found that abnormal fibroblasts can trigger breast cells to change and migrate.
Recent studies conducted at Mayo Clinic have found that MRI is superior to mammography in detecting additional tumors in the same breast and identifying new tumors in the healthy breast. The technology has also revealed distinct patterns between ipsilateral and contralateral tumors, guiding its use.
A study found that breast MRI altered surgical management in 36% of patients, changing the plan from lumpectomy to mastectomy or increasing tissue removal. The change was beneficial in 22 cases, suggesting breast MRI may play a role in staging newly diagnosed breast cancers.
Researchers have confirmed that tamoxifen prevents breast cancer in high-risk women, while a combination of three HER inhibitors slows down tumor growth. Additionally, chemotherapy with rituximab improves overall survival rates for patients with indolent lymphoma, and new lung cancer risk prediction models offer modest accuracy.
Researchers identified loss of Fibulin-2 as a breast cancer progression marker, which can be restored with protein reintroduction. Breast cancer cells can reversibly alter their phenotype through manipulations like antibody binding to fibronectin, and DNA reversion can be overturned by removing the stimuli.
Scientists have found a new hereditary breast cancer gene, TWIST1, linked to Saethre-Chotzen syndrome, increasing breast cancer risk by nearly twenty times. Early mammograms are now recommended for young women with the syndrome to detect breast cancer at an early stage.
A study of 105,716 premenopausal women found no association between abortion or miscarriage and breast cancer risk. Women who carried a pregnancy to term may have a reduced lifetime risk of breast cancer due to accelerated breast cell differentiation.
A new study reveals that recent declines in breast cancer mortality rates have been most significant among women with estrogen receptor (ER)-positive tumors and women younger than 70. These groups experienced a 38% decline in mortality from breast cancer, compared to a 19% decline for ER-negative tumors.
A multi-center study found that MRI screening detected cancer in the opposite breast in 30% of women with recent breast cancer diagnosis. The cancers were missed by previous mammography and clinical exam. The authors recommend MRI screening for high-risk populations, but emphasize its expense and limited ability to detect calcifications.
An international study by the University of Bonn found that MRI can detect up to 30 cancers in the opposite breast of women with recent unilateral breast cancer diagnoses. The study's results show a 99.6% confidence level that no breast cancer is present if an MRI scan is normal, making preventive mastectomy unnecessary.
A major clinical trial shows that MRI scans can quickly identify cancer in the opposite breast of women diagnosed with cancer in one breast. The study found a 90% accuracy rate for detecting contralateral breast cancers.
A large study found that doubling fat intake is linked to a 15% increase in breast cancer risk, regardless of the type of fat consumed. In contrast, higher consumption of lignans, found in plants and whole grains, may be associated with a reduced risk of postmenopausal breast cancer.
Researchers found that changes in breast density over time can predict a woman's risk of breast cancer, with higher densities linked to greater risks. Meanwhile, targeting prostate-specific proteins may lead to effective treatments for prostate cancer and other diseases, leaving non-prostate cells unharmed.
A study of 110,599 women found that long-term strenuous physical activity reduced the risk of invasive and in situ breast cancer by 20% and 31%, respectively. Moderate physical activity did not show a significant impact on breast cancer risk.
A recent USC-led study suggests that long-term recreational physical activity plays a protective role against invasive and in situ breast cancer. Women exercising for five or more hours per week experienced a greater decrease in risk of breast cancer compared to less active women.
Two randomized clinical trials found tamoxifen reduces ER-positive breast cancer risk by 27% and 39%. Long-term benefits persist even after stopping tamoxifen use, with reduced side effects.
Emerging research in breast cancer management includes advanced imaging technologies like 3D mammography and MRI, as well as novel vaccines that stimulate the immune system to attack tumors. This new approach aims to alter current screening and treatment paradigms, improving patient care.
A recent study published in Nature found that a genetic defect in PALB2 elevates the risk of both breast and prostate cancer. The mutation was discovered in Finnish breast cancer families and was also identified in patients with prostate cancer, suggesting its potential role as a susceptibility gene for heritable cancer.
Men diagnosed with breast cancer are at a significantly high risk of developing a second primary cancer, particularly those of the breast, stomach, and skin. The researchers recommend closer monitoring and screening for these men to reduce the risk of second cancer.
Researchers found that radiation therapy significantly reduced breast cancer recurrence and tumor development in older women with early-stage disease. The study, published in CANCER journal, recommends standard therapy for women of all ages and comorbidities, including mastectomy or breast conserving surgery with radiation.
Researchers have found a selective marker in nestin that could lead to earlier detection and better treatment of basal epithelial breast tumors, a highly aggressive form of breast cancer. High levels of nestin were detected in 14 out of 16 tumor samples examined.
Researchers found that breast cancer in men is rare and can often be detected on physical examination. In most cases, a mammogram is not necessary for confirming gynecomastia diagnosis.
A new analysis suggests that the decline in breast cancer incidence between 2002 and 2003 was largely due to the reduction of hormone replacement therapy (HRT) use. The study found a 7% relative decline in breast cancer cases, with an absolute decline of about 14,000 fewer women diagnosed in 2003 compared to 2002.
Research from the Flint Men's Health Study found that African-American men with prostate cancer were more likely to report a family history of both diseases among siblings. This increased risk was particularly notable for having a brother diagnosed with prostate cancer and a sister diagnosed with breast cancer, highlighting the importa...
A study found that elderly women, those with public health insurance, and those who don't visit obstetricians regularly are less likely to receive clinical breast exams and mammogram recommendations. Regular clinical breast exams can detect breast cancer at an early stage, making them comparable to yearly mammograms.
A new Mayo Clinic study reveals that normal aging of breast tissue reduces breast cancer risk, particularly in women who experience complete lobular regression. Women with complete involution have half the risk of developing breast cancer compared to those without.
A study found that African-American women, particularly younger ones, have a significantly higher incidence of breast cancer and die at a younger age than white women. Environmental factors such as hormone-mimicking compounds are suggested to contribute to these disparities.
Researchers developed a formula that takes into account various risk factors, including age, cancer size and grade, and treatment options. The new computer tool helps doctors evaluate the potential benefit of additional radiation therapy for patients with early stage breast cancer.
A new screening tool called the pedigree assessment tool (PAT) effectively identifies women at risk for hereditary breast cancer, outperforming another commonly used tool in assessing individual patient risk. The PAT was 100% sensitive in identifying high-risk patients with potential BRCA mutations.
V. Craig Jordan's research has led to breast cancer prevention drugs like tamoxifen and raloxifene; the new grant aims to develop a treatment model to reverse resistance to anti-estrogen therapy, facilitating access to new breast cancer therapeutic drugs.
A new model developed by scientists from Group Health and seven other health care organizations finds that breast density is a significant predictor of breast cancer risk, with women having highly dense breasts facing nearly four times the risk as those with fat-filled breasts. The study analyzed data from over 1 million women and iden...
Two new breast cancer risk models use breast density to predict individual risks, outperforming the existing Gail model. The models identify high breast density as a significant predictor of breast cancer, with some studies suggesting it may be as powerful a risk factor as age.
DNA damage in stroma tissue may predict breast cancer risk, according to a recent study. The researchers found that specific DNA lesions were more common in women aged 33-46, which corresponds with the rise in breast cancer incidence during this age group.
Researchers found a discrepancy in reported maternal vs paternal relatives with breast cancer, suggesting under-reporting on the paternal side. This could lead to inaccurate family history and missed screenings for breast cancer.