A new University of Colorado at Boulder study shows people can suppress emotional memories through practice, which could lead to new therapies for conditions like post-traumatic stress disorder and depression. The study found two mechanisms in the prefrontal region of the brain are involved in memory suppression.
Research finds genetic links between bipolar disorder and comorbid conditions like anxiety disorders, ADHD, and autoimmune disorders. Comorbidities can complicate treatment and lead to poor health and decreased life expectancy.
Two studies presented at the Seventh International Conference on Bipolar Disorder have identified novel pathways and markers for diagnosing and treating bipolar disorder. The findings suggest a new avenue for treating the underlying cause of the disease, rather than just treating symptoms.
Researchers at the University of Illinois found that brain activity patterns differ between two types of anxiety: anxious apprehension (verbal rumination, worry) and anxious arousal (intense fear, panic). The study used fMRI to identify distinct brain regions active in each type of anxiety.
Early onset type 2 diabetes in adolescents is associated with rapid progression of complications, including hypertension, nephropathy, retinopathy, and psychiatric disorders. The unborn children of pregnant young women are also at increased risk.
A genome-wide study reveals that variations in multiple genes contribute to the development of bipolar disorder. The researchers identified a promising target gene DGKH, which produces an enzyme involved in lithium's therapeutic effects. This discovery may lead to the development of new and more effective medications for bipolar disorder.
A recent study found that bipolar spectrum disorder affects about 1% of the population, with individuals receiving inadequate treatment. The research highlights the importance of identifying subtypes of bipolar disorder and using appropriate medication to effectively manage symptoms.
A survey estimated that approximately 4.4% of U.S. adults may have some form of bipolar disorder during their lifetime, with 2.4% having a sub-threshold condition. The study found that many individuals with bipolar symptoms receive treatment for depression rather than manic symptoms.
According to the study, approximately 10.3% of U.S. adults have problems with drug use or abuse, with 2.6% becoming drug-dependent at some point. The results highlight the need for education and prevention efforts to address these widespread issues.
A study published in The Journal of Pediatrics found that delayed treatment of childhood-onset bipolar disorder results in longer periods of depression, more episodes, and increased substance abuse risk. Adults with untreated childhood-onset bipolar disorder experienced poorer quality of life and were less responsive to treatment.
Eli Coleman, a University of Minnesota professor and director of the Program in Human Sexuality, received the Gold Medal Award 2007 from the World Association for Sexual Health. He has published extensively on topics like sexual orientation and compulsive sexual behavior.
Researchers used physiological data to show how a theoretical model explains behavior in children with attention deficit hyperactivity disorder (ADHD). The study found that the 'go' and 'stop' processes are intricately linked, resolving a long-standing paradox.
A new study found that antidepressants are effective in treating pediatric major depressive disorder and anxiety disorders, with a lower risk of suicidal thoughts compared to FDA estimates. The study suggests antidepressants should be considered as first-line treatment options for children under 19.
A review of studies indicates antidepressants may be effective for treating depression and anxiety in children and teens, despite increased risk of suicidal thoughts and attempts. The benefits appear to outweigh the risks, supporting cautious use of these medications as a first-line treatment option.
A meta-analysis of 27 major studies found antidepressants effective in treating anxiety, OCD, and depression in children and adolescents. The study suggests that while there is a small risk of suicidal thoughts, it is outweighed by the benefits of treatment.
Researchers studied 366 participants with bipolar disorder, finding that adding antidepressants to mood stabilizers did not improve outcomes or trigger manic episodes. The study suggests careful management of mood stabilizer medications may be a reasonable alternative to adding antidepressants.
Researchers at UT Southwestern Medical Center found that the Clock gene, regulating biological clocks, is involved in developing bipolar disorder in mice. The study reveals behaviors similar to humans with bipolar disorder, including hyperactivity and euphoria, which are restored by lithium treatment.
A study found no difference in the relapse rate of people with compulsive-buying disorder when taking escitalopram compared to those on a placebo, contradicting previous research findings. The results may be due to differences in biological roots among individuals with the disorder.
Researchers at the University of Iowa have discovered a link between genetic information in white blood cells and mental health conditions like panic disorder. The study found distinct patterns of gene expression in individuals with and without panic disorder, which could lead to new diagnostic tools and therapies.
Patients with Parkinson's disease who develop the condition at a younger age and have a history of alcohol abuse are more likely to experience pathological gambling as a side effect of dopamine agonist medications. Behavioral characteristics such as impulsivity and risk-taking behavior may also play a role in this increased risk.
A Mayo Clinic study found a link between dopamine agonist medications and compulsive gambling in RLS patients. The medication-induced behavior worsened with increasing doses, but was reversible when the dose was reduced or alternative medication was used.
A new test, Hypomanic symptom check list (HCL-32), has been validated to identify type II bipolar disorder patients. The test, which consists of 32 questions, is more precise than the Mood disorder questionnaire in identifying this underdiagnosed disease.
The incidence of autism and two other childhood neuropsychiatric disorders increased significantly among Danish children between 1990 and 2004. This trend suggests a broader pattern in childhood mental illness, with the exception of obsessive-compulsive disorder.
Researchers at UIC aim to develop a compound blocking mania associated with bipolar disorder, improving on dated 'mood stabilizers' like lithium and valproic acid. The goal is to create safer, more effective treatments for the mental illness affecting over 2 million Americans.
A study found that adults with depressive disorder, Bipolar Disorder, or anxiety disorder are at risk of having undiagnosed Attention-Deficit/Hyperactivity Disorder (ADHD), with 32.0% comorbid in those with depression and 21.2% in those with bipolar disorder. Researchers analyzed medical claims data to identify this comorbidity.
A study of 79 patients diagnosed with obsessive-compulsive disorder (OCD) and compulsive hoarding syndrome found that serotonin reuptake inhibitor (SRI) medication, paroxetine, significantly improved symptoms. Compulsive hoarding is a psychiatric disorder characterized by failure to discard objects due to anxiety and excessive clutter.
A study of 4,181 adults found anxiety disorders independently associated with several physical conditions, increasing disability risk. Anxiety disorders were also linked to poorer quality of life in individuals with both conditions.
Researchers discovered that phosphorylation of MeCP2 at S421 increases transcription of genes required for experience-dependent brain maturation, including BDNF. This study reveals a complex regulatory loop between BDNF and neuronal activity in regulating MeCP2 function.
Researchers found that fluoxetine stimulates new bone formation under normal conditions and reverses total bone loss triggered by inflammation. The study suggests a link between serotonin reuptake inhibitors and improved bone health.
Research found that Parkinson's disease patients developing impulse control disorders show increased rates of depression, appetite changes, and irritability compared to those without the disorder. The study identified nine patients with impulse control disorders, including pathological gambling, hypersexuality, and excessive shopping.
A new gene, Slynar, has been linked to both depression and bipolar disorder, affecting around 10% of cases. Researchers hope the discovery will lead to new treatments for these conditions.
A study of 438 children and adolescents with bipolar spectrum disorders found that those with short episodes of mania were similar to those meeting full diagnostic criteria, suggesting a need for revised diagnostic criteria. The study's results will inform changes to the Diagnostic and Statistical Manual of Mental Disorders-IV.
A new Stanford University School Medicine study finds that nearly as many men as women experience compulsive buying disorder, which is marked by binge buying and financial hardship. The study's findings contradict the widespread belief that most compulsive buyers are women.
Researchers at Duke University Medical Center found two genetic mutations in the SLITRK1 gene linked to trichotillomania, affecting 3-5% of the population. The study validates a biological basis for mental illnesses and opens the door for genetic testing.
A pilot study by Yale School of Nursing and Child Study Center found that Parent Management Training (PMT) successfully controlled moderate to severe levels of oppositional behavior in children with TS, leading to a 51% decline in disruptive behavior. The results showed significant improvement compared to the control group.
Individuals with sleep-related breathing disorders are significantly more likely to develop depression, especially those with moderate or worse disorders. The study found a dose-response association between sleep-related breathing disorder and depression, suggesting a causal link between the conditions.
Panic disorder affects up to 5% of the population, causing recurrent anxiety attacks and agoraphobia. Anti-depressants and cognitive-behavioural therapy (CBT) are effective treatments, but less than half of those in need receive care due to barriers such as diagnosis difficulties and insurance coverage issues.
A recent study by the National Institute of Mental Health found that bipolar disorder exacts twice as much toll on workplace productivity as major depression, costing nearly half as much in lost wages. The researchers attribute this disparity to bipolar disorder's more severe depressive episodes rather than its manic periods.
Researchers discovered that brain neurons combine economic value and spatial information to control decision-making behaviors, contradicting the previous pure economic view. This study has implications for understanding human disorders such as addiction, depression, and obsessive-compulsive disorder.
Children with obsessive-compulsive disorder (OCD) are three times more likely to be bullied than other children, according to a new study. Chronic bullying can exacerbate OCD symptoms, and kids with OCD often face social isolation and loneliness.
A recent study by Carnegie Mellon and Ohio State researchers found that antidepressants are not causally linked to an increased risk of suicidality among most teens. The study suggests that only adolescents with major depressive disorder who take a specific class of antidepressants, SSRIs, may be at higher risk.
Researchers have found a significant association between OCD patients and genetic variations on the SLC1A1 gene, which regulates glutamate flow in brain cells. The study suggests that this gene may be a primary candidate for OCD, potentially leading to improved understanding and treatment of the disorder.
A new study found that neurosurgical treatment of severe anxiety disorders can be effective in relieving symptoms, but also carries a significant risk of side-effects such as apathy and epilepsy. The study monitored 51 patients for up to 23 years after undergoing capsulotomy, a procedure that involves severing nerve fibers in the brain.
A study found that 45% of patients with REM sleep behaviour disorder developed neurodegenerative diseases, highlighting its potential as an early detection tool. Patients who had suffered from the disorder for longer time were more likely to develop a neurodegenerative disease.
A new study reveals that intermittent explosive disorder (IED), a condition characterized by uncontrollable rage, is more prevalent than previously thought. The study found that IED attacks are often out of proportion to social stressors and can be linked to cases of road rage and spousal abuse.
Researchers found that withdrawal contributes to compulsive drug consumption in addicts, creating a vicious cycle. A previously unknown source of drug craving was also identified through Pavlovian conditioning.
Researchers found five predictors associated with bipolar disorder risk: people were unfriendly, co-morbid anxiety, depression diagnosis within five years, family history of bipolar disorder, and legal problems. These findings may help physicians better assess a patient's risk for bipolar disorder.
Research shows that generalized anxiety disorder affects 7% of seniors, causing significant impacts on quality of life. Untreated anxiety can lead to anxious depression and poorer cognition in the elderly. New studies aim to address the need for better treatments and therapies for anxiety disorders in older adults.
A study by Harvard Medical School researchers identifies specific neurons in the orbitofrontal cortex that assign values to different goods. This discovery sheds light on choice deficit disorders such as eating disorders and compulsive gambling.
A team of University of Michigan researchers used fMRI to capture the brain's instant response to costly mistakes. They found that the rostral anterior cingulate cortex (rACC) becomes more active when errors carry consequences, suggesting a key role in emotional responses and decision-making processes.
Researchers at Washington University in St. Louis used a network of interconnected pendulums to demonstrate that introducing disorder can lead to order and synchronization in chaotic systems. The findings have potential applications in understanding neuronal activity and may help explain previously unexplained observations.
Researchers found a common serotonin transporter promoter gain-of-function variant linked to obsessive-compulsive disorder (OCD). The study suggests improved screening, treatment, and medication development for OCD.
Researchers found that children with ADHD or conduct disorder display more extreme personality profiles, including aggressiveness and thrill-seeking behavior. The study suggests a strong connection between personality traits and these disorders, highlighting the importance of considering personality in initial assessments.
Researchers seek to confirm that deep brain stimulation can help patients with severe obsessive-compulsive disorder (OCD) and understand the disrupted brain network. A clinical study will examine the effects of DBS at different sites and assess treatment effectiveness.
The landmark COBY study found bipolar disorder in children and teens progresses differently than in adults, with more frequent mood swings and longer symptom duration. Children and teens often switch between different illness sub-types during the course of follow-up.
Researchers at Yale discovered that brain changes associated with bipolar disorder are diminished in patients taking mood-stabilizing medications, holding promise for halting the progression of the disorder. The study's findings highlight the importance of research on bipolar disorder in youths, who are at high risk for suicide.
Researchers have identified a gene called p11 as being involved in the complex changes underlying depression. Decreased levels of p11 protein are found in both human patients with depression and mouse models of the disease. The study suggests that increasing p11 levels could be a new target for developing anti-depressant compounds.
A new guidance system automates electrode placement in DBS surgery, reducing operating times by up to 80% and improving patient outcomes. The system uses a 3D brain atlas to predict target locations, allowing neurosurgeons to hit the mark on their first try.
Researchers found that CBZ-ERC significantly reduced manic and mixed symptoms for patients with Bipolar I Disorder. The study also showed that the medication was generally well-tolerated, with only 14.3% of patients experiencing a relapse.
Researchers at Yale have identified a genetic link to Tourette's Syndrome in a rare DNA sequence mutation. The study found an abnormal DNA sequence in one family and identical, very rare changes in two unrelated individuals, suggesting the gene plays a role in regulating gene expression through microRNAs.