Researchers developed a predictive model to identify tumor biomarkers of cachexia in lung cancer patients. The study used machine learning to build a muscle loss prediction model based on muscularity, clinical data, and the transcriptional profile from the tumor microenvironment.
A 16-week remote exercise program improved cardiorespiratory fitness, lung function, and functional capacity in severe COVID-19 survivors. The study found significant benefits in health-related quality of life and reduced persistent symptoms.
A study published in Microorganisms shows that melatonin can aggravate Crohn's disease and ulcerative colitis by disrupting the balance of gut microbiota. The hormone, commonly used to improve sleep, had negative effects on bowel inflammation in laboratory mice, depending on their microbiota profile.
Researchers found that Fiocruz's partnership with AstraZeneca was crucial to the success of COVID-19 vaccine production in Brazil. The partnership demonstrated the importance of technology transfer agreements, regulatory support, and political skill. Bio-Manguinhos facility played a significant role in producing vaccines, making over 5...
Researchers have sequenced the genomes of Leatherback and Green sea turtles, revealing similarities in their immune systems and evolution. The study provides clues for understanding fibropapillomatosis, a cancer affecting these species, and informs conservation efforts.
Researchers in Brazil and UK develop process to recycle plastic from used coffee pods into conductive and non-conductive filaments. The filaments have various applications, including sensors and machinery parts.
A study with 116 participants found associations between microRNAs in extracellular vesicles and mental health disorders such as depression and ADHD. While no biomarkers were identified, the results suggest genetic material can be non-invasively accessed through blood samples.
Researchers found that environmental context influences drug dependence by associating psychostimulant effects with specific environments. The study observed behavioral sensitization and brain activation patterns in mice with cocaine dependence, mirroring human cravings for a specific environment or location.
A Brazilian study found that prenatal exposure to cannabinoids increases the risk of sudden infant death syndrome, breathing difficulties, and impaired control of breathing. The study suggests that consumption of cannabis or derivatives during pregnancy can have severe effects on the fetus's neural and physiological functions.
A Brazilian-Chinese research team has demonstrated the coexistence of non-locality and contextuality in a quantum system. The study paves the way for new quantum information processing and communication protocols by reconciling two fundamental principles of quantum theory that were thought to be mutually exclusive.
The study analyzed the growth and productivity of Botryococcus terribilis under different cultivation systems. Stress increased the production of lipids and hydrocarbons by 49% and 29%, respectively, while proteins decreased. The microalgae's metabolites have potential applications in biofuel synthesis, cosmetics, and food.
Researchers found that maternal overweight compromises the placenta's antiviral response, weakening its ability to protect the fetus. The study suggests that adequate antenatal care is crucial in preventing complications from Zika infection.
Researchers discovered a mechanism that helps explain the link between reduced levels of protein PKMzeta and neurological disorders. The study used epigenetics to show that hypermethylation of the gene regulates its expression.
A study found that savanna species in Cerrado biome produce significantly more bark than forest species to protect against frequent fires. This adaptation enables them to survive and regenerate after burning, highlighting the importance of controlled fire management in these ecosystems.
Researchers developed a simple sensor to monitor paracetamol levels in saliva in real-time, enabling personalized treatment and reducing toxic side effects. The device is low-cost, portable, and uses non-invasive collection methods, making it an attractive alternative for therapeutic drug monitoring.
Researchers developed an electrochemical sensor using 3D printing to detect Parkinson's disease at different stages by measuring levels of the protein PARK7/DJ-1. The sensor was miniaturized for portability and could be used for continual monitoring with alerts for physicians and patients.
A study found that mutant strains of Salmonella cause more severe infections in commercial poultry than wild-type bacteria. The deletion of genes ttrA and pduA led to increased immune response and pathogenicity, emphasizing the importance of animal health measures and proper food conservation.
Researchers at the University of São Paulo used artificial intelligence and Twitter to develop a database and models that can detect depression and anxiety before clinical diagnosis. The study found that BERT performed best in predicting depression and anxiety, with a statistically significant difference from LogReg.
A study of high school students in Brazil found that excessive smartphone use is associated with thoracic spine pain (TSP), affecting girls more than boys. The research highlights the importance of health education programs to combat this issue and promote physical activity and good posture.
The study reveals that a lack of community involvement and inadequate governance are major contributors to wildfire management in the Amazon region. Local stakeholders identified deficiencies in institutions, staff cuts, and underinvestment as significant vulnerabilities.
A study found that adding rosmarinic acid to sunscreen increases sun protection factor by over 41% and reduces the need for synthetic chemicals. The natural antioxidant also provides anti-aging benefits, making it a potential multifunctional compound for improved skin health.
A review of scientific literature on reptiles between 1960 and 2021 found that 15% of articles focused on only ten species, with fewer than ten studies published on 90.5% of all species. The authors attribute this bias to factors such as habitat, size, danger of extinction, and proximity to research institutions.
A systematic review of clinical trials found that strength training with moderate to vigorous intensity, two or three times a week, can significantly lower blood pressure in hypertensive patients. The study analyzed over 21,000 scientific articles and concluded that effective results appeared around the twentieth training session.
Researchers at the University of São Paulo developed a kraft paper-based electrochemical sensor that can detect traces of pesticides in fruit and vegetables in real time. The device resembles a glucometer and has been shown to be highly sensitive, fast, and inexpensive.
A study found that regular exercise increases mitochondrial fusion, benefiting muscle cells and maintaining physical fitness even in old age. Daily sessions of exercise throughout life delay the accumulation of dysfunctional mitochondria and decline in physical fitness.
Researchers have developed a novel technology for nanoencapsulation of bioactive compounds, specifically anthocyanin, using pectin and lysozyme. The methodology ensures slow release of the compound, allowing it to survive gut bacteria and digestive enzymes.
Brazilian researchers identified genes that make industrial yeast Saccharomyces cerevisiae SA-1 resistant to fermentation inhibitors generated during sugarcane bagasse preprocessing. The study paves the way for increased efficiency of second-generation ethanol production.
Exercise training after bariatric surgery alters brain networks associated with food intake and energy regulation. The study found that exercise increased connectivity between the hypothalamus and sensory areas, while decreasing links to the default mode network and salience network.
Researchers have developed a novel process to convert nitrogen and hydrogen into ammonia at ambient temperature and pressure with high energy efficiency. The process uses a solid polymeric electrolyte and eliminates the need for purification, producing pure ammonia gas.
A recent study found that the Amazon Rainforest in southwestern Brazil has experienced a significant increase in deforestation and burning, with 4,141 km² of forest destroyed between 2003 and 2019. The region's agricultural activities and infrastructure have contributed to this trend, posing a threat to conservation units and Indigenou...
A study analyzed news reports on Brazilian deer species between 2011 and 2021, finding that news coverage gave different weights to threats compared to the IUCN Red List. News items properly identified main threats like poaching and habitat loss but underestimated livestock diseases and overestimated road kill.
Brazilian researchers used a high-speed camera to capture an image of lightning rods trying to connect to nearby buildings, revealing details of the connections. The image shows that even with multiple lightning rods in place, the strike connected to a smokestack on top of one building, highlighting the importance of proper installation.
The study reveals that more than 70% of patients developed urinary tract infections caused by endogenous E. coli strains from their own gut microbiota. The researchers also found that non-lactose-fermenting E. coli strains, less common in other countries, were present in the gut microbiota of some patients.
A study in Brazil found that agricultural certification can encourage compliance with environmental laws, but doesn't necessarily reduce deforestation or increase natural regeneration. Certified coffee farms showed a general tendency for increased compliance, particularly in protected areas like the Atlantic Rainforest.
Researchers found that COVID-19 survivors with persistent symptoms were more likely to be sedentary, especially those experiencing breathlessness and fatigue. The study, supported by FAPESP, included 614 participants who were analyzed for physical activity and lifestyle habits.
A study of fossilized bones from Brazilian species found that hollow bones with air sacs enabled dinosaurs and pterosaurs to become larger, as they circulated more oxygen and stayed cooler. This trait evolved independently in different groups, including sauropods, herrerasaurids, and birds.
Two compounds, A5 and C1, have shown promising results in inhibiting the growth of glioblastoma cells, a type of aggressive brain cancer. Further research is needed to confirm their effectiveness on normal nerve cells and to move towards clinical trials.
Researchers have discovered a gene mutation that can block chronic pain and provide protection against other stimuli, including heart and brain cells. The TRPV1 receptor mutation, found in avian species, was successfully transplanted into mice, showing reduced pain sensitivity and improved protective effects.
A recent study found that resistance training significantly improved muscle strength and reduced inflammation in older adults with sarcopenia. The research, conducted by Brazilian researchers, also showed that physical exercise can improve sleep quality and reduce chronic inflammation.
Researchers analyzed zika virus effects on tumor cells and healthy cells, discovering its potential to treat prostate cancer but also triggering a persistent inflammatory process that damages the male reproductive system. The study's findings suggest long-term treatment could lead to recurrence of prostate cancer.
Researchers propose a novel approach to analyzing microplastic particles, highlighting the importance of particle size and shape in determining environmental impact. Studies show that even samples with similar numbers of particles can have varying levels of plastic pollution based on mass, volume, and specific surface area.
A Brazilian study found that a strain of brewer's yeast can act as a preventive against asthma in male mice. Daily administration of the probiotic at a dose of 10 billion CFU/mL significantly reduced bronchial hypersensitivity and inflammation. However, airway and lung inflammation was not significantly reduced by lower doses.
Researchers found SARS-CoV-2 in 18.2% of tear samples from patients with COVID-19, and in 12.1% of those collected using the Schirmer strip test. The method may predict patient prognosis and provide an alternative to uncomfortable nasopharyngeal swabbing.
A study published in a book highlights the concentration of land ownership in Brazil, which leads to rural conflicts and violence. The authors argue that the rural population is drastically underrepresented in politics and lacks formal representation to defend its interests.
Researchers used MRI scans and texture analysis to differentiate between two types of benign oral bone lesions, ameloblastomas and odontogenic keratocysts. The study found that certain pixel and voxel organizational parameters in the MRI images were statistically significant, enabling more accurate diagnosis and treatment planning.
A study published in Nature Ecology & Evolution found over 74,000 active fires in the Brazilian Amazon during the period, mainly due to recent deforestation. The research also revealed a sharp increase in forest fires on public lands and areas of Indigenous reservations.
Researchers found that snake species distribution in the Chaco region correlates with adaptations, such as fossorial habits for burrowing and arboreal traits. The study showed that southern species have small eyes and short tails, while northern species have long tails and are tree dwellers.
Researchers produced biogas from apple pomace, reducing greenhouse gas emissions and generating electricity and heat. The bioenergy recovery can supply 19% of the anaerobic reactor's energy needs, contributing to public policy and cutting fossil fuel consumption.
A Brazilian study found that early sugar consumption and interruption of breastfeeding are key factors contributing to dental caries in infants. Extended breastfeeding was shown to protect babies' teeth as long as they didn't receive sugary food, with the risk declining with falling sugar consumption.
The São Paulo School of Advanced Science on Cryogenic Electron Microscopy will be held at the University of São Paulo from July 10-27, 2023. The event will cover theoretical and practical foundations of advanced CryoEM techniques, featuring renowned researchers and hands-on practical sessions.