A recent study by Luiza Cesar Riani Costa and Diene Monique Carlos has provided insights into non-suicidal self-harm among adolescents. The booklet, featuring photographs and experiences of young people, offers a low-cost therapeutic and educational tool to address mental health concerns.
The study identified key proteins and signaling pathways involved in CAR-T cell therapy's efficacy, including cytokines, kinases, receptors, proteases, and chemical messengers. The findings pave the way for new treatment advances and potential biomarkers.
Researchers have developed a sustainable method for extracting sugars, organic acids, and phenolic compounds from corn stover using subcritical water. This process recovers high-value bioderivatives with yields up to six times higher than traditional methods, reducing energy costs and time.
Researchers have developed a method to convert carbon dioxide into methanol, a versatile compound used in fuels and plastics. The process involves hydrogenating CO2 with the help of catalysts, which can produce e-fuels that are sustainable alternatives to traditional fossil fuels.
A study by researchers at the University of São Paulo found that women with low muscle mass have a significantly lower survival rate than those with normal muscle mass. Muscle mass is crucial for patients undergoing cancer treatment, and low levels can predict adverse outcomes, including mortality.
A study found that 72.5% of young Brazilian women suffer from symptoms like itching, discharge, and pain during intercourse, negatively affecting quality of life and sexual health. The research suggests that vulvovaginal symptoms are often normalized, leading to undertreatment and emphasizing the need for more intimate health education.
Researchers have developed a new approach to regularize the theory of critical phenomena by generalizing statistical mechanics. The new method, based on non-additive entropy, provides finite values for quantities that diverge in traditional theories, offering insights into complex systems.
A recent study found that fully protected marine areas in Brazil are contaminated by microplastics, with an average concentration of 0.42 particles per gram of wet tissue. The contamination was detected in all ten integral protection areas studied, with the highest levels found in the Alcatrazes Archipelago Wildlife Refuge.
Researchers found that insulin signaling changes affect both Alzheimer's disease and epilepsy in animal tests. This discovery confirms clinical evidence of increased risk of Alzheimer's in people with epilepsy and highlights the need for a broader therapeutic approach to address the complex nature of Alzheimer's disease.
The São Paulo School of Advanced Science on Ocean Literacy is open to graduate students, postdoctoral researchers and professionals interested in ocean science and sustainability. The school will bring together experts and participants for a transdisciplinary discussion on the UN Ocean Decade's Vision 2030 ambitions.
A new process has been developed to extend the lifetime of perovskite solar cells, allowing them to maintain their efficiency for longer periods. The study found that incorporating formamidinium cations into methylammonium-based perovskites increased their durability and stability.
A study by the University of São Paulo found a direct relationship between personality traits and insomnia, revealing that high levels of neuroticism are common among insomniacs. High openness was associated with low levels of insomnia, while anxiety played a key role in perpetuating the disorder.
Researchers at A.C.Camargo Cancer Center developed a more powerful version of CAR-T cells by inhibiting the epigenetic alterations that made them inefficient against non-Hodgkin's lymphoma and acute lymphoblastic leukemia. This modification resulted in improved treatment efficacy, tumor elimination, and reduced side effects.
Researchers have discovered that microalgae species can remove antibiotic residues from water, including sulfamethoxazole and trimethoprim. This process also produces biomass with potential commercial value, including biodiesel production.
Researchers have developed a low-cost, nanotechnology-based praziquantel formulation that increases efficacy and reduces dosage for treating worms. The new formulation, requiring only half the usual dose, demonstrates greater efficacy in eliminating schistosomes than the active ingredient alone.
Brazilian researchers found that hevin, a glycoprotein produced by astrocytes, increases connections between neurons and improves cognitive function in aged rodents. The study provides insight into the role of astrocytes in Alzheimer's disease and offers potential new treatment strategies.
A study proposes five action fronts for civil defense units to increase their organizational capacity, including professionalization and resource allocation. Municipalities face challenges such as monitoring urban expansion, lack of financial resources, and social participation.
Researchers developed a simple, economical and environmentally friendly purification method for mullite-type bismuth ferrite, improving its efficiency in producing green hydrogen. The process uses light and glycerol to eliminate unwanted compounds, resulting in high-purity material suitable for photoelectrochemical reactions.
Researchers have discovered a new enzyme called CelOCE that can cleave cellulose using an unprecedented mechanism. This discovery has the potential to significantly increase the production of second-generation ethanol from agro-industrial waste, enabling the large-scale production of biofuels.
Researchers at State University of Campinas found that physical exercise prevents the transition from acute to chronic muscle pain by activating an anti-inflammatory signaling pathway in immune cells. This can lead to the development of new treatments for muscle pain, potentially reducing opioid consumption.
A study on Brazilians in their 50s found that those with hearing loss experienced faster cognitive decline than expected for their age. This highlights the importance of addressing hearing health to prevent dementia, which is a growing concern worldwide.
Researchers have discovered that silver nanoparticles produced by the fungus Trichoderma reesei can inhibit the infection of SARS-CoV-2 in hamster lungs, reducing inflammation and viral load. The study also suggests that these nanoparticles could be used to prevent and treat other viral diseases, such as HIV/AIDS, shingles, and influenza.
FAPESP is launching a call for International Thematic Grants to support researchers from abroad in developing innovative projects at the forefront of knowledge. The selected projects will have a maximum duration of 60 months and provide full administrative support, access to facilities, and inclusion in graduate courses.
A Brazilian study of over 700 infants found that ultra-processed food consumption negatively affects gut diversity and abundance, particularly in non-breastfed children. Breastfeeding mitigates this effect, promoting higher Bifidobacterium levels and better health markers.
Researchers found that Brazil's beef production, if left unchecked, would exceed the country's limit for meeting its Nationally Determined Contribution (NDC) target by up to 63GtCO2e by 2030. The study suggests that adopting emission reduction practices could prevent losses of up to $42.6 billion and ensure greater competitiveness.
Researchers identified key tasks in a speech assessment battery to detect primary progressive aphasia, a rare neurodegenerative disease. Early detection can lead to slower disease progression and improved communication skills.
Researchers reconstructed metal pollution history in São Paulo using sediment cores, revealing three periods of increasing pollution. The study highlights the importance of sediments as environmental indicators and offers insights for conservation efforts.
A Brazilian study estimated deer population density in the Atlantic Rainforest, revealing human pressures like hunting and livestock diseases significantly impact deer numbers. The research provides strong evidence for conservation management and protected area protection.
A recent study suggests that aquaculture in the Amazon can be a more sustainable alternative to livestock farming, producing 10 times less greenhouse gases and using 20-100 times less land. This could help achieve food security in the region while minimizing environmental impact.
A study of 352 newborn pairs found that maternal childhood trauma can lead to excessive weight gain in male children as early as the first two months of life. This may increase future risk of obesity and diabetes, highlighting a potential intergenerational effect.
A rodent study found hnRNP A1 regulates myelin production and maintains its integrity, suggesting an impact on neurodegenerative diseases like schizophrenia. The findings provide new insights into the disease's molecular basis and potential treatments.
Scientists have discovered a new bacterial strain, Bacillus thuringiensis RZ2MS9, that can enhance the growth of soybeans and corn when combined with rhizobia. This partnership reduces fertilizer use, saving Brazilian growers an estimated USD 15 billion annually.
Researchers discovered that endoperoxides derived from ergosterol and 7-dehydrocholesterol induce the death of melanoma cells. This finding paves the way for expanding the use of photodynamic therapy in fighting skin cancer.
Researchers developed a new, three times more effective version of the antibothropic serum used to treat snake venom poisoning. The improved serum had increased neutralizing antibodies and fewer proteins associated with side effects, resulting in greater potency and reduced risk of adverse reactions.
A study in the journal Cell Host & Microbe found that a diet rich in soluble fiber can protect against pathogenic bacteria like Clostridioides difficile. Consuming soluble fiber produces compounds like acetate, which regulates immune response and reduces inflammation.
A study in Brazil's Caatinga biome found that removing animals from degraded pastures did not restore soil health after three years. Green manure and strategic tree planting are recommended to accelerate ecological recovery. Soils show severe degradation, with carbon loss and decline in holistic soil health index.
A new method using free software and a drone with a low-cost camera has been developed to select drought-tolerant corn plants. The approach allows for optimized data collection, faster processing, and reduced costs compared to conventional methods.
Researchers developed a biosensor using an Amydetes vivianii firefly enzyme that detects pH changes in mammalian cells, which could be used to study diseases and assess drug toxicity. The technique is non-toxic and stable, providing a stronger glow than previous luciferases.
A new edible biofilm developed by Brazilian researchers extends the shelf life of strawberries by up to 11% while preserving their freshness, taste, and aroma. The film, made from pomegranate peel extract and natural polymers, acts as a barrier to microorganisms, moisture loss, and gas exchange.
A study published in GeroScience found that weight training improves memory and brain anatomy in older adults with mild cognitive impairment. The results showed that strength training protected against atrophy in key brain areas associated with Alzheimer's disease.
The Albert Einstein Jewish Brazilian Hospital launches a project to evaluate the application of quantum computing in developing new drugs and improving disease diagnosis. Researchers aim to use machine learning and quantum optimization algorithms to analyze rainfall data and predict heavy rainfall events.
The FAPESP Investigator Grant for International Researchers aims to recruit top talent globally to boost São Paulo's scientific and technological leadership. The call is open to researchers living abroad for at least 2 years, with a focus on leadership capacity and research potential.
Researchers have studied the mechanism of action of bioactive compounds from papaya, passion fruit, and medicinal plant extracts. Modified pectins extracted from these plants show potential as supplements or food ingredients to boost biological activity against colon cancer and gut microbiota.
A study predicts that over 80% of amphibian species in the Upper Paraguay River Basin will lose suitable habitats by 2100. The region, which includes the Pantanal and its surroundings, is expected to experience local extinctions under both optimistic and pessimistic greenhouse gas emissions scenarios.
The world is facing critical challenges like climate change and inequality, which require international cooperation. However, scientific freedom is under threat due to illiberal and authoritarian governments, economic power, and digital media. FAPESP has played a crucial role in defending scientific freedom in Brazil.
Researchers developed a new geospatial intelligence methodology to accurately delineate areas of natural vegetation and agricultural production by crop type. The results showed 95% accuracy in mapping, providing support for public policies aimed at agricultural production and environmental conservation.
The event aims to promote research partnerships between researchers from São Paulo and European countries. FAPESP Week Germany saw strong scientific and technological cooperation growth between the state of São Paulo and Germany in recent years, with 2,000 articles published in partnership with German colleagues.
The São Paulo School of Advanced Science on Emerging Pollutants will tackle the challenges of monitoring and regulation of emerging pollutants. Applications can be submitted until April 20, 2025.
Brazil's state of São Paulo is expanding scientific and technological cooperation with European partners Germany, UK, and France to strengthen regional relations. The country aims to be competitive in the wake of a favorable trade agreement between Mercosur and the EU.
A study of 130 volunteers found a drastic decrease in heart rate variability after COVID-19, even in mild cases. The researchers observed an imbalance between the sympathetic and parasympathetic nervous systems, suggesting a higher risk of adverse cardiovascular outcomes.