Researchers identified the PRL-3 gene, which is consistently overexpressed in metastatic liver cells from colon cancers. This enzyme codes for a tyrosine phosphatase that may play a role in colon cancer metastasis.
The Cables protein inhibits cell growth through a chain reaction effect, prompting decreased division. Its expression may thwart uncontrolled cell growth indicative of cancer.
Researchers found protein Nrd1 helps RNA polymerase II recognize 'stop sign' for certain genes. This mechanism may help understand HIV's hijacking process and fundamental mechanisms of regulating gene expression in yeast.
Scientists at UIC found that increasing FoxM1B gene expression restored liver cell growth rates and division activity in aged mice, potentially treating aging-related diseases such as cancer and Alzheimer's. This breakthrough could lead to new therapies for the elderly using gene therapy.
Gene expression is found to be highly variable in cloned mice, with imprinted genes showing widespread aberrant regulation. This variability may contribute to the large offspring and respiratory problems commonly seen in clones.
Scientists discovered that even seemingly normal-looking clones may have subtle aberrations in gene expression, which can affect development. The study found that mouse clones made from embryonic stem cells exhibited irregular gene expression, highlighting the potential risks of reproductive cloning.
Researchers have discovered a potential cause of male infertility, identifying the ZNF214 gene as a candidate gene. The gene is linked to impaired spermatogenesis and may be inherited from mothers. Further research will help understand its role in sperm production and develop targeted treatments.
Researchers used gene array technology to analyze brain gene expression in human alcoholism, identifying extensive reprogramming of the frontal cortex. This study provides insight into the molecular neurocircuitry altered by chronic alcohol abuse, shedding light on tolerance, dependence, and neurotoxicity.
Scientists at the University of Pittsburgh have engineered a novel gene therapy to treat Duchenne Muscular Dystrophy (DMD), a genetic disorder causing progressive muscle weakening and death. The mini-gene AAV vector effectively delivers functional dystrophin protein, correcting muscle dysfunction and degeneration.
Researchers at Thomas Jefferson University have developed a new gene therapy system that uses DNA and bacterial proteins to deliver genes to specific places in human DNA, avoiding viruses and their associated immune reactions. The technique shows promise for treating genetic diseases such as hemophilia and sickle cell anemia.
A new statistical method, called gene-shaving, identifies distinct sets of genes with similar expression patterns in tumors. This technique allows researchers to predict patient survival and treatment efficacy with greater accuracy.
Researchers at Rosetta Inpharmatics used high-quality gene expression data and computational methods to identify novel gene functions. The company's approach enables the deciphering of previously uncharacterized genes, with applications in new drug discovery and development.
Researchers at Duke University Medical Center have successfully used a heat-sensitive gene to slow down tumor growth in mice by 300-400 times over baseline. The gene therapy, which uses hyperthermia, also boosts the immune system's ability to fight cancer.
A genetically stripped down HIV-based vector has been developed that can deliver genes to target cells in the body safely. The vector can also be turned off with a common antibiotic, which suggests doctors may one day be able to control gene expression in people treated with HIV-based gene therapy vectors.
Dusty Miller, PhD, received the National Hemophilia Foundation's 1999 Dr. Murray Thelin Researcher of the Year Award for his work on gene therapy, a potential treatment for hemophilia. His pioneering research has led to the development of retroviral gene-transfer kits and promising early-stage gene-therapy trials.
Researchers aim to uncover molecular signatures of cancer initiation using gene expression profiles. They will compare genes in hereditary colon, breast, and kidney cancers with normal tissues to identify altered genes and target potential chemopreventive agents.
Researchers created a DNA microarray called Lymphochip to analyze gene expression in normal and malignant cells, revealing two distinct forms of DLBCL with different clinical outcomes. The study improved diagnosis and treatment of these lymphomas by providing a detailed molecular portrait of the disease.
Researchers suggest a genetic expansion in the development of limbs, allowing early vertebrates to develop toes and fingers. The discovery sheds light on how nature has reused existing genes to create new adaptations for life on land.
A new study in mice suggests that increasing copies of the SMN2 gene can produce sufficient amounts of survival motor neuron (SMN) protein, potentially treating human SMA patients. The research found that activating the expression of this gene may provide a strategy for treating human SMA patients.
Researchers at Thomas Jefferson University have used gene therapy to replace a damaged Rb2 gene with a healthy version, dramatically shrinking lung cancer tumors in mice. The study provides direct evidence that Rb2 is a tumor suppressor and demonstrates its potential as a target for human gene therapy trials.
A team of UI researchers has advanced understanding of how gene therapy might effectively treat cystic fibrosis by addressing two fundamental problems: inefficient gene transfer and lack of gene persistence. They demonstrated efficient and lasting gene transfer into airway cells using a new vector from the retrovirus family, feline imm...
A new study found that anger expression fluctuates according to situational factors, rather than being a stable personality trait. State measures of anger expression were significantly associated with the person triggering anger, location, mood, and appraisal variables.
Researchers identified a gene called Irx-4 that helps maintain the boundaries between heart chambers. The discovery opens up new avenues to understand heart chamber formation and may also shed light on the cause of certain heart defects.
A Cedars-Sinai researcher has identified a gene associated with malignancy in brain, liver, breast, colon, kidney, and reproductive organs, but not in healthy adults. The discovery could lead to the development of a method to block the gene's expression using antisense technology, potentially stopping cancer before it spreads.
Scientists have successfully administered gene therapy orally, effectively curing lactose intolerance in rats. The study demonstrates the potential for an oral delivery system to treat other diseases, such as diabetes.
Researchers at Penn State have identified new molecular players involved in gene expression and discovered unexpected dynamics among these molecules. The study reveals how these molecules interact with each other to activate genes, shedding light on the complex process of gene regulation.
Researchers demonstrate intratumoral delivery of the E1A gene, downregulating HER-2/neu expression and tumor responses. The study shows promise for using E1A gene therapy to treat a broad range of cancers.
Scientists at Ohio University and Progenitor Inc. use a nonviral gene expression system to eliminate human cancer cells in animals, achieving a 60 percent tumor regression rate. The T7 system allows for transient gene expression and has been shown to be effective against various types of cancers.
Researchers at Ohio University develop a faster gene function identification system using a nonviral gene expression system in zebrafish, reducing identification time from three years to two days. The technique allows scientists to study gene function without destroying the gene, making it valuable for studying genetic disease.
Researchers successfully transferred a normal human beta globin gene into mice bone marrow cells, achieving long-term expression and high levels of production. This breakthrough holds promise for the treatment of sickle cell disease and beta thalassemia.
Researchers have developed a gene therapy technique that restricts the activity of genes used for gene therapy to specific cell types, bypassing safety hurdles. This discovery could lead to targeted treatment of cardiovascular diseases and other disorders.
A new gene, AIB1, has been discovered in breast cancer cells that amplifies their growth. The gene is part of a family known as SRC-1 and interacts with steroid hormone receptors, enhancing tumor cell growth.
Researchers discovered that abnormal expression of the WT1 gene is linked to nearly 70% of breast cancers, which may lead to new treatments. The study suggests restoring functional tumor suppressor genes like WT1 could help combat breast cancer.
A new study in Saccharomyces cerevisiae, also known as Brewer's yeast, indicates that mRNA localization regulates differential gene expression in the organism. The localization of a protein called ASH1 to the tip of budding daughter cells controls its expression.
Researchers successfully cloned the Clock gene, a key regulator of circadian rhythms in mammals. The gene's identification provides insight into the molecular mechanisms underlying circadian rhythm entrainment and expression, potentially leading to new treatments for sleep disorders and jet lag-related issues.
Researchers at Ohio University have developed a nonviral gene therapy system that can express genes outside the nucleus of a cell, making it easier to deliver disease-fighting genes to tumor cells. This system has been successfully used in cell cultures and mouse models to promote anti-cancer activity.
Researchers at Penn State have discovered a new gene called KiSS-1 that suppresses the metastasis of melanoma in laboratory mice. The gene, located on chromosome 1, reduces the spread of melanoma by at least 50 percent of the time and may be the most potent gene to block or suppress metastasis in human cancer.
Researchers at Ohio University found evidence that memory loss with aging may be connected to malfunctioning genes controlling spatial memory. The study identified unique DNA sequences in old mice brains, which could lead to the development of therapies targeting age-related cognitive decline.
A study found that certain genetic variants next to the human obesity (OB) gene are associated with obesity in young women, as well as depression and anxiety. The results suggest a direct link between the OB gene variants and depression, rather than just secondary effects.
A University at Buffalo study finds that certain genetic variants near the human obesity gene are associated with obesity in young women, as well as depression and anxiety. The study also suggests that these genes may contribute to the development of behavioral disorders in young women.