Researchers developed a decision tool called the Pediatric Asthma Risk Score (PARS) to predict asthma in young children. PARS is 11% more sensitive than existing tools and delivers personalized risk scores.
Researchers have developed a gene therapy treatment that is reversing disease symptoms in two adults with Sickle Cell Anemia. The treatment, which uses reduced-intensity preconditioning, shows promise for transportability to resource-challenged parts of the world where SCA is most common.
A daily hydroxyurea pill has been shown to improve health outcomes for young children with sickle cell anemia in resource-challenged sub-Saharan Africa. The treatment reduced rates of pain episodes, infections, malaria, transfusions, and death by significant margins.
A new study suggests that a neck collar may help protect the brain of female high school soccer players from cumulative head impact exposure. The Q-Collar, designed to increase brain blood volume during collisions, showed no significant white matter changes in those who wore it.
Scientists successfully inserted human DNA into transgenic laboratory mice, allowing them to study the biology of preterm birth. They discovered a stress hormone called corticotrophin-releasing hormone (CRH) and its interaction with a transcription factor called DLX3 in the placenta.
A new study warns that HLH diagnoses can hide underlying malignancies, leading to delayed curative therapy for cancers. Researchers recommend using alternative diagnostic techniques to identify cancer prior to administering HLH therapy.
Researchers at Cincinnati Children's Hospital Medical Center describe a new method to improve the bone marrow transplant process, utilizing CASIN to mobilize higher quality donor HSCs and condition transplant recipients. This approach has potential to reduce toxicity and increase engraftment efficiency for vulnerable patients.
Researchers at Cincinnati Children's Hospital Medical Center successfully grew human esophageal organoids using pluripotent stem cells, enabling the study of diseases like esophageal cancer and gastroesophageal reflux disease. The bioengineered tissues were compared to patient biopsies and showed striking similarities in composition.
A recent study found that counties with higher population well-being had lower Medicare spending per beneficiary, even after adjusting for household income and healthcare capacity. The researchers suggest that positive environmental and social conditions can lead to health-related benefits and reduced healthcare costs.
Researchers at Cincinnati Children's Hospital Medical Center created a database of daily gene activity rhythms, linking them to drug metabolism. This could lead to improved timing of medication administration by synchronizing with the body's internal clock.
Researchers at Cincinnati Children's Hospital Medical Center genetically deleted Ago2 from the livers of mice, stabilizing energy metabolism and preventing obesity and diabetes. The study provides a solid basis for further research into novel therapeutic approaches to treat chronic metabolic disorders.
A new study identifies HIF1A, a gene that regulates metabolic changes and oxygen levels in cells, as a potential therapeutic target for treating myelodysplastic syndromes (MDS). The researchers found that inhibiting HIF1A reversed a broad spectrum of MDS symptoms in genetic mouse models.
Researchers discovered that cholesterol disruption causes PAP, a condition where air sacs clog with surfactant. A clinical trial to test statin therapy is planned, showing improved respiratory function in patients and laboratory models.
Researchers at Cincinnati Children's Hospital Medical Center have found a potential therapeutic target for acute myeloid leukemia (AML), a deadly blood cancer with a dismal survival rate. By targeting the F-box protein Skp2, they were able to kill AML cells and induce healthy white blood cell regeneration in preclinical tests.
Researchers at Cincinnati Children's Hospital Medical Center have uncovered the biological role of the CHD8 gene in developing oligodendrocytes, cells that form a protective insulation around nerves. Modulating CHD8 activity may help restore neuronal connections and reduce symptoms in people with autism spectrum disorder.
Researchers at Cincinnati Children's Hospital Medical Center found that a protein called AMPK drives aggressive and deadly brain cancers like glioblastoma. Blocking AMPK may produce therapeutic benefit for patients with few treatment options. Additional research is needed to translate the findings into patient care.
A study published in Communications Biology has linked the protein PARP1 to an aggressive form of pediatric liver cancer called hepatoblastoma. Researchers found that inhibiting PARP1 slowed or stopped cancer progression in laboratory tests, providing a potential treatment target for this disease.
A new study published in PNAS reveals that a protein called hamartin plays a central role in shutting down the nephron formation process in preterm infants. By reducing hamartin levels, researchers found that preterm babies could develop 25% more nephrons than control groups.
Researchers have identified a control switch that regulates genetic signals during embryonic development, which could help prevent birth defects and cancers. The study found that externally driven fluctuations in gene signaling are suppressed by the Notch pathway, a potential target for modulating genetic signals.
Tissue-engineered human pancreatic islets developed a circulatory system and secreted hormones like insulin, resolving the disease in transplanted mice. The self-condensation cell culture process promotes vascularization, offering a potential curative strategy for type 1 diabetes.
Scientists from Cincinnati Children's and UCSF have discovered a mechanism behind an unusual form of tissue regeneration in mice with Alagille syndrome, a rare liver disease. This discovery may lead to a viable treatment for human disease by instructing other types of liver cells to switch identities.
Scientists have identified three distinct subtypes of eosinophilic esophagitis, an emerging food allergic disease. The discovery provides a framework for developing precision medicines tailored to specific patient groups.
A pilot study found that machine learning algorithms can accurately predict students at risk of perpetrating school violence, outperforming human assessments in some cases. The technology has the potential to aid in preventing school violence by identifying high-risk individuals and providing targeted interventions.
Researchers at Cincinnati Children's Hospital Medical Center mapped critical brain-to-spinal cord nerve connections that drive voluntary movement in forelimbs. The study identified specific neurons that control different skilled movements and provided insights into the organization and function of corticospinal circuits.
Researchers propose novel molecular therapy to treat deadly pediatric brain cancer, effective in preclinical tests and humanized mouse models. The compound triggers DNA damage in cancer cells, disrupting telomere function and killing brain cancer stem cells.
A new study found the Epstein-Barr virus is linked to seven serious diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), and type 1 diabetes. The virus affects nearly 8 million people in the US, highlighting a common cause of chronic illness.
Researchers used an experimental therapy to block fibronectin protein, reducing scarred muscle tissue and saving mouse models from heart failure. The treatment restored function in damaged heart cells and reduced fibrosis.
Researchers at Cincinnati Children's Hospital Medical Center have identified a new molecular target, FOXF1, that slows or stops idiopathic pulmonary fibrosis (IPF) in preclinical laboratory tests. The study found that FOXF1 inhibits IPF disease process by regulating genes involved in lung scarring and inflammation.
A new study reveals a significant increase in dementia risk among adults born with congenital heart disease, with a 60% increased risk compared to the general population. The risk was even higher for those under 65 years old, with a 160% increase.
Researchers found that ancient proteins in insect and mammal brains share common ancestry as regulators of body temperature rhythms crucial to metabolism and sleep. This discovery may lead to new treatments for circadian clock diseases and sleep problems.
Researchers crack genetic code of malignant peripheral nerve sheath tumors and identify Lats1/2 as a gene that suppresses cancer, leading to rapid cell expansion. Disrupting overactive TAZ-YAP signaling reduces tumor growth in mice and human cells, offering new hope for MPNST treatment.
Scientists at Cincinnati Children's Hospital Medical Center have developed an experimental molecular therapy that restores nerve insulation in mice, improving limb function and reducing discomfort. The treatment targets the enzyme HDAC3, which is involved in epigenetic changes that restrict myelin regeneration.
Researchers discovered that glands in the uterus must connect directly with the embryo for it to implant and begin a healthy pregnancy. The Vangl2 gene plays a crucial role in this process, producing molecules essential for embryo development.
Researchers from Cincinnati Children's Hospital Medical Center and Yokohama City University report a high-volume production method for bioengineered human gut and liver tissues that avoids tumor risks. The new approach uses genetically stable posterior gut endodermal progenitor cells, which can be programmed to form different tissue ty...
Researchers identified the role of Gimap5 in regulating T cell function and found that GSK3 inhibitors can improve immune system function in mice and restore normal T cell function in human cells. This discovery may lead to new treatments for autoimmune diseases such as Type 1 diabetes, systemic lupus erythematosus, or asthma.
Infants born in opioid withdrawal after utero exposure show a significant increase in torticollis and plagiocephaly. These abnormalities can be prevented with early preventive measures, such as occupational and physical therapy.
New research reveals obesity causes durable and harmful changes to hematopoietic stem cell compartment, potentially impacting blood cancer development. The study also suggests lifestyle choices like diet may durably impact blood formation.
Exposure to air pollution just prior to conception or during the first month of pregnancy increases the risk of birth defects, such as cleft lip or palate. The study found that fine particulate matter is a significant health hazard and public health efforts should minimize population-level exposure.
Scientists have successfully developed a biologically accurate mass-production platform for bioengineering human liver tissues suitable for therapeutic transplant into people. The new process allows researchers to generate single batches of up to 20,000 genetically matched, three-dimensional and highly functional liver micro-buds.
Researchers at Cincinnati Children's Hospital Medical Center have identified a strong biomarker candidate for early diagnosis and treatment of biliary atresia, a rare disease causing liver damage in infants. The test, using matrix metalloproteinase-7 (MMP-7), shows high sensitivity and specificity in detecting the condition.
Researchers at Cincinnati Children's Hospital Medical Center discovered that some women who develop symptom-free Zika infections may acquire immunity that protects them from future infections and their offspring. This finding suggests the possibility of developing diagnostic tests to identify naturally immune women, which could help pr...
A new study published in Pediatrics found that routine laboratory screenings for children entering foster care carry high costs and questionable medical benefits. Targeted screening may be a more cost-effective approach, particularly for conditions such as anemia, lead poisoning, chlamydia, and gonorrhea.
Researchers at Cincinnati Children's Hospital Medical Center found that blocking a molecular pathway can stop or slow cardiac fibrosis, organ enlargement, and preserve heart function. The study provides new insights into what causes cardiac fibrosis and opens the potential for finding new therapeutic approaches.
New research reveals up to 40% of children with hearing loss have capacity for higher language levels, challenging current assessment methods. Therapists can recognize mismatches at young ages and intervene to bring children up to their ability.
Researchers at Cincinnati Children's Hospital Medical Center have identified Polycomb Repressive Complex 1 (PRC1) as a key molecular switch that activates healthy sperm production in males. The study reveals that PRC1 sheds reproductive germline gene components, allowing fertile sperm to develop when the time is right.
Researchers warn that off-road vehicles can produce airborne asbestos and erionite, posing a risk to children and others. The study highlights the need for precautions, such as wearing safety masks and goggles, when using ORVs in areas with naturally occurring asbestos deposits.
A study of nearly 400 preschool children found that only one adhered to the 5-2-1-0 guidelines for a full 24-hour period. The study suggests room for improvement in dietary intake, physical activity, and screen time among young children.
Researchers at Cincinnati Children's Hospital Medical Center report encouraging preclinical results on an experimental molecular treatment for heart failure. By inhibiting a protein that regulates the heart's response to adrenaline, they alleviated disease processes in mouse models of human heart failure.
Researchers found that blocking molecular nerve pruning in mice enhanced manual dexterity and allowed them to grab and eat food faster than wild-type mice. The study identified a protein called PlexA1, which controls the formation of long nerves and fine motor skills.
Researchers found a molecular link between obesity, inflammation, and cardiovascular diseases. Targeting thrombin with dabigatran protected mice from diet-induced obesity-related disease.