A recent study published in EBioMedicine found that yellow fever virus causes myocardial fibrosis, cardiomyocyte hypertrophy, and vascular endothelium alterations, leading to cardiac conduction system disruption. The research provides new insights into the pathogenesis of YF-associated heart injury.
Nanoparticles loaded with antibiotics and antimicrobial compounds inhibit TB progression and overcome resistance without cell damage. The technology shows promise for a shorter treatment strategy against multidrug-resistant strains of Mycobacterium tuberculosis.
Brazilian researchers developed a 3D zinc oxide photocatalyst that efficiently degrades sertraline, an emerging pollutant contaminating groundwater. The material's high photocatalytic activity and stability make it suitable for wastewater treatment.
Photodynamic action weakens resistance to antibiotics in bacteria that attack airways, reducing the persistence of both standard and clinical strains. The study found that five cycles of PDI were sufficient to break the resistance of resistant bacteria.
Recent research has identified the gut-skin axis as a critical factor in atopic dermatitis, with alterations to gut microbiome composition contributing to disease severity. The review article highlights promising therapeutic approaches, including diet, probiotics, and fecal transplants.
Air quality in São Paulo fell far below standards and WHO recommendations despite reduced emissions during the pandemic. The study identified four main sources of aerosols: heavy vehicles, soil dust, light vehicles, and local sources, including industrial emissions and fires.
Embedding nanodiamonds in polymer can advance quantum computing and biological studies. The technique, developed at the University of São Paulo, enables integration of quantum emitters into photonic devices and cell marking applications.
The São Paulo School of Advanced Science on Precision Livestock Farming aims to empower graduate students and early-career researchers with machine learning, statistical tools, and database systems. The school will provide a platform for them to process vast amounts of data and develop a multidisciplinary approach to PLF.
Researchers at UNICAMP developed a new technology to create bridges between superconducting circuits and optical fibers, enabling efficient transmission of information in the electromagnetic spectrum. This breakthrough paves the way for the development of advanced quantum networks with potential applications in computing and communicat...
Scientists in Brazil have developed a method to obtain a substance similar to estrogen from soy isoflavones, which may help alleviate menopause symptoms. The researchers extracted equol from soybean oil production residue and found it to be more bioavailable than glycosylated forms.
The São Paulo School of Advanced Science on Quantum Materials will select and support 100 graduate students and young researchers to focus on fundamental, theoretical, and experimental aspects of quantum materials. The program will cover topics like superconductivity, electronic topology, and complex magnetic configurations.
A fungus-based biopesticide is less lethal to mammals than synthetic insecticides but can wipe out colonies of wasps that benefit plants by feeding on pests and performing pollination. The study found that infected wasps are not detected by nestmates, potentially threatening the survival of these species.
Researchers at the Center for Development of Functional Materials created a sensor to monitor metronidazole levels in organisms and the environment. The sensor, combining magnetic fluorescent nanoparticles, showed good sensitivity and practical advantages, enabling real-time analysis and ease of handling.
A Brazilian study found that damage to small blood vessels in the lungs causes severe COVID-19. The researchers observed high prevalence of microscopic blood clots in lung endothelial cells, which led to organ damage and ischemic tissue injury.
Researchers have discovered that a nanoemulsion made from copaiba oil has antiviral effects against zika virus, showing 80% viral RNA inhibition. The study's results pave the way for developing medications or specific vaccines against zika.
The São Paulo School of Advanced Science on Transdisciplinarity for Transformative Change is a training opportunity for graduate students and researchers to co-produce knowledge for global sustainability. The school will focus on transdisciplinarity in social-environmental sciences, offering state-of-the-art science and research results.
A study by UNICAMP researchers found high concentrations of contaminants in the Piracicaba, Capivari and Jundiaí River Basin, including PFAS compounds, pesticides, and industrial chemicals. The study highlights the severity of pollution in the region, which supplies water for drinking, irrigation, and industry.
Researchers found that a rise in South Atlantic temperature caused a release of trapped CO2 into the atmosphere, affecting climate regulation. This process has implications for current climate change and potential collapse of the AMOC.
The review highlights Brazil's importance in global sustainability efforts, with the country having twice as many articles on sugarcane as the US. Genetic engineering techniques need improvement to increase ethanol production while minimizing crop expansion. CRISPR-Cas9 gene editing is a promising approach for precise modifications.
A computational study conducted by Brazilian researchers found that current density and active species concentration are the main variables affecting capacity loss. The approach successfully mitigated cross-contamination, providing an optimal flow between electrolyte tanks under different operating conditions.
A new fossil assemblage in Brazil has added to the complexity of classifying silesaurid phylogeny, a family of dinosauriforms that lived during the Triassic period. The study suggests that these animals were part of the evolutionary history of dinosaurs, but their classification remains uncertain due to ambiguous anatomy.
Researchers at São Paulo State University developed a novel biomaterial that speeds up osteoblast differentiation, mimicking a low-oxygen environment. The cobalt-doped calcium phosphate material has the potential to be used in future bone regeneration procedures, reducing surgery risks and hospital stays.
Researchers found rabies virus variants closely related to those in White-tufted marmosets in bats, highlighting potential for human transmission. Genetic sequencing revealed complex spillover dynamics between hosts, emphasizing the need for public health measures and animal conservation.
Scientists developed a high-throughput method to study oxidized lipids in ALS. Analysis of blood plasma from rats with ALS revealed 17 oxylipin alterations associated with oxidative stress and inflammation. Oxylipins may serve as biomarkers for monitoring disease progression.
Researchers identified a novel bacterial protein, MceF, that can prolong cell longevity by acting directly on mitochondria. The discovery could lead to new treatments for diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders.
Researchers at the University of São Paulo have tested a synthetic molecule called AD-9308, which has shown potential in treating heart failure by activating the enzyme aldehyde dehydrogenase 2. The study found that the molecule improved mitochondrial filtration, eliminating cellular pollutants and boosting heart function by up to 40%.
Researchers developed a PCR test that accurately identifies the causative agent of visceral leishmaniasis, a neglected disease affecting Brazil and Latin America. The test can detect co-infection by both Leishmania infantum and Crithidia, with infection by Crithidia more frequent than previously thought.
Scientists identify pyroglutamination, a spontaneous chemical change, in peptide synthesis, leading to an amyloidal structure and potential implications for neurodegenerative diseases like Alzheimer's and Parkinson's. The process favors aggregation of molecules, forming plaques that interrupt neuronal flow.
Thyroid cancer incidence is significantly higher in more affluent areas of São Paulo State, Brazil, compared to less developed regions like Barretos. The study suggests overdiagnosis may be responsible for this trend, with mortality rates remaining similar across socioeconomic groups.
Researchers developed a low-cost anti-inflammatory hydrogel containing annexin A1 that accelerated complete skin wound healing in mice with induced type 1 diabetes. The hydrogel modulated the wound microenvironment and favored tissue regeneration, reducing inflammation and improving blood vessel formation.
Researchers found that most allegedly biodegradable plastic items sold by Brazilian supermarkets are actually oxo-degradable plastics banned in several countries. The products cost 125% more than conventional alternatives and failed to meet minimum requirements for genuine biodegradability.
Research found that nematodes can sense danger by smell, triggering a neural circuit that induces a response in other tissues, leading to a longer lifespan and less protein aggregation. The study suggests that manipulating perceptions of chemical substances could be a route to intervention in neurodegenerative diseases.
A study in sustainable-use reserves found local game species abundance decreases about 5 kilometers from nearest human community. Human impact on biodiversity is mitigated by management strategies, supporting community-based wildlife management for food security and conservation.
A research project involving citizens in flood-prone areas improves data collection and increases resilience. The methodology shows a combination of digital technologies, participatory methods, and co-production of new understandings to enable just and sustainable transformations.
Brazilian researchers found that Zika-infected mice with microcephaly have lower Ndel1 enzyme activity, which plays a key role in neuron differentiation and migration. The study suggests that Ndel1 may be a biomarker for early diagnosis of microcephaly and offers hope for treatment options.
Researchers at São Paulo State University found that Cerrado plant species employ two strategies to protect themselves from fire: producing thick bark and hiding organs beneath the ground. This allows them to resprout quickly after a fire event.
A recent study using SENTINEL-2 satellite images estimated burned areas with 96% accuracy, revealing a much larger area affected by wildfires than previously thought. This higher precision will help improve estimates of greenhouse gas emissions and inform fire management decisions.
Researchers have identified polyalthic acid, a compound in copaiba oil, with potent antibacterial activity against Gram-positive bacteria. The study's findings pave the way for developing alternative medications to combat antimicrobial resistance.
A recent study reveals 15%-18% of the Brazilian Amazon is at high risk of ecological disruption by 2050. The regions, often near 'deforestation arc', exhibit low research frequencies and are threatened by climate change.
A Brazilian physicist has developed an alternative method that reduces calculation time for simulating light absorption by molecules from two days to a few hours. This allows for high-resolution microscopy and the creation of precise 3D structures for data storage, with potential applications in medicinal treatments.
A novel biomaterial developed at the Federal University of São Paulo can deliver medication directly to the gastrointestinal tract of fish, enhancing the efficacy of conventional drugs. The material is administered orally in powder form and has shown high penetration into epithelial cells without cytotoxic effects.
The Cerrado, Brazil's second-largest biome, is experiencing record levels of native vegetation destruction due to agricultural expansion. Scientists warn that the loss of vegetation contributes to extreme weather events, threatens crop yields, and endangers food security policies.
Research found that poor sleep quality is associated with less muscle strength and mass, more body fat, anxiety, and depression in obese older people. The study emphasizes the importance of addressing sleep quality to prevent negative health outcomes in this population.
Researchers have discovered a key mechanism involved in dental pulp inflammation and root apex damage, which could lead to the development of medications against bone loss due to endodontic infections. The study found that tumor necrosis factor-α receptor-1 (TNFR1) plays a crucial role in protecting teeth from inflammatory processes.
Brazilian researchers screened 160 existing drugs and identified six compounds effective against Toxoplasma gondii. Almitrine, a COPD treatment, showed significant reduction in brain parasite load. Further studies are needed to repurpose these drugs for toxoplasmosis treatment.
A recent study conducted at the University of São Paulo's Medical School found that isolating patients with carbapenem-resistant Enterobacteriaceae (CRE) in emergency departments (ER) for over two days can significantly reduce CRE transmission. The researchers also discovered that the ER structure, including bed layout and hand hygiene...
A study of almost 1,000 vegan diet followers in Brazil found less than a tenth the average prevalence of dysfunctional eating behaviors. The researchers identified disordered eating attitudes among only 0.6% of participants, primarily associated with motivations for dieting rather than diet type.
Researchers have developed a standardized synthetic molasses with a fully known composition that can be used as a culture medium for yeast fermentation. This breakthrough enables scientists to study the influence of specific components and develop bioprocesses worldwide, facilitating comparative research and industrial applications.
A study published in The Journal of Physiology found that exercise suppresses hunger by acting on hormones and metabolites. Researchers suggest that understanding these mechanisms could lead to new treatments for obesity.
Researchers at São Paulo State University have developed a technique to remove glyphosate, a widely used herbicide, from contaminated water. By using functionalized cellulose fibers from sugarcane bagasse, they can effectively adsorb and remove glyphosate residues from an aqueous medium.