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Fundação de Amparo à Pesquisa do Estado de São Paulo


Biosensor identifies protein linked to depression and schizophrenia in saliva

Researchers at the University of São Paulo developed a low-cost, portable biosensor that can quickly identify altered levels of BDNF associated with psychiatric disorders. The device detects extremely low concentrations of BDNF in human saliva, which is crucial for growth and maintenance of neurons and development of brain functions.

Plant biomass substance helps combat weeds

A study found that lignin, a polymer from plant cell walls, can improve the performance of nanoparticles with herbicide. Lignin was subjected to a green process and showed distinct properties, making it suitable for customizing different applications. The substance demonstrated potential for sustainable agricultural pest management.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalACS Sustainable Chemistry & Engineering·DateOct 29, 2025

South American long-necked dinosaur could easily stand on two legs

Researchers used computational engineering techniques to simulate weight and gravitational stress on sauropod femurs. They found that two South American genera, Uberabatitan and Neuquensaurus, could generally remain standing for extended periods, allowing them to feed on high branches and defend against predators. The simulations sugge...

Technique allows estimation of the force acting on each grain of sand in a dune

Brazilian researchers have developed a technique that estimates the force exerted on each grain of sand in a dune from images, enabling the study of previously unmeasurable physical processes. The method uses numerical simulations and artificial intelligence to transform the study of granular system dynamics.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalGeophysical Research Letters·DateOct 23, 2025

Portable sensor detects synthetic cannabinoids in e-cigarettes and biological fluids

Researchers developed a portable sensor to detect synthetic cannabinoids in e-cigarette liquids and biological fluids, allowing for early intervention and harm reduction. The device shows high selectivity and sensitivity, detecting concentrations as low as 0.2 µM and identifying specific peaks that quantify substances present.

Super-resistant bacteria found in wild birds at a rehabilitation center on the coast of São Paulo state, Brazil

Antibiotic-resistant Escherichia coli clones were found in two colonized birds, a vulture and an owl, at the Santos Municipal Orchid Garden rehabilitation center. The presence of these strains in animals raises concerns about potential impact on wildlife health.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalVeterinary Research Communications·DateSep 25, 2025

Group creates tool to predict whether multiple sclerosis medication will be effective for patients

Researchers have developed a tool that can predict how patients with multiple sclerosis will respond to natalizumab treatment, allowing for targeted treatments with fewer side effects. The tool uses high-content imaging and machine learning to analyze cell morphology and identify individuals who are unlikely to respond to the medication.

Study identifies candidates for therapeutic targets in pediatric germ cell tumors

Researchers have identified distinct immune profiles for different subtypes of pediatric germ cell tumors, which could lead to more targeted therapies. The study found that certain tumor subtypes respond well to immunotherapy and others exhibit an immunosuppressive environment, making them more aggressive.

Plant-derived compound has antimicrobial and anti-inflammatory effects against periodontal disease

Researchers developed a powder based on morin, extracted from plants like guava leaves, apple peels, and figs, to combat periodontal disease. The study found that the substance can be slowly released through polymers, providing an alternative to antibiotics for controlling microorganisms.

Green tea improves insulin sensitivity and glucose tolerance in obese mice

A recent study found that green tea extract improved glucose sensitivity and insulin resistance in obese mice, preserving muscle morphology. The treatment reduced body weight by up to 30% and increased the expression of genes related to glucose metabolism, suggesting a selective effect on excess body fat.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCell Biochemistry and Function·DateSep 10, 2025

Variations in glucose levels may indicate severity of heart attack damage

Research in Brazil found that glycemic delta, a measure of blood sugar variability, is associated with the size of the heart attack and the strength of heart contractions. The study suggests that high glycemic delta may be a biomarker for worse outcomes in patients who have experienced their first acute myocardial infarction.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalDiabetology & Metabolic Syndrome·DateSep 4, 2025

Study confirms that inactive parents contribute to sedentary behavior in their children

A study by São Paulo State University found a direct association between adults' levels of physical activity and their children's sedentary behavior. Children of inactive parents tend to be more sedentary, but when mothers and fathers maintain an active routine, their children usually follow suit.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalSports Medicine and Health Science·DateSep 4, 2025

Deforestation reduces rainfall by 74% and increases temperatures by 16% in the Amazon during the dry season, study says

Researchers found that deforestation is responsible for a significant reduction in rainfall and increase in temperature in the Amazon during the dry season. The study quantifies the impact of forest loss and global climate change on the biome, highlighting the importance of preserving standing forests to maintain climate resilience.

Study points out that a synthetic molecule helps reduce visceral fat and improve sleep

A synthetic molecule called Pep19 has been shown to reduce visceral fat and improve sleep quality in overweight adults, with no side effects observed. The study involved 24 volunteers who took either a placebo or Pep19 in capsules, and found a 17% reduction in visceral fat and improved sleep quality in those who received the molecule.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalDiabetes/Metabolism Research and Reviews·DateAug 28, 2025

New bacterium discovered in the Amazon is closely related to Andean species that causes human bartonellosis

A new species of bacteria of the genus Bartonella has been found in the Amazon National Park, Brazil. The DNA is similar to that of two other Andean species, B. bacilliformis and B. ancashensis, which cause Carrión's disease. No evidence suggests this new species can cause disease, but further studies are needed.

Deadly bone disease wiped out long-necked dinosaurs in what is now the interior of the state of São Paulo, Brazil

Researchers found signs of osteomyelitis in sauropod fossils from the Cretaceous period, suggesting a fatal bone disease that killed animals quickly. The study identified three previously unknown manifestations of osteomyelitis and provides insights into the environment that favored pathogens.

SARS-CoV-2 infects testicular cells and uses cellular machinery to replicate and form

The COVID-19 virus replicates using cellular machinery responsible for testosterone production, altering lipid metabolism and potentially leading to lower testosterone levels. This study reveals the mechanism by which SARS-CoV-2 targets testicular cells, offering insights into male vulnerability to COVID-19.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalFrontiers in Cellular and Infection Microbiology·DateAug 21, 2025

Researcher from FAPESP-supported center participates in international initiative to improve oxylipin analysis

An international team of researchers established standardized guidelines for analyzing oxylipins, bioactive lipids related to inflammation and disease. The guidelines aim to improve reproducibility in laboratories and facilitate the transfer of scientific discoveries to clinical practice.

Indigenous researcher revives traditional medical practices of his people

An ethnobotanist from the Pataxó Hã-Hã-Hãi Indigenous Land in Brazil has revived ancestral healing knowledge to treat diseases like parasitic worms, diabetes, and hypertension. He discovered 43 medicinal plants used for these diseases, with 79% consistent with recent scientific literature.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Ethnobiology and Ethnomedicine·DateAug 14, 2025

Fermentation method transforms unripe fruits into specialty coffees

Researchers developed a fermentation method using unripe fruit beans, producing high-quality beverages comparable to those made from ripe fruits. The process, known as self-induced anaerobic fermentation, adds value to the product while minimizing its defects, making it attractive to domestic and foreign markets.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalFood and Bioprocess Technology·DateAug 13, 2025

Laser therapy enhances treatment of fungus resistant to conventional medication

Researchers have successfully increased the susceptibility of Candida albicans to drug treatment through light-activated therapy. Combining photodynamic inactivation with antifungal amphotericin B reduced fungal growth by up to 87.5% and demonstrated potential as an alternative to combat antimicrobial resistance.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPhotochemistry and Photobiology·DateAug 12, 2025

Corals in Brazilian archipelago capture carbon equivalent to the burning of 324,000 liters of gasoline per year

A single species of coral in the Alcatrazes Archipelago retains about 20 tons of carbon per year, equivalent to the carbon emissions from burning 324,000 liters of gasoline. This stored carbon can last for centuries or millennia, making subtropical coral reefs like Alcatrazes potential greenhouse gas sinks.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalMarine Environmental Research·DateAug 5, 2025