The São Paulo School of Advanced Science on High-Dimensional Modeling offers minicourses and sessions to enhance data professionals' training in machine learning and finance. Key challenges related to forecasting, asset allocation, and climate econometrics will be addressed through state-of-the-art science and research.
A recent study has identified 51 amyotrophic lateral sclerosis (ALS)-associated mutations in mitochondrial DNA that could help diagnose the disease. The mutations, which include 13 that increase the risk of ALS and 38 protective ones, were found to be significantly associated with an increased or decreased risk of developing the disease.
Researchers found that participants with Parkinson's who performed rapid side-to-side eye movements showed reduced body sway and improved posture. In contrast, those with Parkinson's who made vertical saccadic eye movements experienced increased body instability.
Brachycephalus dacnis is the seventh species of flea toad identified in the genus Brachycephalus. The study published by a group at the State University of Campinas provides detailed information about its anatomy, skeleton, and internal organs.
Researchers at UNICAMP suggest that many species thought to be cosmopolitan may actually be misidentified, leading to a greater diversity of tardigrade species in Central and South America. The study proposes ignoring historical records and focusing on recent descriptions to better understand the species' distribution patterns.
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.
A new work plan will facilitate joint funding of research projects in areas like Cultures, Agri-food, Technology, and Health. The first joint call for proposals is scheduled for April 2025.
A Brazilian study found that high blood pressure hardens the bronchi and increases airway resistance, reducing respiratory capacity. Regular physical activity may partially protect against this hardening.
The article discusses how AI tools are transforming the architectural design process, enabling faster production of options for clients. Startups like Arqgen and SleepUp are leveraging generative design techniques to create innovative solutions for interior design and real estate development, respectively.
The school will focus on methods to address structural safety and infrastructure resilience challenges in a climate change context. Key findings include the importance of increasing infrastructure resilience to reduce social wellbeing impacts.
Researchers analyzed mice infected with herpes virus and found that removing STING from nociceptors resulted in significant reduction of pain without affecting inflammation or viral load. The discovery may apply to other viral and bacterial infections, including COVID-19.
Brazilian researchers are transforming Agave sisalana into a sustainable bioenergy source for the semi-arid climate region, requiring less water and fertilizer than sugarcane. The team has developed genetically modified yeasts to metabolize inulin and biostimulants to accelerate agave growth.
Researchers have characterized a novel class of proteins in the parasite Leishmania infantum involved in regulating its cell cycle, which could lead to the development of more effective drugs against visceral leishmaniasis. The discovery highlights six F-box proteins essential for L. infantum growth and development, providing potential...
Researchers at São Paulo State University used condensed matter physics concepts to describe protein compartmentalization in cells. The study proposes a cellular Griffiths-like phase that may be linked to the origin of life and the emergence of primordial organisms.
Researchers found that extreme temperatures and humidity projected for the Amazon under climate change may increase methane-producing microorganisms in flooded areas and reduce methane uptake in upland forests by 70%. This could lead to a shift in the balance of greenhouse gas emissions, with significant global impacts.
A study found that environmental factors like sea surface temperature, wave energy, and freshwater discharge have a greater impact on marine organisms' size and abundance than ecological processes. In colder waters, marine organisms are larger, with filter feeders growing up to 130% larger.
A Brazilian study published in PNAS suggests that life on Earth was more diverse than classical theory suggests 800 million years ago, with multiple lineages of amoebae and ancestors of plants, algae, and animals already established. The study's findings challenge the long-held paradigm for the Neoproterozoic period and provide new ins...
A study published in Science reveals that ancient asteroid impact may have led to the evolution of fungus-farming ants, which were able to cultivate fungi due to a shortage of food sources. The findings support the hypothesis that this relationship defines the emergence of agriculture.
Researchers found that prenatal exposure to synthetic cannabinoid led to cardiovascular problems in female rats and increased respiratory sensitivity to carbon dioxide in male rats. Sleep quality also deteriorated in both sexes, with males experiencing sleep fragmentation due to frequent wakefulness episodes.
Researchers at the University of São Paulo developed a synthetic peptide that mimics the ACE2 receptor, blocking SARS-CoV-2 invasion and reducing inflammation in human lung cells and mice. The peptide could be customized for every variant, offering a fast-acting molecular shield against the virus.
In Dominica, Hurricane Maria killed most Purple-throated caribs, allowing other birds to pollinate heliconia plants. Researchers found that specialized pollination systems can become generalized after natural disturbances, showing resilience in ecosystems.
The Pantanal's soda lakes, characterized by high pH and salinity, have practically dried up due to rising temperatures and wildfires. The study found that certain types of lakes, such as eutrophic turbid lakes, emit methane due to cyanobacterial blooms and decomposing organic matter.
Researchers propose a two-pronged attack on the enzyme glutaminase and protein HuR to combat breast cancer. Simultaneous inhibition of both is shown to significantly reduce breast cancer cell growth and invasion by increasing dependence on glutamine.
A study found that nitrogen-fixing bacteria in soil enhance flowers' attractiveness to bumblebees. Plants with these bacteria grew significantly taller and larger than those without, and their flowers became more vibrant and attractive to pollinators.
A recent study published in Perspectives in Ecology and Conservation highlights the urgent need for Brazil to reinforce protection of its forests to achieve its greenhouse gas emission reduction targets. The research emphasizes the importance of strengthening socioenvironmental actions and policies focusing on conserving or restoring f...
A recent study tested the standard model of solar flares by comparing computer simulations with observational data from the McMath-Pierce telescope. The researchers found a significant delay in the paired chromospheric sources, which challenges the current energy transport mechanism by electron beam. This delay suggests that other fact...
Researchers at the University of São Paulo have discovered a way to detect peroxymonocarbonate, a potent oxidant derived from CO2, in human cells. The novel method uses fluorescent molecular probes and has implications for understanding the impact of high CO2 levels on human health.
A study by University of São Paulo shows that expansion of cattle ranching to meet growing domestic demand has contributed more than any other driver to Amazon's original vegetation degradation. Domestic markets exert far greater pressure on deforestation, according to the study.
Researchers found that Brazilian vegans' diets consisted mainly of unprocessed foods, with a significant reliance on ultra-processed proteins like textured soy protein to meet their protein needs. The study's findings contradict the stigma surrounding veganism and its ability to provide adequate nutrition.
Researchers confirm 15 new species in Characidium genus, including genetic distance smaller than 2% between species with significant morphological differences. The study highlights the need for reevaluation of species classification and evolutionary history.
A study published in PNAS estimates that over 3,000 species are at risk of extinction due to earthquakes, hurricanes, tsunamis, and volcanic eruptions. The researchers found that 42% of these species live in regions where one or more of the four natural hazards have occurred in the past 50 years.
A study published in Metabolism revealed a new mechanism for glucose production in the liver during stress. CREB and CRTC2 proteins were found to be involved in activating gluconeogenesis, a key metabolic function of the liver that helps maintain normal blood sugar levels.
A study found that high-intensity interval training (HIIT) combined with muscle strength exercises was the most efficacious in improving cardiovascular parameters, including waist circumference, blood pressure, and arterial stiffness. HIIT was more beneficial than moderate exercise or resistance training alone.
A Brazilian research team has identified a key gene responsible for the virulence of Aspergillus fumigatus, a fungus that causes severe lung infections. By silencing this gene, the researchers found that the fungus became less virulent and more susceptible to existing medications.
A study analyzing 47 fatal COVID-19 cases reveals two distinct disease pathways: one characterized by high viral load and low inflammation, the other by exacerbated lung inflammation. The findings suggest that understanding these molecular mechanisms can inform treatment decisions for critical cases.
Researchers at Tecnolat have identified three Lactobacillus strains with probiotic properties, safe for consumption, and beneficial to human health. These strains can also enhance the sensory diversity and microbiological quality of traditional Brazilian cheeses.
A study found that Brazilian women are giving birth too early, impairing the health of their babies, due to manipulation of birth timing around Carnival. Preterm deliveries via cesarean section lead to reduced gestational age and birth weight, especially in high-risk pregnancies.
Scientists at the University of São Paulo found that converting degraded land to climate-smart agricultural practices can significantly reduce greenhouse gas emissions in Brazil. The study highlights the need for more data and research opportunities to support the development of carbon markets and green finance mechanisms.
A study in Current Biology mapped a brain circuit responsible for detecting threats and forming fear memories. The hippocampus and subiculum are key structures involved, with the subiculum transferring information to the hypothalamus.
A study of over 900 children with autism spectrum disorder found that brain overgrowth is associated with increased social and communication symptoms. The research used MRI brain images and mini-brain experiments to show that enlarged brains are linked to altered Ndel1 enzyme activity, potentially affecting brain development.
SARS-CoV-2 uses machinery of defense cells to induce expression of unproductive isoforms of key antiviral genes, disrupting normal protein production and immune response. The study provides fundamental information on potential targets for antiviral medications and immunomodulatory interventions.
A study at UFSCar found that remote testing can be reliable for functional mobility and muscle strength, especially for those with dementia. This new methodology enables more frequent health sessions and better patient tracking.
Researchers found a Leishmania amazonensis strain resistant to amphotericin B, a widely used treatment for cutaneous leishmaniasis. The study highlights the urgent need for alternative drugs to combat the disease, which affects over 15,000 people in Brazil annually.
A study by researchers at São Paulo State University found that dopaminergic medication levodopa improves sleep quality in Parkinson's disease patients. The number of times patients woke up during the night fell by 25% and the amount of time they remained awake fell 30% on average.
Researchers have developed a chip-based quantum system that can detect unauthorized access in quantum communication, using entangled four-photon states. This technology has the potential to strengthen data security and protect sensitive information from cyber threats.
A study in São Paulo state found that peer-to-peer certified organic farms had an average of 58.8 organic items, while conventionally certified farms had only 22.2. This greater diversity includes native and medicinal species, contributing to a more sustainable and biodiverse organic farming system.
A group of scientists discovered that the Black and white tegu lizard can raise its own body temperature during the reproductive season, even in a dark burrow. The study found that this phenomenon is due to the increased production of mitochondria and a protein called ANT, which generates heat.
The study found that Tipuana tipu grows faster at higher temperatures and can contribute to urban climate resilience. The tree can thrive in restrictive weather conditions, providing ecosystem services such as carbon capture and temperature regulation.
A study by UNESP found that smoke from two concentrations stimulates germination in 32% of plant species, with some grasses growing faster. The results could aid restoration strategies for degraded areas and offer a competitive advantage to certain Cerrado species after fires.
Researchers discovered that strigolactones, previously only associated with plant development, directly influence flowering and fruiting in tomatoes. By regulating the microRNA319 pathway and gibberellin levels, strigolactones promote faster and better flowering, leading to increased yields.