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Fundação de Amparo à Pesquisa do Estado de São Paulo


Study explains how a fungus can control the Corn leafhopper, an extremely harmful pest

The study found that the fungus begins affecting the insect's behavior two days after spraying bioinsecticides, reducing its feeding activity and pathogen transmission. The fungus is a natural, wild species that does not pose a hazard to human or animal consumption, making it a potential alternative for organic crop control.

Restoration of degraded areas in semi-arid region contributes to ‘return’ of soil microorganisms, study shows

A study reveals that restoration strategies in the semi-arid region of Brazil have led to a return of native ecosystem services by improving soil microbial properties. The techniques, including removal of cattle and cultivation of cover crops, have resulted in higher biodiversity and crop yields.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Environmental Management·DateMar 5, 2024

Factors that increase risk of frailty in old age are different in men and women

A study analyzing ELSA data found that osteoporosis, heart disease, and poor hearing increased frailty risk in men, while high fibrinogen levels, diabetes, and stroke were linked to higher risks in women. This highlights the importance of gender-specific action plans and intervention for older people.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalArchives of Gerontology and Geriatrics·DateFeb 28, 2024

Novel material increases efficiency and stability of perovskite solar cells

Researchers at São Paulo State University developed a method to enhance perovskite solar cells using MXene Ti3C2Tx, increasing power conversion efficiency by 15% and stability by three times. This breakthrough has promising implications for large-scale industrial production of stable high-performance solar cells.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Materials Chemistry C·DateFeb 26, 2024

Metal in glitter impairs aquatic plant growth, study shows

A study found that glitter's metal coating reduces light penetration, impairing photosynthesis of Large-flowered waterweed Egeria densa and affecting aquatic plant growth. The experiment showed a significant decrease in photosynthesis rates with the presence of glitter, highlighting the need for sustainable alternatives.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalNew Zealand Journal of Botany·DateFeb 26, 2024

Novel treatment strategy reduces inflammation and cardiometabolic risk in adolescents with obesity

A one-year interdisciplinary therapy program reduced inflammation and cardiometabolic risk in obese adolescents, improving insulin resistance and weight management. The semi-intensive model produced better results than previous intensive models, reversing hyperlipidemia and promoting energy balance.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Environmental Research and Public Health·DateFeb 21, 2024

Nanoparticles containing natural substance treat visceral leishmaniasis with scant side effects

Researchers at São Paulo State University developed a novel technique using lipid nanoparticles to administer lupeol, killing Leishmania protozoan parasites. The therapy eliminated parasites from organs in animal tests, reducing spleen and liver parasite numbers by 99.9% with minimal side effects.

Entrepreneurship on the periphery: between precarious work and the search for a meaningful life

A Brazilian study analyzed how low-income communities deal with the effects of the economic crisis in São Paulo city. The research found that entrepreneurship is a main strategy used by members of poor communities to participate in the economy, with over 15 million people registered as micro-entrepreneurs nationwide.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Urban and Regional Research·DateFeb 16, 2024

An important molecular pathway for control of aging is discovered

Researchers found that dysregulation of RNA transfer between cells in different tissues shortens lifespan in roundworms. They demonstrated that this phenomenon, termed Intercellular/Extracellular Systemic RNA imbalance (InExS), can be caused by an increase in RNA uptake from the environment, leading to a reduction in organism's lifespan.

Overconsumption of fructose by parents increases risk of cardiometabolic disease in offspring, study shows

Rats fed high-fructose diets exhibit disturbances in autonomic nervous and cardiovascular systems, increasing risk of chronic diseases like diabetes and obesity. Fructose consumption by parents is also associated with impaired physiological regulation of their offspring's cardiovascular system.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Obesity·DateFeb 15, 2024

Study reveals mechanism that aggravates tuberculosis and reduces survival rates

Researchers found that an imbalance of CD4+ T cells in the lungs can exacerbate tuberculosis, leading to increased disease severity and reduced survival rates. Removing a specific receptor that recognizes extracellular ATP can improve the response of these T cells and potentially lead to new therapeutic interventions.

Scientists discover that a protein associated with neurodegenerative diseases is also linked to childhood brain cancer

A study conducted at a FAPESP-supported research center discovered a link between the protein VAPB and tumor cell proliferation in medulloblastoma, one of the most common and aggressive brain tumors in children. High expression of VAPB correlated with reduced patient survival.

Prior zika infection increases risk of subsequent severe dengue and hospitalization, study concludes

A Brazilian study found that prior zika infection significantly increases the risk of developing severe dengue and being hospitalized. The study analyzed samples from over 1,000 laboratory-confirmed dengue patients and identified a higher viral load and inflammatory cytokine levels in those with prior zika infections.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPLOS Neglected Tropical Diseases·DateFeb 6, 2024

Biodegradable sensor monitors levels of pesticides via direct contact with surface of fruit and vegetables

The biodegradable sensor, made from plant-based material, can detect pesticide levels in minutes and has the potential to help assure food safety. The study showed that washing and immersion were insufficient to remove residues of pesticides, highlighting the need for reliable detection methods.

Study shows that Rio Grande Rise was once a giant mineral-rich tropical island near Brazil

Researchers at the University of São Paulo found evidence of a tropical island with rich mineral deposits, including cobalt and nickel, in the South Atlantic Ocean. The team's analysis of seafloor sediment samples suggests the area was once home to vegetation and had volcanic activity between 30-40 million years ago.

Butantan Institute’s dengue vaccine protects 79.6% of those vaccinated, study shows

The Butantan-DV vaccine has been shown to be effective in preventing dengue development in 79.6% of vaccinated individuals, regardless of age group or prior exposure history. The vaccine also demonstrated safety for all participants, with mild to moderate side effects reported.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateFeb 1, 2024

Ethnic disparities in cancer mortality in the capital and northeast of the State of São Paulo, Brazil

Cancer kills more Black people than White individuals in the Barretos region, whereas in São Paulo city, it is the opposite, according to a study published in Cancer Causes & Control. The disparity is most pronounced for breast and cervical cancer among Black women.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCancer Causes & Control·TypeData/statistical analysis·DateJan 30, 2024

Study helps explain why stress in adolescence can lead to predisposition to mental illness in adulthood

A study in rats found that excessive adolescent stress alters genes associated with energy metabolism, leading to behavioral problems and psychiatric disorders in adulthood. The prefrontal cortex's response to stress was also affected, suggesting a link between mitochondrial function and emotional regulation.

Study explains why protein-poor diet during pregnancy increases risk of prostate cancer in offspring

Researchers at São Paulo State University found a link between a protein-poor diet during pregnancy and an increased risk of prostate cancer in offspring. The study detected changes in the expression of over 700 genes in offspring, including the gene ABCG1, which is associated with prostate cancer.

Novel methodology projects growth of native trees, enhancing return on investment in forest restoration

A study published in Perspectives in Ecology and Conservation proposes a novel methodology for projecting native tree growth and optimizing timber production in forest restoration. This approach reduces the time to harvest by 25% and increases stand density by 38%, making large-scale forest restoration more attractive to landowners.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPerspectives in Ecology and Conservation·DateJan 19, 2024

A single session of aerobic exercise improves blood pressure in rheumatoid arthritis patients

Rheumatoid arthritis patients who underwent a single session of aerobic exercise experienced temporary reductions in blood pressure at rest and under stress. The study, conducted at the University of São Paulo, demonstrates the benefits of moderate-intensity walking for cardiovascular management and blood pressure control.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Human Hypertension·DateJan 16, 2024

More than 80% of tree species endemic to the Atlantic Rainforest are threatened with extinction

A study published in Science reveals that 82% of endemic species and 65% of all tree species in the Atlantic Rainforest are threatened with extinction. The researchers used a novel conservation assessment methodology to estimate the degree of threat, which significantly increased the number of threatened species.

Study reveals key molecular mechanisms involved in development of tomato plant

The study shows how interaction between plant hormone gibberellin and small RNA molecules enables the development of ovaries, followed by fruit and seeds in tomatoes. This knowledge serves as a basis for ways to increase tomato yield by manipulating the genetic and physiological basis of microRNA and hormone interactions.

Intravaginal sponge can make treatment of candidiasis more comfortable and effective

Researchers developed a biodegradable sponge that releases medication slowly into the organism, improving treatment efficacy for vulvovaginal candidiasis. The device is made from soft, biocompatible materials and can be inserted by patients themselves, making treatment more comfortable.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Pharmaceutics·DateJan 8, 2024

Diversity of bioluminescent beetles in Brazilian savanna has declined sharply in 30 years

A recent study found a significant decline in bioluminescent beetle diversity in the Brazilian savanna over the past three decades. The researchers recorded 51 species, mostly fireflies, click beetles, and glow worms, which have declined sharply due to agricultural expansion and artificial lighting.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalAnnals of the Entomological Society of America·DateJan 2, 2024