Researchers at Columbia University Irving Medical Center found that inhibiting serotonin synthesis in the gut effectively cured osteoporosis in mice and rats. The compound, LP533401, prevents bone breakdown while building new bone, offering a potential treatment for millions of osteoporosis sufferers.
A new study from Columbia University Medical Center researchers found that even mild cases of chronic obstructive pulmonary disease (COPD) can limit the heart's ability to pump effectively. The study, which involved over 2,800 adults, suggests a link between lung function and heart function.
A new study suggests that reducing salt in the American diet by just one-half teaspoon per day could prevent nearly 100,000 heart attacks and 92,000 deaths annually. This reduction in salt intake could also save the US around $24 billion in healthcare costs.
A new study reveals that Caribbean-origin Hispanics have a higher prevalence of hypertension, while Mexicans are more susceptible to diabetes. The research highlights the importance of considering crucial distinctions among Hispanic ethnic subgroups to prevent adverse cardiovascular events.
A study from Columbia University Medical Center found that an excess of one type of serotonin receptor in the brain's center may cause antidepressants to fail for half of patients. Researchers created a mouse model with high and low receptor levels, showing that reducing receptors can transform non-responders into responders.
Researchers have identified two genes, C/EPB and Stat3, which are responsible for the most aggressive forms of human brain cancer. These genes work together to transform normal brain cells into highly aggressive cells, making them a major target for new treatments.
Dr. Bergman's work developed a glucose 'disposition index' that quantifies the nature of interactions between insulin sensitivity and pancreatic secretion, predictive of type 2 diabetes development. The awards ceremony recognizes his contributions to understanding carbohydrate metabolism and identifying risk factors for type 2 diabetes.
A new study linked erythropoiesis-stimulating agents (ESAs) to a higher risk of venous thromboembolism in cancer patients. The analysis, published in the Journal of the National Cancer Institute, suggests that ESAs may not be worth the increased risk of blood clots.
The 4th annual Katz Prizes in Cardiovascular Research recognize outstanding contributions by senior scientist Elizabeth G. Nabel and young investigator John P. Morrow, who are judged by an independent panel of peers.
The study found that students taught by participating teachers passed Regents science exams at a rate 10.1 percentage points higher than non-participating teachers' students. The program provides hands-on laboratory experience and funds for science supplies, encouraging teachers to implement more interactive exercises in their classrooms.
Researchers at Columbia University Irving Medical Center found a new type of adult stem cell, CARNs, in the prostate that can give rise to cancer if tumor suppressor genes are inactivated. The discovery resolves controversy over the origin of prostate cancer cells and may help develop better treatments.
Researchers at Columbia University Irving Medical Center have identified an area of the brain involved in the earliest stages of schizophrenia. Activity in this region, known as the CA1 subfield, may help predict disease progression and provide opportunities for more targeted drug development to block the mechanism.
Researchers at Columbia University Medical Center found that a cancer drug can restore memory deficits in patients with Alzheimer's disease by targeting a previously unknown defect in the brain. The drug works by increasing DNA spool acetylation and gene transcription, leading to improved memory performance.
Researchers at Columbia University Medical Center have identified a previously unknown leptin-serotonin pathway in the brain that simultaneously promotes appetite and bone mass accrual. The discovery reveals that leptin acts on serotonin in the brain stem, increasing appetite and bone mass.
A protein called Huwe1 normally functions to eliminate unnecessary proteins, acting as a tumor suppressor in brain cancer. Deregulation of Huwe1 function is involved in tumor development and may be an important factor in the development of brain cancer.
A new observational study found that being physically active and adhering to a Mediterranean-type diet are associated with reduced risk of Alzheimer's. The study, published in the Journal of the American Medical Association, followed 1880 elderly subjects over five and a half years.
Researchers at Columbia University Medical Center have discovered a protein called NGAL that can help diagnose kidney disease caused by HIV. High levels of the protein in urine may indicate the presence of HIV-associated nephropathy, allowing for earlier intervention and potentially preventing kidney failure.
Researchers aim to develop an optimal early intervention strategy to treat first episode psychosis, reducing disability and mortality. The Recovery After Initial Schizophrenic Episode (RAISE) study will test culturally appropriate interventions in community-based sites.
A team of experts at Columbia University will conduct the largest ever study on suicide and mental health among military personnel, using $50 million in funding. The study aims to identify risk and protective factors for suicide among soldiers and provide a science base for effective interventions.
A new study found that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races, even when controlling for medical treatment and socioeconomic factors. The analysis of over 20,000 patient records suggests a potential role for genetic factors in the survival gap.
Researchers found that gastrin stimulates gastric acid secretion and plays a significant role in the development of Helicobacter-induced stomach cancer. High levels of gastrin may increase cancer risk, while low levels may lead to more tumors in specific parts of the stomach.
Researchers found subtle seizures may prolong recovery and worsen outcome among ICU patients, emphasizing the importance of continuous EEG monitoring. The studies suggest treating clinically silent seizures with anti-seizure medications may help prevent neuronal damage and improve patient outcomes.
A phase I clinical trial of Zyflamend, a novel herbal therapy, demonstrates its safety and tolerability in men with high-grade prostatic intraepithelial neoplasia (HGPIN), a precursor to prostate cancer. The study confirms that Zyflamend is well-tolerated when administered orally for up to 18 months.
Researchers have identified a specific gene and protein that contribute to the development of deadly arterial plaques. Deleting this gene in mice resulted in smaller, less unstable plaques. The study suggests that therapies targeting cellular stress may be useful in treating heart disease.
Researchers identified small steps healthcare providers can take to improve compliance with immunization appointments, such as discussing vaccine importance and having open lines of communication. A significant association was found between missed visits and under-immunization, highlighting the need for educational campaigns and online...
Researchers at Columbia University Irving Medical Center have identified a protein called oct3 that plays a critical role in both Parkinson's disease and addictive drugs. The protein helps toxic chemicals reach dopamine neurons, leading to cell death in patients with Parkinson's disease.
Researchers at Columbia University Medical Center found that dopamine, a calcium channel, and alpha-synuclein act together to kill brain cells in Parkinson's disease. The discovery gives hope for saving neurons and stopping the progression of the disease by targeting just one of the three factors.
A recent study published in Journal of Insurance Medicine found that the economic impact of undiagnosed celiac disease is significant, resulting in cost savings for the healthcare system after diagnosis. The study suggests that increased awareness and diagnosis of celiac disease can lead to health care costs savings.
A team of Columbia University researchers has identified a new investigational therapy for bladder cancer, inhibiting the mTOR signaling pathway with rapamycin. The discovery demonstrates that p53 and PTEN tumor suppressor genes are inactivated in invasive bladder cancer.
Researchers found significant discrepancies between self-reported fatigue and actigraphy readings, suggesting a link between heart failure, sleep disorders, and impairments in health-related quality of life. The study may lead to different approaches to patients suffering from anergia or 'lack of energy'.
Researchers at Columbia University Medical Center found that diabetes and high cholesterol are associated with faster cognitive decline in Alzheimer's patients. The study also suggests that controlling vascular conditions may help delay the progression of the disease.
A study at Columbia University Medical Center found that experimental heart failure drugs may slow muscle loss in Duchenne muscular dystrophy, a fatal genetic disorder. The new class of drugs targets the same microscopic leak that weakens both skeletal and cardiac muscles.
A Columbia University study found that a diet rich in fish oils can prevent fat accumulation in arteries and lower cholesterol levels. The researchers discovered that omega-3 fatty acids inhibit the entry of 'bad' cholesterol into arteries, providing new insights into heart health benefits.
Researchers have identified a new gene, ELP4, linked to Rolandic epilepsy, a common form of childhood epilepsy. The discovery supports a new theory about the causes of epilepsy and offers insights into other cognitive and behavioral disorders such as ADHD, speech dyspraxia, and DCD.
Lung airway epithelial cells initiate an immune response to inhaled bacteria by signaling white blood cells to move into the lungs. Researchers have identified a way to inhibit proteases and restrict junctions between cells, reducing inflammation and allowing optimal white blood cell response.
A study by Columbia University Medical Center researchers found that rising blood glucose levels may contribute to normal cognitive decline in aging. Exercise has been suggested as a potential strategy to improve cognitive health by lowering glucose levels and improving brain function.
Researchers at Columbia University Medical Center discovered a chemical that counters the negative impact of leptin on drug-eluting stents used in diabetic patients. This finding could lead to improved outcomes for diabetics who receive stents.
Researchers at Columbia University Medical Center have designed a new way to grow bone and other tissues by co-transplanting hematopoietic and mesenchymal stem cells. This approach results in faster regeneration of vascularized tissues compared to previous methods.
Researchers at Columbia University discovered that gut serotonin plays a crucial role in bone formation, challenging the long-held belief that the skeleton controls bone growth. The study found that inhibiting serotonin release can increase bone mass and potentially treat osteoporosis.
A study of smokers with attention deficit and hyperactivity symptoms found those with elevated hyperactivity and impulsivity showed lower quit rates compared to those with inattention or no A.D.H.D. symptoms.
Columbia University Irving Medical Center honors Dr. Bruce Spiegelman with the Naomi Berrie Award for his groundbreaking work on metabolic pathways of obesity and diabetes research. Dr. Spiegelman's discoveries have identified key molecules critical in fat cell differentiation, insulin resistance, and energy expenditure. Meanwhile, jun...
Researchers found that blocking Cyclophilin D and developing surrounding mitochondrial targets may be viable strategies for preventing and treating Alzheimer's disease. The study provides new insights into the mechanism underlying amyloid beta-mediated mitochondrial stress, which links to synaptic plasticity and learning/memory.
Researchers at Columbia University Medical Center have discovered that elevated levels of interleukin-1 beta can initiate the progression towards stomach cancer. The study found that IL-1β works by activating myeloid derived suppressor cells, which are pro-inflammatory and contribute to gastric inflammation.
A simple blood test to detect Alzheimer's disease is within sight, with a specific peptide in the blood plasma indicating increased risk. The decline of this peptide may reflect the compartmentalization of amyloid Beta 42 in the brain, occurring in people with Alzheimer's.
Researchers discovered that turmeric-treated mice were less susceptible to developing Type 2 diabetes and showed reduced inflammation in fat tissue and liver. Curcumin's anti-inflammatory properties may lessen insulin resistance and prevent the disease.
Researchers have discovered a new kidney protein, NGAL, that can diagnose sudden kidney failure days sooner than current tests. A simple urine test for NGAL can help emergency department physicians accurately diagnose kidney failure and make evidence-based treatment decisions.
A study by Columbia University Irving Medical Center researchers has identified rare spontaneous copy number mutations in the genomes of individuals with schizophrenia, accounting for at least 10% of non-familial cases. These genetic mutations were found to be present in affected individuals but not in their biological parents.
The HORIZONS-AMI trial shows that bivalirudin reduces adverse clinical events by 24%, mortality by 33%, and cardiac mortality by 38% compared to heparin and GPI in heart attack patients. This is the largest study ever to focus on anticoagulant medications in STEMI patients undergoing primary PCI.
Researchers at Columbia University Irving Medical Center have discovered a previously unknown alteration in microRNA production linked to schizophrenia. By modeling mice with the same chromosome 22q11.2 deletion as humans with schizophrenia, they found that abnormalities in microRNAs can lead to synaptic and behavioral deficits.
The Naomi Berrie Diabetes Center will receive $21 million for non-reimbursed clinical care, new pilot research, and more. The center aims to develop a cure for diabetes through focused clinical and basic science research efforts.