Researchers have successfully transplanted human intestinal organoids into mice, creating a model to study intestinal diseases and potentially treat conditions like Crohn's disease. The findings could lead to bioengineering personalized human intestinal tissue for treatment.
Scientists at Cincinnati Children's Hospital Medical Center developed a new cell transplantation therapy to treat mice with a rare lung disease. The therapy, using macrophages, corrected the disease in mice and showed promise for treating other human lung diseases caused by dysfunctional immune cells.
Researchers discovered that disrupting a tumor suppressor gene disrupts the formation of the protective insulating sheath on peripheral nerves, leading to muscle wasting and neuropathy. The study suggests that normal molecular function of Lkb1 is essential for proper myelination.
Eosinophilic gastritis is a chronic inflammatory condition characterized by high levels of eosinophils in the blood and gastrointestinal tract. The study found that it involves allergy-associated-immune mechanisms and has a distinct gene expression pattern, paving the way for improved diagnosis and treatment.
Research found that environment plays a significant role in the development of eosinophilic esophagitis, a severe and often painful food allergy. The study also identified several environmental risk factors, including food allergies and high twin birth-weight difference.
Researchers have identified a gene network that fuels aggressive Acute Myeloid Leukemia and its precursor disease Myelodysplastic Syndrome. Inhibiting a key protein in this network may prevent leukemia cell growth and expansion.
A novel molecular pathway has been identified that causes aggressive medulloblastoma, and suggests repurposing an anti-depressant medication could help combat the disease. Elevated levels of cAMP may enhance the potency of Sonic hedgehog inhibitors, currently being tested in clinical trials.
A crucial molecular key, Wnt5a, has been identified for healthy embryo implantation and pregnancy. Disruption of this signaling pathway can lead to infertility, miscarriage, or preterm birth.
Researchers at Cincinnati Children's Hospital Medical Center have identified a molecular pathway in the esophagus that causes eosinophillic esophagitis, a chronic inflammatory disorder of the esophagus. The study suggests new therapeutic strategies by targeting an enzyme called calpain14, which can be inhibited by drugs.
A new study challenges the use of stem cells in heart attack patients, finding that they do not regenerate damaged heart tissue at high enough rates. The study suggests that any potential benefit from injecting c-kit-positive cells into the hearts of patients may come from improving circulation rather than generating new cardiomyocytes.
New studies reveal a connection between diabetes and low milk supply in new mothers. Women with gestational diabetes are more likely to experience lactation issues, highlighting the need for targeted therapies to support breastfeeding success.
A new study reveals that severely obese teens are at risk of nutritional deficiencies, particularly low iron and mild anemia, even those who did not undergo weight loss surgery. Researchers found durable weight loss in teens who received gastric bypass surgery, but significant nutritional problems persisted.
A recent study published in the Journal of the American Medical Association found that high doses of steroids are ineffective in improving medical outcomes for infants with end-stage pediatric liver disease. The research also suggests that steroid treatment may lead to earlier onset of serious adverse events.
A new study from Cincinnati Children's Hospital Medical Center found that nearly three-quarters of heavily breastfed infants in the US do not receive adequate dietary diversity until age 2. The researchers suggest that better education on introducing multiple food groups may be necessary to address this issue.
A new study finds that air pollution from traffic dramatically increases the odds of hospital readmission for asthma among white children. In contrast, black children were not found to have increased risk despite having higher rates of asthma readmission overall.
A new blood test helps solve the dilemma of confounded clinical trials for septic shock by identifying low-risk and high-risk patients. The tool combines five protein biomarkers to accurately estimate mortality risk and determine which patients should receive experimental therapeutic intervention.
A study involving twin sisters has identified a novel molecular target, SETD2, which can become a way to treat recurring and deadly malignancies. The researchers found that the SETD2 gene mutation contributes to the initiation and progression of leukemia by promoting the self-renewal potential of leukemia stem cells.
Researchers at Cincinnati Children's Hospital Medical Center have successfully treated mouse models of Hurler syndrome with gene therapy delivered via platelets and bone marrow cells. The treatment resulted in complete metabolic correction of the disease, normalizing IDUA levels in peripheral organs.
A new study found that financial and social hardships are a major contributor to hospital asthma readmissions among black children. Nearly 23% of black children were re-admitted within a year, compared to 11% of white children.
A new study published in Pediatrics reveals that HPV vaccine perceptions do not influence subsequent sexual behaviors in teenage girls and young women. The vast majority of participants maintained safer sex habits after vaccination, regardless of their beliefs about the vaccine's effectiveness.
A new diagnostic tool, PERSEVERE, has been developed to predict mortality risk in children with septic shock. The tool, which measures five biomarkers and combines patient information, estimates the probability of survival and helps guide treatment decisions.
A quality improvement initiative in a primary care setting improved asthma control and outcomes for high-risk teenagers through standardized care, self-monitoring, and care coordination. The study showed significant improvements in patients' chronic asthma not well-controlled, with increased adherence to treatment.
A new study finds that exposure to secondhand smoke at home or in the car increases the odds of children being readmitted to the hospital within a year of being admitted for asthma. Cotinine levels measured in the blood and saliva of over 600 children showed a significant correlation between tobacco exposure and increased risk of futur...
Researchers found that metformin inhibits mTOR pathway, which supports cancer growth, rather than activating AMPK. Metformin may still be useful for cancer treatment, but clinicians should use caution when interpreting data.
Researchers used genetic information from fruit fly studies to develop a therapeutic strategy that stops an aggressive form of leukemia in laboratory models. They found that targeting microRNAs can significantly improve current therapies for acute myelogenous leukemia, a deadly disease with poor prognosis.
Researchers developed a molecular test based on a 96 gene expression profile to improve diagnosis and treatment of EoE. The test identified patients with approximately 96% sensitivity and 98% specificity, providing a reliable next-generation diagnosis.
Researchers have identified a new pathway that kills eosinophils before they can cause harm. The study found that targeting this pathway could lead to new therapies for devastating eosinophilic disorders.
Research at Cincinnati Children's Hospital Medical Center reveals that newborn infants' immune systems suppress helpful bacteria colonization by CD71+ cells, leading to infection susceptibility. The study proposes a new explanation for neonatal infections and suggests temporary immune suppression extends beyond the intestines.
A new study found that obesity is the largest predictor of earlier onset puberty in girls, with white girls experiencing breast development at a median age of 9.7 years. The study suggests that greater obesity may be the cause of this phenomenon, highlighting potential psychosocial and biologic outcomes for affected girls.
A new study published in Pediatrics found that widespread vaccination of adolescents for pertussis was linked to a modest reduction in infant hospitalizations. The research suggests increasing vaccination rates among teens and adults is crucial to stem the ongoing pertussis epidemic among infants.
Researchers found that an unexpected flip in the Wnt signaling pathway causes hematopoietic stem cell aging. Blocking this protein, Wnt5a, rejuvenated aged HSCs in mice.
Researchers found that RhoA is necessary for proper regulation of cytokinesis in hematopoietic progenitor cells, which produce specific types of blood cells. The study showed that RhoA deficiency causes hematopoietic failure and defective blood cell production.
A national study of 2 to 5 year olds shows that psychotropic prescription use has leveled off since 2006. The likelihood of receiving behavioral diagnoses increased during this time but was not accompanied by a corresponding increase in psychotropic prescriptions.
A study published in Pediatrics shows a significant increase in emergency room visits for children with sports-related traumatic brain injuries, including concussions. The number of admissions also rose, with patients with less severe injuries being treated in the hospital more frequently.
A new study published by Cincinnati Children's Hospital Medical Center found a strong link between exposure to diesel exhaust and increased asthma severity in children. The research suggests that neutralizing the protein IL-17A could be a useful potential therapeutic strategy to counteract the effects of traffic-related air pollution.
A new study found that 92% of new moms reported at least one breastfeeding concern three days after birth, with infant feeding issues being the most common. The study suggests a two-pronged approach to support breastfeeding mothers, including strengthening protective factors and ensuring professional lactation support.
A new imaging technique, MRE, can accurately detect fibrosis in children with chronic liver disease, including non-alcoholic fatty liver disease. The study showed high accuracy in detecting advanced fibrosis in obese patients, potentially reducing the need for costly and invasive liver biopsies.
Researchers found that defects in the NF1/Ras molecular pathway trigger production of harmful oxidative nitric oxide molecules in glial brain cells, leading to behavioral issues. Antioxidant treatment reversed symptoms in mouse models of NF1 and Costello syndrome, suggesting a potential therapeutic approach for related human conditions.
Researchers at Cincinnati Children's Hospital Medical Center have developed an antibody that prevents Candida albicans from binding to heparin, stopping biofilm formation in a rat model. The study suggests that standard anticoagulants may facilitate biofilm formation by microbes, highlighting the need for new prevention strategies.
A biomarker test has been shown to accurately detect acute kidney injury (AKI) in a diverse group of patients admitted from the emergency department. The test measures neutrophil gelatinase-associated lipocalin (NGAL) and can provide results within 15 minutes, allowing for timely treatment.
A new study identified an underlying molecular process causing DFNB49 non-syndromic hearing loss, which may also affect other organs. Researchers found that a mutation in the TRIC gene disrupts tricellulin production, leading to structural changes and potential cellular damage.
Researchers have identified a molecular signature in human tissue samples from women who experienced premature birth. A combinatory treatment strategy involving rapamycin and progesterone effectively prevented preterm birth in mice model, suggesting potential for reducing incidence in high-risk women.
Researchers from Cincinnati Children's Hospital Medical Center found that inhibiting RUNX1 protein could be a promising therapeutic strategy for acute myeloid leukemia. The study suggests that blocking this protein may stop the development of leukemia cells, offering potential new treatment options.
Researchers found that texting significantly affected drivers' speed and lane position for all study participants, with added risks for drivers with ADHD. The study used a driving simulator to test 61 16- and 17-year-old drivers with varying levels of ADHD diagnoses.
A study suggests blocking part of a DNA repair complex can increase chemotherapy effectiveness and enhance survival in therapy-resistant leukemia. Researchers found that combining mTOR inhibitors with chemotherapy was far more effective at treating T-cell acute lymphoblastic leukemia (T-ALL) than standalone treatments.
A new therapeutic approach to treating prostate cancer has been identified through a study on the FoxM1 protein. Depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation, metastasis, and new blood vessel formation.
A new study reveals that pressure ulcers in children are more common than previously thought, with medical devices such as facemasks and pulse oximeters identified as major contributors. Cincinnati Children's researchers developed a quality improvement initiative that reduced pressure ulcers by 50 percent.
A new study shows that everolimus dramatically reduces seizures in patients with tuberous sclerosis complex (TSC), a genetic disease characterized by benign tumors on multiple organ systems. The drug also improves overall quality of life, with significant reductions in seizure frequency and duration.
Scientists have successfully targeted a malfunctioning immune system enzyme to eliminate diseased cells from patients with myelodysplastic syndrome (MDS), a blood disorder and precursor to leukemia. The research provides a molecular target for designing new drugs, offering a promising treatment option.
A new study by Cincinnati Children's Hospital Medical Center and the University of California Davis has made a significant discovery about insulin's role in lactation. Insulin plays a crucial role in regulating the production of breast milk, particularly for mothers with sub-optimal glucose metabolism.