The Butantan-DV dengue vaccine, developed in Brazil, shows 80.5% effectiveness against severe cases over five years, with no hospitalizations in the vaccinated group. The vaccine was 65% effective in preventing symptomatic dengue during the five-year monitoring period.
The study's findings reveal the evolution of venom toxins in the golden lancehead, a venom-rich species isolated from its mainland counterparts. The genome sequencing data can inform conservation policies and potentially lead to the development of anticoagulant drugs or blood pressure-lowering treatments.
Researchers have developed an index to measure the health of mangrove soils, revealing that healthy mangroves provide ecosystem services at nearly maximum capacity. The Soil Health Index (SHI) helps managers set conservation and restoration priorities, providing a tool to monitor ecosystem restoration and recovery.
A study of over 1 million diagnosed individuals reveals genetic links between 14 psychiatric conditions, grouping them into five major factors. The findings may facilitate future treatments and drug repurposing, with potential applications in schizophrenia and substance abuse
A study analyzing 47 termite species found that genome expansion occurred before the division into wood- and soil-feeders, allowing termites to adapt to various environments. The research provides a comprehensive toolbox for future studies on social behavior, immunity, and ecological adaptations.
A network of genes connected to the nervous and immune systems can predict liver cancer risk, fatigue, and depression from viral hepatitis infection. The neuroimmunoma biomarker may monitor disease progression and indicate possible psychiatric complications.
The study found that the extract reduced cell damage compounds by over 75% and preserved skin health with over 60% of cells remaining alive. The researchers developed a natural dye, produced by Talaromyces amestolkiae fungus, which can be used in cosmetic formulations while maintaining safety and functionality.
A Brazilian study found that babies from families experiencing socioeconomic vulnerability showed delays in motor development, such as grabbing objects and rolling over, at just six months old. However, with simple stimuli like tummy time and interactive play, these delays can be easily reversed.
Researchers from São Paulo State University detected plastic rocks on Trindade Island, Brazil's easternmost territory, where green turtle nests are conducive to plastic accumulation and burial. The study highlights the need for public policies to manage plastic waste and coordinated actions to clean up beaches.
A study published in the Chemical Engineering Journal proposes a new method for environmental remediation of pharmaceutical pollutants in water. The researchers used high-energy sparks to degrade pollutants, achieving better results than conventional methods.
Residents of favelas in São Paulo exhibit less daily movement variability than those living in formal areas with similar incomes. Despite higher economic conditions, infrastructure challenges impact mobility access and stability. The study uses mobile phone data to analyze movement patterns over several weeks.
A study by São Paulo State University found that an iron-based compound eliminated lung infection in mice after 30 days of treatment. The researchers developed lipid nanoparticles to improve stability and duration of action, outperforming standard antibiotics in eliminating the bacterial load.
Researchers have discovered that two osteoporosis drugs, etidronate and tiludronate, can bind to excess iron, reducing oxidative stress and preventing cell damage. This finding holds promise for patients with iron overload diseases, but further studies are needed to confirm its potential as a treatment.
Researchers at the Center for Cell-Based Therapy developed a new approach to enhance CAR-NK cell cytotoxicity, combining optimized co-stimulation with reversible pharmacological control. The study showed increased tumor control in animal models, paving the way for improved cancer treatment.
Researchers have identified a field of tektites in Brazilian territory, which may have been formed by a single cosmic collision event. The geraisites, named after the Brazilian state of Minas Gerais where they were first discovered, have distinct geochemical signatures and date back approximately 6.3 million years.
A Brazilian study analyzing 4,280 adolescents and their guardians found that parental attitudes play a significant role in preventing alcohol and drug use among young people. The 'authoritative' parenting style, which combines acceptance and monitoring, is the most effective in mitigating the risk of repeated consumption patterns.
A study using satellite data found that deforestation in the Amazon increases surface temperature by 3°C during the dry season, with a 25% decrease in rainfall. This leads to greater forest degradation, increased tree mortality, and susceptibility to forest fires, threatening biodiversity.
Researchers developed a methodology that uses remote sensing to map the impact of frost on corn crops, reducing exposure to climate risks. The model allows users to customize variables, making it useful for other crops in different agricultural contexts.
Researchers from FAPESP-supported center create novel molecular architecture to efficiently degrade emerging water contaminants. The material demonstrates removal efficiencies greater than 95% and potential for sustainable solar-powered applications.
A study funded by FAPESP found that most Brazilian women are unaware of their labor rights during pregnancy and postpartum. The research revealed that over half reported experiencing some type of workplace violation, with the risk increasing for those in greater social vulnerability contexts.
A study found that childhood obesity can lead to premature vascular damage in children as young as six, increasing the risk of diseases such as atherosclerosis and heart attack. The research identified early signs of inflammation and dysfunction in the endothelium, highlighting the need for public policies to prevent childhood obesity.
A study published in Progress in Neurobiology found that synthetic oxytocin carbetocin can prevent anxiety-related behaviors in laboratory rats exposed to social stress. The researchers observed that carbetocin had a preventive effect on anxiety without having direct anxiolytic effects.
A new treatment developed by EMBRAPA uses modulated UV-C light to combat anthracnose in guavas. The technique increases the fruit's natural resistance to microorganisms, preserving quality and shelf life.
A recent study analyzed seabird carcasses and blood from six species in Brazil, finding similar concentrations of persistent organic pollutants (POPs) among species with different diets. The researchers discovered that the great shearwater had the highest levels of PCBs and mirex, possibly due to its migratory routes and feeding habits.
A recent study analyzing 6,049 contamination records revealed that 46% of the world's aquatic environments are classified as 'dirty' or 'extremely dirty'. The most critical contamination cases are found in mangroves, with plastics and cigarette butts accounting for nearly 80% of the waste.
New formulations of nanopesticides with natural ingredients have appeared in specialized literature, but there is no consensus on what constitutes a green pesticide. Researchers warn that terms such as 'sustainable' must be used correctly and that the natural components of these products do not eliminate environmental concerns.
A study by UNICAMP researchers found that women with a history of yo-yo dieting have increased body fat, worse metabolic indicators, and reduced brown fat activity. The 'yo-yo effect' impairs metabolism and reduces BAT activity in women.
Researchers develop a synthetic compound that acts on all three stages of the disease cycle, eliminating parasites from human blood and liver, and preventing transmission to mosquitoes. The molecule has shown effectiveness against P. vivax and P. falciparum species.
Researchers propose redesigning health systems in the Brazilian Amazon to account for climate change, extreme weather events, and food insecurity. They suggest integrating traditional knowledge and care practices adapted to local communities' specific needs.
A Brazilian study developed a new statistical analysis method that better predicts landslide risk. The approach uses the Gaussian distribution to define the weight of each contributing factor objectively. It was validated based on an inventory of landslides in São Paulo, where 65 people were killed.
The study confirms that ancient lichens played a key role in forming the first soils and structuring terrestrial ecosystems. Researchers identified the presence of chitin, nitrogen compounds, and calcium microparticles compatible with modern lichen minerals.
Researchers found a new species of filter-feeding pterosaur, Bakiribu waridza, in fossilized vomit from 110 million years ago. The pterosaur had fine teeth and was likely swallowed by a predator that regurgitated its skull and four fish, which were well-preserved.
The São Paulo School of Advanced Science on Immigration, Environmental Violence and Colonialism is an interdisciplinary laboratory fostering critical training and collective knowledge production. Up to 100 students will be selected for the course, which will feature internationally renowned researchers as speakers.
A recent study led by researchers at State University of Campinas confirms that the Bd-Brazil fungal strain originated in Brazil and spread globally through international trade. The strain has already contributed to the decline of over 500 species of anuran amphibians, including toads and frogs.
The study found that even with immunosuppressants, innate immunity remains activated, indicating a need for new therapies to prevent organ rejection. Researchers recommend combining therapies targeting innate immunity with advanced genetic engineering in donor pigs.
Researchers developed an artificial saliva containing sugarcane protein, CANECPI-5, to aid in treating teeth of patients with head and neck cancer. The solution significantly reduced bacterial activity and tooth demineralization when combined with fluoride and xylitol.
A study published in Molecular Oncology developed a liquid biopsy panel that can detect specific gene mutations in lung cancer patients, offering a potential solution for early detection and guiding patient treatment. The test showed promising results, detecting mutations in 65.6% of samples, including those in frozen samples without s...
Researchers describe a new species of spider-parasitic mite found on juvenile spiders in the Butantan Institute collection in Rio de Janeiro. The larvae were collected and examined using microscopy techniques, resulting in the first description of this family in Brazil.
The study found that consuming bananas grown in soil impacted by iron mining waste poses a possible health risk to children aged six years or younger. The team correlated the risk to human health with the transfer of toxic elements from the soil to the plant, revealing high concentrations of cadmium, chromium, and other metals.
A comprehensive analysis of 503 fish found high levels of 13 heavy metals and toxic substances, making consumption inadvisable due to health risks. The study highlights the persistence of contamination in the Doce River basin, with ongoing mineral exploitation and industrial activities contributing to pollution.
A recent study analyzing over 1,400 cases of squamous cell carcinoma found that more aggressive histopathological variants occur at a rate of 4.6%, significantly lower than previous estimates. The researchers highlight the importance of considering regional differences in tumor origin and behavior to improve treatment outcomes.
Researchers from UNICAMP found that bromeliad water fertilizes the soil beneath branches, facilitating growth of plants with high nutritional demands. This process, known as remote plant interaction, occurs between physically distant organisms and enhances functional diversity in the system.
Researchers discovered that SARS-CoV-2 interacts with infected lung cells' genetic material in an unprecedented way, manipulating RNA to shut down the immune system. The virus uses methylation to destabilize RNA structures, weakening interferon signaling and impairing the immune response.
A Brazilian study of nearly 900 adults under 40 found that obesity and systemic inflammation accelerate lung aging and increase the risk of chronic obstructive pulmonary disease (COPD). Smoking remains the main risk factor for lung function loss, but these two conditions can also contribute to COPD.
A study of over 3,200 terrestrial mollusk species found that nearly half were described by non-local researchers, highlighting a neocolonial practice. This 'helicopter science' or 'parachute science' harms local researchers and can lead to less robust studies.
Researchers from Brazil confirm the safety and efficacy of Alternanthera littoralis (Joseph's Coat) in reducing inflammation and modulating inflammatory mediators. The study's findings support the plant's medicinal potential and suggest a safety profile at therapeutic doses.
Researchers found that inadequate characterization of the menstrual cycle in studies contributes to conflicting results. A new study aims to investigate the relationship between hormonal fluctuations and physical exercise, seeking to broaden understanding of women's immunity.
A new study reveals that the genus Escovopsis emerged 56.9 million years ago but didn't start associating with leafcutter ants until 38 million years ago, suggesting a complex evolutionary history. The fungus's adaptations to its ant hosts likely contributed to its success as a symbiont.
A review of 467 studies confirms that firearm ownership increases suicides, intensifies psychological fragility, and amplifies violence. Safe storage of firearms reduces but does not eliminate the risk, researchers say.
Researchers recorded lemon sharks preying on jaguar cichlids, an invasive species introduced to Fernando de Noronha, in Sueste Bay. The bay's saltwater environment allows for the interaction due to freshwater inflows after heavy rains. This observation suggests that sharks may play a role in controlling invasive species populations.