Researchers develop an experimental therapy that shuts down the Olig2 gene, halting tumor growth and blocking tumor formation. The approach uses a gene therapy to eliminate Olig2-positive cells, sensitizing them to targeted molecular treatment.
Researchers use machine learning to analyze factors influencing patient recruitment, predicting acceptance rates of up to 72% compared to traditional methods. The algorithm analyzes objective and subjective factors, including demographics, attitudes towards medical research, and health conditions.
Researchers at Cincinnati Children's Hospital Medical Center propose a new drug to treat life-threatening lung damage caused by infections, cancer treatments, and premature birth. The treatment targets FOXF1, a transcription factor that promotes recovery from acute lung injury.
Researchers identified an underlying cause of immune suppression in spinal cord injuries and proposed a possible treatment using chemogenetic agents. Chemogenetic silencing reversed the immune suppressive reflex, reversing spleen atrophy and increasing white blood cell counts in mouse models.
A new study predicts severe obesity can be identified at 6 months of age using a simple BMI measurement. Pediatricians are advised to measure BMI during infant well-child visits to identify high-risk children and provide targeted education on healthy lifestyles.
Researchers have developed a novel mouse model of acute myeloid leukemia, offering a new tool for understanding the disease and identifying potential therapeutic targets. The model has revealed insights into the genetic mechanisms underlying AML, including the role of Dnmt3a mutations.
Researchers discovered a gene associated with CHARGE syndrome disrupts molecular pathways controlling myelin sheath formation in nerves and bones. The study suggests a potential molecular framework for identifying therapeutic targets to promote myelin regeneration.
The hospital will facilitate collaborations among researchers and make genomic data available to accelerate discovery of the genetic mechanisms of congenital heart defects. The goal is to uncover genetic mutations that affect both heart and brain development in children with severe heart defects.
A new study suggests that moderate fish consumption during pregnancy may have beneficial effects on infant neurobehavior and development. The research found that infants of mothers with higher mercury exposure and greater fish consumption showed improved attention and reduced special handling needs.
A new study published in Breastfeeding Medicine found a significant association between diabetes during pregnancy and low milk supply. Women with maternal glucose intolerance were more likely to experience lactation difficulties, highlighting the need for targeted therapies to support breastfeeding mothers.
Researchers at Cincinnati Children's Hospital Medical Center found a strong link between autism and maternal obesity-diabetes, with pregnant mothers 1.5 times more likely to have a child with ASD. The study used electronic medical records and analyzed birth data from over 35,000 mothers.
Dr. Sing Sing Way, a pediatrician specializing in infectious diseases, has made significant contributions to understanding pregnancy complications and infection susceptibility in newborns. His research has the potential to develop vaccines that protect against pregnancy complications.
A new study published in Environmental Health found a 19% increased risk of preterm birth among women exposed to high levels of small particle air pollution. The study also identified higher risks among mothers over 40, black mothers, and those with lower education levels.
A new study found a significant racial disparity in premature births among black women, which may explain much of the racial disparity in infant mortality. The study suggests that public health efforts should focus on access to prenatal care and preventive measures for high-risk black women.
Researchers have identified a molecular target for DNA repair defects behind Fanconi anemia, a complex genetic disorder responsible for birth anomalies, organ damage, anemia, and cancer. The study reveals a potential therapeutic strategy and raises important questions about a compensatory DNA repair process.
A study of 201 infants found that buprenorphine therapy was more effective than methadone in reducing the duration of treatment and length of hospital stay for newborns born in opioid withdrawal. Infants treated with buprenorphine had a shorter course of treatment, averaging 9.4 days, compared to 14 days on methadone.
A study by Cincinnati Children's Hospital Medical Center found that hospital-to-home transitions can cause mental exhaustion, emotional toll, and uncertainty among family caregivers. The researchers identified a need for in-home follow-up visits, telephone calls from nurses, and enhanced care plans to improve the transition.
Researchers identified genetic risk factors for a deadly hyperinflammatory disorder triggered by viral infections in susceptible individuals. The study found that people with certain gene mutations may be prone to the disorder, known as reactive HLH or hemophagocytic lymphohistiocytosis.
A new study published in the American Journal of Preventive Medicine found that only 3 in 10 children get at least 60 minutes of outdoor recess time, despite guidelines recommending it. Preschoolers in child care centers with ample outdoor time were more active over 24 hours.
Eight-year follow-up study shows significant weight loss and improved lipid profiles in gastric bypass surgery patients, with no improvement seen in non-surgical counterparts
A study of over 14,000 adults found those born with congenital heart disease have a 3.5 times higher risk of heart attack before age 50 and twice the risk after. Mortality rates are also significantly higher, with some cases showing a mortality rate four times that of the general population.
Researchers at Cincinnati Children's Hospital Medical Center used computer-based modeling to improve outcomes for infants born in drug withdrawal. The study reduced methadone treatment duration from 16.4 to 14.1 days and inpatient treatment from 21.7 to 18.3 days.
Researchers at Cincinnati Children's Hospital Medical Center have identified a way to test RNA and specific genetic signatures in amniotic fluid to determine fetal lung maturity. This test could help doctors decide when it is safe to deliver premature babies, allowing for better preparation and care for neonatal morbidities.
A new computer program analyzing functional brain MRIs of hearing-impaired children can predict effective language skills after cochlear implant surgery. The study identified two brain regions that effectively predict successful outcomes, providing potential biomarkers for clinicians.
A new study at Cincinnati Children's Hospital Medical Center found no increased risk of cardiovascular side effects or death in children with ADHD and severe heart conditions treated with stimulants. The medication also showed significant improvements in ADHD symptoms. Researchers are next studying the effect on electrocardiograms.
Researchers discovered a new cell type that produces IL-9, amplifying anaphylactic shock in response to ingested food. The 'IL-9-producing mucosal mast cells' require the presence of specific immune cells and proteins to produce severe allergic reactions.
A new treatment protocol has been shown to improve outcomes for infants born in withdrawal from drugs, resulting in shorter hospital stays and reduced opioid treatment durations. The protocol, developed by the Ohio Children's Hospital Neonatal Research Consortium, increased adherence rates and improved overall patient care.
A recent study by Cincinnati Children's Hospital Medical Center found that preschool-age children consume more calories and fewer fruits, vegetables, and milk outside of child-care centers. The study suggests excess calorie consumption away from the center is significantly associated with being overweight.
Children's hospitals have reduced CT scan usage for 10 common childhood diagnoses, opting for alternative imaging methods like ultrasound and MRI instead. This shift is attributed to growing evidence linking ionizing radiation from CT scans to increased cancer risk and the adoption of electronic health records.
BioWardrobe, a user-friendly platform, enables researchers to analyze large transcriptomic and epigenomic datasets without programming expertise. The platform was developed to bridge the gap between data and knowledge, facilitating research on basic biology and disease.
Researchers developed a new tool called SpDamID that precisely marks where regulatory proteins bind DNA in living cells. This allows scientists to track the combined action of multiple transcription factors and identify differences between healthy and diseased cells.
A pediatrician at Cincinnati Children's Hospital Medical Center warns that recycling older electronic equipment poses a lead poisoning risk to children. Elevated blood lead levels have been detected in two cases, highlighting the importance of preventing take-home exposure to hazardous chemicals and substances.
A multi-institutional team of researchers has identified an apparently successful treatment for a genetic immune disorder that causes a multitude of health problems. The FDA-approved drug abatacept was tested on a small group of patients, resulting in improved lung function and reduced autoimmunity.
Researchers found that genetically distinct cells in pregnant mothers, known as microchimeric cells, promote reproductive health and prevent pregnancy complications like prematurity and stillbirth. These cells help the immune system recognize and accept non-inherited maternal antigens, suppressing an immune system attack on the fetus.
Research by Cincinnati Children's Hospital Medical Center found that children hospitalized for bronchiolitis and pneumonia tend to live in areas with less optimal socioeconomic conditions. The study identified specific inner-city neighborhoods as 'hot spots' for hospitalization, suggesting targeted prevention and cost containment efforts.
Children and teens with Down syndrome are at higher risk for behavioral medications, study finds. The odds of being on a stimulant increased with age, while antidepressant use rose with age, suggesting changing mental health needs over time.
Research suggests that general anesthesia before age 4 may lead to diminished language comprehension, lower IQ, and decreased gray matter density in the brain. The study highlights the potential need for mitigating strategies to improve child health outcomes.
Researchers have identified a validated tool to measure symptoms and impact in eosinophilic esophagitis (EoE), a severe food allergy. The Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) v2.0 questionnaire corresponded with clinical and biologic features of EoE, suggesting that eosinophil activity and mast cells contribute to d...
A new study found an association between pyrethroid pesticide exposure and attention deficit hyperactivity disorder (ADHD) in children and young teens, especially in terms of hyperactivity and impulsivity. Boys were three times more likely to have ADHD than girls with detectable urinary biomarkers.
Researchers found that HER2-positive breast cancer cells become addicted to the ERAD pathway, allowing them to survive chemotherapy. Inhibiting this pathway and promoting JNK activation selectively kills these cancer cells. The study proposes a new strategy for cancer treatment by maximizing cell stress.
A new study suggests pharmacies can reduce asthma-related illnesses by dispensing more asthma controller medications. Pharmacies located in high utilization census tracts dispense more rescue medications than controller medications.
Researchers identified a genetic pathway linked to poor response to corticosteroid treatment in children with asthma. Targeting the VNN-1 pathway may offer new therapeutic strategies for difficult-to-treat patients.
A new study from Cincinnati Children's Hospital Medical Center suggests that breastfeeding may not be a reliable method for preventing childhood obesity. The research highlights the complex relationship between breastfeeding and obesity, citing factors such as maternal obesity and alterations in digestive system processing.
Researchers at Cincinnati Children's Hospital Medical Center found that the size and patterning accuracy of an embryo depend on the amount of reproductive resources invested in by mothers before eggs leave the ovary. The study used fruit flies to develop a mathematical model, TEMS, which links core pieces of the developmental picture. ...
Researchers found that restricting maternal immune cells from the placenta can protect against pregnancy complications during maternal infection and complications not triggered by prenatal infection. Blocking CXCR3 effectively eliminated fetal resorption and restored healthy live offspring to Listeria infected mice.
A new study has linked Attention Deficit Hyperactivity Disorder (ADHD) and conduct disorder to increased tobacco and alcohol use in young teens. Teens with these conditions were more likely to initiate substance use at a younger age, highlighting the importance of early prevention strategies.
Scientists at Cincinnati Children's Hospital Medical Center have identified a class of lead compounds that successfully recognize a key target in the Ras signaling pathway, opening the door to future development of therapies. The lead compound NSC-658497 was found to be effective at blocking SOS1-mediated molecular signaling in the Ras...
Researchers developed a standardized approach to reducing cardiac monitor alarms, resulting in an 80% reduction in daily alarms and a 95% increase in caregiver compliance. The process increased staff's ability to address significant alarms promptly, improving patient safety.
Researchers found that children hospitalized for asthma are nearly twice as likely to be rehospitalized if they live in areas with high housing code violations. Integrating housing data with health data can help target patients for medical interventions and improve healthcare delivery at the population and patient level.
Researchers at Cincinnati Children's Hospital Medical Center successfully generated functional human stomach tissue in a laboratory using pluripotent stem cells. This breakthrough enables the study of stomach development and diseases, including cancer and diabetes.