Researchers at the Center for Redox Processes in Biomedicine have identified new inhibitors of h15-LOX-2, a protein involved in inflammatory and metabolic processes. These compounds may provide promising candidates for developing new drugs to boost studies on the enzyme's biological role.
Researchers found that lemon leafcutter ants increase their cleaning behavior one week and a month after initial contact with a pathogenic fungus, but not after 60 days. The ants recognize the pathogen and recruit more workers to fight it even after multiple re-exposures, indicating a social immune memory.
Researchers found that cannabidiol stimulates the biomineralization of teeth even under inflammatory conditions, promoting tissue repair. The substance also inhibited the synthesis of inflammatory mediators in macrophages, suggesting an anti-inflammatory effect.
Researchers identified the prion protein as a key player in the progression of glioblastoma, a type of brain tumor. The study found that blocking the production of this protein using genetic editing reduced the ability of tumor stem cells to proliferate and invade tissues.
A new Brazilian technology developed by brain4care has been shown to measure absolute values of intracranial pressure (ICP) more accurately than existing non-invasive methods. The technology analyzes ICP's morphology and trend, allowing for early detection of neurological changes and enabling doctors to intervene quickly and accurately.
Researchers discovered a novel coronavirus in bats in Brazil with similarities to the Middle East respiratory syndrome virus. The five bats belonged to two species and showed significant genetic diversity, prompting experiments to determine whether it can infect humans.
A recent study on the governance of public policy in the Brazilian state of Amazonas recommends an experimentalist governance system that integrates local efforts and values traditional knowledge. The approach prioritizes the conservation of ecosystems while promoting socio-economic development and attracting investment to the region.
Researchers developed a cell phone application that detects posture and advises users on how to improve alignment through voice commands, vibrations, or images. The app helps patients with hemiparesis, a common sequelae of strokes, regain lost body awareness and perform daily tasks.
Researchers developed a simple test that detects antibodies against four dengue virus serotypes and zika virus. The test achieved high sensitivity (87.8%) and specificity (91.4%), indicating its potential to monitor specific antibodies produced in response to exposure to the viruses.
Researchers found that added sugars contribute between 7% and 21% to the risk of gastric cancer, while sodium intake is the main mediating factor. Healthy diets characterized by high vegetable and fruit consumption can reduce this risk.
Researchers found that administration of fish oil reduced insulin resistance and improved blood sugar levels in non-obese rats, reversing a condition similar to type 2 diabetes. The study suggests that omega-3 fatty acids may be a key factor in reducing inflammation and improving glucose metabolism.
A study found that caterpillars of two species interact solely with one ant species each, secreting a sugary liquid for recognition and protection. However, switching the pairings led to aggressive attacks from ants, highlighting the specificity of these interactions.
Researchers identified 19 metabolites and found that levels of certain compounds correlated with increased blood pressure, worse obstetric outcomes, and poorer end-organ function. The study expands scientific knowledge of preeclampsia and its mechanisms, paving the way for future therapeutic strategies.
A study of over 3,600 adolescents found that spending more than 3 hours a day engaged in sedentary behaviors increases the risk of psychological distress. In contrast, moderate screen exposure invested in educational activities was linked to less psychological distress.
A study analyzing 12 sunglasses models found that only one met international safety limits for UV radiation exposure. The lenses lose their ability to block UV radiation over time, increasing the risk of eye damage. To minimize this risk, scientists suggest adopting ICNIRP limits as standard practice.
A study of over 6,000 Brazilians found that consuming polyphenols from foods like fruits, coffee, chocolate, and wine can reduce the risk of metabolic syndrome by up to 23%. The study also found that flavan-3-ols in red wine were associated with a lower risk of developing the condition.
A study of 17,972 wells in Brazil reveals that more than half of the country's rivers could suffer reduced flow due to groundwater seepage. The São Francisco River basin and MATOPIBA region are particularly critical areas, with intensive agricultural activity and climate change exacerbating the problem.
New discoveries about the mechanisms of oxidative phosphorylation reveal a novel role for sodium in mitochondrial respiration. This correction aims to update textbooks on the electron transport chain, highlighting a significant shift from previous understanding.
A study of 153 people between the ages of 60 and 89 suggests a modification to the well-established clinical test for assessing balance in the elderly to make it more efficient, accessible, and predictive. The assessment can predict the risk of falling over a six-month period with accuracy.
The reemergence of dengue virus serotype 3 (DENV-3) in Brazil could worsen fresh outbreaks as the population is not immunized against this serotype. Researchers found a rise in DENV-3 cases since late 2023, with 31 blood samples testing positive for the virus.
A global study analyzed brain images of over 2,500 people with Parkinson's disease to identify patterns of neurodegeneration and create metrics for each clinical stage. The research could lead to better diagnostic tools and enable new treatments to be tested and monitored.
Researchers used single-cell sequencing to characterize different cell types in brain lesions and identify subpopulations involved in disease progression. The study provides a cellular view of focal cortical dysplasia, a malformation leading to drug-resistant epilepsy.
Researchers have discovered that chameleon shrimp can disguise themselves in exotic algae from other oceans, regardless of their evolutionary history. The crustaceans prefer to hide in invasive species with complex structures that offer better protection from predators.
A study on six serodiscordant couples found that women who were immune to SARS-CoV-2 had elevated expression of the gene IFIT3 compared to their male partners. This suggests that overexpression of IFIT3 may offer protection against COVID-19 by inhibiting viral replication and preventing cell invasion.
The São Paulo Advanced School on Precision Health will bring together 100 students from Brazilian and international universities to discuss precision health through a One Health vision. The school features state-of-the-art science presentations and interactions with world-class researchers and health startup founders.
A study of 242 couples undergoing assisted reproductive treatment found that men experienced higher levels of work-family conflict, while women were more affected by stress. The researchers used online questionnaires to assess the couples' emotional well-being and job performance.
Biofilm produced by Pseudomonas alcaligenes has unique structural properties and thermal stability, exhibiting antioxidant, emulsification and flocculation activity. The EPS can be used as a natural additive for the pharmaceutical and food industries with potential applications in developing sustainable or ecofriendly additives.
Researchers found that capuchin monkeys in Brazil's Serra da Capivara National Park learn from each other's actions and that social tolerance is crucial for this process. The study showed that partners in collective activities, such as searching for parasites and playing games, are more likely to learn new skills from their companions.
A comprehensive survey predicts that 36% of anurans' habitats worldwide will be threatened by rising temperatures and water scarcity. The Amazon and Atlantic Rainforest, home to the most diverse anuran species, will face devastating effects from drought events.
Researchers at the University of São Paulo's Medical School have developed a COVID-19 vaccine using virus-like particles (VLPs), which proved highly protective, safe, and versatile in animal trials. The vaccine can be easily updated to combat variants of concern without requiring an adjuvant.
Researchers have synthesized a molecule inspired by Nectandra leucantha and found it to be four times more potent than the prototype, killing Leishmania infantum selectively. The compound's bioavailability was improved, allowing it to circulate in the rat's organism for longer periods.
The São Paulo School of Advanced Science on University, Memory and Reparation will address the connections between academic research and reparation processes. Internationally renowned researchers will participate in discussions on the role of universities in promoting the right to memory and social reparation.
Researchers found that methanolic extract and palmatine from Annona squamosa leaves exhibit analgesic, anti-inflammatory, and anti-hyperalgesic properties. Palmatine may be responsible for the plant's anti-arthritic effects. Further studies are needed to confirm these findings and assess their therapeutic potential.
A study on capybaras infected with a rabies variant linked to vampire bats has been published in the journal Veterinary Research Communications. The research found that the viral strain was transmitted by vampire bats, which likely fed on the capybaras' blood during habitat disturbance.
Brazilian researchers claim that in relativistic space-time, time is the fundamental constant that measures all physical quantities, eliminating the need for separate length and mass standards. High-precision clocks are sufficient to describe all quantities, even in Galilean space-time.
The ARC will promote research groups and consolidate others to control greening, especially in areas not currently covered. The center aims to mitigate the disease's impact on citrus production, which has declined by 36.5% and fruit production costs are approximately 20% higher.
Researchers found a link between El Niño events and increased fire risk in the Amazon region, particularly where groundwater storage is compromised. The study highlights the critical role of groundwater in sustaining vegetation during droughts, emphasizing the need for prevention efforts during extreme climatic conditions.
A study found that El Niño is associated with increased larval infestations of Aedes aegypti mosquitoes in open-air disused containers in São Paulo state. The index of positive containers rose by 1.30 in El Niño years compared to neutral or weak events.
A Brazilian researcher at Harvard identified serotonin as the central role in postprandial hypoglycemia, a common complication of bariatric surgery. The study found that serotonin levels increase significantly after meals in affected individuals, unlike those without symptoms.
A study of 2,788 participants with impulse control disorder found that people with ICD are more likely to exhibit both overt and covert suicidal behavior. The study identified shared and specific risk factors for each type of behavior, including depressive symptoms and low self-direction.
The addition of jabuticaba peel flour increased the bread's fiber content by over 50% and raised its antioxidant capacity by 1.35-3.53 times, leading to improved blood sugar control and insulin response. The study found that satiety increased after consuming the bread with jabuticaba peel flour, suggesting a lower glycemic index.
A pioneering study of 192 Brazilian patients with pancreatic ductal adenocarcinoma identified genetic variants associated with the disease. The researchers found that 6.25% had pathogenic germline variants in genes predisposing to pancreatic cancer, and 13% had variants in genes associated with limited or previously unknown associations.
A new method to enhance pea protein solubility, combining heat treatment and guarana extract, offers potential as an ingredient in plant-based beverages. The approach improves emulsion stability and vitamin D3 preservation.
A Brazilian study of 89 father-mother-baby triads found that paternal overweight is linked to lower birth weight and may influence the baby's health in adulthood. The research suggests that fathers should prioritize healthy habits during pregnancy to support fetal development.
Indigenous women in the Amazon region of Brazil created varnished gourds with complex decorations inspired by local flora and fauna as well as European and Asian embroidery patterns. The craft was recognized at the beginning of the 18th century and was mainly produced for the European market, participating in a process of globalization.
Brazilian scientists have discovered ancient maize specimens in caves that exhibit primitive traits similar to those of the ancestral plant from Mexico, where domestication began. The findings support the theory that domestication may also occurred in South America.
Four FAPESP-funded deep tech startups are looking to expand internationalization plans and enter new markets. The startups aim to establish strategic partnerships with universities, local companies, and research centers to validate their technologies and gain a better understanding of the challenges and specifics of the European market.
Researchers from São Paulo and Spain aim to strengthen links through FAPESP Week Spain, promoting research partnerships and identifying gaps for increased collaboration. The event also discusses the importance of international collaboration in improving the quality of science and innovation.
Researchers from Brazil and Spain developed computer models to estimate crop maturity and yield using remote sensing technologies, increasing productivity and reducing CO2 emissions. They also created a system to estimate soil moisture levels with high accuracy, helping growers manage water usage more efficiently.
Researchers have developed a 3D artificial skin model with all three layers, simulating diseases and injuries more accurately. The model can replace animals in toxicological studies of medicines and cosmetics, enabling the development of new treatments without animal testing.