A new technology has reduced overall radiation exposure from CT scans in children by 37 percent, according to a recent study. The software uses mathematical calculations to determine the lowest possible radiation dose for each patient, allowing radiologists to precisely control the amount of radiation based on patient size.
A new study reveals that medical devices contribute to complications in children with complex medical conditions. The research found that vascular access devices and nervous system devices were the most common types of devices associated with adverse events, which often affected young children under the age of 2.
Researchers found anesthesia-induced cell death in neurons is not limited to the immature brain, but targets neurons of a certain age and maturational stage. This finding may have implications for millions of children and adults undergoing surgical anesthesia annually.
A new study reveals that pediatric nurse staffing ratios are significantly associated with hospital readmissions for children with common medical and surgical conditions. Children treated in hospitals meeting a contemporary staffing benchmark of no more than four patients per nurse were less likely to be readmitted within 15-30 days.
A new study finds that half of high school football players would continue to play with headache symptoms, and only 54% report concussions to coaches. The study raises concerns about concussion education in adolescent athletes.
Researchers at Cincinnati Children's Hospital Medical Center have successfully tested a catheter-based procedure that diverts bile into the small intestine, producing significant weight loss and metabolic benefits in obese rats. The study suggests manipulation of bile acids may be sufficient to recreate the effects of bariatric surgery.
Researchers have linked 17 genes to juvenile idiopathic arthritis, a significant increase from previous findings of three genes. The study analyzed over 2,800 patient DNA samples and provides new insights into the disease process.
A study published in Microbiome identified two distinct microbial imbalances in the digestive tract that precede necrotizing enterocolitis (NEC) in preterm infants. The findings suggest a predictive value of over 80% for NEC using a simple urine analysis.
A new study found that adolescent girls who were abused or neglected had a teenage childbirth rate of 20.3%, more than double the national average. The study suggests that primary prevention programs targeting sexual activity could help mitigate this risk.
An international research team has discovered a possible alternative treatment for lymphoid leukemia that eradicated the disease in mouse models. The targeted molecular therapy could make leukemia more susceptible to chemo and radiation therapies, benefiting patients with Acute Lymphoid Leukemia (ALL).
Researchers developed a small-molecule inhibitor Y16 that blocks a hard-to-target part of a protein complex linked to several types of invasive cancer. The compound, combined with Rhosin/G04, suppresses RhoA cell signaling and downstream molecular events fueling cancer growth in breast cancer cells.
Researchers have developed an experimental molecular therapy that crosses the blood-brain barrier to reverse neurological lysosomal storage disease in mice. The therapy uses a modified enzyme called IDUAe1, which penetrates the blood-brain barrier and delivers large-molecule therapeutic agents to treat brain diseases.
Scientists at Cincinnati Children's Hospital Medical Center and the University of California, San Francisco, discovered a light-response pathway that controls retinal neuron development during pregnancy. This finding has significant implications for understanding fetal eye development and ocular diseases caused by vascular disorders.
A new study published in Pediatrics reveals that 30% of teen girls have met offline with someone they met online. Abuse or neglect increases this risk, with victims more likely to present themselves provocatively online. High-quality parenting and parental monitoring can reduce these risks.
A study published in The Lancet found that approximately one of every five individuals with kidney tumors common in patients with tuberous sclerosis complex has had a kidney removed unnecessarily due to misdiagnosis. Everolimus successfully shrinks these tumors, offering an alternative to surgery.
A preclinical study using a molecularly targeted treatment has successfully shrunk large majority of neurofibromas in mice with Neurofibromatosis 1 (NF1). The treatment, PD0325901, blocked MEK protein signaling, reducing tumor growth and feeding blood vessels.
Researchers found that teenage girls who smoke accumulate less bone during a critical growth period and carry a higher risk of developing osteoporosis later in life. The study suggests that strategies to help prevent osteoporosis should focus on preventing smoking, particularly among adolescent girls.
Researchers will track brain development in infants with TSC using advanced imaging techniques to identify those at high risk for autism. The study aims to open new avenues of research and treatment for autism, not only in TSC but also in other causes.
A drug originally developed to prevent organ rejection has been shown to dramatically reduce a particular kind of brain tumor in patients with tuberous sclerosis complex (TSC). The study found that 35% of patients experienced at least a 50% reduction in tumor volume after treatment with everolimus.
A new study uses geographic social risk index to predict asthma readmission risk in children, highlighting the importance of addressing socioeconomic disparities. The researchers found that children from high-risk areas were 80% more likely to be rehospitalized or visit emergency rooms.
Scientists at Cincinnati Children's Hospital Medical Center identify a molecular pathway critical to body repair processes after injury, leading to potential new anti-fibrotic or anti-inflammatory agents. The discovery could provide a targeted intervention point in fibrotic diseases, including heart failure and muscular dystrophy.
A new study published in Nature suggests that vaccines could be developed to prevent premature birth and pregnancy complications by stimulating the production of immune suppressive cells. These cells, which are generated during pregnancy, can tolerate foreign antigens and provide protection to the fetus.
Researchers at Cincinnati Children's Hospital Medical Center discovered a biological mechanism that causes brain seizures in mice with molecular disruptions in small neurons called granule cells. Treating epileptic mice with a drug that blocks the mTOR pathway stopped seizures, solidifying the link to the PTEN-mTOR pathway.
Fruit flies exhibit a daily temperature preference rhythm that mirrors human body temperature rhythms, controlled by a circadian clock. The discovery opens up new avenues for studying human development and disease using fruit flies as models.
A study found that abnormal endocannabinoid signaling in mouse embryos can disrupt placental development and lead to pregnancy problems. Researchers hope the findings will inform studies on the causes of preeclampsia, a medical condition affecting mothers and children.
A study published in Pediatrics found a strong association between persistent and loud snoring in young children and problem behaviors such as hyperactivity, depression, and inattention. The study suggests that doctors should routinely screen for and track snoring in children from poorer families to prevent preschool behavior problems.
A study published in Pediatrics found that HPV vaccination significantly reduced infection rates among both vaccinated and unvaccinated young women. The vaccine's effectiveness was particularly notable among sexually experienced participants.
A new study suggests adding a modified echo to current screenings to identify student athletes with heart problems that could lead to sudden death. The study found that an abbreviated echo can increase the sensitivity of finding heart defects in competitive athletes.
A landmark randomized clinical trial is testing whether earlier treatment can prevent or delay heart damage in people with Duchenne muscular dystrophy. The study uses enhanced cardiac magnetic resonance imaging to detect early changes in heart function and evaluate the effectiveness of an anti-fibrosis drug regimen.
A study in Nature Medicine reveals that boosting a protein pathway in the body's blood-making system can protect against radiation poisoning. The researchers found that pharmacologic enhancement of the Thbd-aPC pathway can accelerate recovery of hematopoietic progenitor cell activity and reduce harmful effects in mice.
Researchers at Cincinnati Children's Hospital Medical Center have developed a new candidate drug, Rhosin, that inhibits breast cancer cell growth and promotes the growth of nerve cells. The drug targets RhoA, a key component of a cell signaling protein complex involved in various cancers and neurologic disorders.
Scientists have identified a new protein function that protects heart cells from damage during extreme hypertension and cardiac pressure overload. The discovery could lead to the development of treatments for conditions like cardiovascular disease and Alzheimer's.
Scientists at Cincinnati Children's Hospital Medical Center have found that inhibiting the protein Cdc42 can reverse the aging of hematopoietic stem cells, restoring their functional efficiency. This breakthrough has significant implications for understanding and combating age-related diseases.
Researchers have identified a genetic signature for regulation of IL-13, a key immune hormone involved in allergic reactions. MicroRNA miR-375 is regulated by IL-13 and plays a role in asthma and eosinophilic esophagitis (EoE), a severe food allergy.
A new study of three diets with obese children shows that all diets are effective in managing weight. The reduced glycemic load diet may be the most promising approach for pediatric weight management.
A genetic signature has been identified for eosinophilic esophagitis (EoE), a disease causing painful food allergies, inflammation, and swallowing difficulties. The microRNA signature is reversible with steroid treatment, offering an opportunity for non-invasive diagnosis and precise analysis.
Scientists developed a unique compound that blocks inflammation-causing molecules in blood cells, fueling diseases like cancer and cardiovascular disease. The compound, Phox-I, precisely targets an enzyme network, reducing ROS production without causing toxicity.
Researchers found that shortening telomeres in cancer cells makes them more sensitive to radiation treatment, leading to faster cell death. The study's results may lead to safer and more effective combination therapies for pediatric brain cancers.
A new study suggests that increasing the expression of certain developmental genes in the uterus at precise times may improve IVF success rates. The researchers found that these genes, Msx1 and Msx2, play a crucial role in ensuring uterine receptivity for successful embryo implantation.
Researchers at Cincinnati Children's Hospital Medical Center have identified a new molecular signature for biliary atresia, a devastating pediatric liver disease. The study found that some children with the condition exhibit high levels of Th2 immune system activity, providing a potential target for new therapies.
A novel mouse model has identified a molecular signaling pathway underlying preterm labor, which may lead to new strategies for combating the major global health issue in humans. The study suggests that inhibiting mTORC1 signaling with rapamycin could prevent premature aging and birth.
A study found that children with specific dopamine system gene variants showed improved response to methylphenidate, the most commonly prescribed ADHD medication. The findings suggest a potential way to predict treatment course and tailor approach for each child.
The five-year study aims to determine the medication of choice for preventing migraines in children and teens, addressing a significant gap in evidence-based research. The trial will compare amitriptyline and topiramate, investigating their efficacy and safety profiles in this age group.
A new study reveals a dramatic increase in medication poisoning cases among young children, with opioids and sedatives being the most commonly ingested substances. The PROTECT Initiative aims to improve storage devices and child-resistant closures to reduce the risk of accidental overdoses.
A study published in Journal of School Health found that a suicide prevention program significantly reduced teen suicidal behaviors, with significant decreases in considering, planning, and attempting suicide. The Surviving the Teens program taught self-confidence and positive behavior to help teens cope with stress and depression.
Scientists discovered that the intestinal membrane receptor protein, GC-C, is also expressed in critical brain areas. The study found that GC-C's activation amplifies dopamine responses, leading to hyperactivity and attention deficits in mice. Treatment with a PKG activator reversed these behavioral problems.
Researchers at Cincinnati Children's Hospital Medical Center have developed a tool to predict violence and aggression in children and teens hospitalized on psychiatric units. A study validated the Brief Rating of the Child and Adolescent Aggression (BRACHA) tool, which showed that 14 out of 16 items were significantly associated with a...
Researchers found that orphan disease genes encode hub proteins with multiple protein-to-protein interactions vital to cell function. Deleting about 43% of these gene homologs is lethal or causes premature death, highlighting their essential survival role.
Researchers discovered a novel molecular pathway used by myeloid cells to regulate blood vessel patterning in the developing retina. The pathway, involving the Wnt protein signaling network, has potential as a therapeutic option for fighting retinal diseases and cancers.
Researchers use a genetically re-engineered herpes virus that selectively infects cancer cells, prompting them to secrete a biomarker that can be detected. The technology has the potential to improve cancer diagnosis and monitoring, especially in less developed parts of the world.