A recent study identified four genes associated with treatment resistance to immunotherapy in melanoma patients. The genes, CD24, NFIL3, FN1, and KLRK1, were found to be linked to mechanisms of immune evasion and suppression of the inflammatory response. Patients with high expression of these genes had significantly lower overall survi...
The São Paulo School of Advanced Science in Systems Change and Sustainability brings together leading academics to discuss cutting-edge knowledge on sustainable transformation. Applications will be selected based on résumé, academic transcript, letters of recommendation, and proposal submission.
Researchers at the University of São Paulo propose an inelastic DM model that interacts with ordinary matter through a vector mediator. This interaction could open a new window for dark matter research, providing a more precise understanding of its properties and behavior.
Researchers reanalyzed the coelacanth's skull musculature and found that only 13% of previously identified evolutionary muscle novelties were accurate. The study also identified nine new evolutionary transformations related to feeding and respiration, revealing a more similar anatomy to cartilaginous fish and tetrapods.
A preference for domestic vaccines was observed in various countries during the pandemic, including Brazil, Mexico, India, Iran, and the US. Researchers identified a clear pattern of people choosing vaccines from their own country or those from Western nations like Germany, the UK, and the US.
A study analyzing data from 2002 to 2022 found a 50% decline in economic gains from fishing due to the introduction of exotic species. The size of native fish decreased, while invasive species increased in body size and abundance.
The Amazon has experienced a 163% increase in degradation and a 54% decrease in deforestation between 2022 and 2024. This 'negative balance' of biome protection threatens Brazil's international climate commitments, particularly its target to reduce greenhouse gas emissions by 59-67% by 2035.
A Brazilian study maps the direct and indirect impacts of marine resource-dependent economic activities, revealing strong connections between coastal and inland regions. The research highlights the importance of the blue economy in Brazil's GDP and employment, with regional specializations varying across states.
Researchers have identified a new genus of frog, Dryadobates, comprising at least 12 species, with three already declared extinct. The study utilized historical DNA analysis to clarify the taxonomic classification of previously single-species frogs, revealing hidden diversity and extinctions in the Atlantic Forest.
A study by USP and Sapienza Università di Roma researchers has synthesized fullerenes with up to 190 carbon atoms using an electrochemical route. The process involves natural graphite, ethanol, water, and sodium hydroxide under ambient conditions, paving the way for new organic synthesis and technological applications.
Researchers at UNICAMP found that a reduction in prey availability was a decisive factor in the extinction of saber-toothed tigers. The study also shows that an increase in predator diversity led to a decline in herbivore species diversity among antilocaprids, which are now represented by a single species: the American bison.
A newly developed AI-based tool uses protein expression to create a stemness index that analyzes tumor similarity to pluripotent stem cells. The model predicts tumor aggressiveness and identifies potential targets for new therapies, offering hope for improved cancer treatment.
Researchers have discovered batzelladins, which rapidly eliminate parasites that cause malaria, including strains resistant to conventional antimalarial drugs. The efficacy of these substances was proven through tests on blood samples from patients and infected mice.
The study identified a rare genetic alteration associated with high levels of the ADAM10 protein, which plays a role in breaking down beta-amyloid precursor protein. The researchers aim to develop a panel of prognostic biomarkers to differentiate Alzheimer's disease from other types of dementia.
Researchers found that adding partially defatted sunflower seed flour (SF) to bread increased its protein and fiber content. SF also boosted antioxidant levels and showed inhibitory activity against digestive enzymes, promoting health benefits. However, high proportions of SF compromised sensory characteristics.
A pilot intervention project involving playful sensory-motor activities improved reading speed and eye movements in children with dyslexia. The study found promising results in improving eye movements and reading speed in eleven children aged 10-12 who underwent a two-month protocol of cognitive engagement, reducing reading time and in...
Researchers found that hyperactivation of the PARP1 protein after exhaustive training is associated with decreased performance, fatigue, and behavioral symptoms of overtraining. A study published in Molecular Metabolism suggests that excessive protein expression may be the cause of the syndrome.
A team of scientists has simulated spontaneous symmetry breaking (SSB) at zero temperature using a quantum processor. The system evolved from an antiferromagnetic state to a ferromagnetic quantum state, revealing the formation of ordered patterns and quantum entanglement.
A study by the Center for Redox Processes in Biomedicine presents a valuable new experimental model for investigating the interaction between the proteasome and mitochondrial function. The proteasome plays a role in protein quality control, while mitochondrial metabolism affects protein degradation efficiency.
Researchers have discovered how FGF19, produced in the intestine, acts on specific regions of the brain to regulate energy expenditure. The hormone stimulates thermogenic adipocyte activity, leading to increased fat burning and improved blood glucose levels in obese animals.
Brazilian researchers have identified a link between the oral bacteria Fusobacterium nucleatum and head and neck cancer, finding that its presence is associated with a more favorable prognosis. The study suggests that F. nucleatum may regulate immune factors, boosting the immune system's response and making tumors less aggressive.
Researchers found high mercury levels in fish and shellfish consumed by lagoon residents, leading to systemic oxidative stress and metabolic alterations. The study's findings suggest a link between mercury contamination and chronic diseases like diabetes and hypertension.
A team of researchers from the University of São Paulo identified agrin as a crucial protein in maintaining bone mass and quality. The study found that osteocytes produce agrin, which plays an essential role in preserving bone health. Without agrin, bone tissue becomes less dense and more fragile, making bones susceptible to fractures.
A study found that droughts can decrease nectar calories in zucchini flowers by up to 95%, harming pollinators and plants. Increased rainfall can positively affect nectar calorie production, but heavy rainfall events can have devastating consequences for ecosystems.
A team of researchers developed a plant-based meat substitute using sunflower flour, which is rich in protein and has a neutral taste. The product's texture and composition were found to be comparable to traditional meat products.
The experimental drug SANA has been shown to prevent fat accumulation, treat existing obesity, and reverse associated metabolic disorders. In animal tests, it activated thermogenesis through an unconventional mechanism, targeting adipose tissue cells to produce heat without involving the UCP1 protein.
Research reveals that children with OCD have significantly higher rates of rare copy number variants in their DNA compared to healthy children. The study's findings support previous studies and pave the way for future research into earlier diagnosis and targeted treatments.
A study published in Scientific Reports found that a combination of exercise and omega-3 supplementation significantly improves the immune response and reduces the severity of chronic apical periodontitis. The researchers induced apical periodontitis in rats, dividing them into three groups: one received no intervention, while the othe...
FAPESP is hosting researchers and startups from São Paulo in France to present their health and aeronautics research, strengthening international collaborations. The event includes scientific forums, startup pitches, and networking opportunities.
A new tool, called the Condition Assessment Framework, makes it possible to assess the ecological equivalence of an area to be restored or protected in relation to a degraded area. It considers three important attributes: biodiversity, landscape, and ecosystem services.
The article discusses how emerging contaminants like agricultural pesticides and medicines are impacting water quality in developing countries. The presence of these pollutants is linked to toxic effects on humans and ecosystems, with many being undetected or under-regulated.
A wearable device developed by researchers in Brazil uses a camera and tactile signals to warn visually impaired users of obstacles above the waistline. The device was tested on 11 blind adults and showed promising results, with participants reporting feeling more secure and completing routes with ease.
Researchers from USP and FAPESP will present their work on various topics, including health, agriculture, and artificial intelligence. The event aims to promote strategic connections and international visibility for startups and researchers.
A recent study by Luiza Cesar Riani Costa and Diene Monique Carlos has provided insights into non-suicidal self-harm among adolescents. The booklet, featuring photographs and experiences of young people, offers a low-cost therapeutic and educational tool to address mental health concerns.
The study identified key proteins and signaling pathways involved in CAR-T cell therapy's efficacy, including cytokines, kinases, receptors, proteases, and chemical messengers. The findings pave the way for new treatment advances and potential biomarkers.
Researchers have developed a sustainable method for extracting sugars, organic acids, and phenolic compounds from corn stover using subcritical water. This process recovers high-value bioderivatives with yields up to six times higher than traditional methods, reducing energy costs and time.
Researchers have developed a method to convert carbon dioxide into methanol, a versatile compound used in fuels and plastics. The process involves hydrogenating CO2 with the help of catalysts, which can produce e-fuels that are sustainable alternatives to traditional fossil fuels.
A study by researchers at the University of São Paulo found that women with low muscle mass have a significantly lower survival rate than those with normal muscle mass. Muscle mass is crucial for patients undergoing cancer treatment, and low levels can predict adverse outcomes, including mortality.
A study found that 72.5% of young Brazilian women suffer from symptoms like itching, discharge, and pain during intercourse, negatively affecting quality of life and sexual health. The research suggests that vulvovaginal symptoms are often normalized, leading to undertreatment and emphasizing the need for more intimate health education.
Researchers have developed a new approach to regularize the theory of critical phenomena by generalizing statistical mechanics. The new method, based on non-additive entropy, provides finite values for quantities that diverge in traditional theories, offering insights into complex systems.
A recent study found that fully protected marine areas in Brazil are contaminated by microplastics, with an average concentration of 0.42 particles per gram of wet tissue. The contamination was detected in all ten integral protection areas studied, with the highest levels found in the Alcatrazes Archipelago Wildlife Refuge.
Researchers found that insulin signaling changes affect both Alzheimer's disease and epilepsy in animal tests. This discovery confirms clinical evidence of increased risk of Alzheimer's in people with epilepsy and highlights the need for a broader therapeutic approach to address the complex nature of Alzheimer's disease.
The São Paulo School of Advanced Science on Ocean Literacy is open to graduate students, postdoctoral researchers and professionals interested in ocean science and sustainability. The school will bring together experts and participants for a transdisciplinary discussion on the UN Ocean Decade's Vision 2030 ambitions.
A new process has been developed to extend the lifetime of perovskite solar cells, allowing them to maintain their efficiency for longer periods. The study found that incorporating formamidinium cations into methylammonium-based perovskites increased their durability and stability.
A study by the University of São Paulo found a direct relationship between personality traits and insomnia, revealing that high levels of neuroticism are common among insomniacs. High openness was associated with low levels of insomnia, while anxiety played a key role in perpetuating the disorder.
Researchers at A.C.Camargo Cancer Center developed a more powerful version of CAR-T cells by inhibiting the epigenetic alterations that made them inefficient against non-Hodgkin's lymphoma and acute lymphoblastic leukemia. This modification resulted in improved treatment efficacy, tumor elimination, and reduced side effects.
Researchers have discovered that microalgae species can remove antibiotic residues from water, including sulfamethoxazole and trimethoprim. This process also produces biomass with potential commercial value, including biodiesel production.
Researchers have developed a low-cost, nanotechnology-based praziquantel formulation that increases efficacy and reduces dosage for treating worms. The new formulation, requiring only half the usual dose, demonstrates greater efficacy in eliminating schistosomes than the active ingredient alone.
Brazilian researchers found that hevin, a glycoprotein produced by astrocytes, increases connections between neurons and improves cognitive function in aged rodents. The study provides insight into the role of astrocytes in Alzheimer's disease and offers potential new treatment strategies.
A study proposes five action fronts for civil defense units to increase their organizational capacity, including professionalization and resource allocation. Municipalities face challenges such as monitoring urban expansion, lack of financial resources, and social participation.