Researchers found that dysregulation of RNA transfer between cells in different tissues shortens lifespan in roundworms. They demonstrated that this phenomenon, termed Intercellular/Extracellular Systemic RNA imbalance (InExS), can be caused by an increase in RNA uptake from the environment, leading to a reduction in organism's lifespan.
Rats fed high-fructose diets exhibit disturbances in autonomic nervous and cardiovascular systems, increasing risk of chronic diseases like diabetes and obesity. Fructose consumption by parents is also associated with impaired physiological regulation of their offspring's cardiovascular system.
A study by Brazilian researchers reveals that bixin, a carotenoid pigment extracted from annatto tree seeds, is also present in other organs. Genetic analysis and modifications found increased production of the pigment in the adult phase and linked to stress-related hormone abscisic acid.
A study found that crop diversification in the Cerrado biome leads to increased numbers of native mammals and a decrease in invasive species such as wild boars. Diversified crops helped control invasive species that cause damage to farmers.
Researchers found that an imbalance of CD4+ T cells in the lungs can exacerbate tuberculosis, leading to increased disease severity and reduced survival rates. Removing a specific receptor that recognizes extracellular ATP can improve the response of these T cells and potentially lead to new therapeutic interventions.
Researchers found that artepillin C interacts intensely with tumor cells, altering their fluidity and triggering autophagy. The study's results contribute to a deeper understanding of the substance's action mechanisms and provide insights for future research.
A study conducted at a FAPESP-supported research center discovered a link between the protein VAPB and tumor cell proliferation in medulloblastoma, one of the most common and aggressive brain tumors in children. High expression of VAPB correlated with reduced patient survival.
A Brazilian study found that prior zika infection significantly increases the risk of developing severe dengue and being hospitalized. The study analyzed samples from over 1,000 laboratory-confirmed dengue patients and identified a higher viral load and inflammatory cytokine levels in those with prior zika infections.
A Brazilian researcher led a team that described a rare medusa, Santjordia pagesi, discovered at a depth of 812 meters in the Sumisu Caldera. The species has a unique bright red stomach and may possess an arsenal of venoms unlike those discovered to date.
The biodegradable sensor, made from plant-based material, can detect pesticide levels in minutes and has the potential to help assure food safety. The study showed that washing and immersion were insufficient to remove residues of pesticides, highlighting the need for reliable detection methods.
Researchers at the University of São Paulo found evidence of a tropical island with rich mineral deposits, including cobalt and nickel, in the South Atlantic Ocean. The team's analysis of seafloor sediment samples suggests the area was once home to vegetation and had volcanic activity between 30-40 million years ago.
The Butantan-DV vaccine has been shown to be effective in preventing dengue development in 79.6% of vaccinated individuals, regardless of age group or prior exposure history. The vaccine also demonstrated safety for all participants, with mild to moderate side effects reported.
A Brazilian study developed a method using AI to identify crop-livestock integration areas from satellite images. The approach can benefit agriculture by optimizing land use, diversifying farming activities, and encouraging sustainable practices.
Cancer kills more Black people than White individuals in the Barretos region, whereas in São Paulo city, it is the opposite, according to a study published in Cancer Causes & Control. The disparity is most pronounced for breast and cervical cancer among Black women.
A study in rats found that excessive adolescent stress alters genes associated with energy metabolism, leading to behavioral problems and psychiatric disorders in adulthood. The prefrontal cortex's response to stress was also affected, suggesting a link between mitochondrial function and emotional regulation.
Researchers at São Paulo State University found a link between a protein-poor diet during pregnancy and an increased risk of prostate cancer in offspring. The study detected changes in the expression of over 700 genes in offspring, including the gene ABCG1, which is associated with prostate cancer.
The FAPESP School of Advanced Science on Biodiversity aims to train young environmental scientists and technicians to critically analyze biodiversity data. The school will bring together leading researchers with representatives from different user segments to cover topics such as conservation, climate change, and ecosystem services.
Researchers developed a luminescent material that reveals concrete deterioration when exposed to ultraviolet light. The material's color change indicates the amount of carbonate absorbed, allowing for real-time detection of degradation.
Researchers at State University of Campinas discovered genes favoring colossal growth in whales also inhibit cancer development. The study found that certain regulatory regions influence both size and cancer suppression, offering new insights into the evolution of cetacean gigantism.
A study published in Perspectives in Ecology and Conservation proposes a novel methodology for projecting native tree growth and optimizing timber production in forest restoration. This approach reduces the time to harvest by 25% and increases stand density by 38%, making large-scale forest restoration more attractive to landowners.
The study identifies Morro do Príncipe as a priority area for conservation of the endangered Johngarthia lagostoma land crab in Brazil. Praia dos Andradas is also considered vital for breeding. The researchers highlight the importance of preserving vegetation to ensure the species' survival.
Researchers analyzed over 770,000 cases of chikungunya and zika in Brazil, finding a decline in spatial variations for both diseases but an increase in case numbers in 85% and 57% of clusters. High-risk areas are linked to higher temperatures, low rainfall, urbanization, and social inequality.
Rheumatoid arthritis patients who underwent a single session of aerobic exercise experienced temporary reductions in blood pressure at rest and under stress. The study, conducted at the University of São Paulo, demonstrates the benefits of moderate-intensity walking for cardiovascular management and blood pressure control.
A study published in Science reveals that 82% of endemic species and 65% of all tree species in the Atlantic Rainforest are threatened with extinction. The researchers used a novel conservation assessment methodology to estimate the degree of threat, which significantly increased the number of threatened species.
The Caatinga's ecosystem is projected to lose up to 87% of its mammal species and 70% of plant assemblages due to climate change. This will result in a loss of ecological functions, such as seed dispersal, and make the ecosystem less resilient.
The study shows how interaction between plant hormone gibberellin and small RNA molecules enables the development of ovaries, followed by fruit and seeds in tomatoes. This knowledge serves as a basis for ways to increase tomato yield by manipulating the genetic and physiological basis of microRNA and hormone interactions.
Researchers developed a biodegradable sponge that releases medication slowly into the organism, improving treatment efficacy for vulvovaginal candidiasis. The device is made from soft, biocompatible materials and can be inserted by patients themselves, making treatment more comfortable.
Entanglement is crucial for quantum computing, and researchers have proposed a condition to maximize it. The study, published in Physical Review B, uses the Hellmann-Feynman theorem as a reference point to explore finite temperature and quantum critical points.
A Brazilian study found that incomplete notification of snakebites and underreporting hinder public health actions. Researchers advocate for training health workers to recognize ophidic accidents and complete notification forms correctly.
Researchers from Brazil have discovered two novel peptides with biotechnological potential in the venom of the pit viper Cotiara and the South American bushmaster. The peptides, including Bc-7a and Lm-10a, show promise as potential treatments for high blood pressure.
Growth hormone influences regulation of anxiety via a specific group of neurons, according to researchers at the University of São Paulo. The study identified somatostatin-expressing neurons as key players in modulating GH's anxiolytic effect, with increased anxiety observed in mice lacking these neurons.
A recent study found a significant decline in bioluminescent beetle diversity in the Brazilian savanna over the past three decades. The researchers recorded 51 species, mostly fireflies, click beetles, and glow worms, which have declined sharply due to agricultural expansion and artificial lighting.
A new map showing all above-ground biomass in the Brazilian Amazon has been published, derived from a study combining airborne laser scanning, satellite imagery, and forest inventories. The results show an average of 174 metric tons of biomass per hectare and a maximum of 518 tons per hectare.
A recent study published in EBioMedicine found that yellow fever virus causes myocardial fibrosis, cardiomyocyte hypertrophy, and vascular endothelium alterations, leading to cardiac conduction system disruption. The research provides new insights into the pathogenesis of YF-associated heart injury.
Nanoparticles loaded with antibiotics and antimicrobial compounds inhibit TB progression and overcome resistance without cell damage. The technology shows promise for a shorter treatment strategy against multidrug-resistant strains of Mycobacterium tuberculosis.
Brazilian researchers developed a 3D zinc oxide photocatalyst that efficiently degrades sertraline, an emerging pollutant contaminating groundwater. The material's high photocatalytic activity and stability make it suitable for wastewater treatment.
Photodynamic action weakens resistance to antibiotics in bacteria that attack airways, reducing the persistence of both standard and clinical strains. The study found that five cycles of PDI were sufficient to break the resistance of resistant bacteria.
Recent research has identified the gut-skin axis as a critical factor in atopic dermatitis, with alterations to gut microbiome composition contributing to disease severity. The review article highlights promising therapeutic approaches, including diet, probiotics, and fecal transplants.
Air quality in São Paulo fell far below standards and WHO recommendations despite reduced emissions during the pandemic. The study identified four main sources of aerosols: heavy vehicles, soil dust, light vehicles, and local sources, including industrial emissions and fires.
Embedding nanodiamonds in polymer can advance quantum computing and biological studies. The technique, developed at the University of São Paulo, enables integration of quantum emitters into photonic devices and cell marking applications.
The São Paulo School of Advanced Science on Precision Livestock Farming aims to empower graduate students and early-career researchers with machine learning, statistical tools, and database systems. The school will provide a platform for them to process vast amounts of data and develop a multidisciplinary approach to PLF.
Researchers at UNICAMP developed a new technology to create bridges between superconducting circuits and optical fibers, enabling efficient transmission of information in the electromagnetic spectrum. This breakthrough paves the way for the development of advanced quantum networks with potential applications in computing and communicat...
Scientists in Brazil have developed a method to obtain a substance similar to estrogen from soy isoflavones, which may help alleviate menopause symptoms. The researchers extracted equol from soybean oil production residue and found it to be more bioavailable than glycosylated forms.
The São Paulo School of Advanced Science on Quantum Materials will select and support 100 graduate students and young researchers to focus on fundamental, theoretical, and experimental aspects of quantum materials. The program will cover topics like superconductivity, electronic topology, and complex magnetic configurations.
A fungus-based biopesticide is less lethal to mammals than synthetic insecticides but can wipe out colonies of wasps that benefit plants by feeding on pests and performing pollination. The study found that infected wasps are not detected by nestmates, potentially threatening the survival of these species.
Researchers at the Center for Development of Functional Materials created a sensor to monitor metronidazole levels in organisms and the environment. The sensor, combining magnetic fluorescent nanoparticles, showed good sensitivity and practical advantages, enabling real-time analysis and ease of handling.
A Brazilian study found that damage to small blood vessels in the lungs causes severe COVID-19. The researchers observed high prevalence of microscopic blood clots in lung endothelial cells, which led to organ damage and ischemic tissue injury.
Researchers have discovered that a nanoemulsion made from copaiba oil has antiviral effects against zika virus, showing 80% viral RNA inhibition. The study's results pave the way for developing medications or specific vaccines against zika.
The São Paulo School of Advanced Science on Transdisciplinarity for Transformative Change is a training opportunity for graduate students and researchers to co-produce knowledge for global sustainability. The school will focus on transdisciplinarity in social-environmental sciences, offering state-of-the-art science and research results.
A study by UNICAMP researchers found high concentrations of contaminants in the Piracicaba, Capivari and Jundiaí River Basin, including PFAS compounds, pesticides, and industrial chemicals. The study highlights the severity of pollution in the region, which supplies water for drinking, irrigation, and industry.