Researchers have developed a method to control genetically altered bacteria to release medicines to tumors or the gut, using temperature regulation. This technology has applications in novel therapeutics for cancer and other diseases.
Researchers develop domain-swapped T cell receptors that increase the safety of TCR gene therapy by preventing mispairing between introduced and resident chains. These new receptors retain functional domains and prevent autoimmune disease in mice and human cells, offering a promising tool for cancer treatment.
A recent study by Caltech researchers Konstantin Batygin and Mike Brown suggests that the large, undiscovered planet Planet Nine is responsible for the sun's tilted orbit. The planet's massive size and unique orbit cause a multi-billion-year wobble in the solar system, resulting in a six-degree tilt.
A team led by Caltech's Changhuei Yang and Edward Zhou developed a device that selectively cancels scattered light, revealing dimly reflective objects. The technology, termed 'coherence gated negation,' has potential applications in satellite exploration and biomedical imaging.
Researchers at Caltech have discovered a new breed of optical soliton wave that can travel in the wake of other solitons, hitching a ride on their energy. This phenomenon has been observed in light waves and has applications in highly accurate optical clocks and microwave oscillators.
A team of scientists engineered protein-shelled nanostructures called gas vesicles to exhibit properties useful for ultrasound technologies. The modified gas vesicles were shown to produce distinct signals, target specific cell types, and help create color ultrasound images.
Researchers at Caltech develop efficient synthesis route for ryanodol, a key intermediate on the path to producing the insecticide ryanodine. The new method reduces reaction steps by five, enabling faster production of the molecule. This breakthrough also opens up possibilities for studying biological function and developing new drugs.
New data from NuSTAR reveals large numbers of black holes sending out high-energy X-rays, helping astronomers understand growth patterns and evolution of supermassive black holes. The study resolves 35% of the high-energy X-ray background, uncovering details about the most obscured black holes hidden in gas and dust.
Researchers at Caltech investigate the genetic switch that directs cells to become T cells, discovering a multi-tiered process involving four proteins that work together in three distinct steps. This finding has potential applications in boosting T-cell populations and fighting diseases such as AIDS.
Researchers at Caltech use DNA origami to precisely place glowing molecules within microscopic light resonators, creating a microscopic reproductions of Vincent van Gogh's The Starry Night. By mapping out a checkerboard pattern of hot and cold spots, they can position fluorescent molecules to make lamps of varying intensity.
A team of Caltech-led researchers has discovered the youngest fully-formed exoplanet ever detected, K2-33b, which orbits a young star at 5 to 10 million years old. The planet's proximity to its star and large size suggest it may have formed quickly or challenged the migration theory.
Researchers detected propylene oxide, a chiral molecule, in the Sagittarius B2(N) molecular cloud using radio astronomy. The finding sheds light on the origins of life and homochirality, with implications for understanding life elsewhere in the universe.
Researchers at Caltech discovered quasicrystals in laboratory experiments after simulating asteroid collisions. The team hypothesized that the energy released during a collision could trigger a rapid cycle of compression and cooling, leading to the formation of these rare structures.
Researchers discovered that genetic mutations in certain genes can impair the immune-enhancing effects of beneficial bacteria, leading to reduced efficacy of probiotic therapies in treating Crohn's disease. The study suggests a new potential cause for the disorder and may lead to advances in personalized medicine.
Caltech researchers have mapped out a circuit of neurons that control motor impairment in patients with Parkinson's disease. The study used two laboratory techniques to identify the pathways of cholinergic neurons in the brainstem, revealing their role in both locomotion and reward-based behaviors.
The NOvA particle physics experiment has successfully detected the transformation of muon-type neutrinos into electron-type neutrinos, a process known as neutrino oscillation. This discovery provides valuable insights into the subatomic world and the evolution of the universe.
Researchers found that observing others' risk-taking behavior changes one's own attitude towards risk, with the brain responding to this change in activity levels. The study also found that participants could learn and predict the risk-taking preferences of an observed peer.
Researchers found a previously unknown type of neuron called J-RGCs that signal color to the brain by comparing signals from ultraviolet cones and rods. This discovery may help explain why humans perceive the color blue in dim light, as proposed by Van Gogh's Starry Night painting.
Researchers used electron cryotomography to visualize bacterial 'motors' in three dimensions, revealing the complexity of type IVa pilus machine and flagellum structures. The study provides insights into pilus assembly, structure, and function, as well as correlations between motor strength and torque-generating protein complexes.
Researchers at Caltech demonstrate that nanoparticles can selectively target tumors while leaving adjacent healthy tissue intact. The study's findings suggest the presence of the EPR effect in humans, which could lead to more effective cancer therapies with fewer side effects.
Researchers develop approach to understand chromatin regulators, which modify DNA to alter gene expression. They found that regulators control the probability of gene expression in a population, not just individual cells.
A new study by Caltech researchers finds that experimental economics studies have a high replication rate of 61%, indicating that published results are reliable. The success of replication is linked to sample size and p-values, suggesting good methodological practices in the field.
Researchers at Caltech have developed a visual readout method using analytical chemistries and image processing to quantify single nucleic-acid molecules, enabling the use of any cell-phone camera. This technology has potential applications in limited-resource settings for disease diagnosis.
Researchers identified a gene, neuromedin U (Nmu), that regulates sleep in zebrafish. Overexpression of Nmu causes severe insomnia, while its absence leads to reduced activity during the day. The study improves understanding of sleep regulation and suggests Nmu as a potential candidate for new therapies to address sleep disorders.
Researchers found that hormone AVP increases willingness to cooperate in humans, mimicking pair bonding in rodents. The study used a game to test the effect of AVP on cooperative behavior, with participants who received the hormone more likely to cooperate than those who did not.
Caltech biologists have developed a vector capable of noninvasive delivery of genetic cargo to adult mice brains, holding promise for novel therapeutics. The approach overcomes the blood-brain barrier problem, allowing for efficient gene delivery and targeting specific brain cells.
Researchers have discovered molecules that act as cellular identification tags on neurons in the fruit fly Drosophila, guiding the development of the neuromuscular and visual systems. The finding validates a theory proposed by Roger Sperry in the 1950s and provides insight into brain development.
Researchers at Caltech developed a novel technique called TRUME that utilizes microbubbles to focus light inside biological tissue. The technique can be used as an effective 'guidestar' to target specific locations in tissues, enabling minimally invasive treatments such as tumor destruction and diagnostic imaging. This innovation has t...
Researchers used supercomputer simulations to understand how magnetic fields amplify in collapsing stars, enabling jets that power supernovae and gamma-ray bursts. The study found a dynamo process creates large-scale fields needed for these explosions.
Researchers propose a photochemical process that could have evolved the Martian atmosphere without creating excess carbon. The mechanism, which involves ultraviolet photodissociation, enriched carbon-13 in the atmosphere, resolving the long-standing issue of 'missing' carbon.
Astronomer Evan Kirby measures high concentration of dark matter in small dwarf galaxy Triangulum II, potentially making it a leading candidate for direct detection. The galaxy's unique characteristics and minimal background noise make it an ideal location to search for gamma-ray signals from colliding dark matter particles.
Researchers discovered that intrinsic neural connections can be used to help the blind detect their environment, making tasks easier and more intuitive. The study used a sensory substitution device to translate images into sound, allowing blind people to associate different sounds with features of their environment.
Researchers found a new type of multipolar order in strontium-iridium oxide, which could lead to breakthroughs in electronic device functionalities and high-temperature superconductivity. The discovery was made using an optical harmonic generation technique that exploits changes in crystal symmetry.
Researchers used asteroseismology to probe magnetic fields in the cores of red giants, finding them strongly magnetized. The strong fields disrupt gravity waves, causing energy loss and affecting star evolution.
A new study finds that cells activate and deactivate proteins in a series of unpredictable pulses, allowing them to control gene expression. The timing of these pulses may play an important role in cellular processes such as information processing and stress response.
A team of researchers from Caltech analyzed eggshells from sauropod dinosaurs, bird-like oviraptorid dinosaurs, and Titanosaurs to determine their body temperatures. The results showed that smaller dinosaurs had lower basal metabolisms, while larger ones maintained warm temperatures similar to modern mammals.
A new paper published in Science reveals that Mars had a more massive atmosphere billions of years ago and a wet climate, with long-lived lakes filling Gale Crater. The discovery contradicts existing climate models and sheds light on the planet's ancient past, similar to the resolution of Earth's continental drift puzzle.
A team of Caltech biologists has created a non-surgical approach to deliver long-term contraception using a single shot, rendering animals infertile for up to two months. The technique targets the 'master regulator of reproduction,' gonadotropin-releasing hormone (GnRH), neutralizing its effects and preventing conception.
Researchers at Caltech have developed a polymeric fuel additive that reduces the intensity of postimpact explosions in jet engines, without affecting fuel performance. The additive works by inhibiting droplet breakup under impact conditions, thereby reducing explosion size and turbulence.
The Global Relay of Observatories Watching Transients Happen (GROWTH) project aims to improve understanding of cosmic transients by extending night-time observing hours. The network, supported by NSF's PIRE program, enables researchers to monitor rare events like neutron star mergers and heavy element synthesis.
Scientists have discovered a fractal pattern at the atomic level in metallic glasses, contradicting previous assumptions about empty space. This finding enables the study of material properties and has implications for fields like mathematics, physics, and computer science.
Researchers at Caltech found that ocean microbes can consume large amounts of methane using electrons to share energy over long distances. The microbes use a symbiotic relationship to break down methane, which could help mitigate climate change.
Researchers at Caltech have identified a broadly neutralizing antibody that can recognize HIV's envelope spike in different conformations, making it easier to detect and neutralize the virus. This discovery could lead to the development of combination therapies to fight HIV, which is currently evolving rapidly.
A team of Caltech researchers detects a galaxy called EGS8p7, which is more than 13.2 billion years old, making it the farthest galaxy ever found. The detection challenges our understanding of the universe's evolution, particularly reionization.
A Caltech team has successfully created synthetic structures made of both protein and DNA, opening up numerous applications. The hybrid material combines the versatility of proteins and the programmability of DNA, enabling new possibilities for medical treatments and industrial applications.
Researchers at California Institute of Technology have developed an artificial leaf that can harness sunlight to produce hydrogen fuels, achieving a high efficiency rate. The system consists of three components: photoanode, photocathode, and membrane, which work together to split water molecules into oxygen and hydrogen gas.
Researchers at Caltech have successfully observed and controlled quantum motion in a large mechanical device, defying classical physics. By manipulating the inherent quantum noise, they were able to reduce its impact on measurement precision.
The study provides the first complete account of the Gorkha earthquake's physical process, revealing a contained rupture at depth. The findings suggest that while the earthquake did not cause widespread destruction, it increased stress on an adjacent portion of the fault, potentially leading to future earthquakes.
A team of Caltech astronomers has discovered a giant swirling disk of gas 10 billion light-years away, which is actively being fed cool primordial gas tracing back to the Big Bang. The finding provides the strongest observational support yet for the cold-flow model of galaxy formation.
A team of astronomers led by Gregg Hallinan has discovered that brown dwarfs, which are cool and dim objects, host powerful auroras near their magnetic poles. The findings suggest that these so-called failed stars behave more like giant planets with highly active magnetic fields.